Introduction

Child Neurology Division

 

 The Child Neurology Division at the Department of Pediatrics, AIIMS, New Delhi caters to a significant proportion of in-patients and out-patients. It also runs the first D.M. programme in Pediatric Neurology in South Asia (started in 2004). The Division is also involved in undergraduate and postgraduate teaching and caters to training of National and International long-term and short-term fellows / trainees from time to time. The Division has continuously produced high quality research in diagnostics and therapeutics aimed at benefitting individual patients as well as the community.

The division is involved in high quality and cross-cutting research in Childhood Neurodevelopmental Disorders translating into around 20 publication every year in indexed International and National journals. It actively disseminates awareness and knowledge to health care professionals, health care providers and public in the field of child neurology. It is involved in advocacy at National and International level. Currently the Division has three faculty members, 2 electrophysiology technicians and one specialty nurse as permanent staff. The Division also gets support from the departmental Nutritionist, Physiotherapist and Social Service Officer. In addition, we have dedicated secretarial and project staff. The Division has 15-18 bedded in-patient unit (as a part of Unit 2, Department of Pediatrics) and caters to around 25000 outpatients annually. Apart from twice a week routine morning out-patients, the Division runs 5 specialty clinics (Developmental clinic, Neurocysticercosis clinic, Pediatric Neurology Clinic, Autism clinic, Neuromuscular disorders clinic) on a weekly basis attending to around 6000 patients in a year.

The Division launched a website on 3rd December, 2014 to augment the level of knowledge and skills of health care professionals throughout the country for early detection and management of childhood neurological and  neurodevelopmental disorders. A separate platform has been developed where parents and care givers can post their queries that is subsequently answered by experts. This will selectively ensure “personalized care” for children with neurological and neuro-developmental disorders  and their caregivers and parents.

A state of the art, Centre of Excellence and Advanced Research for Childhood Neurodevelopmental Disorders, is providing high quality affordable care for all sections of the society, performing high end diagnostic/ therapeutic research and acting as an education/training hub. The centre (Funded by AIIMS Grant in aid {supported by Ministry of Health and Family Welfare} and India Infrastructure Finance Company Limited {IIFCL, as a part of its CSR, MOU signed on 1st December, 2017}) has the following thrust areas:

1. Development of a National Registry for Childhood Neurodevelopmental Disorders

2. National Knowledge & Training Centre for Childhood Neurodevelopmental Disorders

3. Childhood Neurodevelopmental Disorders: Advanced Diagnostics

4. Childhood Neurodevelopmental Disorders: Advanced Therapeutics/Rehabilitation

5. Child Neurology Helpline and Teleconsultation services

 

Our Team

Faculty

 

 Dr. Sheffali Gulati, MBBS (Gold medalist; AIIMS), MD (AIIMS), FRCPCH (UK), FAMS,   FIAP, FIMSA

Designation: Professor and Faculty -in- charge, Child Neurology Division, Department of Pediatrics

Office address: 3059, Teaching Block, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029

E-mail:  यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए. , यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए. , यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

Telephone: 011-26594679

Areas of interest: Autism, neuromuscular disorders, cerebral palsy, ADHD and specific learning disability

 

  

 Dr. Biswaroop Chakrabarty, MBBS, MD, DM

Designation: Additional Professor, Child Neurology Division, Department of Pediatrics

Office Address: 7, Ground floor, Old OT Block, Near nursing College,  All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029

E-mail: यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

Telephone: 011-26594679

Areas of interest: Neurocysticercosis, Epilepsy, Status Epilepticus, Pediatric Sleep, Neuroimmunology

  

 

 Dr. Prashant Jauhari, MBBS, MD, DM

Designation: Additional Professor, Child Neurology Division, Department of Pediatrics

Office address: 3057, Teaching Block, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029

E-mail: यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

Telephone: 011-26594679

Areas of interest: Immune mechanisms in epileptic encephalopathies; Noninvasive neuromodulation (TMS) in pediatric epilepsy & movement disorders; Pediatric EEG, CNS Tuberculosis

  

