Dr. Ajay Godwin Potnuri

Scientist -I

Department of Pharmacology

A.I.I.M.S, New Delhi-110029

डॉ. अजयगॉडविनपोटनुरी

वैज्ञानिक-I

भेषजगुणविज्ञानविभाग,

अ. भ. आ. सं., नईदिल्ली-110029

Contact Details: 4th Floor, Department of Pharmacology, Teaching Block, All India Institute of Medical Sciences (AIIMS), New Delhi 110029

Telephone: 011-26593677

Email ID:  यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

Education:

• B.Pharmacy from Andhra University, Visakhapatnam
• M.S (Pharm) in Pharmacology and Toxicology from National Institute of Pharmaceutical Education and Research, Guwahati
• Ph.D in Biological Sciences from Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thriuvananthapuram
• ICMR PDF from ICMR NARFBR, Turkapally, Shamirpet, Hyderabad

Research Interest/ area:

Cardiovascular Pharmacology and toxicology with a special emphasis on hypertensive heart disease and vascular biology

Past Position:

• Assistant Research Officer (Pharmacology) at National Ayurveda Research Institute for Panchakarma, Cheruthuruthy, Thrissur, Kerala (Jan’ 2021 – Sep’ 2022)

Ongoing Projects:

• Evaluation of Guduchi Sattva for its anti-platelet and thrombolytic potential using in-vitro and in-vivo experimental models, funded by Indian Council for Medical Research. [Budget:15,90,000]

Completed Projects:

• Acute and 90 days Toxicity profiling of AYUSH 64, funded by Central Council for Research in Ayurvedic Sciences. [Budget:18,97,450]
• Understanding the role of FFAR2 In Modulating atherosclerosis in WNIN/Ob rat, funded by Indian Council for Medical Research. [Budget:21,60,000]

Selected Publications:

1. Targeting histamine-2 receptor for prevention of cardiac remodeling in chronic pressure overload AG Potnuri, L Allakonda, A Appavoo, S Saheera, RR Nair Int J Card, 2016 202, 831833.

2. Histamine 2 receptor antagonism elicits protection against doxorubicin induced cardiotoxicity in rodent model, SK Kondru, AG Potnuri, L Allakonda, P Konduri, Molecular and Cellular Biochemistry, 1-12 , 2018

3. Syk–GTP RAC-1 mediated immune-stimulatory effect of Cuscuta epithymum, Ipomoea batata and Euphorbia hirta plant extracts VS Sudam, AG Potnuri, NJP Subhashini, Biomedicine & Pharmacotherapy 96, 742-749, 2018

4. Modulation of cardiac stem cell characteristics by metoprolol in hypertensive heart disease, S Saheera, AG Potnuri, RR Nair, Hypertension Research, Nature Publishing Group 2018 Feb 15. doi: 10.1038/s41440-018-0015-7.

5. Histamine-2 receptor antagonist Famotidine Modulates Cardiac Stem Cell characteristics in hypertensive heart disease, S Saheera, AG Potnuri, RR Nair, PeerJ. 2017 Oct 9;5:e3882. doi: 10.7717/peerj.3882. eCollection 2017.

6. Crocin attenuates cyclophosphamide induced testicular toxicity by preserving glutathione redox system, AG Potnuri, L Allakonda, M Lahkar, Biomedicine & Pharmacotherapy 2018 101, 174180

7. Association of histamine with hypertension induced cardiac remodelling and reduction of hypertrophy with Histamine 2-receptor antagonist famotidine in comparison with beta blocker metoprolol, AG Potnuri, L Allakonda, A Appavoo, S Saheera, RR Nair 2018. Hypertension Research, Nature Publishing Group

8. Protective effect of antioxidant Tempol on cardiac stem cells in chronic pressure overload hypertrophy, S Saheera, AG Potnuri, RR Nair, life sciences 2019, 222, 88-93

9. Involvement of Histamine 2 receptor in Alpha 1 adrenoceptor mediated cardiac hypertrophy and oxidative stress in H9c2 cardio myoblasts, AG Potnuri, L Allakonda, S Saheera, J Cardiovasc Transl Res. 2021 Feb;14(1):184-194.

10. Beta 1 adrenoceptor blockade promotes angiogenesis in hypertrophied myocardium of TAC Rat, L Allakonda, A. Kakaraparthi, AG Potnuri. Clinical and Experimental Pharmacology and Physiology 48 (1), 121-128.

