Dr. Neeta Singh
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- Last Updated on Friday, 19 September 2014 12:49
Dr. Neeta Singh
Professor & Head
Room No 3012, Department of Biochemistry, All India Institute of Medical Sciences Ansari Nagar, New Delhi-110029 Ph. No. 011-26589617 (O) Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Dr. Neeta Singh received her MSc (Medical Biochemistry) in 1972 and Ph.D. in Biochemistry in 1976 from Delhi University, Delhi, India. She joined AIIMS as Associate Professor in 1987 and became Professor in 2000. She was a Visiting Associate from 1992-93 at National Cancer Institute, USA under NIH Fogarty Program. She served a Post Doctoral Research Fellowship from 1979-1980 at Neurochemical Institute, Copenhagen, Denmark and from 1983-85 at Swiss Institute for Experimental Cancer Research, Switzerland. She received Danish Govt. Fellowship (DANIDA), Swiss Govt. Fellowship, ICRETT award of International Union against Cancer (UICC) in 1989 and 1997, UNDP award, Universitat/Witten award, Visiting Associateship of NIH Fogarty, USA, Fellowship of National Academy of Medical Sciences, India, membership of International Union against Cancer (UICC), American Association for Cancer Research, New York Academy of Sciences. She has distinguished herself in the field of cancer research and has made a significant contribution in understanding chemical carcinogenesis, ROS & signal transduction mechanisms, role of telomeres, telomerase in various cancers, HPV in cervical cancer, impact of apoptosis in health and disease (cancer), experimental cancer therapeutics and chemoprevention, effect of non-ionizing Electro Magnetic Field (EMFs-Mobile phone) on human health. She has 167 research publications to her credit.. She has 38 years of teaching experience. She is Vice President of Indian Association of Cancer Research.
Professional Society Membership:
- American Association of Cancer Research
- Indian Association of Cancer Research
- Association of Clinical Biochemists of India
- Society of Biological Chemists (India).
- International Union against Cancer (UICC).
- Association of Cell Biology (India)
- Indian Society of Lung Cancer
- Indian Women Scientists Association
- Society of Free Radical Research – India
- AGOICON
- Aogin-India
Fellow of National Academy of Medical Sciences, India
STUDENTS
- MD: Dr Seema Patel: Evaluation of effects of metformin on epithelial ovarian cancer (2011- ongoing)
- PhD:
- Sujata Pathak: Insights into the role of one carbon metabolism in the progression of cervical carcinogenesis (2013 –submitted )
- Ayan Bannerjee: Role of mitochondria in epithelial ovarian cancer – an in vivo and in vitro study (2013 – submitted )
- Deepti Bajpai: Evaluation of genetic alterations in DNA repair genes and mitochondrial DNA HPV associated cervical cancer progression (2010 – ongoing)
- Wahiduzzaman: Development of HPV18 candidate vaccine prototype (2011 – ongoing)
RESEARCH & IMPORTANT PUBLICATIONS
- Research interests :
- Chemical Carcinogenesis
- Apoptosis and its signaling pathways in human cancer
- Telomeres and Telomerase in Cancer
- Reactive oxygen species signaling and its relationship to cancer
- Experimental cancer therapeutic and preventives
- Human Papilloma Virus and Cervical Cancer
- Effect of non-ionizing Electro Magnetic Field (EMFs-Mobile phone) on human health
- Important Publications in the past 5 yrs:
- Singh M and Singh N. Induction of apoptosis by hydrogen peroxide in HPV-16 positive cancer cell lines – Involvement of mitochondrial pathway. Mol. & Cellular Biochemistry. 310(1-2): 57-65, 2008.
- Sharma H, Datta P, Singh A, Sen S, Bhardwaj NK, Kochupillai V and Singh N. Gene expression profiling in practitioners of Sudhershan Kriya. J. of Psychosomatic Research. 64(2): 213-18; 2008.
- Sen S, Bushra A, Sharma H, Datta P, Dutta GP, Bal S, Kumar A, Singh N. Molecular profiling of genes in squamous cell lung carcinoma in Asian Indians. Life Sciences. 82: 772-9; 2008.
- Sen S, Sharma C, Pal A, Kar R, Singh N. Multiple anticancer targets of chemopreventor Curcumin squamous cells lung carcinoma in vitro (Abst.). Eur. J. Cancer (Suppl.) 6:53; 2008.
- Singh A, Singh N. HPV and cervical cancer pathogenesis. Proc. American. Assoc. Cancer Res. 49: 2008.