Other staff  

• Sister Mabel Jossy, Speciality Staff Nurse
• Mrs. Sushila Yadav, Technical Officer
• Mr. Suresh Kumar, Laboratory Technician

 

Current DM Senior Residents

a)      Dr. Sayoni Datta Roy Chowdhury

b)      Dr. Arvinder Wander

c)      Dr. Rishi Sharma

d)     Dr. Ankit Kumar Meena

e)      Dr. Puneet Kumar Choudhary

f)       Dr. Richa Tiwari

g)      Dr. Sakshi Ojha

h)      Dr. Pawan Ghanghoriya

i)        Dr. M. Aakash

j)        Dr. Kaushik Ragunathan

 

What diseases/conditions do we treat? 

• Seizures and Epilepsy
• Global developmental delay/Intellectual disability; Cerebral palsy
• Autism spectrum disorders
• ADHD, SLD
• Other neurodevelopmental disorders
• CNS infections
• CNS Autoimmune disorders
• Neuromuscular disorders
• Stroke
• Headache
• Neurocysticercosis
• Neurometabolic disorders
• Neuroectodermatoses

 

Patient information materials:

• http://pedneuroaiims.org/parents_information_matrials.html, available in Hindi and English
•  Website: www.pedneuroaiims.org  

E-learning modules for healthcare professionals:  http://pedneuroaiims.org/,Dropdown under Academics, Autism and ADHD.  

Division services overview: https://docs.google.com/document/d/1ew3xZnnF6WP0QG7OMrhkHz_DaX3d9gIkWFYGhF789C8/edit?usp=sharing

Key Publications of the division :