ON-GOING  PROJECTS

AWARENESS/ OUTREACH

Project Title: “Assessment of awareness, perception and KAP (Knowledge, Attitude & Practices) related to common poisons and development of scientific communication modules for lifestyle modulation & year-round strategy for public awareness towards prevention of poisoning”.

Supported by- DST

PI- DR. SWATI SHARMA

National Poisons Information Centre (NPIC) in Department of Pharmacology, AIIMS, New Delhi initiated an outreach project with a theme BE CAUTIOUS, BE POISON SAFE. This theme aims to increase awareness towards poisons and poisoning among general public including Children, Parents and Occupational Workers. It also intends to increase knowledge regarding poisons and poisonous substances and disseminate knowledge of poison prevention measures that can be practiced to reduce the risk of accidental poisonings. It also advocates to adopt safe practices and enforce effective poison control measures.

Awareness activities organized in the past by National Poisons Information Centre (NPIC), AIIMS, New Delhi

Name: Dr. Devendra Singh

Designation: Scientist

Department: Pharmacology, AIIMS, New Delhi

Email: यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

Educational Qualification:

M. Pharm (Pharmacology Toxicology and Therapeutics), from BVCOP, Navi Mumbai, University of Mumbai.

Ph.D. (Pharmacology) from All India Institute of Medical Sciences, New Delhi.

Awards:

Qualified GATE 2009

Qualified GPAT 2010, 2012 and 2013

Area of Interest:

Neuropharmacology, Ischemic Stroke, Alzheimer’s Disease, Preclinical research

List of Publications:

1. Joshi B*, Singh D*, Wasan H, Sharma U, Dinda AK, Reeta Kh. Tideglusib ameliorates ischemia/reperfusion damage by inhibiting GSK-3β and apoptosis in rat model of ischemic stroke. J. stroke Cerebrovasc. Dis. 2022 Apr;31(4):106349. (IF- 2.677) (* equal first authorship)
2. Wasan H*, Singh D*, Joshi B, Deept Upadhyay, Sharma U, Dinda AK, Reeta Kh. Dihydromyricetin alleviates cerebral ischemia-reperfusion injury by attenuating apoptosis and astrogliosis in peri-infarct cortex. Neur. Res. 2021 Dec 9;1-12. doi: 10.1080/01616412.2021.1997010. (IF-2.529) (* equal first authorship)
3. Wasan H, Singh D, Joshi B, Sharma U, Dinda AK, Reeta Kh. Post stroke safinamide treatment attenuates neurological damage by modulating autophgy and apoptosis in experimental model of stroke in rats. Mol. Neurob. 2021 Aug 28. doi: 10.1007/s12035-021-02523-6. (IF-5.682)
4. Singh D, Wasan H, Reeta KH. Preclinical Stroke Research and Translational Failure: A Bird’s Eye View on Preventable Variables. Cell. Mol. Neurobiology. 2021 doi.org/10.1007/s10571-021-01083-6. (IF-4.231)
5. Wasan H, Singh D, Kh R. Safinamide in neurological disorders and beyond: evidence from preclinical and clinical studies. Brain Res. Bull. 2020 Dec 30: S0361-9230(20) 30735-8. (IF-3.715)
6. Verma V*, Singh D*, Reeta KH. Sinapic acid alleviates oxidative stress and neuro-inflammatory changes in sporadic model of Alzheimer’s disease in rats. Brain Sciences, 2020 Nov; 10(12): 923. (IF-3.333) (* equal first authorship)
7. Singh D, Wasan H, Reeta KH. Heme oxygenase-1 modulation: A potential therapeutic target for COVID-19 and associated complications. Free Radic. Biol. Med. 2020 Oct 19;161:263-271. (IF-8.101)
8. Singh D, Wasan H, Mathur A, Gupta YK. Indian perspective of remdesivir: A promising COVID-19 drug. Indian J. Pharmacol. 2020 May-Jun;52(3): 227-228. (IF-2.833)
9. Singh D, Reeta KH, Sharma U, Jagannathan NR, Dinda AK, Gupta YK. Neuro-protective effect of monomethyl fumarate on ischemia reperfusion injury in rats Role of Nrf2HO1 pathway in peri-infarct region. Neurochem. Int. 2019 June; 126: 96-108. (IF-4.297)
10. Reeta KH, Singh D, Gupta YK. Chronic treatment with taurine after intracerebroventricular streptozotocin injection improves cognitive dysfunction in rats by modulating oxidative stress, cholinergic functions and neuroinflammation. Neurochem. Int. 2017 Sep; 108: 146-156. (IF-4.297)