- Sen S, Sharma C, Pal A, Kar R, Chattopadhyay, Singh N. Antioxidant activity of curcumin facilitates its cancer chemotherapeutic potential in squamous cell lung carcinoma in vitro. Annals of Oncology. 19 (Suppl. 8) 2008.
- Singh M, Singh N. Molecular mechanism of curcumin induced cytotoxicity in human cervical carcinoma cells. Mol Cell Biochem. 325 (1-2): 107-19; 2009.
- Pathak S, Sharma C, Jayaram HN, Singh N. Apoptotic signaling induced by benzamide riboside: an in vitro study. Mol Cell Biochem. 328 (1-2): 67-73; 2009.
- Singh A, Datta P, Jain SK, Bhatla N, Duttagupta S, Dey B, Singh N. Human papilloma virus genotyping, variants and viral load in tumors, squamous intraepithelial lesions, and controls in a north Indian population subset.. Intl. J. Gynecol. Cancer. 19 (9): 1642-8; 2009.
- Pillai MR, Hariharan R, Janki Mohan Babu, Lakshmi S, Chiplunkar S V, Patkar M, Tongaonkar H, Dinshaw K, Jayshree RS, Reddy BKM, Siddiqui M, Soma Roychoudury, Baisakhi Saha, Abraham P,Manu Gnanamony, Peedicayil Abraham, John S, Ram TS, Bindu Dey, Sharma C, Jain SK,Singh N. Molecular variants of HPV-16 associated with cervical cancer in Indian Population. Intl. J. Cancer. 125(1):91-103; 2009.
- Datta P, Bhatla N, Dar L, Patro AR, Gulati A, Kriplani A, Singh N. Prevalence of human papillomavirus infection among young women in North India. Cancer Epidemiol. 34(2): 157-61; 2010.
- Pillai RM, Babu JM, Jissa VT, Lakshmi S, Chiplunkar SV, Patkar M, Tongaonkar H, Reddy KB, Chakka KN, Siddiqui M, Roychoudury S, Abraham P, Peedicayil A, Gnanamony M, Subashini J, Ram TS, Dey B, Singh N, Singh A, Jain SK, Jayshree RS. Regionwise distribution of hrHPV types in squamous cell carcinoma of the cervix in India. Intl.J.Gynaecol.Cancer. 20(6):1046-51 2010.
- Kar R, Jayanth P, Sharma C, Chattopadyay P, Kumar S, Kumar L and Singh N.Treatment with Survivin siRNA augments cytotoxicity of Paclitaxel in primary ovarian cancer cells. Proceedings of American. Assoc. Cancer Res. 2010
- Singh M and Singh N. Curcumin counteracts the proliferative effect of estradiol and induces apoptosis in cervical cancer cells. Molecular Cell Biochemistry. 347(1-2):1-11; 2011.
- N Bhatla, S Vashist, S Mathur, S Rai, A Kripline, N Singh, N Agarwal, L Dar, V Sreenivas, R Sankaranarayanan. Evaluation of a “Screen-vaccinate” Strategy in a low resource setting (Abst.). 27th International Papillomavirus Conference and Clinical Workshop from September 17-22, 2011 at Berlin, Germany. P-09.18:Pg 182
- Bajpai D, Kumar S, Singh N. Polymorphisms in DNA repair genes and cervical cancer risk in Indian population. Molecular Cancer Therapeutics 10 (11) suppl 1 B30 (Abstr) 2011.
- Kar R and Singh N. Modulating survivin expression to overcome chemoresistance in primary cultures of ovarian cancer cells – a step towards patient tailored therapy (Abst.). Proceedings of 2nd Intl. Conf. on Stem cells and cancer (ICSCC-2011): proliferation, differentiation and apoptosis held from 15th – 18th October 2011 at Pune.
