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All India Institute Of Medical Sciences, New Delhi

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Aims and Objectives

Details
Last Updated on Monday, 13 October 2014 12:24
  1. To stimulate research in Ophthalmology at its highest level.
  2. To develop pattern of post graduate education in Ophthalmology.
  3. To undertake training of the Ophthalmologists, Optometrists etc.
  4. To create facilities for the training of health personnel in Preventive Ophthalmology.
  5. To provide facilities for research in Ophthalmology :-
    1. Clinical research
    2. Experimental research
    3. Development of new instruments and appliances (diagnostic and therapeutic).
    To provide facilities for the training of personnel for the rehabilitation of the blind.
  6. To provide facilities for refresher courses in ophthalmology for practicing ophthalmologists and general pracitioners.
  7. To provide facilities for the training, organisation and research in Eye Bank, including corneal grafting and tissue trasplantation.

Dr. N.C. Chandra

Details
Last Updated on Friday, 19 September 2014 12:26

Dr. N.C.Chandra

Assistant Professor

Room no. 3016, Department of Biochemistry,

All India Institute of Medical Sciences,

New Delhi

Phone: 011-26594267

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Brief profile:

PhD : University of Calcutta

Post doctoral training: Harvard Medical School , USA

University of Notre Dame, USA

Lecturer: M. S. University of Baroda. : 1996 – 1998

Lecturer: D. Y. Patil Medical College, Mumbai: 1998 – 2001

Assistant Professor: Dept. of Biochemistry, AIIMS, New Delhi presently.

Running Research projects as principal investigator:

  2. Studies on nuclear cholesterol and expression of cell cycle proteins in normal and tumor cell lines. [Sponsored by ICMR, New Delhi].
  3. An in vitrosilencing of endogenous oxidized-LDL-receptor (LOX-1) gene by siRNA: Study of NF-kB activated expression of proinflammatory cytokines and related atherogenic proteins ------ its evaluation against anti-inflammatory cytokine mediated responses. [Sponsored by DBT, New Delhi].
  4. Intracellular cholesterol homeostasis and cell proliferation. [Sponsored by Dept. of atomic energy, BARC, Mumbai].
  5. Study on feedback regulation of intracellular cholesterol and T cell population in mice by immunogen, mitogen and carcinogen [Sponsored by AIIMS, New Delhi].

Member

  1. Association of Clinical Biochemists, India.
  2. Indian Immunology Society.
  3. Indian Society for Atherosclerosis Research
  4. Indian Society of Cell Biology
  5. Society of Biological Chemistry, India.

STUDENTS:

PhD:Ms Albina Arjuman (July 2008 – June 2013)

Modulation of the oxidized-LDL-receptor and its effect on pro-and anti- inflammatory cytokines.

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MD: Dr. Puja Beriwal (Januaray 2009 – December 2011)

Thesis title: Association of plasma risk factors in obese subjects with leptin, insulin and their receptors – a pilot study.

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Dr.Govind Singh (July 2009 – July 2012)

Thesis title: Cholesterol homeostasis and expression of cell cycle proteins (cyclin E and cdk2) in normal prostate, benign prostatic hyperplasia and carcinoma prostate cases: a pilot study

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Dr. Shrimanjunath (July 2009 – July 2012)

Thesis title: Insights of cholesterol homeostasis in lymphocyte of normal and chronic lymphocytic leukemia subjects: a case control pilot study

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Dr Amarpreet Kaur (July 2010 – July 2013)

Thesis title: Study of feedback regulation of intracellular cholesterol and immunogenic response by T cells using immunogen, mitogen and chemical carcinogen in mice model.

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Dr. Nimisha Saxena (July 2010 – July 2013)

Thesis title: Study of feedback regulation of intracellular cholesterol and immunogenic response by B cells using immunogen ,mitogen and chemical carcinogen in mice model.

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RESEARCH & IMPORTANT PUBLICATIONS

  1. Research interests –
    1. Studies on cholesterol homeostasis by LDL receptor regulation and the effects of insulin, thyroxin, Leptin and their receptors whose deficiencies are associated in developing atherosclerosis.
    2. Intracellular cholesterol homeostasis and cell proliferation.
    3. Cholesterol homeostasis and immune system.
  2. Important Publications –
    1. Nimai C. Chandra, Mary B. Doody and Roger K. Bretthauer. Specific lipids enhance the activity of UDP-GlcNAc:Dolichol Phosphate GlcNAc-1-Phosphate Transferase in intact rat liver endoplasmic reticulum membrane vesicles. Arachives Biochem. & Biophy. 290(2), 345 - 354, 1991.
    2. N.C.Chandra, D.W.Welsh, M.B.Doody and R.K.Bretthauer. Alteration of microsomal UDP-GlcNAc:Dolichol Phosphate, GlcNAc-1-Phosphate Transferase (GPT) activity by nonspecific phospholipid transfer protein.FASEB J. 6(1) , 231, 1992.
    3. Nimai C. Chandra, Mary J. Spiro and Robert G. Spiro. Identification of a glycoprotein from rat liver mitochondrial inner membrane and demonstration of its origin in the endoplasmic reticulum. J. Biol. Chem. 273(31), 19715 - 19721, 1998.
    4. Gopalakrishnan R. and N.C.Chandra. Estradiol regulates Insulin dependent stimulation of LDL-receptor expression in HepG2 cells. Indian J. Clin. Biochem. 21(1), 8 – 14, 2006.
    5. Gomathy Sethuraman, Selvendran Sugandhan, Gautam Sharma, Nimai Chand Chandra, Kudligi Chandramohan, Aggarwal Komal, Vinod K Sharma. Familial homozygous hypercholesterolemia: report of two cases and review of literature. Pediatr Dermatol 24(3), 230 – 234, 2007 .
    6. Gopalakrishnan R, A. Rana and N. C. Chandra. Study of low-density lipoprotein receptor regulation by oral (steroid) contraceptives: desogestrel, levonorgestrel and ethinyl estradiol in JEC-3 cell line and placentral tissue. Contraception 76: 297 – 305, 2007.
    7. G. Ramakrishnan, N.C.Chandra, Regulation of low density lipoprotein receptor activity by insulin and steroids in model cell culture system.Abstract No. 144. J. Clin. Lipidology 2(5S) 2008
    8. Albina Arjuman, Hemlata Pandey and Nimai Chand Chandra. Effect of a combination oral contraceptive (desogestrel + ethinyl estradiol) on the expression of low-density lipoprotein receptor and its transcription factor (SREBP2) in placental trophoblast cells. Contraception 84(2): 160 – 168, 20119.
    9. Shilpa Suneja, Gopalakrishnan Ramakrishnan, Nikhil Tandon and N.C.Chandra. Modulation by insulin of the co-localized LDL receptor in normal and Type-I Diabetic subjects.International Journal of Clinical Medicine. 2(3): 231 – 245, 2011
    10. Hemlata Pandey, Albina Arjuman, Kallol K. Roy, Nimai Chand Chandra. Reciprocal co-ordination of a combination oral contraceptive containing (desogestrel+ethinyl estradiol) on the expression of LOX-1 and LDLR in placental trophoblast cells. Contraception: In Press.

Dr. Nibhriti Das

Details
Last Updated on Thursday, 18 September 2014 16:55

Dr. Nibhriti Das

Professor

Department of Biochemistry,

All India Institute of Medical Sciences, New Delhi-110029

Tel. Office: 011-26593467 Res.: 011-26588842

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Ph.D. in Biochemistry from Lucknow University in the year 1976. Post Doctoral experience at ITRC Lucknow and AIIMS. AIIMS faculty since 1984 in the Department of Biochemistry, Professor in the Department since 2003. Adjunct Faculty of the K.L. Wig CMET, AIIMS.

Got Diploma Certificate in Medical Education Technology from Technology Transfer Centre, University of Dundee, Scotland, UK. Involved in the curriculum reform for UG and PG for the Department of Biochemistry. Served as a faculty at the Arabian Gulf University for 2 years w.e.f. end December 1991, got trained in problem-based learning. Initiated PBL for teaching- learning of Biochemistry by the medical undergraduates.  UG teaching co-coordinator since 1985. Research experience and projects include: Biochemical toxicology and immunotoxicology of pesticides; Influence of pesticides in cardiovascular disorder nutrition and communicable disease like TB; Complement and complement regulatory proteins in the pathophysiology of glomerulonephritis, RA and SLE; Genetic & biochemical risk markers for hypertension and coronary artery disease, severe complications offalciparum malaria; cytokine-complement interactions in autoimmune disorders and role of complement proteins as biomarkers for GN, RA & SLE. Recent interest is in the area of immunoinflammatory mechanisms of coronary artery disease and evaluation of complement proteins as disease markers.

