Dr.Riyaz Ahmad Mir

Dr. Riyaz Ahmad Mir

Additional Professor

 

Address: Room No 3040, 3rd Floor, Teaching block,

Department of Biochemistry

All India Institute of Medical Sciences

Ansari Nagar, New Delhi-110029

 

Official Phone: (O) 011-26593706 (Ext) 3706

Email id: This email address is being protected from spambots. You need JavaScript enabled to view it. , This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Employment record:

Additional Professor	Biochemistry, AIIMS, New Delhi	2023- present
Associate Professor	Biochemistry, AIIMS, New Delhi	2020-2022
Assistant Professor	Biochemistry, AIIMS, New Delhi	2016-2020

 

Research Experience:

Postdoc Fellow	University of Nebraska Medical Center, USA	2011-2016
PhD	Biochemistry, AIIMS, New Delhi	2005-2011

 

 

Reviewer and Editorial Board Member:

1. Frontiers in Oncology

2. GENE

3. Editorial board member Translational pathology and Laboratory medicine

4. Editorial board member Clinical pathology and research Journal

 

Research focus of the lab:

We are a dedicated team of researchers focused on understanding the role of the R2TP complex in malignancy. The R2TP complex is a co-chaperone of Hsp90, involved in the assembly and stabilization of various macromolecular complexes in the cell. The interactions and collaborative functions of the R2TP complex with its clients remain poorly understood and unexplored. Our research delves into the molecular associations of the complex whilst cancer progression and how it can potentially be targeted for therapeutic interventions.

Additionally, we explore the functions of tumour suppressors, crucial proteins that play a pivotal role in preventing the uncontrolled growth of cancer cells. Understanding how these proteins operate and how they can be manipulated is a key aspect of our work.

Furthermore, our lab is also interested in the effects of genetic manipulation in mammalian inner ear cells. This area of research is important for understanding hearing loss and other inner ear disorders, and it has implications for the development of potential treatments.

We are committed to advancing knowledge in these areas and contributing to the development of novel strategies for treatment. To learn more about our ongoing projects and recent discoveries, please email This email address is being protected from spambots. You need JavaScript enabled to view it. .

 

L to R: Ayesha, Pankaj, Hema, Dr Riyaz, Dhiraj and Mahaiwon

Present Lab members:

1. Ms Mahaiwon Shadang, PhD student, SRF-CSIR

Mahaiwon is investigating the molecular associations and clinical significance of the R2TP complex in cervical cancer. She joined the lab in August 2017 and completed her M.Sc. Medical Biochemistry in AIIMS, New Delhi in 2019 with a thesis that analyses the expression of the R2TP complex in Diffuse Large B Cell Lymphoma. She qualified for the CSIR NET JRF in 2017.

 

2. Mr Dhiraj Kumar Singh, PhD Student, SRF-CSIR

Dhiraj started work at AIIMS as JRF in 2018 and enrolled as a PhD student in 2019. He studies the role of PIH1D1 (a subunit of the R2TP complex) in various phases of the cell cycle. He has completed his M.Sc. Bioinformatics from Jamia Millia Islamia University. He also qualified for the CSIR JRF in 2017 with AIR-63.

 

3. Mr Pankaj Keshari, SRF

Pankaj’s work studies the trans-differentiation of inner ear supporting cells. This will provide insight into the development and function of supporting cells, leading to a better understanding of the biological roles these cells play.

 

4. Hema Yadav, PhD student, JRF-DBT

Hema studies the role of the R2TP complex in the etiology of thyroid cancer. She completed her M.Sc. Medical Biochemistry in AIIMS, New Delhi in 2021. Her Master's thesis explored the role of B cells in a spectrum of Tuberculosis. She has qualified CSIR JRF and DBT JRF.

 

5. Ayesha Rahman, PhD student, JRF-ICMR

Ayesha joined in October 2022 and works on “Effect of genetic manipulation in mammalian inner ear cells”. She completed her M.Sc. Biosciences from Jamia Millia Islamia University. She qualified ICMR JRF(AIR-51).

6. Sipriha Saxena (MD Biochemistry) She joined in February 2024

 

 

Key publications:

 

1. Hossain, M.M., Khalid, A., Akhter, Z. et al. Discovery of a novel and highly selective JAK3 inhibitor as a potent hair growth promoter. J Transl Med 22, 370 (2024). https://doi.org/10.1186/s12967-024-05144-4.

2. yadav VS, Bhatia A, Yadav R, Makker K, Singh DK, Mir RA. Effect of initial periodontal therapy on metallothionein levels in smokers and non-smokers with periodontitis. Odontology. 2024 Apr 8. doi: 10.1007/s10266-024-00937-x

3. Boruah Monikongkona, Gaddam Pranitha, Agarwal Shipra, Mir Riyaz Ahmad,Gupta Ranjan, Sharma Mehar C, Deo Suryanarayana V.S, Nilima Nilima. PD-L1 expression in rare and aggressive thyroid cancers: A preliminary investigation for a role of immunotherapy. Journal of Cancer Research and Therapeutics 2023 19(2):312-320,

4. Morankar Rahul, Nitesh Tewari, Vijay Mathur, Atif Mohammad, Kalpana Bansal,Sandeep Agrawal, Riyaz Mir. In-vitro Evaluation for Effects of Intracanal Medicaments on Viability, Proliferation, and Differentiation of Stem Cells From Apical Papilla–A Systematic Review. European Endodontic Journal 2022 (7) 3:167-168

5. Mishra N, Kumar S, Singh S, Bansal T, Jain N, Saluja S, Kumar R, Bhattacharyya S, Palanichamy JK, Mir RA, Sinha S, Luthra K. Cross-neutralization of SARS-CoV-2 by HIV-1 specific broadly neutralizing antibodies and polyclonal plasma. PLoS Pathog. 2021 Sep 24;17(9):e1009958. doi: 10.1371/journal.ppat.1009958. PMID: 34559854; PMCID: PMC8494312.

