Dr. Pramod Kumar Gautam
- Last Updated On :
Dr. Pramod Kumar Gautam
Additional Professor
Room No. 3040, 3rd Floor, Teaching Block,
Department of Biochemistry
All India Institute of Medical Sciences
Ansari Nagar, New Delhi-110029
Official Phone: (O) 011-26594682; (Ext) 4682
Email id: This email address is being protected from spambots. You need JavaScript enabled to view it. , This email address is being protected from spambots. You need JavaScript enabled to view it.
========================================================================
Academic carrier
I am currently working as an additional professor in the Department of Biochemistry. My PhD and post-doctoral fellowship from Banaras Hindu University, Varanasi, India
Academic Activity
UG, PG teaching, and research
Administrative Positions/Activities
-
Member of the transport committee, AIIMS, New Delhi
-
Worked as a nodal officer for COVID control
-
Ph.D. course work in charge
Membership in the Society
-
Life member of the Indian Immunology Society, India
-
Life Member of Cancer Immunotherapy (CIMT), Germany
-
Indian Academy of Biomedical Sciences (IABS)
-
The Indian Association of Cancer Research (IACR)
-
Association of Clinical Biochemistry (ACBI)
Reviewer and Editorial Board Membership
-
The International Journal of Gastrointestinal Cancer
-
Journal of Nano particle research (2016 onward)
-
Journal of Leukemia Research (2016 onward)
-
BMC Cancer
Research Work: - Laboratory of Immunology and Cancer Immunotherapy
The immune system can be likened to a sophisticated army, equipped with various tools and mechanisms to protect the body from infections and cancers. However, during tumor development, cancer cells release substances that suppress the immune system, allowing the tumor to grow and spread. To combat this, researchers are focusing on developing immunotherapies that enhance the body's natural defenses against cancer. These immunotherapies target specific pathways involved in tumor growth, angiogenesis, and immune suppression. By discovering and studying the effects of natural compounds and plant extracts, scientists hope to develop safe and effective treatments for cancer that can be used in combination with existing therapies. The goal is to improve cancer management, early detection, and targeted drug delivery to prevent the progression of the disease. Our research lab utilizes advanced molecular & immunological techniques.
Extramural and Intramural Project:-
-
Elucidating the targeted, therapeutic role of docetaxel-loaded-HSP70 peptide complex in PDX Mouse Models. (PI, Ongoing, ICMR)
-
Role of M1 macrophage on DNA methylation and PI3K-AKT Signaling Pathway analysis in tumor-associated mesenchymal stem cells in Breast cancer.(PI, Ongoing, AIIMS)
-
Development of anti-proliferative agent form boerhaabia diffusa and citrullus colocynthis plant extract in human bladder cancer. (PI, Ongoing, AIIMS)
-
Role of Macrophage in the regulation of Bone and Blood forming stem cell and progenitor cells migration and development. (PI, Completed, DBT)
-
Evaluation of tumor-derived exosomes in blood during pre and post treatment of pancreatic cancer patients(PI, Completed, AIIMS)
-
Development of targeted drug delivery using liposomes/nanoparticles on cancer stem cell using herbal plant extract and hsp70- tumor antigen and to evaluate its anti-tumor function. (PI,SERB, Completed)
-
To emphasis the role of macrophage phenotype on mesenchymal stem cell in breast cancer. (Completed, AIIMS)
-
To study the role of β-defensin on stem cells, cancer stem cells remodelling and its associated microenvironments(AIIMS, Completed)
Group members:-
-
PhD thesis: completed-2; ongoing-1
-
MD Thesis: Completed-1; ongoing-1
-
Post Doc Fellow-1,
-
Research Scientist: 1 (an ICMRfunded project)
-
TARE, SERB, New Delhi—Dr. Qulsum Akhtar.
-
Project Staff: 2
Current lab members: Miss Anita (CSIR-JRF); Rupinder Kaur (CSIR-SRF, NET), Dr. Sreekar; Dr. Neha Singh; Dr. Soni Kumari (Research Scientist-II); Ankit Kumar; and Bharta Sinha (DEO, AIIMS, New Delhi).
