Dr. N.C. Chandra
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Dr. N.C.Chandra
Assistant Professor
Room no. 3016, Department of Biochemistry,
All India Institute of Medical Sciences,
New Delhi
Phone: 011-26594267
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Brief profile:
PhD : University of Calcutta
Post doctoral training: Harvard Medical School , USA
University of Notre Dame, USA
Lecturer: M. S. University of Baroda. : 1996 – 1998
Lecturer: D. Y. Patil Medical College, Mumbai: 1998 – 2001
Assistant Professor: Dept. of Biochemistry, AIIMS, New Delhi presently.
Running Research projects as principal investigator:
- Studies on nuclear cholesterol and expression of cell cycle proteins in normal and tumor cell lines. [Sponsored by ICMR, New Delhi].
- An in vitrosilencing of endogenous oxidized-LDL-receptor (LOX-1) gene by siRNA: Study of NF-kB activated expression of proinflammatory cytokines and related atherogenic proteins ------ its evaluation against anti-inflammatory cytokine mediated responses. [Sponsored by DBT, New Delhi].
- Intracellular cholesterol homeostasis and cell proliferation. [Sponsored by Dept. of atomic energy, BARC, Mumbai].
- Study on feedback regulation of intracellular cholesterol and T cell population in mice by immunogen, mitogen and carcinogen [Sponsored by AIIMS, New Delhi].
Member
- Association of Clinical Biochemists, India.
- Indian Immunology Society.
- Indian Society for Atherosclerosis Research
- Indian Society of Cell Biology
- Society of Biological Chemistry, India.
STUDENTS:
PhD:Ms Albina Arjuman (July 2008 – June 2013)
Modulation of the oxidized-LDL-receptor and its effect on pro-and anti- inflammatory cytokines.
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MD: Dr. Puja Beriwal (Januaray 2009 – December 2011)
Thesis title: Association of plasma risk factors in obese subjects with leptin, insulin and their receptors – a pilot study.
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Dr.Govind Singh (July 2009 – July 2012)
Thesis title: Cholesterol homeostasis and expression of cell cycle proteins (cyclin E and cdk2) in normal prostate, benign prostatic hyperplasia and carcinoma prostate cases: a pilot study
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Dr. Shrimanjunath (July 2009 – July 2012)
Thesis title: Insights of cholesterol homeostasis in lymphocyte of normal and chronic lymphocytic leukemia subjects: a case control pilot study
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Dr Amarpreet Kaur (July 2010 – July 2013)
Thesis title: Study of feedback regulation of intracellular cholesterol and immunogenic response by T cells using immunogen, mitogen and chemical carcinogen in mice model.
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Dr. Nimisha Saxena (July 2010 – July 2013)
Thesis title: Study of feedback regulation of intracellular cholesterol and immunogenic response by B cells using immunogen ,mitogen and chemical carcinogen in mice model.
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RESEARCH & IMPORTANT PUBLICATIONS
- Research interests –
- Studies on cholesterol homeostasis by LDL receptor regulation and the effects of insulin, thyroxin, Leptin and their receptors whose deficiencies are associated in developing atherosclerosis.
- Intracellular cholesterol homeostasis and cell proliferation.
- Cholesterol homeostasis and immune system.
- Important Publications –
- Nimai C. Chandra, Mary B. Doody and Roger K. Bretthauer. Specific lipids enhance the activity of UDP-GlcNAc:Dolichol Phosphate GlcNAc-1-Phosphate Transferase in intact rat liver endoplasmic reticulum membrane vesicles. Arachives Biochem. & Biophy. 290(2), 345 - 354, 1991.
- N.C.Chandra, D.W.Welsh, M.B.Doody and R.K.Bretthauer. Alteration of microsomal UDP-GlcNAc:Dolichol Phosphate, GlcNAc-1-Phosphate Transferase (GPT) activity by nonspecific phospholipid transfer protein.FASEB J. 6(1) , 231, 1992.
- Nimai C. Chandra, Mary J. Spiro and Robert G. Spiro. Identification of a glycoprotein from rat liver mitochondrial inner membrane and demonstration of its origin in the endoplasmic reticulum. J. Biol. Chem. 273(31), 19715 - 19721, 1998.
- Gopalakrishnan R. and N.C.Chandra. Estradiol regulates Insulin dependent stimulation of LDL-receptor expression in HepG2 cells. Indian J. Clin. Biochem. 21(1), 8 – 14, 2006.
- Gomathy Sethuraman, Selvendran Sugandhan, Gautam Sharma, Nimai Chand Chandra, Kudligi Chandramohan, Aggarwal Komal, Vinod K Sharma. Familial homozygous hypercholesterolemia: report of two cases and review of literature. Pediatr Dermatol 24(3), 230 – 234, 2007 .
- Gopalakrishnan R, A. Rana and N. C. Chandra. Study of low-density lipoprotein receptor regulation by oral (steroid) contraceptives: desogestrel, levonorgestrel and ethinyl estradiol in JEC-3 cell line and placentral tissue. Contraception 76: 297 – 305, 2007.
- G. Ramakrishnan, N.C.Chandra, Regulation of low density lipoprotein receptor activity by insulin and steroids in model cell culture system.Abstract No. 144. J. Clin. Lipidology 2(5S) 2008
- Albina Arjuman, Hemlata Pandey and Nimai Chand Chandra. Effect of a combination oral contraceptive (desogestrel + ethinyl estradiol) on the expression of low-density lipoprotein receptor and its transcription factor (SREBP2) in placental trophoblast cells. Contraception 84(2): 160 – 168, 20119.
- Shilpa Suneja, Gopalakrishnan Ramakrishnan, Nikhil Tandon and N.C.Chandra. Modulation by insulin of the co-localized LDL receptor in normal and Type-I Diabetic subjects.International Journal of Clinical Medicine. 2(3): 231 – 245, 2011
- Hemlata Pandey, Albina Arjuman, Kallol K. Roy, Nimai Chand Chandra. Reciprocal co-ordination of a combination oral contraceptive containing (desogestrel+ethinyl estradiol) on the expression of LOX-1 and LDLR in placental trophoblast cells. Contraception: In Press.