Co-editor of a book “Essentials of Practical Biochemistry” CBS Publishers & Distributors

Written several chapters in Textbooks for UG Students. 76 original research papers.

Member of UG and PG Board of different Universities, Selection Committees, External examiner for UG and PG Courses in Biochemistry at different universities and reviewer of projects from DST, ICMR etc. and international journals. Received prestigious Mrs. Talwar and G.P. Talwar Oration award from Association of Clinical Biochemists of India.

Membership of scientific bodies:

Life Member of the

  1. Indian Immunology Society, IUIS, FIMSA
  2. National Environmental Science Academy
  3. Association of Cell Biology
  4. Association of Clinical Biochemists of India
  5. Indian Society for Atherosclerosis Research
  6. International Society for Atherosclerosis Research

Member of the Executive Committee:

  1. Treasurer of the Indian Immunology Society for the year 2012-2014
  2. National Environmental Science Academy, Member of the Executive Committee
  3. Indian Society for Atherosclerosis Research

    Others:

  4. International Complement Society
  5. Professional Member of the American Heart Association
  6. Member of the advisory board of the Biosciences Research Institute, Chennai, India

STUDENTS

  1. M.Sc.:
  2. M.D.:
  3. Ph.D.:
  1. Devyani Anand: Expression and modulation of leukocyte Complement Receptor 1 and CD59 (Protectin) in relation to rheumatoid arthritis
  2. Roma Pahwa: Expression and modulation of complement regulatory proteins DAF (CD55) and MCP (CD46) in relation to the pathophysiology and clinical disease activity of rheumatoid arthritis

RESEARCH & IMPORTANT PUBLICATIONS

  1. Research interests –

    Genetic, biochemical and immunological studies to gain insight into the pathophysiology, susceptibility and risk factors for coronary artery disease (HDL-associated paraoxonase; apo A4, antioxidants, nitric oxide synthase, free radicals, cell adhesion molecules,  and nitric oxide). Modulation of complement regulatory proteins in autoimmune disorders like SLE and RA and significance of complement regulatory proteins as disease markers. The most recent study aims at elucidating the interplay between cytokines and complement regulatory proteins in autoimmune disorders.  A new project to study the relations of leucocyte membrane complement regulatory proteins, MBL and MASP2 with the pathophysiology in acute coronary syndrome funded by ICMR is to be started. Interested in Research and innovations in the area of Medical Education. A new INDO-UK partnership between the University of Liverpool and AIIMS has commenced.

  2. Important Publications in last five years
    1. Das N., Biswas B. and Khera R. Membrane-bound complement regulatory proteins as biomarkers and potential therapeutic targets for SLE.Advances experimental Medicine and Biology: 2013;734:55-81..
    2. R. Pahwa, U. Kumar &N. Das. Role of complement regulatory protein CD46 in rheumatoid arthritis. September 2012, Volume 137, Issue Supplement s1.Immunology.
    3. Imteyaz Ahmad, Rajiv Narang, Anand Venkatraman and Nibhriti Das. Two- and three-locus haplotypes of the paraoxonase (pon1) gene are associated with coronary artery disease in Asian Indians.Gene: 506 (2012) 242–247.
    4. Vaishali Arora, Jyotsna Verma, Vishal Marwah, Ashok Kumar, Devyani Anand andNibhriti Das. Cytokine imbalance in Systemic Lupus Erythematosus: A study on northern Indian subjects.Lupus (2012) 0, 1–8.
    5. Arora V., Grover R., Kumar A., Anand D. andN. Das .Relationship of leucocyte complement receptor 1 transcript and protein with the pathophysiology and prognosis of systemic lupus erythematosus: a follow up study.Lupus 2011. Oct;20(10):1010-8.
    6. Biswas Bintili, Kumar Uma and Das Nibhriti. Expression and significance of leukocyte Membrane Cofactor Protein transcript in Systemic Lupus Erythematosus.Lupus. (2012) Apr;21(5):517-25.
    7. Raini Dutta,Nibhriti Das. Immunomodulation of serum complement (C3) and macrophages by synthetic pyrethroid fenvalerate: In vitro study. 2011. Toxicology. 285: 126–132.
    8. Imteyaz Ahmad, Rajiv Narang, Anand Venkatraman, Nibhriti Das. Frequency distribution of the Single-Nucleotide -108C/T Polymorphism at the Promoter region of the PON1 gene in Asian Indians and its relationship with coronary artery disease.Journal of Community Genetics. 2010.  2:27–32
    9. P. Goel, K. Srivastava,N. Das & V. Bhatnagar. The role of nitric oxide in portal hypertension caused by extrahepatic portal vein obstruction. 2010.Journal of Indian Association of Pediatric Surgeons. Vol. 15, Issue 4.  117-121.
    10. Pradeep Kumar Dabla, Sarika Arora, Shubha Sagar Trivedi,Nibhriti Das, Jayashree Bhattacharjee. Evaluation of endothelial and platelet functions with intergenotypic variation of eNOS Glu298Asp gene polymorphism in relation to postmenopausal women.Int J Biol Med Res. 2010; 1(4): 272-276.
    11. Pradeep K. Dabla, Shubha S. Trivedi,Nibhriti Das and Jayashree Bhattacharjee. The role of endothelial nitric oxide synthase (eNOS) gene glu298asp polymorphism in postmenopausal coronary artery disease risk- a pilot study in north India.International Journal of Pharma and Bio Sciences. Vol.1/Issue-4/Oct-Dec.2010
    12. Shubhangi Arora,, Kamna Srivastav andNibhriti Das. Nitric oxide and eNOS gene in Essential Hypertension"  submitted to and presented in IOMC 2009 for the Best Student Paper Award of IOMC 2009 Conference. International Journal of Collaborative Research on Internal Medicine & Public Health, 2009 Vol. 1 No. 2, published in April 2009. pp. 56-71
    13. Rohan Khera, Mayank Madhukar, Praveen Agarwal, J.C. Samantaray, Shukla Biswas &Nibhriti Das. Relationship of Complement Receptor 1 Density polymorphism at Intron 27 (Hind III RFLP) toPlasmodium falciparum Malaria and its Severity in an Indian Scenario. (Meeting Abstract).Clinical Immunology. 2009. 131: S96.
    14. Rohan Khera &Nibhriti Das. Complement Receptor 1: Disease Associations and Therapeutic Implications. Molecular Immunology. 2009. 46: 761-772.
    15. Nibhriti Das, Vaishali Arora, Vishal Marwah, Jyotsna Verma, Rahul Grover, Ashok Kumar, Devyani Anand, Bintili Biswas & Uma Kumar. Cytokine imbalance and cross talks among cytokines, immune complexes and genetic factors on Complement Receptor 1 (CR!) expression in health and disease (Systemic Lupus Erythematosus). (Meeting Abstract): 2008. Molecular Immunology. 45: 4176.
    16. Shalini Sharma, Urvashi B. Singh, H.K. Prasad, Pawan Sharma andNibhriti Das. Interaction of Mycobacterium tuberculosis secretory antigens ESAT-6 and CEP-10 on complement receptors, calcium signaling and antimicrobial functions of macrophages. (Meeting Abstract): 2008.Molecular Immunology. 45: 4149.
    17. Devyani Anand, Bintili Biswas, Vaishali Arora, Uma Kumar andNibhriti Das. Effect of IFN-g and immune complex on Neutrophil-CR1 transcript and its relationship with CR1 density polymorphism. (Meeting Abstract): 2008. Molecular Immunology. 45: 4178.
    18. Raini Dutta, Abdul Matin Mondal, Vaishali Arora, TC Nag andNibhriti Das. Immunomodulatory effect of DDT (bis[4-chlorophenyl]-1,1,1-trichloroethane on complement system and macrophages. 2008.Toxicology. 252 (1-3): 78-85.
    19. Kamna Srivastava, Rajiv Narang, V. Sreeniwas, Sabari Das &Nibhriti Das. Association of eNOS Glu298Asp Gene polymorphism with essential hypertension in Asian Indians.2008. Clinica Chemica Acta. 387: 80.83.