- Rajarshi Kar, Ayan Bannerjee, P P Chattopadhyay, Sunesh K Jain, Neeta Singh. Curcumin potentiates the response of primary cultures of ovarian cancer cells to carboplatin and paclitaxel: An in vitro study (Abst.). Proceedings of AACR Intl. Conf. on New Horizons in Cancer Research: Biology to Prevention to Therapy. A30:pg74:2011
- Chandresh Sharma, Neeta Singh. Generation of HPV16 chimeric virus-like particles: A proof of concept (Abst.). Proceedings of AACR Intl. Conf. on New Horizons in Cancer Research: Biology to Prevention to Therapy. A59:pg83:2011
- Sujata Pathak, Neerja Bhatla, Neeta Singh. Association of cervical cancer risk with one-carbon metabolism (Abst.). Proceedings of AACR Intl. Conf. on New Horizons in Cancer Research: Biology to Prevention to Therapy. A61:pg84:2011
- Deepti Bajpai, Sunesh K Jain, Neeta Singh. DNA repair, gene polymorphisms, and cervical cancer risk: A case-control study in India (Abst.). Proceedings of AACR Intl. Conf. on New Horizons in Cancer Research: Biology to Prevention to Therapy. A76:pg89:2011
- Sharmistha Choudhuri, Lalit Kumar, Sunesh Kumar, Neeta Singh. Analysis of blood-based biomarkers as potential diagnostic and prognostic tools in epithelial ovarian cancer (Abst.). Proceedings of AACR Intl. Conf. on New Horizons in Cancer Research: Biology to Prevention to Therapy. B16:pg99:2011
- Sudip Sen, Chandresh Sharma, Arnab Pal, Rajarshi Kar, P P Chattopadhyay, Neeta Singh. Chemopreventive curcumin induces DNA damage and antioxidant protein in squamous cell lung carcinoma in vitro (Abst.). Proceedings of AACR Intl. Conf. on New Horizons in Cancer Research: Biology to Prevention to Therapy. C89:pg144:2011
- Sharma Shweta, Tandon Radhika, Mohanty Sujata, Sharma Namrata, M Vanathi, Sen Seema, Kashyap Seema, Singh Neeta. Culture of Corneal Limbal Epithelial Stem Cells: Experience from Benchtop to Bedside in a Tertiary Care Hospital in India (Abst.). Cornea. 30(11): 1223-32; 2011.
- Datta P, Bhatla N, Pandey R M, Dar L, A Rajkumar Patro, Shachi Vasisht, Alka Kriplani, Neeta Singh. Type-Specific Incidence and Persistence of HPV Infection among Young Women: A Prospective Study in North India (Abst.). Asian Pacific J Cancer Prev. 13(3):1019-24; 2012.
- Bajpai D, Banerjee A, Jain S K, Singh N. Polymorphism in XRCC1 ERCC4, ERCC1 and ERCC4 DNA repair genes and cervical cancer risk in Indian population (Abst.). Intl. Symposium on Molecular Pathology held on 28th and 29th January 2012, at New Delhi.
- Choudhuri S, Kumar L, Jain S K, Singh N. Analysis of biomarkers in blood diagnosis and prognosis of epithelial ovarian cancer (Abst.). Intl. Symposium on Molecular Pathology held on 28th and 29th January 2012, at New Delhi.
- Pathak S, Bhatla N, Singh N. Cervical cancer pathogenesis is associated with one-carbon metabolism. Mol Cell Biochem. 2012. DOI 10.1007/s11010-012-1362-3.
- Sharma C, Dey B, Wahiduzzaman M, Singh N. Human papillomavirus 16 L1–E7 chimeric virus like particles show prophylactic and therapeutic efficacy in murine model of cervical cancer. Vaccine.3; 30(36): 5417-24; 2012.
- Gupta R, Singh N. Induction of mitochondrial mediated apoptosis by Morinda Citrofolia (Noni) in human cervical cancer cells. Asian Pacific J Cancer Prev. In press
- Pathak S, Bhatla N, Singh N. Cervical cancer pathogenesis is associated with one carbon metabolism. J. Carcinogenesis 11 (Suppl 1)S45, 2012.
- Bajpai D, Pathak S, Singh N. Decreased expression of DNA repair genes (XRCC1, ERCC1, ERCC2 and ERCC4) in squamous intraepithelial lesions and invasive squamous cell carcinoma of the cervix. Mol Cell Biochem. 2013. In press
Specialty Centers
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- Last Updated on Monday, 08 May 2023 11:40
Message
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- Last Updated on Thursday, 25 September 2014 11:13
Message for your Friends
You have been unfortunate to have this disease, but this is not an end of life. With your experience and knowledge, you can save your friends and relatives from the clutches of this disease. Tell them about your sufferings and also tell them the ways of prevention Encourage them to adopt an healthy, stress-free life style. Campaign against smoking and introduce the people to the hazards of smoking. Make the people understand that the prevention is always better than the cure, and also that there is no real cure.
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- Last Updated on Monday, 08 May 2023 14:06
Prof. Sushma Bhatnagar
Chief, Dr. B.R.A Institute-Rotary Cancer Hospital
Introduction
The DR. BRA-IRCH has the following departments:
Institute Rotary Cancer Hospital (DR. B.R.A. Institute Rotary Cancer Hospital) started functioning in 1983-84 on 35 beds with infrastructure of 2 floors. Recently it has been converted into a 200 bedded, 7th floor building. Prime Minister of India Sh. Atal Bihari Vajpayee, inaugurated this centre on October 5, 2003.
