रेसिडेंट कॉर्नर

Curriculum Vitae

Name: Ranjan Gupta

Designation: Associate Professor

Department and institute: Department of Rheumatology,

A. Professional qualification:

B. Positions held:

C. Personal Statement:

I am a clinician-scientist working in the field of rheumatology with special interest in Systemic Lupus Erythematosus. I have been working on biomarkers of SLE and Lupus Nephritis for last 10 years. I am one of the principal investigators in the project on establishing the largest inception cohort of SLE patients (INSPIRE) in India. My current areas of work in SLE are Autoantibody profile with ANA patterns heterogeneity and serum metabolomics. I am also an associate member of the Autoantibody Standardization Committee (ASC) in Rheumatic and Related Disorders of the International Union of Immunological Societies (IUIS) and working on ANA patterns in SLE. I have ongoing collaborations with IIT, Delhi, Tripura University and University College, London for my research work related to SLE and other rheumatic diseases.

D. Notable Ongoing Research grants & Projects (All as Principal Investigator):

1. International

1. Assessment of the Knowledge Gaps of Primary Care Physicians in the Diagnosis and Management of Rheumatoid Arthritis and Impact of a Short-Term Training Course

2. Comparison of Metabolomics Profiles Between Patients with Proliferative and Membranous Lupus Nephritis in London and New Delhi

2. National

1. Antinuclear Antibody Immunofluorescence Patterns in Systemic Lupus Erythematosus: Diagnostic and Prognostic Evaluation using Artificial Intelligence

2. Magnitude, characteristics and endurance of Immune Response to COVID-19 Vaccination in patients with Systemic Lupus Erythematosus: A multicentric cohort study

3. Multi-institutional network program on Systemic Lupus Erythematosus: Understanding the diversity of SLE

3. Intramural

1. Macrophage Migration Inhibitory Factor (MIF) and CD74/CD44 system as a biomarker of treatment response in Rheumatoid Arthritis

2. Foot-pressure distribution method for detection and localization of foot joint arthritis: A comparison with conventional radiographs

4. Others

1. Soluble Tumor Necrosis Factor (TNF) Receptors TNFRSF1B and TNFRSF6B in Lupus Nephritis as Biomarkers

2. Foot Pressure Distribution Assessment Using Wearable Pressure Insole for Foot Arthritis Diagnosis and Treatment Monitoring in Rheumatoid Arthritis

E. Awards and honors:

1. Young Rheumatologist Oration 2021 awarded by Indian Rheumatology Association

2. Best Paper Award at the Clinical Rheumatology Conference 2022

3. EULAR travel bursary 2022 to attend EULAR Congress at Copenhagen, Denmark

4. ICMR award - Shakuntala Amirchand Prize 2018 given by the ICMR for the best published work in the field of biomedical sciences including clinical research

5. Best paper award - First Prize for the paper presented at the annual meeting of the Delhi Rheumatology Association 2020

6. ARA – APLAR scholarship, 2017 to attend the combined Australian and New Zealand Rheumatology Association Meeting at Auckland

7. International fellow from India for the year 2016 for the fellows exchange program between American College of Rheumatology and Indian Rheumatology Association (did not avail).

8. International Travel Grant, 2016 given by Japanese College of Rheumatology to attend annual meeting at Yokohama, Japan

9. Best oral paper in basic sciences at the Annual meeting of Indian Rheumatology Association (IRA), 2013 at Kolkata

10. Dr. Vithalrao Nathgouda national best annual thesis award, 2012 given by Association of Physicians of India (API) at Kolkata

F. Publications:

1. Sapra L, Saini C, Garg B, Gupta R, Verma B, Mishra PK, Srivastava RK. Long?term implications of COVID?19 on bone health: pathophysiology and therapeutics. (Accepted for publication in Inflammation Research)