1. Shruthi NM, Sinha R, Gulati S. Comatose Child: A practical approach. (Editors: Lodha R, Kabra SK. PICU Protocols of AIIMS, Ind J Pediatr, 8^th edition, 2022, 4-27)
2. Sondhi V, Gulati S. Management of Raised Intracranial Pressure. (Editors: Lodha R, Kabra SK. PICU Protocols of AIIMS, Ind J Pediatr, 8^th edition, 2022, 52-75)
3. Madaan P, Gupta J, Gulati S. Approach to Convulsive Status Epilepticus in Children. (Editors: Lodha R, Kabra SK. PICU Protocols of AIIMS, Ind J Pediatr, 8th edition, 2022, 28-51)
4. Madaan P, Gupta D, Agrawal D, Kumar A, Jauhari P, Chakrabarty B, Sharma S, Pandey RM, Paul VK, Misra MC, Gulati S. Neurocognitive Outcomes and Their Diffusion Tensor Imaging Correlates in Children with Mild Traumatic Brain Injury. J Child Neurol. 2021 Feb 24:883073821996095.
5. Anand S, Agarwala S, Jain V, Bakhshi S, Dhua A, Gulati S, Seth R, Srinivas M, Jana M, Kandasamy D, Bhatnagar V.Neuroblastoma with Opsoclonus-Myoclonus-Ataxia Syndrome: Role of Chemotherapy in the Management: Experience from a Tertiary Care Center in a Resource-limited Setting. J. Pediatr Hematol Oncol. 2021 Mar 23.
6. Pathak P, Sharma MC, Jha P, Sarkar C, Faruq M, Jha P, et al. Mutational Spectrum of CAPN3 with Genotype-Phenotype Correlations in Limb Girdle Muscular Dystrophy Type 2A/R1 (LGMD2A/LGMDR1) Patients in India. J Neuromuscul Dis. 2021;8(1):125–36.
7. Panda PK, Gupta J, Chowdhury SR, Kumar R, Meena AK, Madaan P, Sharawat IK, Gulati S. Psychological and Behavioral Impact of Lockdown and Quarantine Measures for COVID-19 Pandemic on Children, Adolescents and Caregivers: A Systematic Review and Meta-Analysis. J Trop Pediatr. 2021 Jan 29;67(1).
8. Anand V, Shukla G, Gupta N, Gupta A, Sapra S, Gulati S, Pandey RM, Pandey S, Kabra M. Association of sleep apnea with development and behavior in Down syndrome: A prospective clinical and polysomnographic study. Pediatric Neurology, Volume116, March 2021.
9. Jurek L, Balthazar M, Gulati S, Novakovic N, Núñez M, Oakley J, et al. Response (minimum clinically relevant change) in ASD symptoms after an intervention according to CARS-2: consensus from an expert elicitation procedure.  Eur Child Adolesc Psychiatry. 2021 Apr 7.
10. Lakshminarayanan K, Agarawal A, Panda PK, Sinha R, Tripathi M, Pandey RM, Gulati S. Efficacy of low glycemic index diet therapy (LGIT) in children aged 2-8 years with drug-resistant epilepsy: A randomized controlled trial. Epilepsy Res. 2021 Mar; 171:106574.
11. Bhavnani S, Lockwood Estrin G, Arora R, Kumar D, Kakra M, Vajaratkar V, et al. ‘I was Confused … and Still am’ Barriers Impacting the Help-Seeking Pathway for an Autism Diagnosis in Urban North India: A Mixed Methods Study. J Autism Dev Disord. 2021 May 20;
12. Sonali Singh, Gulati S. Genetic polymorphisms of UDP-glucuronosyltransferases and plasma sodium valproate level: Does it really matter? Indian J Pediatr.
13. Zulfiqar L, Chakrabarty B, Gulati S, Jauhari P, Pandey RM, Tripathi M, et al. The Childhood and Adolescent Sleep Evaluation Questionnaire (CASEQ): Development and validation of an ICSD-3-based screening instrument, a community and hospital-based study. J Sleep Res. 2021 Sep 8; e13479.
14. Sudarshan S, Kumar A, Gupta A, Bhari N, Sethuraman G, Kaushal T, Gulati S et al. Mutation Spectrum of Tuberous Sclerosis Complex Patients in Indian Population. J Pediatr Genet. 2021 Dec;10(4):274–83.
15. Borlot, Felippe, Ahmed Abushama, Nadine Morrison-Levy, Puneet Jain, Kollencheri Puthenveettil Vinayan, Musaad Abukhalid, Gulati S et al. ‘KCNT1-Related Epilepsy: An International Multicenter Cohort of 27 Pediatric Cases’. Epilepsia, 61.4 (2020)
16. Gupta J, Madaan P, Chowdhury SR, Gulati S. COVID-19 and Pediatric Neurology Practice in a Developing Country. Pediatr Neurol. 2020 Aug 26; 113:1
17. Gulati S, Gupta J, Madaan P. COVID-19 and Child Neurology Care. Neurol India. 2020 Aug;68(4):952–4.
18. Sinha R, Anand V, Gupta J, Singh S, Gulati S. Infantile spasms and COVID-19: Challenges and solutions in resource-limited settings. Epilepsy Res. 2020 Aug 18; 167:106441.
