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अखिल भारतीय आयुर्विज्ञान संस्थान, नई दिल्ली
All India Institute Of Medical Sciences, New Delhi

Research

RESEARCH :

Funded projects

Ongoing

S. No.

Title of the project

Name of Principal Investigator

Funded by (Name of funding agency)

Duration (years)

Start year – End year

Total funds sanctioned (Rs)

 1

Centre for Medical Innovation and Enterpreunership

Alok Thakar

(AIIMS BioNEST)

4

2020 - Ongoing

4.75 crore

 2

A study on frailty, cognitive dysfunction and associated comorbidities with Hearing loss in Geriatric population

Kapil Sikka

ICMR

3

2024-2027

30.9 Lakhs

 3

Intraglandular Botulinum Toxin BoNT Injection for Postoperative Head and Neck Fistula Healing- A Pilot Study

Smriti Panda

Intramural early career grant

2

2024-2026

5.85 Lakhs

 4

Prevention of Radiotherapy Induced Xerostomia by intraductal administration of N- Acetyl Cysteine in patients with Oropharyngeal malignancies: A Randomized Clinical Trial

Arvind Kumar Kairo

ICMR

4

2020-2024

36 Lakhs

 5

Local application of specific Unani drug for medical management of oral submucosal fibrosis (OSF) a randomized clinical control trial

Arvind Kumar Kairo

CCRUM

2

2023-24

35 Lakhs

 6

Phased pilot study to assess the baseline of serum level of Prestin in healthy individuals and in patients of definite Meniere’s Disease as a biomarker of cochlear outer hair cell functional status

Dr Prem Sagar

AIIMS

 

 

5 Lakhs

 7

To evaluate nasal eosinophilic miRNAs as potentially diagnostic, prognostic and predictive biomarkers in allergic rhinitis

Dr Shuchita Singh

AIIMS

2

2022-24

5 Lakhs

 8

Transorbital approach to infratemporal Fossa - A cadaveric exploratory Study

Dr Anup Singh

AIIMS

1 year

Jan 2024

5 Lakhs

 9

Exome sequencing and molecular characterization in juvenile nasopharyngeal angiofibroma (COLLOBRATIVE PROJECT)

HITESH VERMA/ DR BHUPINDER VERMA

AIIMS

2

2021-23

20 Lakhs

 10

Development of single-cell derived clonal spheroids as a tool for drug discovery in cancer research with focus on Head and Neck Cancer

DR R.P.SINGH/ DR HITESH VERMA

DST

4

2019-23

3 Crores

11 

Prospective study to evaluate the role of Systemic Bevacizumab therapy in patients with aggressive and complex laryngotracheal and pulmonary recurrent respiratory papillomatosis.

Dr Rajeev Kumar

AIIMS Intramural Collaborative Research Project

 

2

2021-23

20 Lakhs

 12

Study to determine the role of mTOR pathway in the pathogenesis of juvenile nasopharyngeal angiofibroma

Dr Rajeev Kumar

AIIMS Intramural Research Project

1

2021-23

5 Lakhs

 13

Phased pilot study to assess baseline serum level of Prestin in healthy individuals and in patients of definite Meniere’s disease and ototoxicity as a biomarker of cochlear outer hair cell functional status

Dr Prem Sagar

AIIMS, New Delhi

Intramural project, A-832

3

2020-23

4.5 Lakhs

 14

Device fabrication and clinical validation of a novel mechanical handheld suction device for tracheostomy tube cleaning: a pilot study

Dr Prem Sagar (chief guide), Dr Ritu Dudi (PG thesis candidate)

AIIMS, New Delhi

2

2023-25

2 Lakhs

 15

Clinical validation of the effectiveness of automated speech therapy for stuttering delivered by digital means

Shuchita Singh Pachaury

BIRAC

2 years 3 months

2020-22

10 Lakhs

 16

To determine the efficacy of outpatient antimicrobial therapy (OPAT) with Liposomal amphotericin B in invasive sinonasal mucurmycosis, a randomised controlled trial

Dr. Poonam Sagar

Research section, AIIMS, Delhi

Two years

2024-2026

10 Lakhs

 

Completed :

 

S. No.

Title of the project

Name of Principal Investigator

Funded by (Name of funding agency)

Duration (years)

Start year –End year

Total funds sanctioned (Rs)

 

Evaluation of factors impacting outcomes of cochlear implants in pediatric population

Kapil Sikka

ICMR

3.5 Years

2029-2023

35.3 Lakhs

 2

Sound4All: Re-Engineering High end audiometric devices for robust and affordable audiological testing phase II

Kapil Sikka

IGSTC (Indo German Science and Technology Center)

4

2019-2023

36 Lakhs

 3

An evaluation of HLA, phagocytic function and trace elements in cases of sinusitis, invasive fungal sinusitis and non-invasive fungal sinusitis

