Research

Research Work

The list of ongoing funded research projects with the departmental faculty as principal investigators (PI)/ Co-PI are given below:

• Development of a Multiplexed Nanostring Based Locus Copy Number and mRNA Expression Evaluation Assay for Classification of Wilms Tumor for Diagnosis, Prognosis and Treatment Planning (Dr. Venkateshwaran K Iyer, ICMR)

• Molecular characterization of Endometrial Cancer and its correlation with Clinicopathological Features (Dr. Sandeep Mathur, AIIMS Research Section)

• To investigate metabolic perturbations in Endometrial Cancer by targeted transcriptomics approach in an Indian cohort (Dr. Sandeep Mathur, ICMR)

• Immunohistochemical characterization of four common viruses in a clinically suspected cases of viral myocarditis (Dr. Ruma Ray and Dr. Sudheer Arava, AIIMS Research Section)

• Clinicopathological correlation and amyloid subtyping in cases of cardiac amyloidosis: AN observational study (Dr. Ruma Ray and Dr. Sudheer Arava, DBT-ICMR)

• Sudden cardiac death in young: An autopsy and molecular study to identify the cause Dr. Ruma Ray and Dr. Sudheer Arava, ICMR)

• To evaluate the genetic association in undiagnosed idiopathic cardiomyopathy patients (Dr. Ruma Ray and Dr. Sudheer Arava, ICMR)

• Comparison of various diagnostic modalities for identification of refractory celiac disease in a cohort of patients with celiac disease unresponsive to gluten -free diet (Dr. Prasenjit Das, ICMR)

• Explainable Deep Learning for Automated Evaluation & Grading of Duodenal Biopsies (Dr. Prasenjit Das, AIIMS-IIT)

• A multi-centre study on determination of prevalence of incidental gall bladder carcinoma in India (Dr. Prasenjit Das, NCDIR-ICMR)

• Correlation of Immunologic Milieu and PD-L1 in Non-Small Cell Lung Carcinoma (Dr. Deepali Jain, AIIMS Research Section)

• Study of HPV association in Sino-nasal epithelial tumors (Dr. Deepali Jain, AIIMS Research Section)

• Immunomodulators in small cell lung cancer: basis for implementation of cancer immunotherapy (Dr. Deepali Jain, DST-SERB)

• Dissecting the molecular pathogenetic mechanisms of covid-19 by RNA-sequencing of lung tissue from deceased patients (Dr. Deepali Jain, AIIMS Research Section)

• Molecular sub-typing of small cell lung carcinoma (SCLC) to unravel the biological heterogeneity in clinical settings (Dr. Deepali Jain, ICMR)

• Tumor mutation burden in advanced non-small cell lung carcinomas: Implications for planning treatment strategies (Dr. Deepali Jain, DST-SERB)

• PDL1 Immunohistochemistry in Lung Carcinoma (Dr. Deepali Jain, AIIMS Research Section)

• Study of Urinary Exosome as a Predictive biomarker for podocytic injury in childhood idiopathic nephrotic syndrome (Dr. Geetika Singh, DBT)

• The Genetic Landscape of Alport Syndrome in India with Phenotypic Correlation (Dr. Geetika Singh, ICMR)

• Development of Labyrinth based mechanical and fast isolation technique for identifying circulating tumor cells of colorectal carcinomas for metastasis evaluation (Dr. Asit Ranjan Mridha, DHR-ICMR)

• Utility of Artificial Intelligence in differentiating Non-invasive Follicular Thyroid Neoplasm with Papillary like Nuclear Features from other follicular-patterned thyroid benign and malignant lesions (Dr Shipra Agarwal, DBT)

• Normal superior and inferior parathyroid glands: Molecularly similar or dissimilar? (Dr Shipra Agarwal, AIIMS Research Section)

• Analysis of circulating DNA for BRAF(T1799A) mutation as a futuristic non-invasive tool for diagnosis of papillary thyroid cancer (Dr Shipra Agarwal, ICMR)

• Identification of novel molecular subtypes of prostate cancer as potential therapeutic targets for immunotherapy (Dr. Seema Kaushal, ICMR)

• To evaluate the role of R2TP Complex as a novel regulator of PI3K/Akt/mTOR and AR signalling pathway in prostate cancer (Dr. Seema Kaushal, DHR-ICMR)

• Evaluation of microsatellite instability (MSI) and PDL1 expression in molecular subtypes of upper and lower tract urothelial carcinoma (Dr. Seema Kaushal, AIIMS Research Section)

• Evaluation of Artificial Intelligence as a Diagnostic Tool for Automated Detection and Grading of Colorectal Cancer (Dr Rajni Yadav, AIIMS-IIT)