Dr. Shyam S. Chauhan

Details
Last Updated on Thursday, 18 September 2014 17:46

Dr. Shyam S. Chauhan

Professor

Room No 3009, Department of Biochemistry,

All India Institute of Medical Sciences

Ansari Nagar, New Delhi-110029

Ph. No. 011-26593272 (O)

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Dr. Shyam S. Chauhan received his Ph.D. in Biochemistry from V.P. Chest Institute, University of Delhi in 1988. He worked as post doctoral fellow at University of Pennsylvania, School of Medicine, Philadelphia, PA, USA from 1987-88 and at National Cancer Institute, NIH Bethesda MD, USA from 1988-1992. Dr. Chauhan joined AIIMS during 1992 as Assistant Professor and was promoted to the post of Professor in 2005. He is life member of Society of Biological Chemists (India), Indian Immunology Society, Association of Clinical Biochemists and Indian Association for Cancer Research. He has authored 60 original research papers and 5 chapters in books. Prof. Chauhan was awarded Fogarty International Research Fellowship to work as a visiting scientist at National Cancer Institute, NIH, Bethesda, MD, USA, (September 1999-October, 2000).

STUDENTS
MSc:
Name & E.mailTitle of the Thesis
Mr. Siddharth Mehra “Expression of cysteine proteases and their endogenous inhibitor in dilated cardiomyopathy”
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PhD:
Name & E.mailTitle of the Thesis
Mr. Satyender Chander Tripathi "Study of potential cancers markers and drug target   in head and neck cancers".
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Mr. Ratanakar Singh "Study of PTEN regulated genes in human link glioblastoma cells".
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Mr. Subhash Chand Prajapati "Expression of dipeptidyl pepsidase III in human cell lines and malignant tissues " .
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Mr. Manish Kumar  A study on clinical significance of hn RNDP, BAF 180, EB-1, and S 100 A2 proteins in oral carcinogenesis.
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Ms. Mansi Manchanda "Regulation of human cysteine cathepsins by liver mansimann fibrotic agents in hepatocytes".
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RESEARCH & IMPORTANT PUBLICATIONS

  1. Research interests –

    Prof. Chauhan’s laboratory works on regulation of gene expression of proteases and peptidases involved in carcinogenesis and tumor invasion and metastasis. His research interests also include identification of newer diagnostic/prognostic markers and therapeutic targets of cancer.

  2. Important Publications–
    1. Prajapati, S.C. and Chauhan, S.S.: Dipeptidyl peptidase III: Multifaceted oligopeptide N-end scissors. FEBS J. ( in press ) 2011.
    2. Samaiya, M., Bakhshi, S., Shukla, A.A., Kumar, L and Chauhan S.S.: Epigenetic regulation of cathepsin L expression in chronic myeloid leukemia. J. Cell. Mol. Med. ( in press), 2011
    3. Fatima, N., Ahmed, S.H., Salhan, S., Rehman, S.M., Kaur, J., Owais, M. and Chauhan, S.S.: Study of methyl transferase (G9aMT) and methylated histone (H3K9) expressions in Unexplained Recurrent Spontaneous abortion (URSA) and normal early pregnancy.Mol Hum Reprod. (in press) 2011
    4. Mir, R.A. and Chauhan S.S.: Down regulation of matrix degrading cysteine protease cathepsin L by acetaldehyde: role of C/EBP α PloS One 6(6): e20768,2011
    5. Mittal, S., Mir, R.A. and Chauhan, S. S.: Post-transcriptional regulation of human cathepsin L expression. Biol.Chem. 392: 405-413, 2011.
    6. Macha, M.A., Matta, A., Chauhan, S.S., Siu, K.W. and Ralhan, R. (2010) Guggulsterone (GS) Inhibits ST/Nicotine modulated NF-kB and STAT3 pathways in Oral cancer SCC4 cells. Carcinogenesis 32: 368-380, 2011.
    7. Macha, M.A., Matta, A., Kaur, J., Thakkar, A., Chauhan, S.S., Shukla, N. K., Datta Gupta, S. and Ralhan, R.: Prognostic significance of nuclear pSTAT3 in oral cancer. Head and Neck 33: 482-489, 2011.
    8. Macha, M.A., Matta. A., Chauhan, S.S., Siu, K.W. and Ralhan, R.: Guggulsterone inhibits ST/nicotine induced phosphorylation of Bad, Bax by modulation of PI3K/Akt pathway in head and neck cancer cells. PLoS One 6(2): e14728, 2011.
    9. Macha, M. A., Matta, A., Chauhan, S. S., Siu, K.W. and Ralhan, R.: 14-3-3 zeta is a molecular target in guggulsterone induced apoptosis in head and neck cancer cells. BMC Cancer 10:655(1-12), 2010.
    10. Ralhan, R., He, H., So, A., Tripathi, S.C., Kumar, M., Hassan, H., Kaur,J. Kashat L., MacMillan, C., Chauhan, S.S., Freeman, J. and Walfish, P.: Nuclear and cytoplasmic accumulation of ep-icd is frequently detected in human epithelial cancers. PLoS One 5(11).e14130, 2010.
    11. Tripathi, S.C., Matta, A., Kaur, J., Grigull, J., Chauhan, S.S., Thakar, A., Shukla, N.K., Duggal, R., Dattagupta, S., Ralhan, R., Siu, K.: Nuclear S100A7 is associated with poor prognosis in head and neck cancer. PLoS One. 2010 Aug 3;5(8):e11939
    12. Jain, M., Bakhshi, S., Shukla, A.A. and Chauhan, S.S.: Cathepsins B and L in peripheral blood mononuclear cells of pediatric acute myeloid leukemia: potential poor prognostic markers. Ann. Hematol., 89: 1223-1232, 2010.
    13. Katara, R., Mir, R.A., Shukla, A.A., Singh, N. and Chauhan, S.S.: Wild type p53-dependent transcriptional up regulation of cathepsin L expression is mediated by C/EBPα in human glioblastoma cells. Biol.Chem., 39: 1031-1040, 2010.
    14. Shukla A. A. Jain M, Chauhan,S. S.: Ets-1/Elk-1 a critical mediator of dipeptidyl peptidase-III transcription in human glioblastoma cells. FEBS J., 277: 1861-1875, 2010
    15. Tomar N, Bora H, Singh, R, Gupta N, Kaur, P, Chauhan, S.S., Sharma, Y.D., Goswami R: Presence and significance of a R110W mutation in DNA binding domain of GCM2 gene in patients with isolated hypoparathyroidism and their family members. Eur. J. Endocrinol., 162: 407-421, 2010<
    16. Mohapatra, S.C., Tiwari H.K., Singla, M., Rathi, B., Sharma, A., Mahiya, K., Kumar, M Sinha , S., and Chauhan, S.S. : Antimalarial evaluation of copper (II) nanohybrid solids: inhibition of plasmepsin II, a hemoglobin-degrading malarial aspartic protease from Plasmodium falciparum. J. Biol. Inorg. Chem.;15: 73-85, 2010
    17. Sansanwal, P., Shukla, A.A., Das, T.K., and Chauhan, S.S.: Truncated human cathepsin L, encoded by a novel splice variant, exhibits cytotoxicity and altered sub-cellular localization. Protein Pept. Lett., 17: 238-245, 2010
    18. Matta, A., Tripathi, S.C., DeSouza, L.V., Grigull, J. Kaur, J. Chauhan, S.S. Srivastava, A., Thakar, A., Shukla, N.K., Duggal, R., DattaGupta, S., Ralhan, R. Siu, K.W.M:. Heterogenous ribonucleoprotein K ( hnRNP K) is a marker of oral leukoplakia and correlates with poor prognosis of squamous cell carcinoma. Int. J. Cancer, 125:1398-406, 2009
    19. Chauhan, S.S., Seth, P. and Katara, R. Expression of cloned cDNAs in mammalian cells from a cryptic promoter upstream to T7 in pGEM4Z cloning vector. Mol Cell Biochem., 322: 119-125, 2009.
    20. Ralhan, R., DeSouza, L.V., Matta, A., Tripathi, S.C., Ghanny, S., Dattagupta, S., Thakar, A., Chauhan, S.S. and Siu, K.W.M. iTRAQ-multidimentional liquid chromatography and tendem mass spectrometery based identification of potential biomarkers of oral epithelial dysplasia and novel networks between inflammation and premalignancy. J. Proteaome Res.8: 300-309, 2009.
    21. Garg, S., Chauhan, S.S., Singh, N. and Sharma, Y.D. Immunological response to a 39.8 kDa Plasmodium vivax tryptophan-rich antigen (PvTRAg39.8) among humans. Microbes Infect. 10:1097-1105, 2008.
    22. Alam M.A., Husain S.A., Narang R, Chauhan S.S., Kabra M, Vasisht S. Association of polymorphism in the thermolabile 5, 10-methylene tetrahydrofolate reductase gene and hyperhomocysteinemia with coronary artery disease. Mol Cell Biochem., 310: 111-117, 2007.
    23. Goulet B, Sansregret L, Leduy L. Bogyo M.., Weber E, Chauhan S.S., Nepveu A. Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation. Mol Cancer Res. 5:899-907, 2007.
    24. Keethivasan, S., Keethivasan G., Mittal, S. and Chauhan, S.S.: Transcriptional upregulation of human cathepsin L by VEGF in glioblastoma cells.Gene. 399: 129-136, 2007

