Aims and Objectives

Details

Last Updated on Monday, 13 October 2014 12:24

Dr. Shyam S. Chauhan

Details

Last Updated on Thursday, 18 September 2014 17:46

Dr. Shyam S. Chauhan

Professor

Room No 3009, Department of Biochemistry,

All India Institute of Medical Sciences

Ansari Nagar, New Delhi-110029

Ph. No. 011-26593272 (O)

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Dr. Shyam S. Chauhan received his Ph.D. in Biochemistry from V.P. Chest Institute, University of Delhi in 1988. He worked as post doctoral fellow at University of Pennsylvania, School of Medicine, Philadelphia, PA, USA from 1987-88 and at National Cancer Institute, NIH Bethesda MD, USA from 1988-1992. Dr. Chauhan joined AIIMS during 1992 as Assistant Professor and was promoted to the post of Professor in 2005. He is life member of Society of Biological Chemists (India), Indian Immunology Society, Association of Clinical Biochemists and Indian Association for Cancer Research. He has authored 60 original research papers and 5 chapters in books. Prof. Chauhan was awarded Fogarty International Research Fellowship to work as a visiting scientist at National Cancer Institute, NIH, Bethesda, MD, USA, (September 1999-October, 2000).

RESEARCH & IMPORTANT PUBLICATIONS

1. Research interests –

   Prof. Chauhan’s laboratory works on regulation of gene expression of proteases and peptidases involved in carcinogenesis and tumor invasion and metastasis. His research interests also include identification of newer diagnostic/prognostic markers and therapeutic targets of cancer.