Hitesh Verma

AIIMS

4

2019-23

10 Lakhs

 4

ACE-2 receptor expression in sino-nasal mucosa in patients with COVID 19 associated mucormycosis

Hitesh Verma

AIIMS

2

2021-23

3.7 Lakhs

 

Departmental projects (including thesis/dissertations) :

Ongoing

S. No.

Title of the project

 1

A pilot study to assess the effect of intraductal N acetyl cysteine on swallowing and voice outcomes of patients with oropharyngeal cancer undergoing radiotherapy

 2

To compare different Cochlear Implantation outcome scores with auditory cortical activity seen on functional near infrared spectroscopy in prelingual profound SNHL patients after Cochlear Implantation

 3

Analysis of voice outcomes after radiation or chemo radiation  in carcinoma larynx and the effect of N acetyl cysteine on voice parameters

 4

Evaluation of respiratory and voice outcomes in patients with unilateral vocal cord palsy post injection laryngoplasty

 5

Exome sequencing and molecular characterization in juvenile nasopharyngeal angiofibroma

 6

A   prospective   study   to   measure   the   objective,   subjective   and   aesthetic Outcomes in patients undergoing Septorhinoplasty

 7

A comparative study to evaluate functional outcomes following tongue reconstruction with radial artery forearm free flap and infrahyoid myocutaneous flap

 8

A single institutional prospective audit of type-1 tympanoplasty and evaluation of factors affecting the outcome.

 9

to compare post cochlear implant outcome in candidates with and without residual hearing (RH) 

 10

 Descriptive study of the anatomical variations of the superficial temporal artery and the posterior auricular artery in the patients with unilateral microtia and its implications on the surgical outcomes in auricular reconstruction surgery 

 11

To evaluate prospective auditory cortical activity changes on functional near infrared spectroscopy in prelingual profound snhl patients undergoing cochlear implantation

 12

Serum prestin and otolin-1 as markers of cisplatin-induced ototoxicity in cervical cancer patientsThesis

 13

Role of Adjuvant Therapy in Early-Stage Oral Cavity Squamous Cell Carcinoma: An Ambispective Analysis

 14

Ambispective study to assess Universal Newborn Hearing Screening Program

 15

Comparative evaluation of CAD- CAM planning versus traditional free fibula planning in surgical outcomes in mandibular reconstruction-A prospective study

 16

Correlation of Depth Of Invasion with Lymph node Metastasis in Laryngeal and Hypopharyngeal carcinoma

 17

A prospective study to evaluate role of various frailty screening instruments in predicting surgical complications in geriatric head neck cancer patients.

 18

Comparative study evaluating Ex-Vivo US aided deep margin assessment with fresh frozen section analysis in T1-T3 tongue carcinoma: Feasibility study

 19

Ambispective study to assess various primary tumour and ipsilateral nodal factors associated with contralateral nodal metastasis in patients with OCSCC

 20

Study evaluating the effectiveness of Barbed suture versus Vicryl suture for pharyngeal closure after total laryngectomy in PCF reduction

 21

Prospective analysis of predictive factors for tracheal stomal stenosis after total laryngectomy for laryngeal and hypopharyngeal malignancies(2021 -2023, Non funded study)

 22

Role of ultrasound in predicting the depth of tumour invasion and lymph node metastasis in early tongue carcinoma.(2017-till date, Non-Funded Study)

 23

Evaluation of short term and long-term effects of cochlear implantation on vestibular function

 24

A prospective cohort study to evaluate the feasibility and accuracy of fetal vibroacoustic stimulation as a prenatal hearing screening tool

 25

Device fabrication and clinical validation of a novel mechanical handheld suction device for tracheostomy tube cleaning: a pilot study

 26

Short & Long term effects on vestibular apparatus of cochlear implant

 27

A Prospective study to measure the objective, subjective and aesthetic outcomes in patient undergoing Septorhinoplasty

 27

Prospective study to correlate rhinomanometry in DNS patients with endoscopy, NOSE score and NCCT PNS study

 28

A Randomized Control Trial to compare the outcomes of endoscopic and microscopic stapes surgery

 29

Prospective study to evaluate the efficacy of PNN as treatment modality in patient with PAR along with medical management

 30

To evaluate poor prognosis factors in laryngotracheal stenosis: An ambispective study

 31

Impact of NACT on surgical decision and perioperative outcome in patient with very advanced buccal cancer

 32

A randomised control trial on the effectiveness of anti fungal and stetoid nasal douching in allergic fungal rhinosinusitis: a clinical, radiological and biochemical corelation

 33

Descriptive study of the anatomical variations of the superficial temporal artery and the posterior auricular artery in the patients with unilateral microtia and its implications on the surgical outcomes in auricular reconstruction surgery