• Histopathological and Molecular Classification of Gastrointestinal Stromal Tumors (Dr Rajni Yadav, AIIMS Research Section)

• Clinical, Pathological and Genetic Characterization of Neonatal Cholestasis (Dr Rajni Yadav, DHR-ICMR)

• To Evaluate The Role Of Cmyc, Bcl2, Bcl6 And Epstein Barr Virus On Survival In Patients With Refractory/Relapsed Primary Diffuse Large B Cell Lymphoma: An Ambispective Study (Dr Saumyaranjan Mallick, DST)

• To Evaluate The Role Of Microenvironment Clonality Assay And 9p24 Alteration In Diagnosis And Prognostication Of Refractory Hodgkin’s Lymphoma (Dr. Saumyaranjan Mallick, DST)

• To Evaluate The Molecular Subtypes Of Peripheral T Cell Lymphomas (Dr. Saumyaranjan Mallick, AIIMS Research Section)

• MUC1 Pulsed DC-derived exosomes for cancer immunotherapy (Dr. Adarsh Barwad, DBT)

• Molecular analysis of Giant Cell Tumour of Bone and its correlation with response to Zoledronic acid treatment (Dr. Adarsh Barwad, AIIMS Research Section)

• Nanotechnological intervention in dental and bone implants: Tailoring smart, multifunctional interface towards improved osseointegrative and anti-bacterial properties (Dr. Adarsh Barwad, DBT)

• Development Of Novel Nanocarrier Based Oral Formulation of AmB as A Therapeutic Alternative (Dr. AK Dinda and Dr Adarsh Barwad, DBT)

• Affordable, Effective Personalised Point-Of-Use Wound Care Patches at Patient Bedside for Large Asymmetric Burn Wound (Dr. AK Dinda and Dr. Adarsh Barwad, DST-SERB)

• Development Of Minimal Invasive Novel Injectable Hydrogel and Nano-Carrier-Hybrid System for Localised Targeted Cancer Therapy (Dr. AK Dinda and Dr. Adarsh Barwad, DHR-ICMR)

• NIRMANN 3D Novel Minimally Invasive Implants for Reconstructive Surgery Using Material Providing Mechanical Instruction and Prepared By 3D Printing (Dr. AK Dinda and Dr. Adarsh Barwad, DBT)

• Evaluation of EGFR mutations, HPV status and PD-L1 expression in pathogenesis of sinonasal squamous neoplasms (Dr. Aanchal Kakkar, AIIMS Research Section)

• Molecular characterization of olfactory neuroblastomas for classification into prognostically and therapeutically relevant subgroups (Dr. Aanchal Kakkar, DST-SERB)

• Molecular characterization of salivary gland carcinomas: A comparative study between AIIMS and North-East regions of India (Dr. Aanchal Kakkar, DBT)

• Evaluation of ALK, ATRX and MYC immunoexpression in Neuroblastoma and their correlation with prognostic parameters (Dr. Aanchal Kakkar, AIIMS Research Section)

• Study of Inherited Mismatch Repair deficiency and its correlation with tumor mutations burden and immune microenvironment in pediatric and adult gliomas (Dr. Kavneet Kaur, ICMR)

• Relook at adult low grade glioneuronal tumors of central nervous system beyond 2016 WHO classification (Dr. Kavneet Kaur, AIIMS Research Section)

• Comparative analysis of host immune and tissue reaction to mucormycosis between SARS-CoV-2 positive and negative patients on surgical specimens (Dr. Kavneet Kaur, AIIMS Research Section)

• Comparative analysis of the activation of EGFR/MAPK/SHH/NFKB pathways and mutation status of USP8/USP48/BRAF genes in clinically functioning and silent corticotroph pituitary adenomas to identify pharmacological targets for medical management of Cushing’s disease (Dr. Aruna Nambirajan, ICMR)

• Assessment of hypoxia inducible factor- 1 alpha pathway activation and its correlation with tumor immune microenvironment and markers of tumor invasiveness in myxopapillary ependymomas (Dr. Aruna Nambirajan, AIIMS Research Section)

• Molecular mechanisms of resistance to EGFR tyrosine kinase inhibitors in EGFR mutant non-small cell lung carcinoma (Dr. Aruna Nambirajan, AIIMS Research Section)

• Novel Molecular Subtypes of Uterine sarcoma (Dr Ruchi Rathore, AIIMS Research Section)

• The prevalence of BRCAness related somatic mutation in uterine leiomyosarcoma (Dr. Ruchi Rathore, AIIMS Research Section)

• Podocytouria in children with nephrotic syndrome: Can urine podocyte level and its growth characteristics predict steroid resistance (Dr. Lavleen Singh, DST)