19. Konanki R, Gulati S, Prasad K, Saini L, Pandey RM, Paul VK. Comparison of telephone with face-to-face consultation for follow up of Neurocysticercosis. Epilepsy Res. 2018 Sep;145:110–5.
20. Sondhi V, Agarwala A, Pandey RM, Chakrabarty B, Jauhari P, Lodha R, Gulati S et al. Efficacy of Ketogenic Diet, Modified Atkins Diet, and Low Glycemic Index Therapy Diet Among Children with Drug-Resistant Epilepsy: A Randomized Clinical Trial. JAMA Pediatr. 2020 Oct 1;174(10):944–51.
21. Manokaran RK, Tripathi M, Chakrabarty B, Pandey RM, Gulati S. Sleep abnormalities and polysomnographic profile in children with drug-resistant epilepsy. Seizure. 2020 Nov;82:59–64.
22. Gupta J, Chakrabarty B, Singh G, Singh S, Kumar A, Xess I, Gulati S. A rare infective cause of stroke in an immunocompetent child. Brain Dev. 2020 Aug 24.
23. Madaan P, Agrawal D, Gupta D, Kumar A, Jauhari P, Chakrabarty B, Gulati S. Clinicoepidemiologic Profile of Pediatric Traumatic Brain Injury: Experience of a Tertiary Care Hospital from Northern India. J Child Neurol. 2020 Aug 4;883073820944040.
24. Gulati S, Shruthi NM, Panda PK, Sharawat IK, Josey M, Pandey RM. Telephone-based follow-up of children with epilepsy: Comparison of accuracy between a specialty nurse and a pediatric neurology fellow. Seizure. 2020 Dec;83:98–103.
25. Joshi, Rupa, Manjari Tripathi, Pooja Gupta, Gulati S, and Yogendra Kumar Gupta. ‘Prescription Pattern of Antiepileptic Drugs in a Tertiary Care Center of India’. Indian Journal of Pharmacology, 52.4 (2020), 283–89.
26. Gulati S, Saini L, Kaushik JS, Chakrabarty B, Arora NK, Pandey RM, et al. The Development and Validation of DSM 5-Based AIIMS-Modified INDT ADHD Tool for Diagnosis of ADHD: A Diagnostic Test Evaluation Study. Neurol India. 2020 Apr;68(2):352–7.
27. Gupta, J., Madaan, P., Gulati, Sh. COVID-19: Implications for Children with Special Needs. Journal for ReAttach Therapy and Developmental Diversities, 2020 Jul 05; 3(1):1-3.
28. Guardian Consortium, Sridhar Sivasubbu, and Vinod Scaria. ‘Genomics of Rare Genetic Diseases-Experiences from India’. Human Genomics, 14.1 (2019), 52
29. Shubham S, Dhochak N, Singh A, Patel SK, Chakrabarty B, Sankar J, Gulati S et al. Polyneuropathy in Critically Ill Mechanically Ventilated Children: Experience from a Tertiary Care Hospital in North India.Pediatr Crit Care Med. 2019;20(9):826–31.
30. Pathak D, Srivastava AK, Gulati S, Rajeswari MR. Assessment of cell-free levels of iron and copper in patients with Friedreich’s ataxia. Biometals. 2019 Apr;32(2):307–15.
31. Sudarshan S, Kumar M, Kaur P, Kumar A, G S, Sapra S, Gulati S et al. Decoding of novel missense TSC2 gene variants using in-silico methods. BMC Med Genet. 2019 26;20(1):164.
32. Madaan P, Jauhari P, Shruthi NM, Chakrabarty B, Gulati S. Intravenous Immunoglobulin for Severe Protracted Pediatric Guillain-Barre Syndrome: Is Single Dose Adequate?  Ann Indian Acad Neurol. 2019 Mar;22(1):123–4.
33. Madaan P, Jauhari P, Chakrabarty B, Gulati S. Ketogenic Diet in Epilepsy of Infancy with Migrating Focal Seizures.  Pediatr Neurol. 2019; 95:92.
34. Madaan P, Jauhari P, Chakrabarty B, Gulati S. Jeavons Syndrome: An Overlooked Epilepsy Syndrome. Pediatr Neurol. 2019; 93:63.
35. Gulati S, Kaushik JS, Saini L, Sondhi V, Madaan P, Arora NK, et al. Development and validation of DSM-5 based diagnostic tool for children with autism spectrum disorder. Plos One. 2019;14(3): e0213242
36. Kumar R, Khakha DC, Gulati S, Kaushik JS. Impact of structured teaching program on the parent’s knowledge of domiciliary management of seizure-A randomized controlled trial. Epilepsy Behav. 2019 Mar;92:191–4.
37. Michael SN, Madaan P, Jauhari P, Chakrabarty B, Kumar A, Gulati S. Selective Pyramidal Tract Involvement in Late-Onset Krabbe Disease. Indian J Pediatr. 2019 Oct;86(10):970–1.
38. Srivastava K, Sehgal R, Konanki R, Jain R, Sharma S, Mittal R, Gulati S et al. Association of Child Neurology-Indian Epilepsy Society Consensus Document on Parental Counseling of Children with Epilepsy. Indian J Pediatr.2019;86(7):608–16.
