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अखिल भारतीय आयुर्विज्ञान संस्थान, नई दिल्ली
All India Institute Of Medical Sciences, New Delhi

Dr. Siddhartha Kundu, MD, PhD (Associate Professor)  

 

Address:

3027B, Department of Biochemistry, AIIMS, New Delhi – 110029

Email:

This email address is being protected from spambots. You need JavaScript enabled to view it. ; This email address is being protected from spambots. You need JavaScript enabled to view it.

Telephone:

+91-11-26546514

 Public profiles:

Orcid || Loop-Frontiers || Exaly || ResearchGate || GoogleScholar ||

Research focus

Mathematical and Computational Biochemistry

Areas of Interest

·         Mathematical analyses of biochemical reactions & metabolic networks

·         Mathematical modelling and simulations of complex biochemical systems

·         Algorithms for molecular biology

   

 Servers/Software developed

Hyperlink

Description

http://doi.org//10.1142/S0219720022500184

https://cran.r-project.org/package=TemporalGSSA

 

 

[Siddhartha_kundu_img1.png]

http://doi.org//10.3389/fmolb.2023.1206502

https://cran.r-project.org/package=ReDirection

 

 

[Siddhartha_kundu_img2.png]

http://doi.org//10.1177/11779322211045878

http://178.63.18.214/ProTG4.html

 

 

[Siddhartha_kundu_img2.png]

http://doi.org/10.1186/s13104-021-05477-z

http://178.63.18.214/Fe2OG.html

 

 

[Siddhartha_kundu_img2.png]

 

Educational qualifications

Degree

Subject

University/Institution

Year

PhD

Computational Biology & Bioinformatics

School of Computational and Integrative Sciences (SCIS),

Jawaharlal Nehru University, New Mehrauli Road, New Delhi 110067

2014-2018

MD

Biochemistry

All India Institute of Medical Sciences (AIIMS),

Ansari Nagar, New Delhi 110029

1999-2001

MBBS

Pre-&Para-/Medical/ Surgical subjects

University College of Medical Sciences (UCMS),

Dilshad Garden, New Delhi 110095

1992-1996

Memberships

1.

Society for Mathematical Biology (SMB): Life member (ID:36503496)

2.

European Society for Mathematical and Theoretical Biology (ESMTB) : Life member   ID: 50143836

3. Elected member Sigma Xi society ( Scientific Research Honors Society)

Award/recognition:

AIIMS excellence research award ( Certificate of commendation)  

1.

2022

Kundu S#*. TemporalGSSA: a numerically robust R-wrapper to facilitate computation of a metabolite-specific and simulation time-dependent trajectory from stochastic simulation algorithm (SSA)-generated datasets. Jour Bioinf. Comp. Biol. 2022, 20(4):2250018. PMID: 35941839

[JBCB2022] (Additional Material).

2.

 

2021

Kundu S#*. Mathematical modeling and stochastic simulations suggest that low-affinity peptides can bisect MHC1-mediated export of high-affinity peptides into “early”- and “late”-phases. Heliyon. 2021, 7(7):e07466. PMID: 34286133

[HYON2021].(Additional Material).

 

Research publications (complete citations)

2024
  1. (Preprint) Kundu S#*. Construction, analysis and assessment of relevance of an algebraic model for a class of biochemical networks. (https://doi.org/10.1101/2024.03.07.583960)

  2. Kundu S#*. A mathematically rigorous algorithm to define, compute and assess relevance of the probable dissociation constants in characterizing a biochemical network. Scientific Reports2024, 14. PMID: 38347039 [SCIR2024] (Additional Material).

2023
  1. Kundu S#*. ReDirection: an R-package to compute the probability dissociation constant for every reaction of a user-defined biochemical network. Front Mol Biosci. 2023, 10. PMID: 37942290  [FMBI2023]. (Additional Material)

 

2022

1.      Kundu S#*. Modeling ligand-macromolecular interactions as eigenvalue-based transition-state dissociation constants may offer insights into biochemical function of the resulting complexes. Math Biosci Eng. 2022, 19(12): 13252-275. [MBE2022] (Additional Material).

2.      Kundu S#*. TemporalGSSA: a numerically robust R-wrapper to facilitate computation of a metabolite-specific and simulation time-dependent trajectory from stochastic simulation algorithm (SSA)-generated datasets. Jour Bioinf. Comp. Biol. 2022, 20(4):2250018. PMID: 35941839[JBCB2022] (Additional Material).)  

2021

         1Kundu S#*. ProTG4: A Web Server to Approximate the Sequence of a Generic Protein From an in Silico Library of Translatable G-Quadruplex (TG4)-Mapped Peptides. Bioinform Biol Insights. 2021, Sep 28;15:11779322211045878. PMID: 34602814.  [BBI2021]  (Additional Material).

 

         2. Kundu S#*.Mathematical modeling and stochastic simulations suggest that low-affinity peptides can bisect MHC1-mediated export of high-affinity peptides into “early”- and “late”-phases. Heliyon. 2021, 7(7):e07466. PMID:.34286133 [HYON2021] (Additional Material)

 

         3. Kundu S#*.Fe(2)OG:An integrated HMM profile-based web server to predict and analyze putative non-haemiron(II)- and 2-oxoglutarate- dependent dioxygenase function in protein sequences. BMC Res Notes. 2021, 14(1):80. PMID: 33648553. [BMRN2021] (Additional Material).

