Name & Designation:    Dr. Deepak Pandey,   Scientist-II,

                                           Department of Reproductive Biology,

                     AIIMS, New Delhi.-29

Contacts:  Email: यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.  ,  यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

                 Phone: +91 11 2659 3941

Qualifications:

• Ph.D. (Biotechnology), Himachal Pradesh University, Shimla, India (2011).
• M.Sc. (Biotechnology), Himachal Pradesh University (HPU), Shimla, India (2005).

Professional training and past positions:

• Worked as Scientist-B at Central Tasar Research & Training institute, Ranchi, Central Silk Board, Ministry of Textiles, Govt. of India (from November 5, 2015 to September 12, 2016).
• Worked as Research Associate on the project entitled “Function of caseinolytic proteases in Mycobacterium tuberculosis pathogenesis” at National Institute of Immunology, New Delhi India (from August 5, 2011 to September 30, 2014).

Research interests:

• Prostate pathologies (BPH & prostate cancer).
• Ovarian cancer.

Research Summary:

The research focus of our lab is on benign prostatic hyperplasia (BPH) and prostate cancer with special emphasis on the interaction between prostate stromal and epithelial cells. As men age, there is a typical alteration in the ratio of estradiol to dihydrotestosterone (DHT). Under the altered levels of these hormones, stromal cells secrete certain paracrine factors that cause proliferation of epithelial cells and lead to either BPH or prostate cancer. This altered stromal-epithelial interaction occurring in vivo is being studied in vitro by culturing the normal prostate stromal and epithelial cell lines. In addition to this, we are interested in identification, characterisation and validation of novel proteins and mi-RNAs as non-invasive biomarkers for prostate pathologies.

Group Members (Past & Present):

Ankit Roychoudhury, Abhishek Singh Yadav, Muninagesh Alapakam, Afsa Junaid  

Projects: ongoing, submitted and past:

• ICMR funded (42.3 Lakhs) project approved in March 2020. To elucidate the impact of micronutrients and vitamins on sex-steroid mediated stromal-epithelial interaction in prostate cells: role in maintenance of normal prostate physiology.
• ICMR funded (91 Lakhs) 2019-2022. Clinico-genetic prognostic signatures for development of metastatic Castration Resistant Prostate Cancer (as Co-Investigator). 
• AIIMS funded (10 Lakhs) 2017-2019. To study the effects of dietary flavonoids on prostate epithelial cells growing under the influence of prostate stromal cells.

Awards/Honours/Fellowships:

• Awarded Scholarship from Department of Biotechnology (DBT), Govt. of India for pursuing MSc Biotechnology, 2003
• Awarded Junior Research Fellowship (JRF), Indian Council of Medical Research (ICMR), 2006
• Awarded Senior Research Fellowship (SRF), Indian Council of Medical Research (ICMR), 2008
• Qualified ICMR-JRF (2005)
• Qualified GATE (Graduate Aptitude Test in Engineering) in life sciences with 97.40 percentile and All India Rank-275 (2006).
• Qualified DBT-JRF (2006)
• Qualified National Eligibility Test (NET- June, 2015) in life science with All India Rank-18

Selected Publications:

1. Pandey D*, Patel SKS, Singh R, Kumar P, Thakur V, Chand D* (2019). Solvent-tolerant acyltransferase from Bacillus sp. APB-6: Purification and Characterization. Indian J Microbiol; 59 (4): 500–507. (doi:  10.1007/s12088-019-00836-8: ^* Co-Corresponding author)
2. Choudhury AR, Gupta S, Chaturvedi PK, Kumar N, Pandey D* (2019). Mechanobiology of cancer stem cells and their niche. Cancer Microenviron; (doi: 10.1007/s12307-019-00222-4: ^*Corresponding author)
3. Choudhury AR, Kumar N, Sandeep K, Pandey D^* (2019). Stem cell repertoire in the prostate epithelium. J Stem Cell Res Ther; 5(2): 44-46. (doi: 10.15406/jsrt.2019.05.00133: ^*Corresponding author)
4. Singh PK, Yadav VK, Kalia M, Sharma D, Pandey D, Agarwal V (2019). Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxo-dodecanoyl)-L-homoserine lactone triggers mitochondrial dysfunction and apoptosis in neutrophils through calcium signaling. Med Microbiol Immunol; 208(6): 855-868. (doi: 10.1007/s00430-019-00631-8)
5. Kumar P, Singh B, Thakur V, Thakur A, Thakur N, Pandey D, Chand D (2019). Hyper-production of taxol from Aspergillus fumigatus, an endophytic fungus isolated from Taxus sp. of the Northern Himalayan region. Biotechnol Rep; 15; 24: e00395. (doi: 10.1016/j.btre.2019.e00395)
6. Yadav D, Sandeep K, Pandey D. Monoclonal Antibodies. In: Sharma AK, Kesarwani RK, Dutt R (Eds). Nanotechnology and Targeted Drug Delivery System. First edition. Studera Press: Delhi; 2019: pp 321-337.
7. Singh R, Pandey D, Dhariwal S, Sood P, Chand D (2018). Bioconversion of acrylonitrile using nitrile hydratase activity of Bacillus sp. APB-6. 3 Biotech; 8(5): 225 (doi: 10.1007/s13205-018-1207-1)
8. Singh R, Pandey D, Devi N, Chand D (2018). Bench scale production of butyramide using free and immobilized cells of Bacillus sp. APB-6. Bioprocess Biosyst Eng; (doi:10.1007/s00449-018-1951-y)
9. Kumar N, Pandey D, Halder A (2018). Preventive, diagnostic and therapeutic applications of baculovirus expression vector system. In: Kumar D, Gong C (Eds). Trends in Insect Molecular Biology and Biotechnology. First edition. Austria: Springer: pp 163-191.
10. Choudhury AR, Kumar N, Sandeep K, Pandey D* (2017). Biotechnological Potential of Stem Cells. J Stem Cell Res Ther; 3(1): 212-219. (doi: 10.15406/jsrt.2017.03.00090: ^*Corresponding author)
11. Kumar P, Pandey D, Thakur V, Thakur A, Chand D (2017). Hyperproduction of tannin acylhydrolase in submerged fermentation from Aspergillus fumigatus. J Adv Microbiol; 3(2): 60-77 (ISSN Online: 2349-7785) 
12. 12. Yadav D, Sandeep K, Pandey D, Dutta RK (2017). Liposomes for Drug Delivery. J Biotechnol Biomater; 7: 276. (doi: 10.4172/2155- 952X.1000276) 
13. Pandey D, Singh R and Chand D (2011). An improved bioprocess for synthesis of acetohydroxamic acid using DTT (dithiothreitol) treated resting cells of Bacillus sp. APB-6. Bioresour Technol. 102, 6579–6586. (doi: 10.1016/j.biortech.2011.03.071)

