Dr. Sharmistha Dey

Prof. Sharmistha Dey

Photograph

Current Designation & Contact Details

Professor

Department of Biophysics, AIIMS, New Delhi

Email: यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

Phone: +91-11-26546435

Brief Research Area

Blood based biomarker of neurodegenerative diseases and cancers and their therapeutic intervention

Awards and Honours

1. ICMR award 2016 “Professor Surindar Mohan Marwah Award- 2016 for outstanding work carried out in the field of Biogerontology

2. Five AIIMS Excellent Awards in 2012, 2014, 2015, 2017, 2018 for best paper research publications

3. First prize in AIIMS Oncology award 2018.

Selected Publications/Patents (Last 5 years)

Google Scholar Link:

https://scholar.google.com/citations?user=0OY1WIgAAAAJ&hl=en

1. Abhinay Kumar Singh, Atul Batra, Ashish Datt Upadhaya, Subhash Gupta, Haresh K P and Sharmistha Dey,Circulatory Level of Inflammatory Cytoskeleton Signaling Regime Proteins in Cancer Invasion and Metastasis. Front. Oncol. 2022; 12:851807. doi: 10.3389/fonc.2022.851807

2. Masroor Anwar, Rashmita Pradhan, Sharmistha Dey, Rahul Kumar. The Role of Sirtuins in Sarcopenia and Frailty Ageing and Disease. 2022; Volume 14, Number 1; doi.org/10.14336/AD.2022.0622.

3. Sharmistha Dey, Abhay Kumar Singh, Abhinay Kumar Singh, Kartik Rawat, Joyita Banerjee, Vertica Agnihotri, Deepak Upadhaya. Critical pathways of oral squamous cell carcinoma: molecular biomarker and therapeutic intervention. Medical Oncology 2022; 39:30. doi.org/10.1007/s12032-021-01633-4

4. Pradhan R, Singh AK, Kumar P, Bajpai S, Pathak M, Chatterjee P, Dwivedi S, Dey AB, Dey S. Blood Circulatory Level of Seven Sirtuins in Alzheimer's Disease: Potent Biomarker Based on Translational Research. Mol Neurobiol. 2022 Jan 7. 59, pages1440–1451. doi: 10.1007/s12035-021-02671-9. Citation: 2

5. Kumari S, Singh A, Singh AK, Yadav Y, Bajpai S, Kumar P, Upadhyay AD, Shekhar S, Dwivedi S, Dey AB, Dey S. Circulatory GSK-3β: Blood-Based Biomarker and Therapeutic Target for Alzheimer's Disease. J Alzheimers Dis. 2022;85(1):249-260. doi: 10.3233/JAD-215347.

6. Masroor Anwar, Saumya Ranjan Mallick, Daizy Paliwal, Shashank Shekhar, Subrat Kumar Panda, Sharmistha Dey, Aparajit Ballav Dey. Impact of physical activity on mitochondrial enzymes, muscle stem cell and anti-oxidant protein Sestrins in Sarcopenic mice. Experimental Gerontology. 2021, Volume 150,, 111358. DOI: 10.1016/j.exger.2021.111358. Citation: 3

7. Kumar R, Tiwari V, Dey S. Role of proline-rich tyrosine kinase 2 (Pyk2) in the pathogenesis of Alzheimer's Disease. Eur J Neurosci. 2021 doi: 10.1111/ejn.15569. Online ahead of print.

8. Banerjee J, Gupta A, Agnihotri V, Pradhan R, Kandel R, Upadhyay AD, Dwivedi S, Kumar L, Dey S, Dey AB. Lung cancer in the older population:Interactive effects of angiotensin converting enzyme gene polymorphism (rs 4340 ID) and tobacco addiction in risk assessment. Indian J Cancer. 2021 Jun 21. doi: 10.4103/ijc.IJC_1082_19. Online ahead of print.

9. Pradhan R, Yadav SK, Prem NN, Bhagel V, Pathak M, Shekhar S, Gaikwad S, Dwivedi SN, Bal CS, Dey AB, Dey S. Serum FOXO3A: A ray of hope for early diagnosis of Alzheimer's disease. Mech Ageing Dev. 2020;190:111290. doi: 10.1016/j.mad.2020.111290. Citation: 6

10. Rajan SP, Anwar M, Jain B, Khan MA, Dey S, Dey AB. Serum sestrins: potential predictive molecule in human sarcopenia. Aging Clin Exp Res. 2020, 33, 1315-1324. doi: 10.1007/s40520-020-01642-9. Citation: 4

11. Singh AP, Nigam L, Yadav Y, Shekhar S, Subbarao N, Dey S. Design and in vitro analysis of SIRT2 inhibitor targeting Parkinson's disease. Mol Divers. 2020; 25, 2261-2270. doi: 10.1007/s11030-020-10116-z. Citation: 2.