Dr D.N. Rao

Details
Last Updated on Thursday, 18 December 2014 15:58

Dr. D.N. Rao
Professor & Head, Department of Biochemistry

AIIMS, New Delhi-110029

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Tel: 91-11-26593545(O), 91-11-26588060 (R) 91-9868592706 (M)

Dr. D.N. Rao, born in the year 1951. Obtained his M.Sc. (1972) and Ph.D (1978) degrees.  After his doctoral degree, he joined as a Research Officer at All India Institute of Medical Sciences, New Delhi and subsequently became a lecturer in the Department of Biochemistry AIIMS,.  Presently, he is a Professor & Head in the Department of Biochemistry, AIIMS.  He was the elected General Secretary of Indian Immunology Society and Vice President of FIMSA during the year 2010-14.  Currently, he is the elected president of Indian Immunology Society. He is recipient of AIIMS Excellence award Ist Prize 2012 awarded by Dr. Robert Huber (Noble Laureat). He is Chairman of the Intramural Research project of AIIMS. He is the reviewer for many National and International journals.  He is recipent of Dr. Pran Nath Chhuttani Oration award 2013 by National Academy of Medical Sciences. He is the recipient of Dr. Sohail Ahmed Oration Award by National Academy of Biomedical Sciences 2014

He is an Editor in Chief of “Indian Journal of Clinical Biochemistry” (IJCB) for about five years. He has received a large number of Awards/oration for his contribution in Biochemistry and Immunology. He is recipient of Prof. B.K. Aikat Oration Award of ICMR for Contribution in Tropical Diseases, 1993; Prof. V.M. Thakor Award for contribution in the field of Biochemistry by Institute of Medical Technology, Udhna (Surat) under the aegis of Span Research Center, 1998; Dr. K.C. Kandhari memorial Oration for contribution in leprosy by AIIMS 1998; Seth GS Medical College & KEM Hospital Oration by ACBI, 1998; Chaturvedin Ghanshyam Das Jaigopal Award for Immunology 1997 by ICMR; Hari Om Ashram Alembic Research Award-2000 Basic Research in Medical Science by MCI; Professor C.R. Krishna Murthi Lecture Award by SBC during 2002; Dr. & Mrs. G.P. Talwar Oration Award 2003 by ACBI; ICMR award for contribution in Biomedical Research 2006 for developing subunit vaccine in Nano Particles, Man of year by American Biographical Institute of USA-2002, Outstanding Scientist Worldwide-2007 by IBC.

He is a member of various scientific organization like Indian Immunology Society, Society of Biological Chemists of India, Association of Clinical Biochemists of India, The Indian Society of Parasitology, Molecular Immunology forum and New York Academy of Sciences, Society of Free Radical Research India. He is a Treasurer of Indian Immunology Society (IIS) for five years. He has organized 9th APCCB International Conference at Ashok Hotel, New Delhi 2002. He has organized 33rd Indian Immunology Society Conference at AIIMS during 28-31 January, 2007 and he also organized SFRR Satellite Meeting 11 & 12 Feb., 2008 at AIIMS. He is Organizing Secretary of 5th FIMSA conference held at New Delhi in March 2012.

He is actively involved the evaluation of projects and fellowships from various funding agencies and peer review member of various national and international journals. He is an examiner, thesis evaluator and selection committee member of various universities and medical colleges. He has delivered a large number of guest and invited lectures in various national and international conferences. He is a Scientific Advisory Committee member of various national funding agencies.

Dr. D.N. Rao is currently involved in teaching Biochemistry and Immunology to various professional courses. His research interest includes Biochemistry and Immunology of infectious diseases. His citation spans developing peptide based immunogens for vaccine design and immuno-diagnostics for diseases like Malaria, HIV, and Plague. His interest also lies in immunology of leprosy. He has guided a large number of students for Ph.D, M.D. and M.Sc degrees. He has generated extramural research grants from DST, DBT, ICMR, DAE, DRDO, CSIR and Ministry of Health and Family Welfare. He reviewed large number of manuscripts of Immunology and Biochemistry published in various international/national journals. He is Officer-in-Charge of both Small Animal and Primate Research Facility. He has attended all the three FIMSA conferences with bursary.

He has published more than 130 research articles in International and National Journals. He has guided 20 Ph.D., M.D. 8, M.Sc. and M. Biotech 20. Currently there are 4 Ph.D. students and four Post Doctoral fellows working with me in various research projects concerned to health problems.

STUDENTS

  1. PhD:
    1. Mr. Dablu Lal Gupta - Role of Immuno-Clinical and cytokine gene polymorphism correlation with recovery in patients with posttraumatic shock
    2. Mr. Pradeep Kumar Nagar - Identification and immunological characterization of epitopes of envelope and capsid proteins of Chikungunya virus
    3. Mr. Tarique Hussain- γ δ T cells and its modulatory role in leprosy
    4. Mr. Ayantika Tulkdar - Coenzyme Q and its immunomodulatory role in idiopathic recurrent abortion cases.

Post-doctoralStudents

  1. Dr. Pramod Pal
  2. Dr. Santwana Bhatnagar
  3. Dr. Reeta Roy
  4. Dr. Chaman
  5. Ms. Priyanka Verma

Project Students

  1. Mr. Sameer
  2. Mr. Santosh

RESEARCH & IMPORTANT PUBLICATIONS

  1. Researchinterests–
    1. Developing peptide based diagnosis for malaria, HIV,Yersinia pestis, chikungunia and dengue.
    2. Chemical synthesis of peptides and study their immunomodulatory, immunochemical and immunoregulatory mechanism associate with malaria, HIV, Y.pestis,Chikungunia and dengue.
    3. T Reg Cells, HAT, HDAC and epigenetic mechanism of Fox P3 in leprosy and autoimmune disease.
    4. Identifying immuno and biochemical markers of miscarriage and premature ovarian failure

FULL LENGTH PAPERS IN NATIONAL AND INTERNATIONAL JOURNALS (IF = Impact Factor)