2. Meena L & Gupta R. Skeletal Fluorosis. N Engl J Med 2021;385:1510

3. Kar S, Gupta R, Malhotra R, Sharma V, Farooque K, Kumar V, Chakraborty S Mitra DK. Interleukin-9 Facilitates Osteoclastogenesis in Rheumatoid Arthritis. Int. J. Mol. Sci. 2021, 22, 10397. https://doi.org/10.3390/ijms221910397

4. Gupta R, Yadav A, Aggarwal A. Urinary soluble CD163 is a good biomarker for renal disease activity in lupus nephritis. Clin Rheumatol. 2020 Aug 18. doi: 10.1007/s10067-020-05343-6

5. Jain S, Dhir V, Aggarwal A, Gupta R, Leishangthem B, Naidu S, Khullar A, Maurya S, Dhawan V, Sharma SK, Sharma A, Jain S. Comparison of two dose escalation strategies of methotrexate in active rheumatoid arthritis: a multicentre, parallel group, randomised controlled trial. Ann Rheum Dis. 2021;80(11):1376-84.

6. Nanda S, Datta SK, Sagar P, Sharma M, Gupta R, Sodani A, Trikha A. Planning and Setting Up of a Communication Program for Hospitalized COVID-19 Patients: Challenges and Potential Solutions in Resource Constrained Setting. J Lab Physicians 2022; 14(01): 032-036

7. Sharma R, Kaur R, Sasidharan R, Gupta R, Laythalling RK. IgG4-Related Disease In Intradural Extramedullary Location- Detailed Case Illustration And Literature Review With Special Emphasis On Role Of Surgery In Its Management. 2021 Sep-Oct;69(5):1176-1183

8. Rathi M, Singh P, Bi HP, Shivanna A, Kavadichanda C, Tripathy SR, Parthasarathy J, Tota S, Maurya S, Vijayalekshmi V, Bhavani D, Jain A, Gupta R, Danda D, Rajasekhar L, Negi VS, Shobha V, Das B, Aggarwal A. Impact of the COVID-19 pandemic on patients with systemic lupus erythematosus: Observations from an Indian inception cohort. Lupus. 2021 Jan;30(1):158-164..

9. Vineeta Shobha, Amita Aggarwal, Liza Rajasekhar, Avinash Jain, Gupta R, Bidyut Das, Ashish J Mathew, Manish Rathi, Parasar Ghosh, Vir Singh Negi, Abhishek Tripathi, Ramnath Misra. Indian SLE Inception cohort for Research (INSPIRE): The Design of a Multi-institutional cohort. Rheumatol Int. 2021 May;41(5):887-894.

10. Ganguly S, Majumdar S, Kumar S, Gupta R, Shobha V, Aggarwal A, Misra RN. Urinary C3d as a marker of active lupus nephritis: longitudinal study. Lupus. 2020 Nov;29(13):1800-1806.

11. Sinha M, Gupta R. Segmental Arterial Mediolysis; Vascular it is, not vasculitis. Indian J Med Res. 2020 Nov; 152(Suppl 1): S119.

12. Gupta R. Pharmacovigilance of biosimilars - Why is it different from generics and innovator biologics?. J Postgrad Med. 2020;66(2):116. doi:10.4103/jpgm.

13. Guleria A, Phatak S, Dubey D, Kumar S, Zanwar A, Chaurasia S, Kumar U, Gupta R, Aggarwal A, Kumar D, Misra. NMR-Based Serum Metabolomics Reveals Reprogramming of Lipid Dysregulation Following Cyclophosphamide-Based Induction Therapy in Lupus Nephritis. J Proteome Res. 2018 Jul 6;17(7):2440-2448.