39. Sehgal R, Gulati S, Gupta YK, Sapra S, Mehta M, Pandey RM, Gulati S et al. Blood Heavy Metal Levels in Children with Autism Spectrum Disorder: A Cross- Sectional Study from Northern India. Journal of Nepal Paediatric Society. 2019 Apr 27;39(1):6–14.
40. Pathak D, Srivastava AK, Padma MV, Gulati S, Rajeswari MR. Quantitative Proteomic and Network Analysis of Differentially Expressed Proteins in PBMC of Friedreich’s Ataxia (FRDA) Patients. Front Neurosci. 2019 Oct 14;13:1054.
41. Shukla G, Gupta A, Chakravarty K, Joseph AA, Ravindranath A, Mehta M, Gulati S et al. Rapid Eye Movement (REM) Sleep Behavior Disorder and REM Sleep without Atonia in the Young. Can J Neurol Sci. 2019 Sep 24;1–9.
42. Kaushik JS, Kadwa RA, Sahu JK, Sharma S, Mittal R, Association of Child Neurology (AOCN)-Indian Epilepsy Society (IES) SOLACE Expert Group Association of Child Neurology-Indian Epilepsy Society Consensus Document on Social and Legal Aspects of Childhood Epilepsy (SOLACE).  Indian J Pediatr. 2019;86(7):599–607.
43. Arora NK, Nair MKC, Gulati S, Deshmukh V, Mohapatra A, Mishra D, et al. Neurodevelopmental disorders in children aged 2-9 years: Population-based burden estimates across five regions in India. Plos Med. 2018;15(7): e1002615.
44. Gulati S, Sondhi V.Cerebral Palsy: An Overview. Indian J Pediatr. 2018 Nov;85(11):1006–16.
45. Hamilton, Eline M. C., Hannemieke D. W. Van der Lei, Gerre Vermeulen, Jan A. M. Gerver, Charles M. Lourenço, Sakkubai Naidu, and others (Part of research group). ‘Natural History of Vanishing White Matter’, Annals of Neurology, 84.2 (2018), 274–88
46. Madaan P, Gulati S, Chakrabarty B, Sapra S, Sagar R, Mohammad A, et al. Clinical spectrum of psychogenic non epileptic seizures in children; an observational study. Seizure. 2018 Jul; 59:60–6.
47. Dantham S, Srivastava AK, Gulati S, Rajeswari MR. Differentially Regulated Cell-Free microRNAs in the Plasma of Friedreich’s Ataxia Patients and Their Association with Disease Pathology. Neuropediatrics. 2018;49(1):35–43.
48. Nambirajan A, Suri V, Kedia S, Goyal K, Malgulwar PB, Khanna G, Gulati S et al. Paediatric diffuse leptomeningeal tumor with glial and neuronal differentiation harboring chromosome 1p/19q co-deletion and H3.3 K27M mutation: unusual molecular profile and its therapeutic implications. Brain Tumor Pathol. 2018 Jul;35(3):186–91.
49. Choudhary A, Gulati S, Sagar R, Sankhyan N, Sripada K. Childhood epilepsy and ADHD comorbidity in an Indian tertiary medical center outpatient population. Sci Rep. 2018 08;8(1):2670.
50. Bajaj J, Tripathi M, Dwivedi R, Sapra S, Gulati S, Garg A, et al. Does surgery help in reducing stigma associated with drug refractory epilepsy in children? Epilepsy Behav. 2018 Mar;80:197–201.
51. Konanki R, Gulati S, Prasad K, Saini L, Pandey RM, Paul VK. Comparison of telephone with face-to-face consultation for follow up of Neurocysticercosis. Epilepsy Res. 2018; 145:110–5.
52. Gulati S. Dietary Therapies: Emerging Paradigms in Therapy of Drug Resistant Epilepsy in Children : Based on 6th Dr. I. C. Verma Excellence in Research Award Oration. Indian J Pediatr. 2018 Nov;85(11):1000–5.
53. Vellarikkal SK, Jayarajan R, Verma A, Ravi R, Senthilvel V, Kumar A, et al. A founder mutation MLC1 c.736delA associated with megalencephalic leukoencephalopathy with subcortical cysts-1 in north Indian kindred. Clin Genet. 2018 Aug;94(2):271–3.
54. Gulati S, Sondhi V, Chakrabarty B, Jauhari P, Lodha R, Sankar J. High dose phenobarbitone coma in pediatric refractory status epilepticus; a retrospective case record analysis, a proposed protocol and review of literature. Brain Dev. 2018 Apr;40(4):316–24.
55. Chakrabarty B, Gulati S. Autism Spectrum Disorder: Sleep Morbidities and Sensory Impairment; Emerging Paradigm in Research and Management. Indian J Pediatr. 2019;86(1):1–2.
56. Jauhari P, Saini L, Chakrabarty B, Kumar A, Gulati S. Juvenile Canavan Disease: A Leukodystrophy without  White Matter Changes. Neuropediatrics. 2018;49(6):420–1.
57. Kakkar A, Sharma MC, Nambirajan A, Gulati S, Bhatia R, Suri V, et al. Pompe disease: An Indian series diagnosed on muscle biopsy by ultrastructural characterization. Ultrastruct Pathol. 2018 Jun;42(3):211–9.