  1. Santwana Bhatnagar, Pradeep Kumar, Priyanka Verma, Teena Mohan, M.M. Parida, S.L. Hoti and D. N. Rao. Evaluation of multiple antigenic peptides (MAP) as better diagnostic for Chikungunya virus using envelope E2 peptides, Viral Immunology, (IF 1.75), (In press).
  2. Chaman Saini, Mohd Tarique, Sudhir Kumar, D.N.Rao. Role of FoxP3+ Treg cells in mediated suppression in leprosy, 2014, manuscript communicated, Current Immunological Review,
  3. Pradeep Kumar Nagar, Santwana Bhatnagar, Priyanka Verma, D.N. Rao, Mapping and immunological response of B and T cell epitopes of E2 glycoprotein of Chikungunya virus., Vaccine, (IF 4.0), Manuscript communicated.
  4. Dablu Lal Gupta1, Sanjeev Bhoi2, Sagar Galwnkar3, Irshad H. Chaudry4, D.N. Rao5 "Association of dynamic changes in serum cytokine levels with severity of injury in hemorrhagic shock patients, 2014, J. Trauma, ( I.F-2.4), manuscript communicated.
  5. Dablu Lal Gupta1, Sanjeev Bhoi2, Amit Gupta3, Arulselvi 4, D.N. Rao5 "Hemorragic shock patients to understand the disease severity in post haemorrhage sepsis, Shock, 2014, (I.F-2.850), manuscript communicated).
  6. Dablu Lal Gupta1, Sanjeev Bhoi2, Sagar Galwnkar3, Irshad H. Chaudry4, D.N. Rao5 "Clinical relevance of cytokine gene polymorphism in recovery of hemorrhagic shock patients, 2014, Critical Care, (I.F-3.6), manuscript communicated.
  7. Dablu Lal Gupta1, Sanjeev Bhoi2, Amit Gupta3, Arulselvi 4, D.N. Rao5 "T cell anergy and Th1/Th2/Th17 and T reg cells profiling in post traumatic sepsis patients" 2014, Critical Care, (I.F-3.6), manuscript communicated.
  8. Current understanding of HIV-1 and T-cell adaptive immunity: progress to date, Teena Mohan, Santwana Bhatnagar, Dablu L. Gupta and Rao D.N., 2014, Microbial Pathogenesis, 73, 1-1, (IF 2.7).
  9. A review article on the plant based delivery system : An approach for the development of vaccines, Teena Mohan and Rao D.N., 2014, Drug Development and Industrial Pharmacy, (in press), (IF 1.9).
  10. Characterization of CD4+TCRγδ+ FoxP3 involved in immunosuppression through TGF-β-II-Smad3 in leprosy patients, Mohd Tarique, Raza Ali Naqvi, Riyasat Ali, Neena Khanna and Rao D.N., 2014, J. Immunol., (submitted) (IF 6.0).
  11. CD4+ CD25+ T regs with acetylated FoxP3 are associated with immune suppression in human leprosy, Sudhir Kumar, Raza Naqvi, Neena Khanna and Rao D.N., 2013, Mol. Immuol., 56, 513-520, (IF 3.4).
  12. FoxP3 provides competitive fitness to CD4+, CD25+ T cells in leprosy patients via transcriptional regulation, Sudhir Kumar, Raza Naqvi, Neena Khanna and Rao D.N., 2014, Eur. J. Immunol., 44, 431-439 (IF 5.6).
  13. IL-10 production from dendritic cells is associated with DC SIGN in human leprosy, Sudhir Kumar, Raza Naqvi, Ajaz A. Bhat, Richa Rani, Riyasat Ali, Abhishek Agnihotri, Neena Khanna and Rao D.N., 2013, Immuno. Biol. 218, 1488-1496 (IF 4.3).
  14. B and T cell epitopes mapping and study the humoral and cell mediated immune response to B–T constructs of YscF antigen of Yersinia pestis. Riyasat Ali, Sudhir Kumar and D.N.Rao, 2013, Comparative Immunology Microbiol and Infectious Disease, 36(4), 365-378 (IF 2.1).
  15. Multiple Antigen Peptide consisting of B- and T-cell epitopes of F1 antigen of Y. pestis showed enhanced humoral and mucosal immune response in different strains of mice, Riyasat Ali, Sudhir Kumar, Raza Ali Naqvi, and D.N.Rao, 2013, Int. immunopharmacology, 15, 97-105 (IF 2.3) .
  16. Evaluation of peptide based IgM/IgG detection for diagnosis of Chikungunya infection, Priyanka Verma, Teena Mohan, Pradeep Kumar, M.M. Parida, S.L. Hoti, Shakir Ali, V. Ravi, V. Lakshmi and Rao D.N., 2014, Clin. Chem. Lab. Med., 52, 297-307 (IF 3.0).
  17. Cell mediated immune response of palmitoyl multiple antigen peptide containing immunodominant epitopes of F1 antigen of Yersinia pestis in murine model, Riyasat Ali, Raza Ali Naqvi, Ajaz AB and D. N. Rao , 2013, Scandinavian J. Immunol, 77 (5), 361-377 (IF 2.3).
  18. Comparative mucosal immunogenicity of HIV gp41 membrane-proximal external region (MPER) containing single and multiple repeats of ELDKWA sequence with defensin peptide, Teena Mohan, Priyanka Verma and Rao D.N., 2014 Immuno Biology, 219, 292-301 (IF 3.1).
  19. Novel adjuvant and delivery vehicle for drgus and vaccine development : A road ahead, Teena Mohan, Priyanka Verma and Rao D.N., 2013, Ind. J. Med. Res. 138, 779-795 (IF 2.061).
  20. Modulation of HIV peptide antigen specific cellular immune response by synthetic a and B defensin peptides, Teena Mohan and Rao D.N., 2013, Vaccine, 31, 1707-1716 (IF 3.6).
  21. Nasal delivery of PLG encapsulated defensin peptides adjuvanted gp41 antigens confers long lasting immunoprotective response against HIV-1, Teena Mohan and Rao D.N., 2014, Immul. Res., 58, 139-153 (IF 3.3).
  22. Detection of histidine rich protein 2 and lactate dehydrogenase antigens of P. falciparum in malaria patients by immunocaputre base diagnostic assay, Priyanka Verma, Vinita Chattree, Ratanesh K. Seth, Sukla Biswas and Rao D.N., 2013, Ind. J. Med. Res., 138, 977-987 (IF 2.0).
  23. Comparative in-vitro functional characterization of synthetic native, neagatively and positively charged variants of defensins against HIV-INL4.3, E.coli, S. aureus and P. aeroginosa, Teena Mohan and Rao D.N., 2013 Int. J. Pep. Res. Ther., 19, 245-255 (IF 2.0).
  24. Immunological response to Parthenium hysterophorus in Indian Patients with Parthenium sensitive atopic dermatitis, Kumar S, Khandpu S, Rao DN, Wahaab S, Khanna N, 2012, Immunol Invest. ;41(1):75-86.
  25. Cell-mediated immune response to epitopic MAP (Multiple antigen peptide) consutruct of LcrV antigen of Yersinia pestis in murine model. Rupesh K. Shreewastav, Riyasat Ali, Jayaprakash Babu and Rao D.N., 2012, Cellular Immunology, 278, 55-62 (IF 2.6).
  26. Evaluation of CD4+/CD8+ T-cell ex-pression and IFN- <gamma> Perforin secretion for B-T constructs of F1 and V antigens of Yersinia pestis, Geetanjali Gupta, Arif Azam Khan, Riyasat Ali & Rao D.N., 2012 International Immunopharmacology, 12, 64-73 (IF 2.0).
  27. Recent Advancement in Development of Vaccines against Y. pestis – A potential agent of Bioterrorism. Riyasat Ali and Rao D.N., Chapter in Bioterrorism, 2012, ISBN 973-953-51-0205-2, Edited by Stephen A Morse, Intech Open Science.
  28. Th3 immune responses in the progression of leprosy via molecular cross-talks of TGF-β CTLA-4 and Cbl-b, Sudhir Kumar, Raza Naqvi, Neena Khanna & Rao D.N., 2011, Clinical Immunology, 141, 133-142 (IF 4.0).
  29. Immunomodulation & Vaccine adjuvant, Teena Mohan, Ajaz A. Bhat and Rao D.N, The book seried of Compendium of Bioactive Natural products M/s Studium Press, LLC, USA. Vol.5.
  30. Enhanced humoral and mucosal immune responses after intranasal immunization with chimeric multiple antigen peptide comprising of defined epitopes of LcrV antigen of Yersinia pestis coupled to palmitate in mice, Jayaprakash Babu U.S., Bhat AA, Anil Sah, Rao D.N., 2011, Vaccine, 29, 9352-9360. ( IF 3.6).
  31. Disruption of HLA-DR raft, deregulation of Lck-ZAP-70-Cbl-b switches and miR181a towards T cell hyporesponsiveness in leprosy, Sudhir Kumar, Raza Naqvi, Neena Khanna & Rao D.N. 2011, Mol. Immun, 48, 1178-1190 (IF 3.0).
  32. Dominant T-cell epitopes of filarial BmALT-2 and their cytokine profile in BALB/c mice, J. Madhumathi, P.R. Prince, D.N. Rao and P. Kaliraj, 2010, Parasite Immunology, 32, 760-763.