14. Gupta V, Aggarwal A, Gupta R, Chandra Chowdhury A, Agarwal V, Lawrence A, Misra R. Differences between adult and pediatric onset Henoch-Schonlein purpura from North India. Int J Rheum Dis. 2018 Jan;21(1):292-298

15. Aggarwal A, Gupta R, Negi VS, Rajasekhar L, Misra R, Singh P, Chaturvedi V and Sinha S. Urinary haptoglobin, alpha-1 anti-chymotrypsin and retinol binding protein identified by proteomics as potential biomarkers for lupus nephritis. Clin Exp Immunol 2017;188(2):254-62

16. Phatak S, Chaurasia S, Kumar S, Gupta R, Agrawal V, AGgarwal A, Misra R. Urinary B cell Activating Factor (BAFF) and A Proliferation Inducing Ligand (APRIL): Potential biomarkers of Active Lupus Nephritis. Clin Exp Immunol. 2017;187(3):376-82

17. Gupta R, Yadav A, Aggarwal A. Longitudinal Assessment Of Monocyte Chemoattractant Protein – 1 In Lupus Nephritis As A Biomarker Of Disease Activity. Clin Rheumatol 2016;35(11):2707-14

18. Gupta R, Misra R. Microbe-triggered arthropathies: reactive arthritis and beyond. Int J Rheum Dis. 2016;19:437-9

19. Gupta R, Misra R. Measuring Anti-drug antibodies: A step towards optimization of biologic therapy. J Assoc Physicians India 2016;64(9):11-12

20. Gupta R, Aggarwal A, Sinha S, Rajasekhar L, Yadav A, Gaur P, Misra R, Negi VS. Urinary Osteoprotegerin: A Potential Biomarker of Lupus Nephritis Disease Activity. Lupus 2016;25(11):1230-6

21. Gupta R, Aggarwal A. Popeye deformity in rheumatoid arthritis. – J Postgrad Med 2016;62(2):33-4

22. Gupta R, Nath AK, Subbian M, Basu D, Hamide A, D'Souza M. Hemorrhagic skin nodules and plaques: A diagnostic clue to underlying primary plasma cell leukemia. Indian J Dermatol 2016;61(2):203-5

23. Gupta R, Yadav A, Misra R, Aggarwal A. Urinary sCD25 as a biomarker of lupus nephritis disease activity. Lupus. 2015 Mar;24(3):273-9

24. Gupta R, Yadav A, Misra R, Aggarwal A. Urinary prostaglandin D synthase as biomarker in lupus nephritis: a longitudinal study. Clin Exp Rheumatol. 2015; 33:694-98

25. Gupta R, Aggarwal A. Exercise and rheumatoid arthritis: A low cost intervention with major benefits Natl Med J India 2015;28(3):32-3

26. Misra R, Gupta R. Biomarkers in lupus nephritis. Int J Rheum Dis. 2015 Feb;18(2):219-32

27. Gupta R, Aggarwal A. High burden of cardiovascular disease in lupus: Is there a way out? Indian Journal of Rheumatology 2015;10:181-82

28. Gupta R, Aggarwal A. An unusual cause of hip pain – National Medical Journal of India 2014; 27(6): 349

29. Venkateswaran R, Gupta R, Swaminathan R P. Bruns nystagmus in cerebellopontine angle tumor. JAMA Neurol. 2013;70(5):646

30. Aggarwal A, Shenoy S, Gupta R. Long term Outcome in Juvenile Idiopathic Arthritis. Indian Journal of Rheumatology 2012;7:22-26

31. Gupta R, Mohindra N, Agarwal V. A rare cause of focal myositis in diabetes. Indian Journal of Rheumatology 2013; (8): 190 – 19

Book Chapters:

32. Gupta R, Aggarwal A. Systemic lupus erythematosus (Book Chapter in a book titled ‘Skin in rheumatic diseases’)

33. Gupta R, Aggarwal A. Case Vignettes (Book Chapter in a book titled ‘Pediatric Rheumatology’

34. Gupta R. Autoantibodies in Systemic Lupus Erythematosus. (Book Chapter in Manual of Rheumatology, 6^th Edition)

35. Gupta R & Arya S. Rationale and safe use of painkillers/NSAIDs. (Chapter in BMJ course on Rheumatic & Musculoskeletal Diseases)