PRADEEP KUMAR CHATURVEDI, MSc, PhD, MNAMS

Professor

Officer in Charge, CRIA Facility

Department of Reproductive Biology

All India Institute of Medical Sciences

New Delhi - 110 029

Phone: 2659 4363 Fax :26588663 mobile 9873395001

E-mail: यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

Rockefeller foundation fellow 1991-1993

 PROFESSIONAL APPOINTMENTS:

July 2015 – Till date      Professor, Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi - 110029, India

Teaching Experiences:

·  More than 25 years of teaching

• PhD Students: Three Chief Guide and Six as co Guide.
• Md Thesis co supervisor: Nine
• Teaching of MD laboratory Medicine, MD Biochemistry
• Training of various laboratory techniques to post graduate students and scientist from various universities and institution
• Setup centralized Instrumentation Lab in the department

Patient Care:

• Providing service for in-house and outpatient for 46 parameters (Thyroid function, Reproductive hormones and cancer marker etc). Total no of test being done more than two lakhs per year
• State of art Technology, Abbott system was brought in to provide quick and International quality results for in-house and out-patient for various hormones and markers
• Setup Andrology lab in the department for providing services for patient care and research

HONOR/AWARDS: Best poster award to our poster at APPICON 2004 at Banglore.

1. Rockefeller foundation Fellowship award USA, 1991-1993
2. Senior Research Associate from Council of Scientific and Industrial Research, New Delhi, India.
3. Member ship of National Academy of Medical Sciences 2012
4. Best poster award at Andrology Conference at IIT Delhi 2011 
5. Best poster award to our poster at APPICON 2004 at Bangalore 
6. 3^rd Best Poster Award in AIIMS Research Day 2019

Research Projects undertaken  

Research Projects

 Research Projects as Co PIs  

List of Publications:  

  MEMBERSHIP IN SCIENTIFIC SOCIETIES  

1. Life Membership of National Academy of Medical Sciences
2. Life Member of Indian Society for the Study of Reproduction and fertility
3. Life Member of Andrology Society of India
4. Life Member of Biotechnology Society of India
5. Life member of APICON

 Conferences  

Organized 3 International conferences and attended number of conferences and presented papers  

Other Involvement:  

Member of Board of Studies of Biotechnology for session 2011-2012 of Mahamaya Technical University, Noida. Reviewer of projects of Department of Biotechnology (DBT). Member Selection Committee for projects ICMR. Reviewer of ICMR projects. PhD examiner IMTech Chandigarh, Guwahati University, Calcutta University, NDRI Karnal  