58. Yoganathan S, Bagga A, Gulati S, Toteja GS, Hari P, Sinha A, et al. Prevalance and predictors of peripheral neuropathy in nondiabetic children with chronic kidney disease. Muscle Nerve. 2018;57(5):792–8.
59. Arora K, Thukral A, Sankar MJ, Gulati S, Deorari AK, Paul VK, et al. Postnatal Maturation of Amplitude Integrated Electroencephalography (aEEG) in Preterm Small for Gestational Age Neonates. Indian Pediatr. 2018 Oct 15;55(10):865–70.
60. Manokaran RK, Gulati S. ‘Sleep and Drug Resistant Epilepsy in Children. Sleep Medicine and Disorders: International Journal, Volume 2. Issue 4 (2018)
61. Gulati S, Patel H, Chakrabarty B, Dubey R, Arora NK, Pandey RM, et al. Development of All India Institute of Medical Sciences-Modified International Clinical Epidemiology Network Diagnostic Instrument for Neuromotor Impairments in Children Aged 1 Month to 18 Years. Front Public Health. 2017; 5:313.
62. Dwivedi R, Ramanujam B, Chandra PS, Sapra S, Gulati S, Kalaivani M, et al. Surgery for Drug-Resistant Epilepsy in Children. N Engl J Med. 2017 26;377(17):1639–47.
63. Joshi R, Tripathi M, Gupta P, Gulati S, Gupta YK. Adverse effects & drug load of antiepileptic drugs in patients with epilepsy: Monotherapy versus polytherapy. Indian J Med Res. 2017 Mar;145(3):317–26.
64. Barua M, Kaushik JS, Gulati S. Legal Provisions, Educational Services and Health Care Across the Lifespan for Autism Spectrum Disorders in India. Indian J Pediatr. 2017 Jan;84(1):76–82.
65. Aathira R, Gulati S, Tripathi M, Shukla G, Chakrabarty B, Sapra S, et al. Prevalence of Sleep Abnormalities in Indian Children with Autism Spectrum Disorder: A Cross-Sectional Study. Pediatr Neurol. 2017 Sep; 74:62–7.
66. Kumar A, Jaryal A, Gulati S, Chakrabarty B, Singh A, Deepak KK, et al. Cardiovascular Autonomic Dysfunction in Children and Adolescents with Rett Syndrome. Pediatr Neurol. 2017; 70:61–6.
67. Tripathy K, Chawla R, Mittal K, Farmania R, Venkatesh P, Gulati S. Ophthalmic examination as a means to diagnose Subacute Sclerosing Panencephalitis: an optical coherence tomography and ultrawide field imaging evaluation.  Eye Vis (Lond). 2017; 4:1.
68. Kakkar A, Rajeshwari M, Nalwa A, Suri V, Sarkar C, Chakrabarty B, et al. Childhood macrophagic myofasciitis: A series from the Indian subcontinent. Muscle Nerve. 2017 Jul;56(1):71–7.
69. Gulati S, Patel H, Chakrabarty B, Dubey R, Arora NK, Pandey RM, et al. Development and validation of AIIMS modified INCLEN diagnostic instrument for epilepsy in children aged 1 month-18 years. Epilepsy Res. 2017; 130:64–8.
70. Israni A,Gulati S, Chakrabarty B, Kumar A, Kumaran S, Paul VK, Sapra S, Singh U. Providing insights into the mechanism of modified Constraint Induced Movement Therapy in hemiparetic cerebral palsy - a functional MRI (fMRI) based study. Development medicine and child neurology.2017:59 (Suppl. 4):71
71. Sehgal R, Gulati S, Sapra S, Tripathi M, Pandey RM, Kabra. Prognostic Utility of Clinical Epilepsy Severity Score Versus Pretreatment Hypsarrhythmia Scoring in Children with West Syndrome. Clin EEG Neurosci. 2017 Jul;48(4):280–7.
72. Israni A, Gulati S, Chakrabarty B, Sapra S, Paul VK, Pandey RM. Diagnostic utility of adapted version of parent administered developmental screening questionnaire ASQ3 (Ages and Stages Questionnaire Revision 3). Development medicine and child neurology.2017:59 (Suppl. 4):125
73. Chakrabarty B, Sharma MC, Gulati S, Sarkar C. Skin Biopsy for Diagnosis of Ullrich Congenital Muscular Dystrophy: An Observational Study. J Child Neurol. 2017 Dec;32(14):1099–103.
74. Saini L, Chakrabarty B, Kumar A, Gulati S. Microcephaly with generalized dystonia: Exception to the rule. Neurol India. 2017 Jun;65(3):669–70.
75. Jose A, Gupta S, Gulati S, Sapra S. Prevalence of Depression in mothers of children having ASD. Current Medicine Research and Practice.2017.7(1)11-15
76. Gulati S. ‘Neurodevelopmental Disorders: The Journey, the Dreams and Their Realization’. Annals of the National Academy of Medical Sciences (India), 53.1 (2017), 30–35.