12. Vertica Agnihotri, Abhishek Gupta, Lalit Kumar, Sharmistha Dey. Serum sHLA-G: Significant diagnostic biomarker with respect to therapy and immunosuppressive mediators in Head and Neck Squamous Cell Carcinoma. Sci Rep. 2020; 10: 3806. Published online 2020 Mar 2. doi: 10.1038/s41598-020-60811-y. Citation: 6

13. Rai N, Dey S. Protective response of Sestrin under stressful conditions in aging. Ageing Res Rev. 2020; 64:101186. doi: 10.1016/j.arr.2020.101186. Citation: 5

14. Nitish Rai, Ashish Datt Upadhyay, Vinay Goyal, Sadanand Dwivedi, Aparajit Ballav Dey, Sharmistha Dey Sestrin2 as Serum Protein Marker and Potential Therapeutic Target for Parkinson's Disease. J Gerontol A Biol Sci Med Sci. 2020 Mar 9;75(4):690-695. doi: 10.1093/gerona/glz234. Citation: 13

15. Shekhar S, Dey S Induction of p73, Δ133p53, Δ160p53, pAKT lead to neuroprotection via DNA repair by 5-LOX inhibition. Mol Biol Rep. 2020; 47(1), 269-274. doi: 10.1007/s11033-019-05127-5. Citation: 4

16. Singh AP, Ramana G, Bajaj T, Singh V, Dwivedi S, Behari M, Dey AB, Dey S. Elevated Serum SIRT 2 May Differentiate Parkinson's Disease From Atypical Parkinsonian Syndromes. Front Mol Neurosci. 2019;12:129. doi: 10.3389/fnmol.2019.00129. eCollection 2019. Citation: 7

17. Sahu V, Mohan A, Dey S. p38 MAP kinases: plausible diagnostic and prognostic serum protein marker of non small cell lung cancer. Exp Mol Pathol. 2019;107:118-123. Citation: 6

18. Shekhar S, Yadav Y, Singh AP, Pradhan R, Desai GR, Dey AB, Dey S. Neuroprotection by ethanolic extract of Syzygium aromaticum in Alzheimer's disease like pathology via maintaining oxidative balance through SIRT1 pathway. Exp Gerontol. 2018;110:277-283. Citation:16

19. Sahu V, Nigam L, Agnihotri V, Gupta A, Shekhar S, Subbarao N, Bhaskar S, Dey S. Diagnostic Significance of p38 Isoforms (p38α, p38β, p38γ, p38δ) in Head and Neck Squamous Cell Carcinoma: Comparative Serum Level Evaluation and Design of Novel Peptide Inhibitor Targeting the Same. Cancer Res Treat. 2019; 51(1):313-325. doi: 10.4143/crt.2018.105. Citation: 15

20. Singh AP, Bajaj T, Gupta D, Singh SB, Chakrawarty A, Goyal V, Dey AB, Dey S. Serum Mortalin Correlated with α-Synuclein as Serum Markers in Parkinson's Disease: A Pilot Study. Neuromolecular Med. 2018;20(1):83-89. doi: 10.1007/s12017-017-8475-5. Citation: 17

21. Rai N, Venugopalan G, Pradhan R, Ambastha A, Upadhyay AD, Dwivedi S, Dey AB, Dey S. Exploration of Novel Anti-Oxidant Protein Sestrin in Frailty Syndrome in Elderly. Aging Dis. 2018; 9(2):220-227. doi: 10.14336/AD.2017.0423. Citation: 21

22. Shekhar S, Yadav SK, Rai N, Kumar R, Yadav Y, Tripathi M, Dey AB, Dey S. 5-LOX in Alzheimer's Disease: Potential Serum Marker and In Vitro Evidences for Rescue of Neurotoxicity by Its Inhibitor YWCS. Mol Neurobiol. 2018;55(4):2754-2762. doi: 10.1007/s12035-017-0527-1. Citation: 12

23. Kumar R, Nigam L, Singh AP, Singh K, Subbarao N, Dey S. Design, synthesis of allosteric peptide activator for human SIRT1 and its biological evaluation in cellular model of Alzheimer's disease. Eur J Med Chem. 2017;127:909-916. doi: 10.1016/j.ejmech.2016.11.001. Citation: 31

24. Kumar S, Sharma VK, Yadav S, Dey S. Antiproliferative and apoptotic effects of black turtle bean extracts on human breast cancer cell line through extrinsic and intrinsic pathway. Chem Cent J. 2017;11(1):56. doi: 10.1186/s13065-017-0281-5. Citation: 13

25. Vertica Agnihotri, Abhishek Gupta, Rahul Kumar, Ashish Datt Upadhyay, Sadanand Dwivedi, Lalit Kumar, Sharmistha Dey. Promising link of HLA-G polymorphism, tobacco consumption and risk of Head and Neck Squamous Cell Carcinoma (HNSCC) in North Indian population. Human Immunology 78 (2017) 172–178. Citation: 18

26. Gupta A, Agnihotri V, Kumar R, Upadhyay AD, Bhaskar S, Dwivedi S, Dey S. Effects of Tobacco Habits on the Polymorphism of NFKB1 and NFKB1A Gene of Head and Neck Squamous Cell Carcinoma in Indian Population. Asian Pac J Cancer Prev. 2017;18(7):1855-1859. Citation: 18

27. Pradhan R, Kumar R, Shekhar S, Rai N, Ambashtha A, Banerjee J, Pathak M, Dwivedi SN, Dey S, Dey AB. Longevity and healthy ageing genes FOXO3A and SIRT3: Serum protein marker and new road map to burst oxidative stress by Withania somnifera. Exp Gerontol. 2017;95:9-15. May 2012. Volume 3, Issue 2, 2012, pp.-49-54. Citation: 10