PERSONAL DATA  

Date of Birth               :           August 18th, 1958  

Publications   

1. Krishna Asuri, Aamir Mohammad, Om Prakash Prajapati, Rajesh Sagar, Atin Kumar, Mona Sharma, Pradeep Kumar Chaturvedi, Shardool Vikram Gupta, Sanjeet Kumar Rai, Mahesh Chandra Misra,Virinder Kumar Bansal A prospective randomized comparison of sexual function and semen analysis following laparoscopic totally extraperitoneal (TEP) and transabdominal pre-peritoneal (TAPP) inguinal hernia repair Surgical Endoscopy doi.org/10.1007/s00464-020-07733-y
2. Gupta V, Singh A, Khadgawat R, Agarwal A, Iqbal A, Mehtab W, Chaturvedi PK, Ahuja V, Makharia GK. The spectrum of clinical and subclinical endocrinopathies in treatment-naïve patients with celiac disease. Indian J Gastroenterol. 2019 Dec;38(6):518-526. doi: 10.1007/s12664-019-01006-w. Epub 2019 Dec 26.
3. Soni S, Agarwal A, Singh A, Gupta V, Khadgawat R, Chaturvedi PK, Ahuja V, Makharia GK. Prevalence of thyroid autoimmunity in first-degree relatives of patients with celiac disease. Indian J Gastroenterol. 2019 Oct;38(5):450-455. doi: 10.1007/s12664-019-00990-3. Epub 2019 Nov 8.
4. Roy Choudhury A, Gupta S, Chaturvedi PK, Kumar N, Pandey D.Mechanobiology of Cancer Stem Cells and Their Niche.Cancer Microenviron. 2019 Apr;12(1):17-27. doi: 10.1007/s12307-019-00222-4. Epub 2019 Apr 19. Review.
5. Kalsi AK, Halder A, Jain M, Chaturvedi PK, Sharma JB. Prevalence and reproductive manifestations of macroprolactinemia Endocrine. 2019 Feb;63(2):332-340
6. Kalsi AK, Halder A, Jain M, Chaturvedi PK, Mathew M, Sharma JB Association of raised levels of IL-4 and anti-TPO with hyperprolactinemia. Am J Reprod Immunol. 2019 Mar;81(3): e13085
7. Ahuja K, Garg B, Chowdhuri B, Yadav RK, Chaturvedi PK. A Comparative Analysis of the Metabolic and Coagulative Profiles in Patients with Idiopathic Scoliosis, Congenital Scoliosis and Healthy Controls: A Case-Control Study Asian Spine J. 2018 Dec;12(6):1028-1036
8. Suresh R, Wig N, Panda PK, Jyotsna VP, Chaturvedi PK, Pandey RM Serum Cortisol Level in Indian Patients with Severe Sepsis/Septic Shock. J Emerg Trauma Shock. 2017;10(4):194-198
9. Niraj Pant, G Kumar, A. D. Upadhyay, Y. K. Gupta, P. K. Chaturvedi: Correlation between lead and cadmium concentration and semen quality. Andrologia, 2015 47(8): 887-91
10. Niraj Pant, M Shukla, A. D. Upadhyay, P. K. Chaturvedi, D. K. Saxena, YK Gupta: Association between environmental exposure to p, p′-DDE and lindane and semen quality Environ Sci Pollut Res DOI 10.1007/s11356-014-2965-x, 2014 online, 2014,21(18)11009-16.
11. Niraj Pant, G. Kumar, A. D. Upadhyay, D. K. Patel, Y. K. Gupta, P. K. Chaturvedi: Reproductive toxicity of lead, cadmium, and phthalate exposure in men Environ Sci Pollut Res DOI 10.1007/s11356-014-2986-5 ,2014 online. 2014, 21(18): 11066-74.
12. Niraj Pant, AB Pant, P K Chaturvedi, M Shukla N Mathur YK Gupta and DK Saxena. Semen quality of environmentally exposed human population: The toxicological consequence Environ Sci Pollut res may21,2013 (online), 2013, 20(11): 8274-81.
13. Bajpai M, Chaturvedi PK, Bal CS, Sharma MC, Kalaivani M. Posterior urethral valves: Persistent renin angiotensin system activation after valve ablation and role of pre-emptive therapy with angiotensin converting enzyme-inhibitors on renal recovery. J Indian Assoc Pediatr Surg. 2013 Apr;18(2):74-8. doi: 10.4103/0971-9261.109357.
14. A Kumar, L Rani, B Dhole, P K Chaturvedi Oxygen as a regulator of MA-10 cell functions: effect of cobalt chloride on VEGF production. Andrologia 2012, 44; 615-620.
15. Anand Kumar, Rupali Dewan, Jyotsna Suri, Suman Kohli, Skand Shekhar, Bodhana Dhole, Pradeep Kumar Chaturvedi Abolition of endocrine dimorphism in hyperthyroid males? An argument for the positive feedback effect of hyper estrogenemia on LH secretion. Andrologia 2012, 44; 217-225.
16. Minu Bajpai, CS Bal, Rakesh Kumar, PK Chaturvedi, M Kalaivani Arun K Gupta Persistant rennin angiotensin system activation after anti reflux surgery and its management J Pediatric Urology 2011, Dec7(6): 616-22
17. Lata Rani, BP Mohanty, P K Chaturvedi, Anand Kumar Hypoxic Modulation of LH action on MA-10 Cells in Book Molecular and clinical aspects of gonadal and nongonadal actions of gonadotropins” Eds CV Rao, USA, Anand Kumar, PK Chaturvedi 2010 Narosa Publishing House, New Delhi
18. Gupta R, Deepanjali S, Kumar A, Dadhwal V, Agarwal SK, Pandey RM, Chaturvedi PK. A comparative study of pregnancy outcome and menstrual irregulaties in northern Indian patients with systemic lupus erthematosus and rheumatoid arthritis Rheumatol Int. 2010 Nov; 30(12): 1581-5. Epub 2009 Oct 14
19. Garima Nirwal, Anand Kumar, Pradeep Kumar Chaturvedi Effect of hCG and cAMP on progesterone production in Leydig cells during hypoxic condition. Biology of Reproduction 2007 spl issue abstract 417
20. Pradeep Kumar Chaturvedi Garima Nirwal, Anand Kumar, Effect of hypoxia on the VEGF secretion in MA-10 Leydig cells. Biology of Reproduction 2007 spl issue abstract 249