 

- Complete list of publications: https://docs.google.com/document/d/1h5Ln_N6-MSa7XvN5GRl6uyOvxELWqeb-y6LMmWHFMIE/edit?usp=sharing

 

Our programmes and services

 1.  OPDs and Specialty Clinics

Day	Clinic	Room No	Timings
Monday	Child Development Clinic	4,5	2:00 PM onwards
	Neurocysticercosis Clinic	11	2:00 PM onwards
Tuesday	Pediatrics OPD	4,5,14 A	09:00 AM onwards
Wednesday	Pediatric Neurology Clinic	4, 5,14 A	2:00 PM onwards
	Autism Clinic	32, 33,34	2:00 PM onwards
Friday	Pediatrics OPD	4, 5, 14A	09:00 AM onwards
	Neuromuscular Disorder Clinic	4, 14 A, 34	02:00 PM onwards

 

 2.  Laboratory Services

• EEG
  • RoutineEEG:is done in Room no 12 in Paediatric OPD. The appointment is given after the child has been seen in Paediatric Neurology division.
  • AmbulatoryEEG:is done bedside when indicated for in-patients who cannot be shifted to EEG room. Two portable combined EEG and EPS machines are available
  • Video-EEG: is performed in C5 ward Neurophysiology laboratory. Long-term video EEG is performed as indicated 

• Polysomnography (PSG): Polysomnographyis performed in Neurophysiology laboratory in C5 ward. 

• Electrophysiology (EPS) studies

EPS machines are stationed in room no 3057, 3^rd floor in Department of Pediatrics and Neurophysiology laboratory in C5 ward where NCS, RNST, Sympathetic skin response and needle EMG are routinely performed on non OPD days. In addition, in collaboration with Eye and ENT departments OAE, BERA and VEP are also done.Ambulatory EPS studies are done as and when needed in inpatients.         

• Neuromodulation and neurorehabilitation

A state of art TMS (trans-cranial magnetic stimulation) machine was installed in room no 3057, 3^rd floor in Department of Pediatrics and currently stationed in room number 12 EEG lab (during the pandemic) in children OPD which is being used for children with epilepsy, cerebral palsy, dystonia and autism spectrum disorder  as a therapeutic tool predominantly in various research activities and also in service mode

3. Procedures

• Biopsies

Skin, muscle and nerve biopsies are done in C5 ward as a day care procedure by Pediatric Neurology residents on Tuesday afternoon and Thursday morning. The appointments for the same are given on OPD basis. The patients then collect the biopsy report from the Pathology department and then follow up in the OPD

• Intracranial Pressure Monitoring

Being carried out in collaboration with Pediatric Critical Care team .and Neurosurgeons.