Best of radiodiagnostic and radiotherapy machines including state of art linear accelerator, brachytherapy, stereotactic radiotherapy and intensity modulated radiotherapy are available at this centre. Vaccum assisted advanced mammography unit, first of its kind in India, has made stereotactic breast biopsy possible. Prostate cancer can be diagnosed at an early stage with help of tranrectal sextant biopsy. Radio frequency ablation of liver cancer has also been initiated.
DR. B.R.A. Institute Rotary Cancer Hospital is one of the few centres in the country to have established hematopoietic stem cell bone marrow transplant programme; more than 250 transplants have been performed. In collaboration with dept. of CTVS, stem cell transplant programme has been extended to treat myocardial ischemia also.
Medical Oncology has established modern techniques utilizing FISH and polymerase chain reaction (PCR) to prognosticate cancer patients. Also, innovative research by this department has demonstrated the liberation of hematopoietic cytokines from fetal liver, with the potential to treat aplastic anemia. This department has researched into our ancient wisdom also and has discovered that combination of yoga, pranayam, meditation and sudershan kriya-a rhythmic breating process induces positive changes in brain. These processes enhance antioxidant defence and immune functions of body, and thus may prevent onset and/or progression of cancer.
Preventive oncology programme to bring awareness about cancer masses has been initiated, also screening programme to detect cancer early, over 10,000 people have been screened so far.
Prevention
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- Last Updated on Thursday, 25 September 2014 11:20
Prevention and Slowing the Progression of Coronary Artery Disease
CABG is not the permanent cure of your coronary artery disease. It is a palliative procedure and your coronary arteries and grafts may get involved in the disease in future as a result of progression of atherosclerotic process. This progression can not be entirely prevented, but with careful lifestyle and proper drug therapy, the rate of atherosclerotic progression can be slowed down. Thus, after surgery, it is important to follow the suggested guidelines. There are several risk factors which you can modify and thus reduce the risk of recurrence of the problem.
- Smoking:Quit smoking. It not only damages your lungs and causes cancer, it also accelerates the process of atherosclerosis and coronary artery disease. Smoking increases the risk of graft blockade, subsequent myocardial infarction and death.
- Sedentary life style and lack of exercise:Change your life style. Physical exercises play a great role in your life. Perform regular exercises. For elderly people, brisk walking is the ideal exercise. You can perform light ‘Yoga’ under supervision. Exercise reduces ‘fat levels, in the blood and also increases circulation to heart muscles and other parts of body.
- Obesity and excess weight :Obesity is one of the most important risk factors for development and progression of atherosclerosis. Thus weight reduction is an important aspect in long term care. Regular exercise and careful diet are two most important means of reducing the weight.
- Diet : Diet rich in fats and carbohydrates may contribute to obesity, high fat levels in blood and thus to development of coronary artery disease. Consume low calorie, fat free diet which is rich in minerals, vitamins, proteins and antioxidants. Antioxidants are substances which reduce progression of atherosclerosis. Fresh fruits, green vegetables and sprouted seeds are important sources of antioxidants. You are advised to use a cooking medium that contains Rice bran oil (Sundrop Heart). You mau avoid salt if you have high blood pressure and sweets if you have diabetes.
- High fat levels in blood:Increased level of cholesterol predisposes to development of atherosclerosis. A balanced diet and regular physical exercise are required to keep cholesterol level under control. However, sometimes drugs are also required to keep the cholesterol level in check.
- Diabetes mellitus:Diabetics is an important predisposing factor in development of coronary artery disease. Thus, proper management of diabetes is essential. Regular physical exercise and dietary regulation help in great way to control the diabetes. Follow your doctor’s advice for diabetes control and maintain regular check-up.
- Hypertension : Proper control of hypertension is essential to retard the progression of coronary artery disease. Decreased intake of salt, weight reduction and avoidance of stressful life also helps in control of high blood pressure. Regular and closely monitored drug therapy is essential for the management of hypertension.
- Stress:Stress is an important risk factor. Change your life style. Stress reducing exercises and meditation help in reducing the stress.
Thus to sum up:
- Quit smoking
- Do regular physical exercise
- Reduce your weight, if you are obese
- Avoid fatty, high calorie food. Eat fresh vegetables and fruits.
- Avoid stress
- Control your diabetes and hypertension vigorously
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