 34

Prospective audit of tympanoplasty and evaluation of factors affecting the outcome

 35

To assess the outcomes of lateral skull base lesions who have been surgically operated with special reference to quality of life

 36

Prospective assessment of auditory and cognitive performance in children undergoing ear surgeries: A comparative study

 37

Comparative analysis of qPCR, mRNA ISH and p16 IHC for detection of high risk HPV on fine needle aspirates and core needle biopsies in patients with metastatic squamous cell carcinoma in cervical lymph nodes

 38

Role of preoperative nutritional intervention in improving surgical outcome of patients with oral squamous cell carcinoma

 39

Effect of intranasal corticosteroids and antihistaminics v/s omalizumab on adenoid hypertrophy

 40

Effect of Palatal Morphology on Eustachian Tube Function in Children with Adenoid Hypertrophy: an Observation Study

 41

Assessment of pre-cervical (perimarginal and lingual) lymph nodes as first echelon for squamous cell carcinoma of oral cavity

 42

Adversity and QOL Post Treatment of Laryngeal and Hypopharyngeal Cancer and Impact of Novel AIMS-IIT-TEP in its Mitigation.

 43

Evaluating the effectiveness of Barbed suture versus Vicryl for pharyngeal closure after total laryngectomy in PCF reduction: A Randomised controlled study

 44

A Study analysing "Back to Normalcy" in Oral Cavity Cancer Survivors

 45

A prospective study to evaluate the role of various frailty screening instruments in predicting surgical complications in geriatric head neck cancer patients.

 46

Sentinel lymph node detection in oral squamous cell carcinoma with negative neck: comparison between [99mTc] Sulphur colloid AND [99mTc] DTPA ANTICytokeratin- Collagenous Nanoparticle (DC-Col NP)

 

Completed :

S.No.

Title of the project

 1

A Prospective Study to evaluate the impact of Oral Sub mucous Fibrosis (OSMF) on occult and overt lymph nodal metastases in Gingivo-buccal complex carcinomas (GBCC) (T1-T4a) of Oral cavity

 2

A prospective study to determine early predictive factors of hypocalcemia in patients undergoing total or completion thyroidectomy

 3

Prospective pilot study to assess the effectiveness of novel Forehead Knuckle Tapping method in localisation of better or worse hearing ear as compared to conventional tuning fork testing

 4

A prospective pilot study to evaluate the effect of Supraglottoplasty on Tracheomalacia in pediatric patients with Congenital Laryngotracheomalacia

 5

An ambispective cohort control study to evaluate the incidence of SARS CoV-2 infection in post Adenoidectomy/Adenotonsillectomy patients

 6

Comparison Of Suction Verses Microdissection Method For Harvesting Supporting Cell From Inner Ear

 7

Observational study to correlate site of obstruction in OSA with eustachian tube dysfunction and reflux disorders

 8

Ambispective study to evaluate the utility of Supraclavicular artery island flap [SCAIF] reconstruction in Head and Neck Cancers

 9

A cohort study on determining the effect of preoperative residual hearing on post cochlear implant outcome

  

Collaborative projects :

Ongoing

S. No.

Title of the project

Collaborating department/institution

 1

To evaluate the role of Kit-based Loop-Mediated Isothermal Amplification (TB-LAMP) assay in the diagnosis of Extra-pulmonary tuberculosis (EPTB)

Medicine Department

 2

Analysis of circulating DNA for BRAF (T 1799A) mutation as a futuristic non-invasive tool for diagnosis, prognostication, targeted therapy and folloW-up of papillary thyroid cancer

Pathology

 3

Phase IIb/III Study to determine efficacy of curcumin and Metformin to reduce the incidence of Second Primary tumors of Aero-digestive tract in patients with history of head and neck squamous cell carcinoma

National Cancer Grid

 4

Clinical validation of the effectiveness of automated speech therapy for stuttering delivered by digital means

BIRAC

 5

Effect of Cochlear implantation on middle ear and saccular function

Collabrative project with AIISH, Mysuru

 6

Molecular characterization of olfactory neuroblastomas for classification into prognostically and therapeutically relevant subgroups.

Dr. Aanchal Kakkar ( Pathology- PI).

 7

Evaluation of Machine Learning Techniques including Deep Learning for the Identification of Malignancy in Tissue Samples.

AIIMS- IIT Delhi Joint Collaborative

Funding 019-2021, Dr. Aanchal Kakkar ( Pathology - PI).

