- Last Updated On :
Dr. Archna Singh, Professor
Address: Room Nos. 3044 & 3046a, Department of Biochemistry, AIIMS, New Delhi.
Phone: 011-26593635; 26593478
Emailid: This email address is being protected from spambots. You need JavaScript enabled to view it. ,'; document.write(''); document.write(addy_text56202); document.write('<\/a>'); //-->\n This email address is being protected from spambots. You need JavaScript enabled to view it. This email address is being protected from spambots. You need JavaScript enabled to view it.
Academic Details:
|
Degree |
University |
Subject |
Year |
|
MBBS |
NalandaMedical College, Patna,India |
Medicine,Surgery, Gynecology |
1998 |
|
M.D. |
AllIndiaInstituteofMedicalSciences,Delhi, India |
Biochemistry |
2004 |
|
Ph. D |
AllIndiaInstituteofMedicalSciences,Delhi, India |
Biochemistry |
2008 |
|
MPH |
UniversityofMichigan,AnnArbor,US |
Environmental Health (Nutritionconcentration) |
2008 |
Position sheld:
-
Position held
Name of Institution/Place
From
To
1.
Professor
AllIndiaInstituteofMedicalSciences,New Delhi, India.
July 2023
Present
2.
Additional Professor
AllIndiaInstituteofMedicalSciences,New Delhi, India.
July 2019
June 2023
3.
Associate Professor
AllIndiaInstituteofMedicalSciences,New Delhi, India.
July 2016
June 2019
4.
Assistant Professor.
AllIndiaInstituteofMedicalSciences,New Delhi, India
Nov 2012
June 2015
5.
Assistant Professor
IIPH-D,PublicHealthFoundationofIndia, New Delhi, India.
Jan 2009
Oct2012
6.
Senior Resident
AllIndiaInstituteofMedicalSciences,New Delhi, India
August 2004
July 2007
7.
Junior Resident
AllIndiaInstituteofMedicalSciences,New Delhi, India.
July2001
June 2004
Society Memberships
-
LifeMemberoftheSocietyforMitochondrialResearchandMedicine,India.
-
LifeMember,IndianAssociationforCancerResearch.
-
LifeMemberofImmunologySocietyof India.
-
LifememberofAssociationofMedicalBiochemistsof India
Research Focus of the Lab:
The broad research focus of my laboratory is on different aspects of lipid metabolism in cancer and obesity. Some of our research revolves around the role of ABCA1, involved in lipid efflux, in maintaining adipocyte homeostasis in obesity since we observed a lower gene expression of this transporter in the visceral adipose tissue of obese individuals. We are looking at pathways related to adipocyte ABCA1 and some lipid species like ceramides that could drive insulin resistance in obesity. We have also studied HDL’s function and quality concerning its key physiological roles i.e., in reverse cholesterol transport, antioxidative capacity, endothelial reactivity etc. We aim to understand the implications of changes in the quality of various HDL- associated molecules such as ApoA1 and Sphingosine-1-phosphate. Our cancer research focuses on analysing various aspects of metabolic reprogramming in pediatric B-ALL. We have recently found inter-tumor heterogeneity in the expression of lipid metabolism enzymes like ACSM3, and ACSL1 among pediatric B-ALL cases and we are planning to apply various approaches to understand the biological implications of this differential expression. Other avenues of interest include bioenergetics, mitochondrial biogenesis and factors regulating mitochondrial DNA copy number in leukemia.
The nutrition research in the lab extends into both the biochemical and public health domains in the context of the dietary quality and nutritional status of indigenous tribal communities of India. Our work among these communities encompasses food systems sustainability research and I am a collaborator on a recently awarded Team Science Grant on this theme in which my role is to develop successful diagnostic technologies for micronutrient assessment that can be feasible and cost-effective for assessing micronutrient status in these vulnerable communities. My interest extends to exploring the nutrient profiles of unique indigenous varieties of foods like mushrooms and indigenous rice varieties. We have also recently started work on a collaborative project with the Department of Cardiology and TGI, India for understanding the effect of foods on inflammatory biomarkers among CAD patients.
We are ably supported in our research work by experienced and sincere laboratory technicians. We are an enthusiastic research group, promoting collaborative work with various departments at AIIMS and between Institutes like IGIB and TGI, India. We endeavour to publish and disseminate our work across the global research community.
In keeping with our interest in metabolism, we enjoy experimenting with various cuisines and enjoy varied culinary experiences to rejuvenate ourselves occasionally.