  33. Crucial epitopes of Wuchereria bancrofti abundant larval transcript recognized in natural infection.
  34. Madhumathi J, Pradiba D, Prince PR, Jeyaprita PJ, Rao D.N., Kaliraj P., Eur. J. Clin Microbiol Infect Dis. 2011, 29, 1481-1486 (IF 2.6).
  35. Evaluation of synthetic peptides of WbSXP-1 for the diagnosis of human lymphatic filariasis, Panduragan Pandiaraja, Chakkaravarthy Arunkumar, Subhash Lasmanappa Hoti, Rao D.N., P. Kaliraj, Dign. Microbiol. Infect. Dis. 2010, 68, 410-415 (IF 2.4).
  36. Identification and characterization of nematode specific protective epitopes of B. malayi TRX towards development of synthetic vaccine construct for lymphatic filariasis, Jayaprakasam Madhumathi, Prabhu Rajaiah Prince, Gandhirajan Anugraha, Pote Kiran, Rao D.N., Maryada Venkata Rami Reddy & Permumal Kaliraj, Vaccine, 2010, 28, 5038-5048 (IF 3.6).
  37. Induction of mucosal and systemic humoral immune responses in murine system by intranasal immunization with peptide antigens of P. vivax and CpG oligodeoxynucleotide (ODN) in microparticle delivery, Ajaz Ahmad Bhat, Ratenesh K. Seth, Sudhir Kumar, Sukla Biswas & Rao D.N., Int. Immuno. Pharmac. 2009, 9, 1197-1208 (IF 3.0).
  38. Acquired immune response to defined Plasmodium vivax antigen in individuals residing in northern India, Ratnesh K. Seth, Ajaz A. Bhat, D.N. Rao & Sukla Biswas, Microbes and Infection, 2010, 12(3), 199-206 (IF 2.9).
  39. Induction of cell mediated immune responses to peptide antigens of P. vivax in microparticles using intranasal immunization, Ajaz Ahmad Bhat, Ratenesh K. Seth, Sudhir Kumar, Sukla Biswas & Rao D.N., Immunological Investigation 2010, 39 (4-5) 483-499 (IF 1.3).
  40. Immunomodulation and Vaccine Adjuvants, Teena Mohan, Ajaz Ahmad Bhat and Rao D.N., chapter in Bioactive Natural Products, Vol.5, Chapter 6, 120-159, 2010 Studium Press LLC, USA.
  41. Protective effect of resveratrol and vitamin E aginst thanol-induced oxidative damage in mice: Biochemical and immunological basis, Subir Kumar Das, Sukhes Mukherjee, Geetanjali Gupta, Rao D.N. and D.M. Vasudevan, 2010, 47, 32-37.
  42. Cell mediated immune response and Th1/Th2 cytokine profile of B-T constructs of F1 and V antigen of Yersinia pestis, Geetanjali Gupta, Arif Azam Khan & Rao D.N., Scand. J. Immunol. 2010, 71, 186-198 (IF 2.0).
  43. Humoral immune responses and protective efficacy of sequential B &T cell epitopes of V antigen of Y. pestis by intranasal immunization in microparticles, Jayaprakash Babu U.S., Ajaz Ahmad Bhat & Rao D.N., Med Microbiol Immunol 2009 198 (4), 247-256 (IF 3.3).
  44. Intranasal administration of peptide antigens of HIV with mucosal adjuvant CpG ODN coentrapped in microparticles enhances the mucosal and systemic immune responses, Par Bahadur Pun, Ajaz Ahmad Bhat, & Rao D.N., International Immunopharmacology 2009, 9,468-477 (IF 3.0).
  45. Time dependent effects of ethanol on blood oxidative stress parameters and cytokines, Das S.K., Vardhan S.G. Gupta, Rao D.N. and D.M. Vasudevan. Ind. J. Biochem. Biolphy. Feb. 2009, 46(1), 116-21.
  46. Protective effect of resveratrol and vitamin E against ethanol-induced oxidative damage in mice: Biochemical and immunological basis, Subir Kumar Das, Sukhes Mukherjee, Geetanjali Gupta, Rao D.N. and D.M. Vasudevan . Ind. J. Biochem. Biolphy. November. 2009, 46, 1-6.
  47. Suppressive effect of Strychnos nux-vomica on induction of ovalumin-specific IgE antibody response in mice, Govinda Rao Duddukuri, A. Naga Brahmam & Rao D.N., IJBB, 45, 341-344, 2008 .
  48. Identifying B and T epitopes and studying humoral, mucosal and cellular immune response of V antigen of Y. pestis, Arif A. Khan, Jaya P. Babu & Rao D.N., Vaccine 2008 26(3), 316-332 (IF 3.6).
  49. Inhibition of apoptosis activation of NKT cells and upregulation of CD40 and CD40L mediated by M. leprae antigen(s) combined with murabutide and Trat peptide in leprosy patients, Vineeta Chattree, Neena Khanna, Vandana Bisht , and D.N.Rao., Mol Cell Biochem. 2008 Feb;309(1-2):87-97 (IF 2.2).
  50. Liposomal delivery of Mycobacterium leprae antigen(s) with murabutide and Trat peptide inhibits Fas-mediated apoptosis of peripheral blood mononuclear cells derived from leprosy patients, Vineeta Chattree, Neena Khanna, Vandana Bisht & Rao D.N., Ind. J. Biochem. Biophy., 2007, 44, 386-393.
  51. Alterations in T cell signal transduction by M. leprae antigens is associated with downregulation of second messengers PKC, calcium, calcineurin, MAPK and various transcription factors in leprosy patients, Vineeta Chattree, Neena Khanna and D.N.Rao. Mol. Immunol., 2007, 44, 2066-2077 (IF 3.0).
  52. Alleviation of collagen-induced arthritis by plumbago zeylanica in Mice, Aparanji Poosarla, B. Veerendra Kumar, T. Raghava Rao, Rao D.N. and Rama Rao Athota., Pharmaceutical Biology, 2007, 45 (1), 54-59.
  53. Effect of lecithin with vitamin-B complex and tocopheryl acetate on long term effect of ethanol induced immunomodulatory activites, Subir Kumar Das, Geetanjali Gupta, Rao D.N. and D.M. Vasudevan, Indian J. Exp. Biol., 2007, 45, 1-6.
  54. Obstructive infertility: Changes in the histology of different regions of the epididymis and morphology and spermatozoa, P.C. Pal, Monika Manocha, M.M. Kapur, D.N. Rao and M. Rajalakshmi. 2006 Andrologia, 37, 1-9 (IF 1.3).
  55. Development of diagnostic reagents: Raising antibodies against synthetic peptides of PfHRP-2 and LDH using microsphere delivery, Deepak Tomar, Sukla Biswas, Vinita Tripathi and Rao D.N., Immunobiol. 2006, 211 (10), 797-805 (IF 4.1).
  56. Inducing systemic and mucosal immune responses to B-T construct of F1 antigen of Yersinia pestis in microsphere delivery, Vinita Tripathi, K.T. Chitralekha, Anand R. Bakshi, Deepak Tomar, R.A. Deshmukh, M.A. Baig and Rao D.N., Vaccine 2006, 24 (16), 3279-3289 (IF 3.6).
  57. Semen quality and sperm functional parameters in fertile Indian men, P.C. Pal, M. Rajalakshmi, M. Manocha, R.S. Sharma, S. Mittal and Rao D.N. (2006) Andrologia 38, 21-25 (IF 1.3).
  58. Enhanced mucosal and systemic immune response with intranasal immunization of mice with HIV peptides entrapped in PLGA microparticles in combination with Ulex Europaeus-I lectin as M cell target, M. Manocha, P.C Pal, M. Chitralekha, Beena Elizabeth Thomas, Vinita Tripathi, Sidhartha Dutta Gupta, Ramesh Paranjape, Smita Kulkarni, and Rao D.N. (2005), Vaccine, 23, 5599-5617 (IF 3.6).
  59. Investigation of the kinetics of histidine-rich protein 2 and of the antibody responses to this antigen, in a group of malaria patients from India, S. Biswas, D. Tomar and Rao D.N. (2005), Annals. Tropical Medicine & Parasitology, 99, 1-10 (IF 1.4).
  60. Induction of Anti-inflammatory and altered T cell proliferative Responses by the Ethanol Root Extract of Plumbago zeylanica in Adjuvant-Induced Arthritic Rats, Aparanji Poosarla, B. Veerendra Kumar, S. Prasanna Kumar, K. Sreedevi, Rao D.N. and Rama Rao Athota, Pharmbiol., (2005) 43, 9, 784-789 (IF 0 .7).
  61. Expression of Costimulatory molecules (CD80, CD86, CD28 and CD152) and other accessory molecules (TCRabgd and CD4, CD8) in PBMC of leprosy patients using M. leprae antigen with murabutide and T cell peptide of Trat protein. K. Sridevi, N. Khanna, Chattree .V, and Rao D.N., 2004, Int. Immuno. Pharmac., 4 ,1-14 (IF 3.0).
  62. Generating neutralizing antibodies, TH1 response and MHC non restricted immunogenicity of HIV-I env and gag peptides in liposomes and ISCOMS with inbuilt adjuvanticity. L. Aggrawal, W. Haq, C.V. Hanson and D.N. Rao, 2003, J. Immune Based Therapies and Vaccines 1 : 5-37 (IF 3.0).