21. Sharma SK, Kumpawat S, Goel A, Banga A, Ramakrishnan L, Chaturvedi P. Obesity, and not obstructive sleep apnea, is responsible for metabolic abnormalities in a cohort with sleep-disordered breathing. Sleep Med. 2007 Jan;8(1):12-7.
22. Kumar A, Chaturvedi PK, Mohanty BP Hypoandrogenaemia is associated with subclinical hypothyroidism. Int. J Andrology 2007, 30(1), 14-20,
23. Mohanty BP, Lata Rani, Chaturvedi PK, Kumar A Effect of cobalt chloride on steroidogenesis of MA-10 cells. Indan J Physiol Pharmacol 2006; 52 (5) 117.
24. Jha A, Sharma SK, Tandon N, Lakshmy R, Kandhiravan T, Handa KK, Gupta R, Pandey RM and Chaturvedi P.K. Thyhyroxine replacement therapy reverse sleep-disordered breathing in patients with primary hypothyroidism. Sleep Medicine 2006 7(1): 55-61, Epub 2005 Sep 28.
25. Kumar A, Halder A, Chaturvedi PK, Chiplunker A, Arora E, Shruti, Mohanty BP, Lata, Garima (2005). Results of Preclinical and Clinical trials of Asokarishta. Indian Journal of Physiology and Pharmacology, 9(5): 92. (Abstract)
26. Kumar A Mohanty BP Chaturvedi PK: Regulation of hypophyseal gonadal axis in thyroid disorders. Indan J Physiol Pharmacol 2004; 48 (5) 223.
27. Sharma RS, Rajalakshmi M, Pal PC, Roy S, Behal VK, Sharma DN, Chaturvedi PK, Pruthi JS.Evaluation of efficacy, safety, and reversibility of combination regimen of cyproterone acetate and testosterone buciclate in bonnet monkey. Contraception. 62:195-201, 2000.
28. A. Kumar, N. Ahmad, P. Chaturvedi, S. Mittal and A. Farooq: Cyclic behaviour of splenic mononuclear cells (MNCs) in the regulation of granulosa cell progesterone (P4) production. Mol. Cell. Endo. (Suppl.) 164: 2000
29. N. Ahmad, P. Chaturvedi and A. Kumar: Inhibition of bovine granulosa cell steroidogenesis by Mycobacterium tuberculosis (M.tb) in vitro. Mol. Cell. Endo. 164: 2000.
30. A. Kumar, N. Ahmad and P. Chaturvedi: Modulation of granulosa cell steroidogenesis by microbes: an in vitro study. Mol. Cell. Endo. 164: 2000.
31. P K Chaturvedi L Johnson: Architectural arrangement of stages within human seminiferous tubule is related to efficiency of spermatogenesis. Cell Tissue Res. 273, 65-70, 1993.
32. P K Chaturvedi, Larry Johnson: Effect of age and daily sperm production on the architectural arrangements of stages of the spermatogenic cycle in human seminiferous tubule. J Andrology (Suppl) 1993.
33. P K Chaturvedi, Wayne C Zeh, Charles A Proshek, Larry Johnson: Effect of age and testicular transplantation on Sertoli cell number in Fischer rats. Biol Rep (Suppl) 48 p94. 1993
34. P K Chaturvedi and Larry Johnson: Relationship between the architectural makeup of seminiferous tubules and efficiency of spermatogenesis in men. J Andrology 1992; (Suppl)
35. L Johnson, P K Chaturvedi and J D Williams: Missing generations of spermatocytes and spermatids in seminiferous epithelium contribute to low efficiency of spermatogenesis in humans. Biol Rep. 47, 1091-1098,1992.
36. P K Chaturvedi, Vibhuti Purwar, T P Singh, R K Tandon: Orange peel oil is a potent cholesterol gallstone Solvent. Indian J Gastroenterology 1990;9:(suppl) A7.
37. P K Chaturvedi, R V S Raju, T Rajindra Kumar, Vibhuti Purwar, T P Singh and Rakesh Tandon. A possible cause of pancreatic stone formation. Ind J Gastroenterology. 8 No 4 (SUPPL) A 12-13 (1989)
38. Vibhuti Purwar, P K Chaturvedi, R V S Raju, P Augustine, and Rakesh Tandon. Biophysical, Biochemical and Morphological comparative study on bile duct stones of North and South Indian Origin. Ind J Gastroenterology. 8 No 4 (SUPPL) A 8-9. (1989).
39. R V S Raju, P K Chaturvedi, Vibhuthi Purwar and Rakesh Tandon. Gall stone - sex dependent. Ind J Gastroenterology. 8 No 4 (SUPPL) A 37. (1989).
40. S.S. Hassan P.K. Chaturvedi: Whole body X-irradiation and impact of dietary factors on brain and testes of albino rats. Strahlentherapaie 164, 37-43, 1988.
41. S.S.Hassan, P.K. Chaturvedi, and A.K.S. Kushwaha: Radiprotective effect of neo-mercazole in the rats during starvation stress. Radiobiolia Radiotherapia 28, 367-379, 1987.
42. P.K.Chaturvedi and S.S.Hassan : effect of two graded doses of X-irradiation on the rat adrenal gland and its protection by S-phenetyl formamidino 4( N-methyl isothioamide) morpholine dihydrochloride. Proc. Ind. Acad. Sci. 94, 523-526, 1985.
43. S.S.Hassan and P.K.Chaturvedi : Irradiation effect on the adrenal gland of rat undergoing inanition stress. Proc. Ind. Acad. Sci. 94, 79-86, 1985.
44. P.K.Chaturvedi and S.S.Hassan : 60 Co radiation induced hazards and use of S-anisyl formamidino 4(N-methyl isothioamide) morpholine dihydrochloride as chemical radioprotector. J. Nucl. Med. Allied. Sci. 28, 1-8, 1984.
45. S.S.Hassan, P.K.Chaturvedi and S.N. Pandey : Effect of two graded doses of whole body X-irradiation and radioprotection by the use of S-phenetyl formamidino 4(N-ethyl isothioamide) morpholine dihydrochloride. Nucl. Med. 22, 237-245, 1983.
46. S.S.Hassan and P.K.Chaturvedi : Response of whole body X-irradiation to inanition stress. Strahlentherapaie 159, 351-357, 1983.