-
Miss Anita
Anita submitted her thesis in the year 2024. Her title of thesis is to elucidate the immunomodulatory and anti-tumor role of m1 macrophage on bone marrow derived mesenchymal stem cells: implications in breast cancer. Anita has been qualified CSIR-JRF and currently working as a research scientist in the Dept. of Pharmacology at AIIMS, New Delhi.
-
Rupinder Kaur
ORCID: 0000-0002-0158-8307
Rupinder Kaur, a 4th year Ph.D. student (2020-present) and CSIR-SRF (Direct) fellow, delves into the fascinating world of cancer-immunology. Her research focuses on unraveling the immunomodulatory effects of tumor-derived exosomes on Gamma-Delta T cells. By exploring this intricate interaction, she aims to uncover potential therapeutic strategies for cancer treatment. Rupinder's work primarily consists of the analysis of differential micro-RNA cargo in extracellular vesicles in peripheral blood of cancer patients. She is also working on elucidating the mysteries of the change in polarity of gamma delta T cells under the effect of tumor derived extracellular vesicles. She completed her Master in Biochemistry in 2019 from Punjab Agricultural University, Ludhiana.
Thesis Title: “To study the immunomodulatory effect of tumor derived exosomes in Gamma-Delta T cells.”
-
Ankit Kumar
Myself, Ankit Kumar and I have done my B.Sc. in Zoology (Hons) from St. Xavier College Ranchi in 2018–21. and currently I have joined as M.Sc student and am working on a thesis titled "Differentially expressed exosomal miRNA derived from Pancreatic Ductal AdenoCarcionoma (PDAC)".
-
Neha Singh
Qualification- PhD in Microbiology
ORCID- https://orcid.org/0000-0001-9802-0445
Current affiliation- Project Student, Department of Biochemistry, All India Institute of Medical Sciences
Project Title-Elucidating the targeted therapeutic role of docetaxel- loaded- HSP70 peptide complex in PDX mouse models.
Expertise- Expert in microbiology, medicinal plants, and cancer biology. Skilled in analyzing microbial interactions, identifying medicinal compounds in plants, and studying cancer cell signaling pathways. Proficient in microbiological techniques, plant extraction methods, and cancer cell culture assays. Experience in research, drug discovery, and contributing to advancements in medical science.
-
Soni Kumari (Research Scientist II)
PhD in Biochemistry
ORCID ID: 0000-0002-9743-3202
I am currently working as a Research Scientist II on an ICMR-funded project titled “Elucidating the Therapeutic Role of Docetaxel-Loaded HSP Peptide Complex in PDX Mouse Model.”
-
Dr. K. V. Sreekar ( MD student)
He has a strong interest in cancer and cancer immunology and is about to embark on research in breast cancer immunology. His focus will be on developing new methods to detect novel biomarkers that can aid in the early diagnosis of breast cancer. He has finished his M.B.B.S. from Dr. NTR university of health sciences, Andhra Pradesh.
Previous Student:-
Dr. Sonam Agarwal (ICMR- RA);Dr.. Khuswant Singh (CSIR-JRF); Dr. Kunal Kumar; Dr. Vijay Mohan (Post Doc Fellow); Pavit Singh (MBBS-STS student).
-
Sonam Agarwal:- complete her work on “Detection of prostate cancer biomarker using sensitive and rapid lateral flow device with diagnostic and prognostic significance” (ICMR-RA)
-
Khushwant Singh:- Submitted his thesis on Determining the immunomodulatory and antitumor function of hsp70 chemotherapeutic drug conjugates on cancer stem cells
-
Marilyn Masih:-Completed her thesis on “Comparative analysis between different stage Cancer patients to discover Novel Blood – based biomarkers for detection of early stage breast cancer- A pilot study”
-
Pavit Singh (MBBS-STS student) “To study the differential exosomal abundance in pancreatic cancer patients”
Publication Details
https://orcid.org/0000-0001-7580-8846
https://scholar.google.co.in/citations?user=PBcBKhwAAAAJ&hl=en