  63. Reversal of T cell energy in leprosy patients: invitro presentation with M. Leprae specific antigens using Murabutide and Trat peptide in liposomal delivery. K. Sridevi, N. Khanna, K.T Chitralekha and Rao D.N., 2003, Int. Immuno. Pharmac., 3, 1589-1600 (IF 3.1).
  64. Yersinia Pestis F1 antigen: A Correlation between antibody titers, subclass distribution and avidity in different inbred strains. Sabhnani L, Manocha M , Tomar. D and Rao D N., 2003, Int. Immuno. Pharmac, 3, 1413-1418 (IF 3.0).
  65. Developing subunit vaccines for plague using B and T cell constructs derived from F1 antigen using novel delivery vehicles. Sabhnani L, Sridevi K , Manocha M , Rayanade R and Rao D N. 2003 FEMS Immunol. Med. Microbiol, 38, 215-229 (IF 2.5).
  66. Comparing modified and plain peptide linked ELISA for detection of HIV-I and 2 antibodies. Immunol. Lett. M. Manocha, K.T. Chitralekha, M. Thakar, R.S. Paranjape & Rao D.N., 2003 85, 275- 278 (IF 2.5).
  67. Suppressive effect of honey on induction of antigen or mitogen driven T cell proliferative responses in vitro. Govinda Rao D, Rao D.N. and Rao R Athota. 2002 Pharmac. Biol. 40, 39-44.
  68. Synthetic peptides as immunoprophylaxis and immunotherapy evtics: Manocha M, Sridevi, K, Deepak. T and Rao D.N., 2002, Proc. Natl Acad. Sci (India), 68, 29-46.
  69. Stabilization of pancreatic ribonuclease A by immobilization on Sepharose-linked antibodies that recognize the labile region of the enzyme. H.Yonus, M.Owais, Rao, D.N and M.Saleemuddin, 2001 .Biochimica et Biophysics Acta (BBA),1548(1):114-20 (IF 4.7).
  70. Inducing cell mediated immune response against peptide antigens of circumsporozoite protein of P. vivax. B. E. Thomas, Sridevi K, W. Haq and Rao, D.N., 2001, Annal. Trop. Med. Parasitol., 95:573-86 (IF 1.4).
  71. Modulation of humoral response to repeat and non repeat sequences of CS protein with novel adjuvant and delivery systems. B.E. Thomas, M.Manocha W. Haq and Rao, D.N., 2001, Annal. Trop. Med. Parasitol., 95(5), 451-472 (IF 1.4).
  72. Immunomodulation of ovalbumin-specific IgG and other classes of antibody response by honey in mice. G.R. Duddukuri, Vasudeva Rao Y, Rao D.N. and Rao R. Athota Ind. J. Clin. Biochem.2001, 16, 89-94.
  73. Isolation and characterization of allergens from the seeds of Vigna Sinensis. Raghava T, Rao D.N. Kotilingam K, and Rao R. Athota. 2000 Asian Pacific J. of Allergy and Immunol. 18, 9-14 (IF 0.8).
  74. Inducing protective antibodies against RESA peptide using modified delivery systems “ISCOMs”. Neeraj Chopra, Beena E. Thomas, L. Sabhnani & Rao, D.N. 2000. Med. Microbiol. Immunol. 189 (2), 75-83 (IF 3.3).
  75. New age adjuvants and delivery systems for subunit vaccines. Sridevi Kurella, Monika Manocha, Leenu Sabhnani, Beena Thomas, D.N. Rao. 2000. Ind. J. Clin. Biochem. 15, 83-100.
  76. Humoral and Cell mediated immune response to cadmium in mice: Dan G, Lall S.B and Rao D.N: Drug and Chem. Toxicol. 23, 349-360, 2000 (IF 1.0).
  77. Identification of immunodominant epitope of F1 antigen of Y. pestis . L. Sabhnani & Rao D.N. FEMS Immunol. Med. Microbiol. 2000, 27: 155-162 (IF 2.5).
  78. Indocyanin Green Clearance Test to Evaluate the Status of Liver Functions in Extrahepatic Biliary Obstruction in Rats- Dutta H, Rao DN and Gupta DK, J. Ind. Pediatr Surg, 1999, 4: 81-83.
  79. Studies on double-headed protease inhibitor from phasedens mango. S. Sharma and Rao DN. J. Plant. Biochem. and Biotech. 1999, 8: 57-60.
  80. Estimation & significance of serum and synovial fluid malondialdehyde levels in rheumatoid arthritis. V. Chaturvedi, R. Handa, Rao.D.N. and J.P. Wali , Ind. J. Med. Res. 1999, 109, 1702-174.
  81. Increase in the immunogenicity of HIV peptide antigens by chemical linkage of polytuftsin (TKPR)40 into their sequence. K. Gokulan, S. Khare and Rao D.N. DNA and Cell Biology, 1999, 18 (8), 623-26 (IF 2.2).
  82. Correlation of T-cell response and lymphokine profile with RESA peptides of Plasmodium falciparum containing a universal T-cell epitope and an immunopotentiator, polytuftsin. P. Kumar & Rao, D.N. Microbiol. Immunol. 1999,43(6),567-76 (IF 1.3).
  83. Potentiation of the Immune response against RESA peptides of Plasmodium falciparum by incorporating a universal T cell epitope (CS.T3) and an immunopotentiator, (Polytuftsin) and delivery through liposomes. P.Kumar, S. Biswas & Rao D.N. Microbiol. Immunol. 1999,43(6),561-66 (IF 1.3).
  84. Bioactive fragment of human IL-1b (163-171) modulates the immune response to synthetic peptides of RESA of P. falciparum. B. Thomas, A. Prasad, K. Gokulan & Rao, D. N. Med. Microbiol. Immunol. 1999,187,165-171 (IF 3.3).
  85. Developing peptide based immunogen(s) against structural sequences of HIV-I with inbuilt immunoadjuvants using liposomes and Iscoms as delivery systems . Rao ,D.N., L. Agrawal and L. Sabhnani in Proceedings of International Congress of Immunology . Editors GP Talwar et al Monduzzi editore ,Italy P 873-881 , 1998.
  86. Influence of iron on growth and extracellular products of Acinetobacter baumannii. Goel, V.K., Kapil, A & Rao, D.N. Japan, J. Med. Sci. Biol. 1998 ,51, 25-33 (IF 0.6).
  87. Liposomes: Novel delivery system for a subunit immunogen against malaria. Rao, D.N. and Kumar, P in recent trends in Mycoses. 1998.145-157. Edited by Dr. Usha Sharma, CBT, New Delhi.
  88. Preparation and standardization of the goat lung surfactant extract. Narayana s, Paul, V.K., Rao, D.N., Vijayaraghan, M & Deorari, A.K. Ind. J. Med. Res. 107,113-117, 1998.
  89. Construction of chimeric immunogens:Bioactive fragment of Human IL-1b or poly tuftsin (PT) capable of eliciting immune reponse to HIV peptides. Gokulan, K., Sangeeta Khare & Rao,D.N. 1998, Ind. J. clin. Biochem. 13,114-121.
  90. Influence of Immunoadjuvants and a promiscous T cell determinants on the Immunigenicity of RESA peptide antigen of P.falciparum. B. Chaba, P. Kumar, , W.Haq, L. Sabhnani and Rao D.N. Int. J. Immunopharmac,20,259-73,1998 (IF 3.1).
  91. Role of adjuvants in the development of malaria vaccine. Sabhnani L, Thomas BE, Agarwal L and Rao DN. J. Parasitic. Dis. 21, 141-151, 1997 (IF 1.8).
  92. Developing peptide based immunogens against human malaria delivered in liposomes containing non-toxic adjuvants. Rao D.N., B. Chaba, P. Kumar, W. Haq and L. Sabhnani. Ind. J. Clin. Biochem. 1997 12,52-54.
  93. Bioactive fragment of human IL-1 b [163-171] modulates the immune response to synthetic peptides of HIV. K. Gokulan, and Rao D.N. Microbiol. Immunol. 1997.41 ,965-74 (IF 1.3).
  94. Advantage of dimeric peptide antigens in serodiagnosis of HIV-1 infection. K.Gokulan,S.P. Tripathi and Rao, D. N.. Microbiol. Immunol. 1997. 41, 215-220, 1997 (IF 1.3).
  95. Modification of delivery system enhances MHC non restricted immunogenicity of V3 loop region of HIV-1 gp120.. Ahulwalia A., Gokulan K., Nath I. and Rao, D.N. Microbiol. Immunol. 41, 779-784, 1997 (IF 1.3).
  96. Quantitative assessment of tuftsin receptor expression and second messengers during in vitro differentiation of leprosy patients. S. Khare, L.K. Bhutani and Rao,D.N.. Mol.. Cellular Biochem. 171, 1-10, 1997 (IF 2.2).
  97. Release of reactive nitrogen intermediates from the peripheral blood derived monocytes/ macrophages of leprosy patients stimulated in vitro by tuftsin. Khare S., L.K. Bhutani and Rao, D.N. Lep.Rev. 68, 16-24, 1997 (IF 1.6).