BOOKS/ABSTRACT BOOKS:  

Editors/Associate Editor

1. Molecular and clinical aspects of gonadal and nongonadal actions of gonadotropins. Eds CV Rao, USA, Anand Kumar, PK Chaturvedi Narosa publishing house, New Delhi (2010)
2. Follicular Growth, Ovulation and Fertilization Eds: Anand Kumar, Amal K Mukhopadhya, Narosa publishing house, New Delhi. 2001.
3. Advance Abstract of papers International symposium on Molecular & Clinical Aspects of the Regulation of Ovarian Function: Impact on the Reproductive Health of Women Eds: Anand Kumar, Amal K Mukhopadhya, 1999.
4. Advance Abstract of papers Indo-Germen Satellite workshop Fertilization: Lessons from in-vitro Approaches Eds: Anand Kumar, Amal K Mukhopadhya, 1999.

Name:                                     DR. SURABHI GUPTA

Designation:                          Associate Professor

Institute/University:             Dept. of Reproductive Biology, AIIMS, New Delhi, INDIA

Email address:                       यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

Education (Post-Graduation onwards & Professional Career)

Position and Employment (Starting with the most recent employment)

Publications

Journal Articles:

1. Bodhana Dhole, Surabhi Gupta, Skand Shekhar, Anand Kumar. A novel antigonadotropic role of Thyroid Stimulating Hormone on Leydig cell – derived Mouse Leydig Tumor Cells – 1 line. Annals of National Academy of Medical Sciences (India). 2020; 56: 30-37.

2. Nidhi Singh, Sumaira Rashid, Safoora Rashid, Nihar Ranjan Dash, Surabhi Gupta, Anoop Saraya. Clinical significance of promoter methylation status of tumor suppressor genes in circulating DNA of pancreatic cancer patients. Journal of Cancer Research and Clinical Oncology. 2020; 146(4): 897-907. doi: 10.1007/s00432-020-03169-y.

3. Ankit Roy Choudhury, Surabhi Gupta, Pradeep Kumar Chaturvedi, Neeraj Kumar, Deepak Pandey. Mechanobiology of cancer stem cells and their niche. Cancer Microenvironment. 2019; 12(1): 17-27. doi: 10.1007/s12307-019-00222-4.

4. Bodhana Dhole, Surabhi Gupta, Senthil Kumar Venugopal, Anand Kumar. Triiodothyronine stimulates VEGF expression and secretion via steroids and HIF-1α in murine Leydig cells. Systems Biology in Reproductive Medicine. 2018; 64(3): 191-201. doi: 10.1080/19396368.2018.1433248.

5. Sumaira Rashid*, Nidhi Singh*, Surabhi Gupta*, Safoora Rashid, Nandini Nalika, Vikas Sachdev, Chandra Sekhar Bal, Siddhartha Datta Gupta, Shyam S. Chauhan, Anoop Saraya. Progression of Chronic Pancreatitis to Pancreatic Cancer: Is There a Role of Gene Mutations as a Screening Tool? Pancreas. 2018; 47(2): 227-232. [*Co-first authors]

6. Nidhi Singh, Surabhi Gupta, Ravindra M. Pandey, Peush Sahni, Shyam S. Chauhan, Anoop Saraya. Prognostic significance of plasma matrix metalloprotease-2 in pancreatic cancer patients. Indian Journal of Medical Research. 2017 Sep; 146: 334-340.

7. Nidhi Singh, Surabhi Gupta, R M Pandey, Shyam S Chauhan and Anoop Saraya. High levels of cell-free circulating nucleic acids in pancreatic cancer are associated with vascular encasement, metastasis and poor survival. Cancer Investigation. 2015 Mar; 33(3): 78-85.

8.  Nidhi Singh, Prasenjit Das, Surabhi Gupta, Vikas Sachdev, Siddhartha Srivasatava, Siddhartha Datta Gupta, R. M. Pandey, Shyam S. Chauhan, Anoop Saraya. Plasma Cathepsin L: A Prognostic Marker for Pancreatic Ductal Adenocarcinoma. World J Gastroenterol. 2014; 20(46): 17532-40.

9. Nidhi Singh, Prasenjit Das, Surabhi Gupta, Siddhartha Datta Gupta, Peush Sahni, R M Pandey, Shyam S Chauhan and Anoop Saraya. Prognostic significance of extracellular matrix degrading enzymes – Cathepsin L and matrix metalloproteases-2 [MMP-2] in human pancreatic cancer. Cancer Investigation. 2013; 31(7): 461-71.

10. Hitoshi Nishimura, Surabhi Gupta, Diana G Myles and Paul Primakoff. Characterization of mouse sperm TMEM190, a small transmembrane protein with the trefoil domain: evidence for co-localization with IZUMO1 and complex formation with other sperm proteins. Reproduction. 2011; 141(4): 437-51.

11.  Diego A Ellerman, Jimin Pei, Surabhi Gupta, William J Snell, Diana G Myles, Paul Primakoff. Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. Mol Reprod Dev. 2009; 76(12): 1188-99.

12. Guo Z Zhu, Surabhi Gupta, DG Myles, P Primakoff. Testase 1 (ADAM 24) a sperm surface metalloprotease is required for normal fertility in mice. Mol Reprod Dev. 2009; 76: 1106-14.