2020

  1. Kundu S#*. Mathematical model of a short translatable G-quadruplex and an assessment of its relevance to misfolding-induced proteostasis. Math Biosci Eng.2020, 17(3): 2470-2493. PMID: 32233549.[MBE2020] (Additional Material)

2019

  1. Kundu S#*. Insights into the mechanism(s) of digestion of crystalline cellulose by plant class C GH9 endoglucanases. J Mol Model. 2019 Jul 23;25(8):240. PMID: 31338614 [JMM-2019] (Additional Material)

2018

  1. Kundu S#*. Mathematical basis of predicting dominant function in protein sequences by a generic HMM-ANN algorithm. ActaBiotheor. 2018 Jun;66(2):135-148. PMID: 29700659,32385619[ACBI2018] (Additional Material)
  2. Kundu S*, Sharma R*. Origin, evolution, and divergence of plant class C GH9 endoglucanases. BMC Evol. Biol. 2018 May 30;18(1):79. PMID: 29848310.[BMEB2018] (Additional Material)

2017

  1. Kundu S#*. Mathematical basis of improved protein subfamily classification by a HMM-based sequence filter. Math Biosci. 2017 Nov;293:75-80. doi:10.1016/j.mbs.2017.09.001. Epub 2017 Sep 13. PubMed PMID: 28916136.  (Additional Material)

2016

  1. Kundu S*, Sharma R*. In silico Identification and Taxonomic Distribution of Plant Class C GH9 Endoglucanases. Front Plant ci. 2016 Aug 12;7:1185. PMID: 27570528 [FPS2016] (Additional Material).
  2. Kundu S#*. Stochastic modelling suggests that an elevated superoxide anion-hydrogen peroxide ratio can drive extravascular phagocyte transmigration by lamellipodium formation. J Theor Biol. 2016 Oct 21;407:143-54. PMID: 27380944. (Additional Material).

2015

  1. Kundu S#*. Co-operative intermolecular kinetics of 2-oxoglutarate dependent dioxygenases may be essential for system-level regulation of plant cell physiology. Front Plant Sci. 2015 Jul 15;6:489. PMID: 26236316.[FPS2015a] (Additional Material).
  2. Kundu S#*. Unity in diversity, a systems approach to regulating plant cellphysiology by 2-oxoglutarate-dependent dioxygenases. Front Plant Sci. 2015 Mar 11;6:98. PMID: 25814993 [FPS2015b] (Additional Material)..

2012

  1. Kundu S#*. Distribution and prediction of catalytic domains in 2-oxoglutarate dependent dioxygenases. BMC Res Notes. 2012 Aug 4;5:410. PMID: 22862831 [BMRN2012] (Additional Material).

2011

  1. Kundu S*, Subodh S. Gradient sensing in vectorial chemotaxis – a novel role for Reactive Oxygen Species. International Journal of Trends in Medicine. 2011 1; 54-59. [IJTM2011]

2002

  1. Singh N, Khanna N, Sharma H, Kundu S, Azmi S. Insights into the molecular mechanism of apoptosis induced by TNF-alpha in mouse epidermal JB6-derived RT-101cells. Biochem Biophys Res Commun. 2002 Jul 5;295(1):24-30. PMID:12083761. [BBRC2002]
   (#) Single author; (*)Corresponding author

Positions held

Position

Subject/Work

University/Institution

Year

Associate Professor

Assistant Professor

Biochemistry

All India Institute of Medical Sciences (AIIMS),
Ansari Nagar, New Delhi 110029

2023-2019-2023

Associate Professor

Biochemistry

Army College of Medical Sciences (ACMS),
Brar Square, Delhi Cantt., New Delhi – 110010

2015-2018

Dr. Baba SahebAmbedkar Medical College and Hospital (BSAMCH), Govt. of NCT of Delhi, Rohini, Delhi 110085 2018-2019

Assistant Professor

Biochemistry

Army College of Medical Sciences (ACMS),
Brar Square, Delhi Cantt.,New Delhi – 110010

2009-2014

Scientist ‘D’ (Medical)

Program Officer

Indian Council of Medical Research (ICMR),
V. RamalingaswamiBhawan,

Ansari Nagar, New Delhi 110029

07-10/2019

Senior Level Consultant

Program Director

Information Technology Research Academy (ITRA),
Digital India Corporation (formerly Media Lab Asia),
Ministry of Electronics and Information Technology,

C-DOT campus, New Delhi 110030
2016-2017

Research Consultant

Computational Biology

India Research Labs (IRL) IBM 2002-2003

Research Associate/Fellow/Scientist

PostDoctoral work

International Center for Genetic Engineering and Biotechnology (ICGEB)

05-10/2014

National Institute of Immunology (NII) 2005-2008
ICMR-National Institute of Pathology (NIOP) 2003-2004
Indian Institute of Technology Delhi (IITD) 01-05/2002
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