• Other Day Care Procedures:
  • Lumbar puncture and CSF manometry
  • Blood/ CSF Lactate
  • Neostigmine challenge test
  • Forearm ischemic test
  • Hand-held Dynamometry
  • Oto-acoustic emission

 

4.  Dietary services

• Ketogenic Diet, Modified Atkins Diet and Low glycemic Index Treatment diets for refractory epilepsy
• Ketogenic Diet in super refractory status epilepticus
• GFCF diet in Autism Spectrum Disorder

 

5.  DM/ fellowship in Pediatric Neurology

• First D.M. programme in Pediatric Neurology in South Asia, started in 2004.
• Short- and long-term fellowships

 

6.  Humanitarian access programmes

• Spinraza treatment to spinal muscular atrophy patients under SIPHAP (SPINRAZA INDIVIDUAL PATIENT HUMANITARIAN ACCESS PROGRAM)
•  Gene therapy (Zolgensma/Onasemnogene abeparvovec xioi) Novartis under Global Access Programme
• Risdiplam

 

7.  Tele-helpline and tele-consultation

• Helpline and teleconsultation for neurodevelopmental disorders.

 

 Broad Research Areas

1. Duchenne Muscular dystrophy (highlights: skin biopsy replacing muscle biopsy, ataluren for DMD with nonsense mutations) and Spinal muscular atrophy: Diagnostics and Newer therapies
2. Autism Spectrum Disorder, ADHD and Learning disabilities: Newer diagnostics (Mobile application based diagnostic tools) and therapies including application of Artificial Intelligence
3. Cerebral palsy and other Neurodevelopmental disabilities: Multidisciplinary rehabilitation and Public health dimension
4. Dietary therapies in epilepsy and autism spectrum disorder - ketogenic diet (first center in North India to start KD), modified Atkins diet, low glycemic index diet, gluten free casein free diet
5. Neuromodulation
6. Drug refractory Epilepsy, Status epilepticus
7. Acute encephalitis syndrome, Autoimmune encephalitis, Acquired Demyelination syndrome
8. Neurocysticercosis, Neuro-tuberculosis
9. Pediatric Movement disorder
10. Pediatric Sleep Disorder

Link-Ongoing projects: https://docs.google.com/document/d/1zNJuAJhtc-JLCDDDJUwkjRrZqLLDEgFsymVhN5nJ6R8/edit?usp=sharing

 

Collaborations   

International

• University of Manchester, University of Reading and University of Birbeck: Autism Spectrum Disorder
• University of Pennsylvania, University of Stanford and University of Wisconsin: Neurodevelopmental disorders
• GOSH, University college of London: FIRES, COE registry

National

• Indian Institute of Technology, Delhi: Virtual reality, augmented reality, artificial intelligence, and robotics
• Indian Institute of Technology, Kanpur: Autism spectrum disorder
• Indian Institute of Technology, Bombay: Autism spectrum disorder
• National Dairy Research Institute, Karnal: Autism spectrum disorder
• Institute of genomics and Integrative Biology: Next generation sequencing in epileptic encephalopathy, muscular dystrophy and autism spectrum disorder
• Postgraduate Institute of Medical Education and Research, Chandigarh:  leukodystrophy
• Shiv Nadar University, Noida: Autism spectrum disorder
• Jawaharlal Nehru University: Autism spectrum disorder
• SANGATH-Delhi and Goa: Autism spectrum disorder and other neuro-developmental disorders
• Indraprastha Institute of Information Technology Delhi: Robotics in autism spectrum disorder, Machine Learning in Status Epilepticus
• INCLEN (International Clinical Epidemiology Network): Neurodevelopmental disorders
• Public Health Foundation of India: Neurodevelopmental disorders
• Indian Music Therapy Association: Autism spectrum disorder
• Centre for Development of Advanced Computing, New Delhi and Thiruvanthapuram: Neurodevelopmental disorders