13. Surabhi Gupta, Paul Primakoff, Diana G Myles. Can the presence of wild-type oocytes during insemination rescue the fusion defect of CD9 null oocytes? Mol Reprod Dev. 2009; 76(7): 602.

14. Zhiyong He, Surabhi Gupta, Diana G. Myles, Paul Primakoff. Loss of EWI-2 on the surface of CD9 null oocytes. Mol Reprod Dev. 2009; 76(7): 629-36.

15. Kathryn E. Runge, JE. Evans, Zhiyong He, Surabhi Gupta, KL McDonald, Henning Stahlberg, P Primakoff, Diana G. Myles. Oocyte CD9 is enriched on the microvillar membrane and required for normal microvillar shape and distribution. Developmental Biology. 2007; 304: 317-25.

16. Michael J. Misamore, Surabhi Gupta, William J. Snell. The Chlamydomonas Fus1 protein is present on the mating type plus fusion organelle and required for a critical membrane adhesion event during fusion with minus gametes. Molecular Biology of Cell. 2003; 14(6): 2530-42.

17. Chandana Das, V. Senthil Kumar, Surabhi Gupta, Sunesh Kumar. Network of cytokines, integrins and hormones in human trophoblast cells. Journal of Reproductive Immunology. 2002; 53(1-2): 257-68.

18. Chandana Das, V Senthil Kumar, S Basak, Surabhi Gupta, Sunesh Kumar. Immunobiology of trophoblast cells. Indian Journal of Clinical Biochemistry. 2000; 15(suppl.): 60-64.

19. Surabhi Gupta, V. Senthil Kumar and Chandana Das. Expression and modulation of cell adhesion molecules in trophoblast cells. The Immunologist. 1998; Suppl. 1: 68.

20. V. Senthil Kumar, Surabhi Gupta and Chandana Das. Interleukins in maternal-fetal interaction. The Immunologist. 1998; Suppl. 1: 69.

21. V Senthil Kumar, Surabhi Gupta and C Das. Endotoxin regulated expression of interleukins in human trophoblast cells. American Journal of Reproductive Immunology. 1998; 40: 263.

Book Chapters:

1. Surabhi Gupta, Mona Sharma, Anand Kumar. Seminal Vesicles. In: Basics of Human Andrology: A Textbook. Eds: Anand Kumar & Mona Sharma. Publisher: Springer (2017) ISBN: 978-981-10-3694-1.

2. Surabhi Gupta, Anand Kumar. Genital Ducts and Other Accessory Sex Glands. In: Basics of Human Andrology: A Textbook. Eds: Anand Kumar & Mona Sharma. Publisher: Springer (2017) ISBN: 978-981-10-3694-1.

3. Surabhi Gupta, Anand Kumar. The Human Semen. In: Basics of Human Andrology: A Textbook. Eds: Anand Kumar & Mona Sharma. Publisher: Springer (2017) ISBN: 978-981-10-3694-1.

4. Surabhi Gupta, Anand Kumar. Systemic Influences on Male Reproduction - Immune System. In: Basics of Human Andrology: A Textbook. Eds: Anand Kumar & Mona Sharma. Publisher: Springer (2017) ISBN: 978-981-10-3694-1.

5. Mona Sharma, Surabhi Gupta, Bodhana Dhole, Anand Kumar. The Prostate Gland. In: Basics of Human Andrology: A Textbook. Eds: Anand Kumar & Mona Sharma. Publisher: Springer (2017) ISBN: 978-981-10-3694-1. 

Ongoing Research Grants

Surabhi Gupta (PI). Embryo-uterine cross-talk for implantation & beyond: Role for exosomal microRNAs. DST-SERB 2018-2021.

Surabhi Gupta (PI). Generation of genome-edited mice using CRISPR/Cas-9 based knock-out/knock-in technology to study mammalian sperm-egg fusion. DBT 2017–2020. 

Completed Research Grants

Surabhi Gupta (PI). Role of 3,5,3’-L-triiodothyronine (T3) in the modulation of VEGF expression and leydig cell function. DBT 2016 – 2019

    Dr. Mona Sharma   MD, DNB, MAMS      

                                            Associate Professor                                                

Department of Reproductive Biology,

Room no. 2087, 2^nd Floor, Teaching Block

                                 AIIMS, New Delhi                                      

Email: यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

9968147821

PROFESSIONAL QUALIFICATION:                                                     

1. DNB (Anatomy) from National Board of Examinations in 2013.
2. MD (Anatomy) from All India Institute of Medical Sciences (AIIMS), New Delhi in May, 2009
3. MBBS from Kasturba Medical College, MAHE, Mangalore, Karnataka in 2003.

EMPLOYMENT DETAILS  

1. Associate Professor in the Department of Reproductive Biology from July 1, 2017 till date.
2. Assistant Professor in the Department of Reproductive Biology from May 23, 2014 to June 30 2017. 
3. Assistant Professor at Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi from September 25, 2012 to May 22, 2014.
4. Senior Residency at AIIMS, New Delhi from June 12, 2009 to June 11, 2012.