2. Important Publications–
   1. Prajapati, S.C. and Chauhan, S.S.: Dipeptidyl peptidase III: Multifaceted oligopeptide N-end scissors. FEBS J. ( in press ) 2011.
   2. Samaiya, M., Bakhshi, S., Shukla, A.A., Kumar, L and Chauhan S.S.: Epigenetic regulation of cathepsin L expression in chronic myeloid leukemia. J. Cell. Mol. Med. ( in press), 2011
   3. Fatima, N., Ahmed, S.H., Salhan, S., Rehman, S.M., Kaur, J., Owais, M. and Chauhan, S.S.: Study of methyl transferase (G9aMT) and methylated histone (H3K9) expressions in Unexplained Recurrent Spontaneous abortion (URSA) and normal early pregnancy.Mol Hum Reprod. (in press) 2011
   4. Mir, R.A. and Chauhan S.S.: Down regulation of matrix degrading cysteine protease cathepsin L by acetaldehyde: role of C/EBP α PloS One 6(6): e20768,2011
   5. Mittal, S., Mir, R.A. and Chauhan, S. S.: Post-transcriptional regulation of human cathepsin L expression. Biol.Chem. 392: 405-413, 2011.
   6. Macha, M.A., Matta, A., Chauhan, S.S., Siu, K.W. and Ralhan, R. (2010) Guggulsterone (GS) Inhibits ST/Nicotine modulated NF-kB and STAT3 pathways in Oral cancer SCC4 cells. Carcinogenesis 32: 368-380, 2011.
   7. Macha, M.A., Matta, A., Kaur, J., Thakkar, A., Chauhan, S.S., Shukla, N. K., Datta Gupta, S. and Ralhan, R.: Prognostic significance of nuclear pSTAT3 in oral cancer. Head and Neck 33: 482-489, 2011.
   8. Macha, M.A., Matta. A., Chauhan, S.S., Siu, K.W. and Ralhan, R.: Guggulsterone inhibits ST/nicotine induced phosphorylation of Bad, Bax by modulation of PI3K/Akt pathway in head and neck cancer cells. PLoS One 6(2): e14728, 2011.
   9. Macha, M. A., Matta, A., Chauhan, S. S., Siu, K.W. and Ralhan, R.: 14-3-3 zeta is a molecular target in guggulsterone induced apoptosis in head and neck cancer cells. BMC Cancer 10:655(1-12), 2010.
   10. Ralhan, R., He, H., So, A., Tripathi, S.C., Kumar, M., Hassan, H., Kaur,J. Kashat L., MacMillan, C., Chauhan, S.S., Freeman, J. and Walfish, P.: Nuclear and cytoplasmic accumulation of ep-icd is frequently detected in human epithelial cancers. PLoS One 5(11).e14130, 2010.
   11. Tripathi, S.C., Matta, A., Kaur, J., Grigull, J., Chauhan, S.S., Thakar, A., Shukla, N.K., Duggal, R., Dattagupta, S., Ralhan, R., Siu, K.: Nuclear S100A7 is associated with poor prognosis in head and neck cancer. PLoS One. 2010 Aug 3;5(8):e11939
   12. Jain, M., Bakhshi, S., Shukla, A.A. and Chauhan, S.S.: Cathepsins B and L in peripheral blood mononuclear cells of pediatric acute myeloid leukemia: potential poor prognostic markers. Ann. Hematol., 89: 1223-1232, 2010.
   13. Katara, R., Mir, R.A., Shukla, A.A., Singh, N. and Chauhan, S.S.: Wild type p53-dependent transcriptional up regulation of cathepsin L expression is mediated by C/EBPα in human glioblastoma cells. Biol.Chem., 39: 1031-1040, 2010.
   14. Shukla A. A. Jain M, Chauhan,S. S.: Ets-1/Elk-1 a critical mediator of dipeptidyl peptidase-III transcription in human glioblastoma cells. FEBS J., 277: 1861-1875, 2010
   15. Tomar N, Bora H, Singh, R, Gupta N, Kaur, P, Chauhan, S.S., Sharma, Y.D., Goswami R: Presence and significance of a R110W mutation in DNA binding domain of GCM2 gene in patients with isolated hypoparathyroidism and their family members. Eur. J. Endocrinol., 162: 407-421, 2010<
   16. Mohapatra, S.C., Tiwari H.K., Singla, M., Rathi, B., Sharma, A., Mahiya, K., Kumar, M Sinha , S., and Chauhan, S.S. : Antimalarial evaluation of copper (II) nanohybrid solids: inhibition of plasmepsin II, a hemoglobin-degrading malarial aspartic protease from Plasmodium falciparum. J. Biol. Inorg. Chem.;15: 73-85, 2010
   17. Sansanwal, P., Shukla, A.A., Das, T.K., and Chauhan, S.S.: Truncated human cathepsin L, encoded by a novel splice variant, exhibits cytotoxicity and altered sub-cellular localization. Protein Pept. Lett., 17: 238-245, 2010
   18. Matta, A., Tripathi, S.C., DeSouza, L.V., Grigull, J. Kaur, J. Chauhan, S.S. Srivastava, A., Thakar, A., Shukla, N.K., Duggal, R., DattaGupta, S., Ralhan, R. Siu, K.W.M:. Heterogenous ribonucleoprotein K ( hnRNP K) is a marker of oral leukoplakia and correlates with poor prognosis of squamous cell carcinoma. Int. J. Cancer, 125:1398-406, 2009
   19. Chauhan, S.S., Seth, P. and Katara, R. Expression of cloned cDNAs in mammalian cells from a cryptic promoter upstream to T7 in pGEM4Z cloning vector. Mol Cell Biochem., 322: 119-125, 2009.
   20. Ralhan, R., DeSouza, L.V., Matta, A., Tripathi, S.C., Ghanny, S., Dattagupta, S., Thakar, A., Chauhan, S.S. and Siu, K.W.M. iTRAQ-multidimentional liquid chromatography and tendem mass spectrometery based identification of potential biomarkers of oral epithelial dysplasia and novel networks between inflammation and premalignancy. J. Proteaome Res.8: 300-309, 2009.
   21. Garg, S., Chauhan, S.S., Singh, N. and Sharma, Y.D. Immunological response to a 39.8 kDa Plasmodium vivax tryptophan-rich antigen (PvTRAg39.8) among humans. Microbes Infect. 10:1097-1105, 2008.
   22. Alam M.A., Husain S.A., Narang R, Chauhan S.S., Kabra M, Vasisht S. Association of polymorphism in the thermolabile 5, 10-methylene tetrahydrofolate reductase gene and hyperhomocysteinemia with coronary artery disease. Mol Cell Biochem., 310: 111-117, 2007.
   23. Goulet B, Sansregret L, Leduy L. Bogyo M.., Weber E, Chauhan S.S., Nepveu A. Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation. Mol Cancer Res. 5:899-907, 2007.
   24. Keethivasan, S., Keethivasan G., Mittal, S. and Chauhan, S.S.: Transcriptional upregulation of human cathepsin L by VEGF in glioblastoma cells.Gene. 399: 129-136, 2007

Dr. N.C. Chandra

Details

Last Updated on Friday, 19 September 2014 12:26

Dr. N.C.Chandra

Assistant Professor

Room no. 3016, Department of Biochemistry,

All India Institute of Medical Sciences,

New Delhi

Phone: 011-26594267

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Brief profile:

PhD : University of Calcutta

Post doctoral training: Harvard Medical School , USA

University of Notre Dame, USA

Lecturer: M. S. University of Baroda. : 1996 – 1998

Lecturer: D. Y. Patil Medical College, Mumbai: 1998 – 2001

Assistant Professor: Dept. of Biochemistry, AIIMS, New Delhi presently.

