Research
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DEPARTMENTAL RESEARCH
Research activities: Dr. Vijay L. Kumar
The focus of research has been in following areas:
- Molecular pharmacology of steroid and growth factor receptors in cancer
We have been working on the clinical implications of steroid and growth factor receptors in hormone dependent cancers and studied their expression in endometrial, breast and prostate cancer. Our work on regulation of androgen receptor (AR) has shown that androgenic deprivation results in up-regulation of AR. We have demonstrated the presence of multiple splice variants of estrogen receptor (ER) in breast cancer and our research has suggested that composite analysis of ER and its variants may serve as a better prognostic marker. Besides, we have also demonstrated expression, amplification and polymorphism of EGFR in prostatic diseases.
2. Development of experimental models to screen anti-inflammatory and cytotoxic drugs
Based on the pro-inflammatory property of the latex of plant Calotropis procera,models were developedfor screening anti-inflammatory and anti-arthritic drugs.
Simple plant-based models were developed to screen compounds exhibiting cytotoxic properties.
3. Medicinal properties of the latex of plant Calotropis procera
We have been working for last several years on the medicinal properties of latex of the plant Calotropis procera and demonstrated that extracts prepared from the latex produce potent anti-inflammatory, analgesic and antipyretic effects in experimental models. Besides beneficial effects in various disease models like arthritis, diabetes, and hepato-cellular carcinoma, the extract derived from the latex has recently been shown to afford protection in colitis and colorectal cancer.
4. Protection against drug-induced toxicity
Drugs and plant-derived preparations are being evaluated for their protective effect against drug-induced toxicity in experimental models, for e.g., hepato-renal toxicity induced by cyclosporine A and other drugs.
5. Evaluation of analgesic and anti-inflammatory property of drugs
Drugs are being evaluated for their analgesic and anti-inflammatory properties using well established experimental models.
Ongoing Projects
Dr. KH Reeta
- Modulation of AMPA receptor: Effect on post-stroke damage after focal cerebral ischemia reperfusion injury in rats, funded by ICMR (Amount = Rs. 51.40 Lakh)
- Genomic and Biochemical Correlation of “Prakriti” Stratified Patients diagnosed with Coronary Artery Disease (CAD): An Integrative Approach towards Personalized CAD Management, funded by DST (Amount = Rs. 31.21 Lakh).
- Role of GSK3β in modulating autophagy and apoptosis in permanent and transient model of ischemic stroke in rats, funded by ICMR (Amount = Rs. 21.58 Lakh)
Dr. Pooja Gupta
- Correlation of Germline HLA Variation by Next Generation Sequencing with Immune Related Adverse Events in Cancer Patients, funded by DST (Amount = Rs. 55 Lakh)
- Preventive Efficacy of Berberine Nanoparticles in Chemotherapy-Induced Cardiotoxicity in Animals, funded by AIIMS (Amount = 10 Lakh)
- ICMR Task Force Centre on Rational Use of Medicines, funded by ICMR (Amount = 45 Lakh)
Dr. HN Yadav
- Anemia: Exploring the role of vitamin D, essential elements and lifestyle in Indian Population (2021-11882), Funded by ICMR (amount = Rs. 75 Lakh)
- Design and development of Nanoscale Integrated system along with Conformal Antenna as Capsule Prototype for Wireless Capsule Endoscopy (D-610), Funded by DST (Amount = Rs. 73.88 Lakh)
- To study the regulatory mechanism of GSK-3β by Ishemic preconditioning against ovariectomized challenged Wistar rats (A-894), Funded by AIIMS (Amount = Rs. 10 Lakh)
Dr. Sudhir Chandra Sarangi
- Effect of antidepressants on neurodegeneration and neuroplasticity in patients with depression, funded by ICMR (Amount = Rs. 29.03 Lakh)
- Association of social cognition and behavioral impairment in persons with epilepsy on antiepileptic drug monotherapy: Correlation with neuroimaging findings and trace elements status, funded by DST (Amount = 37.89 Lakh)
- Study of vitamin D receptor expression and their correlation with seizure control in persons with drug resistant epilepsy after supplementation of vitamin D, funded by AIIMS (Amount = 10 Lakh)
Completed Projects
Dr. KH Reeta
- Evaluation of Safinamide in Experimental Model of Stroke and Post Stroke Seizure Behaviour in Rats (DST).
- Evaluation of Fumaric Acid Esters (FAEs) in Experimental Model of Stroke in Rats (DBT).
- Evaluation of the potential of edaravone, taurine and their combination in sporadic model of Alzheimer’s disease in rats (DST).
Dr. Pooja Gupta
- Topical Urea for Secondary Prophylaxis of Hand Foot Skin Reaction in Cancer Patients on Sunitinib Chemotherapy – A Randomized Double-Blind Placebo Controlled Clinical Trial
- Nano-Berberine for Protection Against Chemotherapy-Induced In Vitro Cardiotoxicity
- CYP2C19 Polymorphism, Bortezomib Concentration and Treatment Response in Multiple Myeloma Patients.
Dr. H N Yadav
- Ameliorative potential of Vinpocetine in experimental Diabetic Cardiomyopathy in Wistar rats (I-1135).
- Effect of Sildenafil Monotherapy versus Vitamin and Sildenafil combination in experiment model of Pulmonary Hypertension in rats (A-711).
- Development of Solid Lipid Nanoparticles for oral delivery of Liraglutide, an Anti-diabetic drug (BT-1942).
Dr. Sudhir Chandra Sarangi
- Pharmacodynamic and pharmacokinetic interactions of the ayurvedic formulation (BGR-34) with glibenclamide in experimental model of diabetes in rats.
- A prospective observational study to find out correlation of serum levels of antiepileptic drugs (AEDs) and other factors associated with seizure recurrence in persons with epilepsy (PWE) undergoing AED tapering
- A prospective observational study to find out correlation of serum levels of antiepileptic drugs (AEDs) and other factors associated with seizure recurrence in persons with epilepsy (PWE) undergoing AED tapering