  98. Immmune response against the non-repeat region of the CS protein of P. Vivax. Shahi S., Kumar P., Kamboj K. and Rao,D.N.. South East Asian J. Trop. Med. Public Health. 28, 748-56,1997.
  99. Developing novel delivery systems against V3 loop region of HIV-1 gp120. A. Ahluwalia, K. Gokulan, L. Agrawal & Rao D. N. Chem & Environ. Res. 5(1-4) 1996.
  100. Polytuftsin: Enhances the immunogenicity of peptide variants of CS protein of P. vivax. R. Gayatri Devi, K. Gokulan and Rao, D.N. J.Parasitic Dis. 19, 117-122, 1995 (IF 1.8).
  101. Immunogenicity of the C-terminal peptide (293-310) of CS protein of Plasmodium vivax as putative B or T cell epitope . S. Shahi, P. Kumar and Rao, D.N. J. Parasitic Dis. 19, 29-34, 1995 (IF 1.8).
  102. Enhancement of the immunogenicity of the RESA peptides of P.falciparum by polytuftsin and its possible effects and mechanism during macrophage activation. Pawan Kumar, P. Dhawan and Rao, D.N.. Proceedings of the International Symposia on vectors and vector borne diseases, 1995. Edited by Dr. A..P. Dash and Dr. K. Satyanarayan. Published by National Academy of Vector Borne Diseases. pp 212-27.
  103. Humoral immune response to the Plasmodium falciparum antigen f155/RESA in adults with differential clinical conditions from an Indian Zone where Malaria is endemic. S. Biswas, Rao ,D.N. & L. Kabilan. South East Asian J.Trop. Med. Public Health. 26, 219-227, 1995.
  104. Polytuftsin augments the immunogenic functions of small peptides. Its possible mechanism. P. Dhawan, I. Nath & Rao,D.N.. Immunology Letters, 46, 177-82,1995 (IF 2.5).
  105. Construction of synthetic immunogens: Use of T cell epitope and natural immunomodulator in malaria vaccine against P.falciparum. Rao, D.N., P. Kumar and R. Gehlawat. In: Tropical diseases: Molecular biology and control strategies. Edited by Sushil Kumar et al. Published by Publication and Information division, CSIR, New Delhi, 1994 pp 345-55.
  106. Construction of synthetic immunogen: Use of natural immunomodulator "Polytuftsin" in malaria vaccine against P.falciparum. P. Kumar, B.B. Ivanov, L. Kabilan and Rao, D.N. Vaccine, 12, 819-24, 1994 (IF 3.6).
  107. Strategies for the development of vaccines against malaria. P. Kumar and Rao, D.N. Imunotechnology Biology Education, Oct-Dec, 220-225, 1993.
  108. Modulation of peripheral blood derived monocytes/macrophages from leprosy patients using tuftsin for the production of reactive oxygen intermediates. S. Khare, Bhutani, L.K. and Rao, D.N. Lepr. Rev. 64, 208-18 1993 (IF 1.6).
  109. Modulation of peripheral blood derived monocytes/macrophages from leprosy patients for immunogenic functions in vitro by tuftsin. S. Khare, R.R. Iyer and Rao, D.N Ind. J. Med. Microbiol. 10(3), 164-75, 1992 (IF 0.5).
  110. Construction of synthetic immunogen: use of T & B cell epitopes of CS and RESA proteins of P.falciparum. Ritu, G. and Rao, D.N.. Vaccine, 10, 761-66, 1992 (IF 3.6).
  111. Enzyme immunoassay of phagocytosis stimulating tetra-peptide, tuftsin in normal and leprosy sera. Kaur, Jagdeep, S. Khare, L.K. Bhutani and Rao, D.N.. In:Immunology: Perspectives in reproduction and infection. Editor S.K. Gupta. Oxford and IBH Co. Pvt. Ltd., New Delhi, pp 327-35, 1991.
  112. Enzyme immunoassay of phagocytosis stimulating tetrapeptide, tuftsin in normal and leprosy sera. Kaur, Jagdeep, S. Khare, L.K. Bhutani and Rao, D.N..Int. J. Lepr. 59(4), 576-81, 1991 (IF 2.8).
  113. Antibodies to plasmodium falciparum Ring Infected Erythrocyte Surface antigen and P. falciparum & P. vivax CS protein. K.J. Manzar and Rao, D.N.. Med. Sci. Res. 19, 345-49, 1991 (IF 1.8).
  114. Transfusion malaria in operated neurosurgical cases - A report of two cases. A.K. Mahapatra and Rao, D.N..Ind. J. Malariology, 27, 243-45, 1990.
  115. Effects of tuftsin stimulation on the microbicidal activity exerted by blood monocyte-macrophages of leprosy patients. Iyer, R.R., H.K. Prasad, L.K. Bhutani and Rao, D.N.. Int. J. Immuno. Pharmac. 12, 859-69, 1990 (IF 3.0).
  116. Modulation of human lepromatous monocyte-macrophage functions in vitro by tuftsin. Iyer, R.R., H.K. Prasad, L.K. Bhutani and Rao, D.N.. Int. J. Immuno. Pharmac. 12, 847-58, 1990 (IF 3.0).
  117. Detection of human antibodies against Plasmodium falciparum and P. vivax sporozoites using synthetic peptides. K.J. Manjar and Rao, D.N. Med. Sci. Res. 18, 721-23, 1990 (IF 1.8).
  118. New approaches to molecular vaccines. Kaur, Jagdeep and Rao, D.N. Natl. Med. J. Ind. 3, 58-63, 1990.
  119. Chemical synthesis and immunological properties of immunodominant peptide of P.falciparum. V. Anuradha and Rao, D.N., Med. Sci. Res. 17, 477-79, 1989 (IF 1.8).
  120. Chemical synthesis and immunological properties of immunodominant peptide of P.vivax. R. Malini and Rao,D.N., Med. Sci. Res. 17, 473-76, 1989 (IF 1.8).
  121. A novel synthetic route to a phagocytosis stimulating tetra peptide "Tuftsin". Rao, D.N., Ravi R. Iyer, H.K. Prasad & I. Nath. Med. Sci. Res. 15, 1199-1201, 1987 (IF 1.8).
  122. An improved immunogenic conjugate of the B-subunit of Human Chorionic Gonadotropin with tetnus toxoid using the SPDP method. Rao, D.N. and Om Singh. Med. Sci.Res. 15(12), 701-03, 1987 (IF 1.8).
  123. Serum angiotensin-converting enzyme (SACE) activity in sarcoidosis. S.K.Sharma, Rao, D.N., J.N.Panda and J.S. Guleria. Ind. J. Med. Res., 85, 638-44, 1987 (IF 1.5).
  124. High affinity specific monoclonal antibodies against progesterone. S.K. Gupta, Rao, D.N., C. Das, Elof, D.B. Johanssons and G.P. Talwar. Ind. J. Med. Research, 85, 542-49, 1987 (IF1.5).
  125. New dimensions in vaccinology- the prospects of synthetic vaccines. Rao, D.N. Biochemical Education, 15, 3-7, 1987.
  126. Improved immunogenic formulation for antigonadotropin response. N.C. Sharma, Rao, D.N., C. Das and G.P. Talwar. In: Immunological approaches to contraception and promotion of fertility, Edited by Dr. G.P. Talwar, New York, Plenum press, pp. 37-41, 1986.
  127. Enhancement of antigonadotropin response to subunit of ovine lutenizing hormone by carrier conjugation and combination with subunit of human chorionic gonadotropin. G. P. Talwar, Om Singh, Vinod Singh, Rao, D.N., N.C. Sharma, C. Das and L.V. Rao. Fertility & Sterility, 46, 120-26, 1986.
  128. Nuclear magnetic resonance and its applications in medicine. Moudgil, K.D., Rao, D.N. and Narang, B.S. Ind. J. Paed. 52, 231-42, 1980 (IF 1.0).

CHAPTERS IN BOOKS

  1. Preparation of Peptide microspheres using tumor antigen-derived peptides. Bhatnagar S, Naqvi RA, Ali R, Rao DN., Methods Mol Biol., Cancer Vaccine Methods and Protocols, Chapter 42, 2014;1139:443-52. doi: 10.1007/978-1-4939-0345-0-34.
  2. Handbook of Running, Jogging Brisk Walking & Walking for health A sustainable lifestyle approach edited by Mr. Narain Medury "A chapter on Immune System & Humane Health Effects of Running, jogging and walking, Dr. Vineeta Chattree Kashyap & Rao D.N.
  3. Trends in Clinical Biochemistry and Laboratory Medicine proceedings of 9th APCCB held at New Delhi, 2002 published by IJCB (ACBI) as Chief Editor.
  4. Handbook of Practical Biochemistry - Chapter on "Chromatography" published by Prentice Hall of India, Pvt. Ltd. 2002.
  5. Text book of "Biochemistry and Human Biology". Edited by Dr. L.M. Srivastava et al. Chapter on Mononuclear phagocytes-macrophages. CBS publication, New Delhi, 2002.

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