We have a vibrant and enthusiastic team in the lab that is always striving to enhance their academic and extra-curricular skills.
ListofLabmembers
-
Dr.BhanupriyaAwasthi,PostdoctoralFellow.
-
Mr. Sovik Roy (Ph.D scholar)
-
Ms. Haripriya Santosh (Ph.Dscholar)
-
Ms. Urooj Jahan(Ph.D scholar)
-
Mr.AdarshSuman(Ph.D scholar)
-
Dr.Shravya Kethuri (M.D. student)
-
Ms.AanchalSingh(M.Sc. student)
-
Ms. Dolly Rathore,Laboratory Technician.
-
Mr.MudassirAli, Laboratory Technician.
-
Mr.RamVikasYadav, LaboratoryTechnician.
-
Mr.NidhiBailwal,Laboratory Technician.
-
MeghaSuresh,NutritionResearchAssociate.
-
SabihaKhan,SeniorNutritionResearchFellow.
Positions Available:ExpectedinJanuary2024.
Some Keypublications:
-
Thakkar H, Vincent V, Roy A and Singh A. Thakkar H, Vincent V, Roy A, Singh A. High densitylipoproteinheterogeneity & function among Indians with coronaryartery disease.Indian J Med Res. 2023;158(3):292-302. doi:10.4103/ijmr.ijmr_1212_22.
-
SharmaG,TranTM,BansalI,etal.RNAbindingproteinIGF2BP1synergizeswithETV6- RUNX1 to drive oncogenic signaling in B-cell Acute Lymphoblastic Leukemia. JExp Clin Cancer Res. 2023;42(1):231. Published 2023 Sep 5. doi:10.1186/s13046-023-02810-1.
-
Sachan,A,Aggarwal,S,Pol,MM,Singh,A,Yadav,R..ExpressionanalysisofMMP14: Key enzyme action in modulating visceral adipose tissue plasticity in patients with obesity. Clinical Obesity, 2023 e12607. doi:10.1111/cob.12607.
-
Bansal A, Singh A, Nag TC, Sharma D, Garg B, Bhatla N, Choudhury SD, Ramakrishnan L. Augmenting the Angiogenic Profile and Functionality of Cord Blood Endothelial Colony- Forming Cells by Indirect Priming with Bone-Marrow-Derived Mesenchymal Stromal Cells. Biomedicines.2023May5;11(5):1372.doi:10.3390/biomedicines11051372.PMID:37239042; PMCID: PMC10216643.
-
SinghA,DhasmanaA,BandhuA,KapoorR,BaalasubramanianS,Ghosh-JerathS.Contributionof natural food environments to nutritional intake and biomarker status: insights from the women of indigenous santhal communities of Jharkhand, India. BMC Nutr. 2023 Jan 27;9(1):20. doi: 10.1186/s40795-023-00669-1. PMID: 36707902; PMCID: PMC9881317.
-
SinghA,BaalasubramanianS,KalaivaniM,KapoorR,BhagwatK,Ghosh-JerathS.Standardisation and application of a novel multiplex assay for estimating micronutrient status and inflammatory markers in women of Sauria Paharia and Santhal tribes of Jharkhand. Br J Nutr. 2022:1-16. doi: 10.1017/S0007114522000320.
-
Sen A, Singh A, Roy A, Mohanty S, Naik N, Kalaivani M, Ramakrishnan L. Role of endothelial colony forming cells (ECFCs) Tetrahydrobiopterin (BH4) in determining ECFCs functionality in coronaryarterydisease(CAD)patients.SciRep.2022;12(1):3076.doi:10.1038/s41598-022-06758-PMID:35197509.SinghR,JainA,PalanichamyJK,NagTC,BakhshiS,SinghA.Ultrastructural changesincristaeof lymphoblasts in acute lymphoblastic leukemia parallel alterations in biogenesis markers. Appl Microsc. 2021 Dec 29;51(1):20. doi: 10.1186/s42649-021-00069-4. PMID: 34964922.
-
Sachan A, Singh A, Shukla S, Aggarwal S, Mir I, Yadav R. An immediate post op and follow up assessment of circulating adipo-cytokines after bariatric surgery in morbid obesity. Metabol Open. 2021 Nov 1;13:100147. doi: 10.1016/j.metop.2021.100147. PMID: 34993466; PMCID: PMC8713110.