Running Research projects as principal investigator:

2. Studies on nuclear cholesterol and expression of cell cycle proteins in normal and tumor cell lines. [Sponsored by ICMR, New Delhi].
3. An in vitrosilencing of endogenous oxidized-LDL-receptor (LOX-1) gene by siRNA: Study of NF-kB activated expression of proinflammatory cytokines and related atherogenic proteins ------ its evaluation against anti-inflammatory cytokine mediated responses. [Sponsored by DBT, New Delhi].
4. Intracellular cholesterol homeostasis and cell proliferation. [Sponsored by Dept. of atomic energy, BARC, Mumbai].
5. Study on feedback regulation of intracellular cholesterol and T cell population in mice by immunogen, mitogen and carcinogen [Sponsored by AIIMS, New Delhi].

Member

1. Association of Clinical Biochemists, India.
2. Indian Immunology Society.
3. Indian Society for Atherosclerosis Research
4. Indian Society of Cell Biology
5. Society of Biological Chemistry, India.

STUDENTS:

PhD:Ms Albina Arjuman (July 2008 – June 2013)

Modulation of the oxidized-LDL-receptor and its effect on pro-and anti- inflammatory cytokines.

e.mail: This email address is being protected from spambots. You need JavaScript enabled to view it. '; document.write(''); document.write(addy_text27711); document.write('<\/a>'); //-->\n This email address is being protected from spambots. You need JavaScript enabled to view it.

e.mail: This email address is being protected from spambots. You need JavaScript enabled to view it. '; document.write(''); document.write(addy_text71626); document.write('<\/a>'); //-->\n This email address is being protected from spambots. You need JavaScript enabled to view it.

e.mail: This email address is being protected from spambots. You need JavaScript enabled to view it. '; document.write(''); document.write(addy_text34852); document.write('<\/a>'); //-->\n This email address is being protected from spambots. You need JavaScript enabled to view it.

e.mail: This email address is being protected from spambots. You need JavaScript enabled to view it. '; document.write(''); document.write(addy_text54257); document.write('<\/a>'); //-->\n This email address is being protected from spambots. You need JavaScript enabled to view it.

e.mail: This email address is being protected from spambots. You need JavaScript enabled to view it. '; document.write(''); document.write(addy_text71133); document.write('<\/a>'); //-->\n This email address is being protected from spambots. You need JavaScript enabled to view it.

e.mail: This email address is being protected from spambots. You need JavaScript enabled to view it. '; document.write(''); document.write(addy_text30625); document.write('<\/a>'); //-->\n This email address is being protected from spambots. You need JavaScript enabled to view it.

1. Research interests –

   Genetic, biochemical and immunological studies to gain insight into the pathophysiology, susceptibility and risk factors for coronary artery disease (HDL-associated paraoxonase; apo A4, antioxidants, nitric oxide synthase, free radicals, cell adhesion molecules,  and nitric oxide). Modulation of complement regulatory proteins in autoimmune disorders like SLE and RA and significance of complement regulatory proteins as disease markers. The most recent study aims at elucidating the interplay between cytokines and complement regulatory proteins in autoimmune disorders.  A new project to study the relations of leucocyte membrane complement regulatory proteins, MBL and MASP2 with the pathophysiology in acute coronary syndrome funded by ICMR is to be started. Interested in Research and innovations in the area of Medical Education. A new INDO-UK partnership between the University of Liverpool and AIIMS has commenced.