RESEARCH WORK  

1. Principal investigator: High Resolution Sex Chromosome Genome Analysis in Pathogenesis of Premature Ovarian Failure (A-360).
2. Principal investigator: Study of potential sperm factors and related signaling pathways in eliciting oocyte intracellular calcium rise (A-631).
3. Chief-guide: Mutational Analysis of HS6ST2: A Candidate Gene in Idiopathic Premature Ovarian Failure.
4. Chief-guide: Effect of L-acetyl carnitine on TNF-α Induced Apoptosis in mice follicles.
5. Chief-guide: Citrate synthase expression in human sperm and oocyte activation in mice.
6. Chief-guide: Role of L-carnitine in oocyte activation.
7. Chief-guide: Effect of sperm vitrification on PLC-zeta expression.
8. Co-guide: Epigenetic changes during epithelial to mesenchymal transition in trophoblast cells under physiological and pathological conditions.
9. Co-guide: A correlative study of feto-maternal hydrogen sulfide production with umbilical artery velocimetry in preeclampsia.
10. Co-guide:  Pre and post-vasectomy sperm parameters.
11. Co-guide: Effect of tyrosine kinase inhibitors on sperm parameters and pituitary gonadal axis in males with chronic myelois leukemia.
12. Co-guide: Etiopathology of hyperprolactinemia.
13. Co-guide: Biomarkers in polycystic ovarian syndrome.
14. Co-guide: Genomics and epigenomics of polycystic ovarian syndrome
15. Co-guide: Role of placental derived exosomes in decidualization in recurrent pregnancy loss patients
16. Co-guide: Genetic determinants of premature ovarian failure patients.
17. Thesis research: “Apoptosis in Trophoblastic Cells of Human Placenta in Preeclampsia”
18. DC member: Role of micro RNA-30 in cystathionine gamma lyase mediated trophoblast cell invasion and status in preeclampsia.
19. DC member: To elucidate the role of osteoimmune system in regulating fertility
20. DC member: Delineating the role of insulin/insulin like growth factor signaling in C.elegans reproductive aging.
21. DC member: HDAC inhibitors mediated genome-wide dynamics in c.elegans embryogenesis and aging.
22. DC member: Characterization of TEX29 protein and its potential role in mammalian fertilization.
23. Embryological basis of anatomical variations in humans as part of UG, PG teaching program. 

PROJECTS

AIIMS intramural research funding:

Completed: Intramural project titled “High Resolution Sex Chromosome Genome Analysis in pathogenesis of Premature Ovarian Failure” (array cGH)

Ongoing: Intramural project titled “Study of potential sperm factors and related signaling pathways in eliciting oocyte intracellular calcium rise.” (Heterologous ICSI) 

Technically approved” Role of mitochondrial fatty acid shuttle system in premature ovarian failure”DHR/GIA