-
Thakkar H, Vincent V, Roy A, Gautam AK, Kutum R, Ramakrishnan L, Singh S, Singh A. Determinants of high-density lipoprotein (HDL) functions beyond proteome in Asian Indians: exploringthefattyacidprofileofHDLphospholipids.MolCellBiochem.2021.doi:10.1007/s11010- 021-04304-0. Epub ahead of print. PMID: 34843015.
-
ThakkarH,VincentV,ShuklaS,SraM,KangaU,AggarwalS,SinghA.Improvementsincholesterol efflux capacity of HDL and adiponectin contribute to mitigation in cardiovascular disease risk after bariatricsurgeryinacohortwithmorbidobesity.Diabetol MetabSyndr.2021Apr17;13(1):46.doi: 10.1186/s13098-021-00662-3. PMID: 33865458; PMCID: PMC8053301.
-
Thakkar H, Vincent V, Sen A, Singh A, Roy A. Changing Perspectives on HDL: From Simple QuantityMeasurementstoFunctionalQualityAssessment.JLipids.2021Apr26;2021:5585521.doi: 10.1155/2021/5585521. PMID: 33996157; PMCID: PMC8096543.
-
Ghosh-JerathS,KapoorR,SinghA,DownsS,BarmanS,FanzoJ.LeveragingTraditionalEcological Knowledge and Access toNutrient-Rich Indigenous Foods to Help Achieve SDG2: AnAnalysis of the Indigenous Foodsof Sauria Paharias,aVulnerableTribal Community inJharkhand, India. Front Nutr. 2020 Jun 2;7:61. doi: 10.3389/fnut.2020.00061. PMID: 32582750; PMCID: PMC7280452.
-
ThakkarH,VincentV,RoyA,SinghS,RamakrishnanL,KalaivaniM,SinghA.HDLfunctionsand their interaction in patients with ST elevation myocardial infarction: a case control study. Lipids Health Dis. 2020 Apr 15;19(1):75. doi: 10.1186/s12944-020-01260-4. PMID: 32293456; PMCID: PMC7158160.
-
Vincent V, Thakkar H, Verma A, Sen A, Chandran N, Singh A. A novel flow cytometry-based quantitative monocyte adhesion assay to estimate endothelial cell activationin vitro. Biotechniques. 2020;68(6):325-333. doi:10.2144/btn-2019-0169. PMID: 32283953.
-
Ghosh-Jerath S, Downs S, Singh A, Paramanik S, Goldberg G, Fanzo J. Innovative matrix for applying a food systems approach for developing interventions to address nutrient deficiencies in indigenous communities in India: a study protocol. BMC Public Health. 2019;19(1):944. doi:10.1186/s12889-019-6963-2. PubMed PMID: 31307415.
-
Tyagi A,Pramanik R,Bakhshi R,Singh A,Vishnubhatla S,Bakhshi S.Expression of mitochondrial genes predicts survival in pediatric acute myeloid leukemia. IntJHematol.2019Aug;110(2):205- 212. doi: 10.1007/s12185-019-02666-2.
-
Vinnyfred Vincent, Himani Thakkar, Sandeep Aggarwal, Asit Mridha, Lakshmy Ramakrishnan, Archna Singh. ATP binding cassette transporter A1 (ABCA1) expression in adipose tissue and its modulation with insulin resistance in obesity. Diabetes Metab Syndr Obes.2019; 12:275-284. doi: 10.2147/DMSO.S186565.
-
Suparna Ghosh-Jerath, Archna Singh,TanicaLyngdoh,MelinaS Magsumbol, Preeti Kamboj, Gail Goldberg.Estimates of indigenous food consumption and their contributiontonutrientintakein Oraontribal women of Jharkhand, India. Food and Nutrition Bulletin.2018Dec;39(4):581-594.doi: 10.1177/0379572118805652.
-
Tyagi A,Pramanik R,VishnubhatlaS,AliS,Bakhshi R,Chopra A,Singh A,Bakhshi S.Pattern of mitochondrialD-loopvariationsand their relation with mitochondrialencodedgenesin pediatricacutemyeloidleukemia. Mutat Res.2018Jul;810:13-18.doi: 10.1016/j.mrfmmm.2018.05.002.
-
Jain A, Bakhshi S, ThakkarH, Gerards M,Singh A. Elevatedmitochondrial DNA copy numbersin pediatric acute lymphoblastic leukemia: A potential biomarker for predicting inferior survival. Pediatr Blood Cancer. 2018;65(3). doi: 10.1002/pbc.26874.