6. Lone M, Shadang M, Akhter Q, Kumar M, Mallick S, Gogia A, Nilima N, Chauhan SS, Mir RA. The Expression of the RUVBL1 Component of the R2TP Complex Correlates with Poor Prognosis in DLBCL. Pathobiology. 2022;89(3):146-156. doi: 10.1159/000520723. Epub 2022 Jan 25. PMID: 35078195.

7. Yadav VS, Mir RA, Bhatia A, Yadav R, Shadang M, Chauhan SS, Dhingra K, Kharbanda OP, Yadav R, Garg R. Metallothionein levels in gingival crevicular fluid, saliva, and serum of smokers and non-smokers with chronic periodontitis. J Periodontol. 2021 Sep;92(9):1329-1338. doi: 10.1002/JPER.20-0314. Epub 2020 Nov 9. PMID: 33107036.

8. Sharma R, Kumar V, Logani A, Chawla A, Mir RA, Sharma S, Kalaivani M. Association between the concentration of active MMP-9 in pulpal blood and pulpotomy outcome in permanent mature teeth with irreversible pulpitis - a preliminary study. Int Endod J. 2021 Apr;54(4):479-489. doi: 10.1111/iej.13437. Epub 2020 Dec 13. PMID: 33128238.

9. Olou AA, Sarkar A, Bele A, Gurumurthy CB, Mir RA, Ammons SA, Mirza S, Saleem I, Urano F, Band H, Band V. Mammalian ECD protein is a novel negative regulator of the PERK arm of unfolded protein response. Mol Cell Biol. 2017 28;37(18). pii e00030-17

10. Dar MS, Singh P, Mir RA, Dar MJ. Βeta-catenin N-terminal domain: An enigmatic region prone to cancer-causing mutations. Mutat Res Rev Mutat Res. 2017 Jul;773:122-133. doi: 10.1016/j.mrrev.2017.06.001. Epub 2017 Jun 12. PMID: 28927523.

11. Mir RA, Lovelace J, Schafer NP, Simone PD, Kellezi A, Kolar C, Spagnol G, Sorgen PL, Band H, Band V, Borgstahl GEO. Biophysical characterization and modeling of human Ecdysoneless (ECD) protein supports a scaffolding function. AIMS Biophys. 2016;3(1):195-208. doi: 10.3934/biophy.2016.1.195. Epub 2016 Mar 9. PMID: 28492064; PMCID: PMC5421643.

12. Mir RA, Bele A, Mirza S, Srivastava S, Olou AA, Ammons SA, Kim JH, Gurumurthy CB, Qiu F, Band H, Band V. A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression. Mol Cell Biol. 2015 Dec 28;36(6):886-99. doi: 10.1128/MCB.00594-15. PMID: 26711270; PMCID: PMC4810467.

13. Bele A, Mirza S, Zhang Y, Mir RA, Lin S, Kim JH, Gurumurthy CB, West W, Qiu F, Band H, Band V. The cell cycle regulator ecdysoneless cooperates with H-Ras to promote oncogenic transformation of human mammary epithelial cells. Cell Cycle. 2015;14(7):990-1000. doi: 10.1080/15384101.2015.1006982. PMID: 25616580; PMCID: PMC4614725.

14. Chaturvedi NK, Mir RA, Band V, Joshi SS, Guda C. Experimental validation of predicted subcellular localizations of human proteins. BMC Res Notes. 2014 Dec 15;7:912. doi: 10.1186/1756-0500-7-912. PMID: 25510246; PMCID: PMC4301851.

15. Kumar R, Tripathi V, Ahmad M, Nath N, Mir RA, Chauhan SS, Luthra K. CXCR7 mediated Giα independent activation of ERK and Akt promotes cell survival and chemotaxis in T cells. Cell Immunol. 2012;272(2):230-41. doi: 10.1016/j.cellimm.2011.09.015. Epub 2011 Oct 20. Erratum in: Cell Immunol. 2014 Aug;290(2):251. PMID: 22070874.

16. Mir RA, Chauhan SS. Down-regulation of a matrix degrading cysteine protease cathepsin L, by acetaldehyde: role of C/EBPα. PLoS One. 2011;6(6):e20768. doi: 10.1371/journal.pone.0020768. Epub 2011 Jun 8. PMID: 21687683; PMCID: PMC3110794.

17. Mittal S, Mir RA, Chauhan SS. Post-transcriptional regulation of human cathepsin L expression. Biol Chem. 2011 May;392(5):405-13. doi: 10.1515/BC.2011.039. Epub 2011 Mar 14. PMID: 21395501.

18. Katara R*, Mir RA*, Shukla AA, Tiwari A, Singh N, Chauhan SS. Wild-type p53-dependent transcriptional upregulation of cathepsin L expression is mediated by C/EBPα in human glioblastoma cells. Biol Chem. 2010 Sep;391(9):1031-40. doi: 10.1515/BC.2010.103. PMID: 20536385. *Equal authorship