PUBLICATIONS  

1. Asuri K, Mohammad A, Prajapati OP, Sagar R, Kumar A, Sharma M, Chaturvedi PK, Gupta SV, Rai SK, Misra MC, Bansal VK. A prospective randomized comparison of sexual function and semen analysis following laparoscopic totally extraperitoneal (TEP) and transabdominal pre‑peritoneal (TAPP) inguinal hernia repair. Surg.endo.2020. https://doi.org/10.1007/s00464-020-07733-y
2. Rishi I, Halder A, Sharma JB, Jain M and Sharma M. Single Strand Conformation Polymorphism and sequencing to detect HS6ST2 gene mutations in patients of idiopathic premature ovarian failure.JCDR; Jan 2020:1-9.
3. Sharma Y, Sharma M. Sperm Cryopreservation: Principles and Biology. Accepted for publication in Journal of infertility and Reproductive biology, 2020.
4. Sharma M. Assisted oocyte activation. March 2019; Indian Fertility Society.
5. Sharma M. Recent evidence for PGS/PGD; July 2019; Indian Fertility Society.
6. Sharma M. Oocyte Activation following Intracytoplasmic Sperm Injection: Current Status from Bench to Bedside; 2019; Indian Society for the study of Reproduction and Fertility.
7. Kumar A, Sharma M. Basics of Human Andrology. 1^st ed. Springer Nature, Singapore. 2017; 1-536.
8. Sharma M, Gupta S, Dhole B, Kumar A. The Prostate gland. In: Basics of Human Andrology, 1^st ed. Kumar and Sharma, eds. Springer Nature, Singapore. 2017; 17-35
9. Gupta S, Sharma M, Kumar A. Seminal Vesicles. In: Basics of Human Andrology, 1^st ed. Kumar and Sharma, eds. Springer Nature, Singapore. 2017; 37-45.
10. Sharma M, Kumar A. Neurovascular supply and lymphatic drainage of male reproductive organs. In: Basics of Human Andrology, 1^st ed. Kumar and Sharma, eds. Springer Nature, Singapore. 2017; 55-65.
11. Sharma M, Kumar A. The Sperm. In: Basics of Human Andrology, 1^st ed. Kumar and Sharma, eds. Springer Nature, Singapore. 2017; 171-203.
12. Sharma M, Kumar A. Male Sexual Function. In: Basics of Human Andrology, 1^st ed. Kumar and Sharma, eds. Springer Nature, Singapore. 2017; 251-281.
13. Sharma M, Chadda RK, Anish PK,  Kumar A. Male Behaviors I: Brain areas regulating male behaviors. In: Basics of Human Andrology, 1^st ed. Kumar and Sharma, eds. Springer Nature, Singapore. 2017; 293-313.
14. Sharma M, Kumar A. Male II: Neural pathways regulating male behaviors Behaviors. In: Basics of Human Andrology, 1^st ed. Kumar and Sharma, eds. Springer Nature, Singapore. 2017; 315-339.
15. Sharma M, Kumar A. Male Behaviors III: Brain polymorphism and sexual orientation. In: Basics of Human Andrology, 1^st ed. Kumar and Sharma, eds. Springer Nature, Singapore. 2017; 341-347.
16. Sharma M, Kumar A. Male Behaviors IV: Ageing brain. In: Basics of Human Andrology, 1^st ed. Kumar and Sharma, eds. Springer Nature, Singapore. 2017; 349-362.
17. Shivi Goel, Jyoti Arora, Vandana Mehta, Mona Sharma, Rajesh Kumar Suri and Gayatri Rath. Unusual disposition of lateral circumflex femoral artery – anatomical description and clinical implications. World J Clin Cases 2015 January 16; 3(1): 85-88.
18. R. Hansdak, J. Arora, M. Sharma, V. Mehta, R K Suri, S. Das. Unusual branching pattern of brachial artery-Embryological basis and clinicoanatomical insight. La Clinica Terapeutica,March 2015, 166: 2;65-7.
19. Shivi Goel, Jyoti Arora, Vandana Mehta, Mona Sharma, Rajesh Kumar Suri and Gayatri Rath, Das S. Adductor accessorius- an unusual supernumerary adductor muscles of thigh. La Clinica Terapeutica, 2015, May-Jun;166 (3): 117-7.
20. Rustagi SM, Sharma M, Singh N, Mehta V, Suri R, Rath G. Peripheral communications   of the Intercostobrachial Nerve in relation to the Alar Thoracic Artery. Advanced Medical Research, Feb 2015, 1-4.
21. Gandhi S, Sharma M, Pakhiddey R, Thakur A, Mehta V, Suri R, Rath G. Unduly extensive uncinate process of pancreas in conjunction with pancreatico- duodenal fold. Anat Cell Biol, March 2015; 48: 81-83. 
22. Sharma M, Hansdak R, Mehta V, Arora J, Suri R, Rath G. An unusual branching pattern of the median cubital vein and its relations with lateral cutaneous nerve of forearm in the upper extremity-anatomicoclinical notes. JSA, 2014 (4)1:49-53. 
23. Mona S, Renu D. Possible developmental origin and clinical implications of a brachial plexus variation. GJRA; 3(2): 60-62, 2014. 
24. Thakur A, Tapas S, Sharma M, Mehta V, Suri R, Rath G. Anatomical description of a variant abductor digiti minimi accessorious muscle and its clinical correlation with ulnar neurovascular entrapment syndrome. Journal of Surgical Academia 2014; 4(2):41-44. 
25. Sharma M, Kumar R, Dhingra R. “Apoptosis: Researching the clinical implications”. JIMSA July-Sept. 2014;27(3). 
26. Gandhi S, Sharma M, Pakhiddey R, Mehta V, Suri RK, Rath G. “Unilateral aberrant gonadal venous anatomy coexistent with a distinct intrarenal cleft”. OA Anatomy 2013 Nov 01;1(3):28.
27. Sharma M, Kumar R, Bhatla N, Dhingra R. "A Comparative study of apoptosis in placentas of normal and preeclamptic Indian pregnant women by TUNEL assay and M30 immunostaining.  Journal of clinical laboratory analysis; 2012: 26: 459-466.
28. Sharma M, Kumar R, Dhingra R. “An immunohistochemical study of the syncytial knots in the preeclamptic placentas". International journal of pharmaceutical research and bioscience; 2012: 1(4) 228-239.
29. Sharma M, Dhingra R, Kumar R. “Relevance of placental pathological changes of maternal inflammatory syndrome along with the obstetric and clinical parameters in preeclampsia”. International journal of scientific and research publications, 2012; 2(8): 313-320.
30. Sharma M, Kumar R, Dhingra R. “Apoptosis: Understanding of the signaling pathways”. International journal of biological and medical research. 2012; 3(3):2029--2031.
31. Sharma M, Kumar R, Dhingra R. “Apoptosis: Searching for the detection techniques”. International journal of biological and medical research. 2012; 3(3):2172-2175.

AWARDS AND ACHIEVEMENTS

Best Poster Award for paper titled “Role of l-carnitine in TNF-α induced mice oocyte apoptosis” Rana R, Halder A, Sharma M; at ISSRF World congress,  February 2020 at ICMR-SMVDU, Centre for Advanced Research, SMVDU, Katra. Jammu & Kashmir, India

Best Poster Award for paper titled“Evaluation of Parameters to Standardize Single Strand Conformation Polymorphism for Detecting Gene Mutations in Patients of Idiopathic Premature Ovarian Failure”.  Isha Rishi, J B Sharma, Manish Jain, Mona Sharma,  at ISSRF, 2019, JNU, New Delhi

Elected as member of National Academy of Medical Sciences

Reviewer of a book proposal titled “Molecular mechanisms in spermatogenesis and male infertility” submitted to CRC Press. 

Reviewer of a book proposal titled “Thyroid and human reproductive functions” submitted to CRC Press.

DBT project reviewer

Editor, Indian Fertility Society, Newsletter “ReproGenQ”

Memberships :

Academy of Clinical Embryologists

Indian Fertility Society

Endocrine Society of India

Indian Society for the Study of Reproduction and Fertility

Society for Reproductive Biology and Comparative Endocrinology 

Invited Talks

1. Guest Lecture: “Puberty awareness”. In CME on child abuse, held on 12-11-19 in AIIMS, New Delhi
2. Guest lecture on “Recent advances in infertility” on November 11, 2018 during 66^th NATCON-ASI at AIIMS Rishikesh
3. Guest Lecture on “Non invasive methods of preimplantation and prenatal diagnosis” on 4^th April 2015 in the Department of Anatomy, VMMC & Safdarjung hospital, New Delhi.