 8

Inter- institutional program for maternal neonatal and infant science : A translational approach- interdisciplinary group for advanced research on birth outcome

DBT India initiative ( GARBH- Ini-Phase II)

 9

A study on the effect of genetic manipulation on mammalian inner ear cells

Dept of Biochemistry

 10

Exome sequencing and molecular characterization in juvenile nasopharyngeal angiofibroma

Biotechnology/ AIIMS

 11

Evaluation of specific molecular alterations and tumor immune microenvironment for detection of clinically actionable targets in high grade salivary gland carcinomas

ICMR Funded, Department of Pathology

 12

The SWOAR trial: A phase III trial evaluating dysphagia-aspiration related structures & submandibular gland sparing Intensity modulated radiotherapy (SWOAR-IMRT) versus standard IMRT in Head and neck squamous cell carcinoma

Department of Radiotherapy

 13

The tumour immune microenvironment of follicular cell -derived thyroid carcinomas across different grades utilizing gene expression and spatial proteomic profiling

Department of Pathology

 14

Role of celecoxib in reducing cognitive impairment in patients receiving definitive chemoradiation for head and neck carcinoma: A phase II randomized placebo controlled trial

Department of Medical Oncology

 15

Potentially malignant lesion atlas project: Validating the efficacy of a novel, Point-of -care diagnostics and developing an integrated multidimensional, prognostic nomogram

ICMR funded, Department of Preventive Oncology, NCI AIIMS

 16

Comparative analysis of qPCR, mRNA ISH and p16 IHC for detection of high risk HPV on fine needle aspirates and core needle biopsies in patients with metastatic squamous cell carcinoma in cervical lymph nodes

Collaborative Intramural, AIIMS

 17

A Phase III , Randomized Controlled Study of Utility of Pectoralis Major Myofascial Flap in Reducing Pharyngocutaneous Fistula Rates After Salvage Total Laryngectomy.

TMH

 18

A randomised, sham controlled, double blind study to evaluate the efficacy of and safety of intra-thecal OAV101 in patients with later onset type-2 spinal muscular atrophy who are ≥ 2 to < 18 years of age, treatment naive, sitting, and never ambulatory.

A phase 3 Clinical trial (STEER) by Novartis Pharmaceuticals. ClinicalTrials.gov Identifier: NCT05089656.

 19

Prevalence and pattern of traumatic dental injury in children and adolescents with severe to profound hearing impairment reporting to a tertiary care centre in North India

Pediatric Dentistry, CDER, AIIMS, New Delhi

 20

Comparison of pulsed radio-frequency versus conventional radio-frequency in secondary glossopharyngeal neuralgia: a randomised controlled trial

Department of Anaesthesiology, AIIMS, New Delhi

 21

Perioperative anaesthetic management of paediatric congenital laryngomalacia- A retrospective study

Department of Anaesthesiology, AIIMS, New Delhi

 22

A Phase II trial of Pentoxiphylline and alpha tocopherol (PAT) in prevention of radiation induced dysphagia in head and neck squamous cell carcinoma

Radio-therapy

 23

A Phase III prospective randomised trial comparing dysphagia-aspiration related structures & submandibular gland sparing Intensity modulated radiotherapy (SWOAR-IMRT) versus standard IMRT (s-IMRT) paring in locally advanced oropharyngeal and laryngeal carcinomas

Radio-therapy

 24

Ultrasonographic assessment of tonsillar volume in children undergoing tonsillectomy : a predictor of post operative morbidity

Anaesthesiology

 

 

Complete

S. No.

Title of the project

Collaborating department/institution

 

To Understand the Biochemical and Molecular Basis of Mucormycosis in COVID-19 Patients

Dept of Biotechnology

 2

Evaluation of genetic profile of olfactory neuroblastoma

Department of Pathology

3

Comparison between kit based and in-house preparation of Tc -99m Ubiquicidin

Department of Nuclear Medicine

 4

Utility of 99m Tc- Ubiquicidin scintigraphy in diagnosis of sinonasal mucormycosis

Department of Nuclear Medicine

 5

Utility of Ga - 68 - NOTA- UBI in infectious and non- infectious lesions

Department of Nuclear Medicine

 6

A phase II study of EMF (Erlotinib+ Methotrexate+ Celecoxib) in platinum refractory recurrent /metastatic head neck squamous cell carcinoma

Department of Medical Oncology

 7

Assessment of Oral Microbiome and its significance in upper aerodigestive tract cancers

Department of Medical Oncology

 8

A cohort study to assess the feasibility of WHO ICOPE approach in tertiary health centres

Department of Geriatrics, AIIMS, New Delhi

 9

A longitudinal Survey to assess Patient Satisfaction for Nurse Initiated Follow Up Tele-Consultation among patients discharged from a selected tertiary care hospital

Nursing department

 10

An OMR sheet based feed-back survey on in-patient satisfaction regarding various hospital services in a selected tertiary care hospital

Nursing department

 

 

 

 

 

 

 

 

 

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