2. Important Publications in last five years
   1. Das N., Biswas B. and Khera R. Membrane-bound complement regulatory proteins as biomarkers and potential therapeutic targets for SLE.Advances experimental Medicine and Biology: 2013;734:55-81..
   2. R. Pahwa, U. Kumar &N. Das. Role of complement regulatory protein CD46 in rheumatoid arthritis. September 2012, Volume 137, Issue Supplement s1.Immunology.
   3. Imteyaz Ahmad, Rajiv Narang, Anand Venkatraman and Nibhriti Das. Two- and three-locus haplotypes of the paraoxonase (pon1) gene are associated with coronary artery disease in Asian Indians.Gene: 506 (2012) 242–247.
   4. Vaishali Arora, Jyotsna Verma, Vishal Marwah, Ashok Kumar, Devyani Anand andNibhriti Das. Cytokine imbalance in Systemic Lupus Erythematosus: A study on northern Indian subjects.Lupus (2012) 0, 1–8.
   5. Arora V., Grover R., Kumar A., Anand D. andN. Das .Relationship of leucocyte complement receptor 1 transcript and protein with the pathophysiology and prognosis of systemic lupus erythematosus: a follow up study.Lupus 2011. Oct;20(10):1010-8.
   6. Biswas Bintili, Kumar Uma and Das Nibhriti. Expression and significance of leukocyte Membrane Cofactor Protein transcript in Systemic Lupus Erythematosus.Lupus. (2012) Apr;21(5):517-25.
   7. Raini Dutta,Nibhriti Das. Immunomodulation of serum complement (C3) and macrophages by synthetic pyrethroid fenvalerate: In vitro study. 2011. Toxicology. 285: 126–132.
   8. Imteyaz Ahmad, Rajiv Narang, Anand Venkatraman, Nibhriti Das. Frequency distribution of the Single-Nucleotide -108C/T Polymorphism at the Promoter region of the PON1 gene in Asian Indians and its relationship with coronary artery disease.Journal of Community Genetics. 2010.  2:27–32
   9. P. Goel, K. Srivastava,N. Das & V. Bhatnagar. The role of nitric oxide in portal hypertension caused by extrahepatic portal vein obstruction. 2010.Journal of Indian Association of Pediatric Surgeons. Vol. 15, Issue 4.  117-121.
   10. Pradeep Kumar Dabla, Sarika Arora, Shubha Sagar Trivedi,Nibhriti Das, Jayashree Bhattacharjee. Evaluation of endothelial and platelet functions with intergenotypic variation of eNOS Glu298Asp gene polymorphism in relation to postmenopausal women.Int J Biol Med Res. 2010; 1(4): 272-276.
   11. Pradeep K. Dabla, Shubha S. Trivedi,Nibhriti Das and Jayashree Bhattacharjee. The role of endothelial nitric oxide synthase (eNOS) gene glu298asp polymorphism in postmenopausal coronary artery disease risk- a pilot study in north India.International Journal of Pharma and Bio Sciences. Vol.1/Issue-4/Oct-Dec.2010
   12. Shubhangi Arora,, Kamna Srivastav andNibhriti Das. Nitric oxide and eNOS gene in Essential Hypertension"  submitted to and presented in IOMC 2009 for the Best Student Paper Award of IOMC 2009 Conference. International Journal of Collaborative Research on Internal Medicine & Public Health, 2009 Vol. 1 No. 2, published in April 2009. pp. 56-71
   13. Rohan Khera, Mayank Madhukar, Praveen Agarwal, J.C. Samantaray, Shukla Biswas &Nibhriti Das. Relationship of Complement Receptor 1 Density polymorphism at Intron 27 (Hind III RFLP) toPlasmodium falciparum Malaria and its Severity in an Indian Scenario. (Meeting Abstract).Clinical Immunology. 2009. 131: S96.
   14. Rohan Khera &Nibhriti Das. Complement Receptor 1: Disease Associations and Therapeutic Implications. Molecular Immunology. 2009. 46: 761-772.
   15. Nibhriti Das, Vaishali Arora, Vishal Marwah, Jyotsna Verma, Rahul Grover, Ashok Kumar, Devyani Anand, Bintili Biswas & Uma Kumar. Cytokine imbalance and cross talks among cytokines, immune complexes and genetic factors on Complement Receptor 1 (CR!) expression in health and disease (Systemic Lupus Erythematosus). (Meeting Abstract): 2008. Molecular Immunology. 45: 4176.
   16. Shalini Sharma, Urvashi B. Singh, H.K. Prasad, Pawan Sharma andNibhriti Das. Interaction of Mycobacterium tuberculosis secretory antigens ESAT-6 and CEP-10 on complement receptors, calcium signaling and antimicrobial functions of macrophages. (Meeting Abstract): 2008.Molecular Immunology. 45: 4149.
   17. Devyani Anand, Bintili Biswas, Vaishali Arora, Uma Kumar andNibhriti Das. Effect of IFN-g and immune complex on Neutrophil-CR1 transcript and its relationship with CR1 density polymorphism. (Meeting Abstract): 2008. Molecular Immunology. 45: 4178.
   18. Raini Dutta, Abdul Matin Mondal, Vaishali Arora, TC Nag andNibhriti Das. Immunomodulatory effect of DDT (bis[4-chlorophenyl]-1,1,1-trichloroethane on complement system and macrophages. 2008.Toxicology. 252 (1-3): 78-85.
   19. Kamna Srivastava, Rajiv Narang, V. Sreeniwas, Sabari Das &Nibhriti Das. Association of eNOS Glu298Asp Gene polymorphism with essential hypertension in Asian Indians.2008. Clinica Chemica Acta. 387: 80.83.