DR. SURENDER K. SHARAWAT

DR. SURENDER K. SHARAWAT (PhD)

401, 4^TH FLOOR, DR.B.R. AMBEDKAR IRCH
ALL INDIA INSTITUTE OF MEDICAL SCIENCES

ANSARI NAGAR, NEW DELHI, 110029
sk यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए. , यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

Area of Working:

• Leukemia Genetics and Cytogenetics

• Leukemia Transcriptomics (Long and circular non-coding RNA)

• Leukemia Stem cells

Professional Experience:

Educational Qualifications:

 Research Projects (Funded): Ongoing:

1. Project Title: “Role of HOTAIRM1 long non-coding RNA in chemo resistance of acute myeloid Leukemia”. Funded by DST, Budget 48.49 Lacs [Role: As PI, Duration 3 Years, 2019-2022]

2. Project Title: “The significance of UCA1 long non-coding RNA in pediatric acute myeloid leukemia. Funded by DST, Budget 10 Lacs [Role: As PI, Duration 2 Years, 2020-2022]

3. Project Title “Elucidation of the role of long non-coding RNA-Ginir as a biomarker in lung tumorigenesis”. Funding Agency: DBT; Duration: 03 years; Funds: 89 lakhs (In collaboration with NCCS, Pune (Role: Co-investigator)

4. Project Title “Evaluation of regulation of programmed death-ligand 1 (PD-L1) expression by microRNA in lung cancer”. Funding Agency: ICMR; Duration: 8/2019-8/2022; Funds: 47.64 lakhs (Role: Co-investigator)

5. Project Title “Study of Clinical Significance of Genetic Alterations and Feasibility of Adopting Children Oncology Group (COG) Risk-based Stratification of Wilms Tumor in Indian Children” Funding Agency: ICMR; Duration: 8/2020-8/2023 (Role: Co-P investigator)

List of Publications

1. Pandey M, Mukhopadhyay A, Sharawat SK, Kumar S. Role of microRNAs in regulating cell proliferation, metastasis and chemoresistance and their applications as cancer biomarkers in small cell lung cancer. Biochim Biophys Acta Rev Cancer 2021; 1876(1):188552. [PubMed PMID: 33892053]

2. Kumar S, Pandey M, Mir IA, Mukhopadhyay A, Sharawat SK, Jain D, Saikia J, Malik PS, Kumar S, Mohan A. Evaluation of the programmed death-ligand 1 mRNA expression and immunopositivity and their correlation with survival outcomes in Indian lung cancer patients. Human Cell 2021. [PubMed PMID: 34786661]

3. Sharawat SK*, Bansal AK*, Gupta R, Vishnubhatla S, Bakhshi S. Serial Evaluation of T cell Subsets in Paediatric Acute Myeloid Leukaemia- a Prospective Study (Accepted in Indian Journal of Hematology and Blood Transfusion, ahead of print) *Contributed Equally

4. Kumar S, Pandey M and Sharawat SK Biological Functions of Long Non-Coding RNAs and Circular RNAs in Small Cell Lung Cancer. Epigenomics. 2020 Oct;12(19):1751-1763[PubMed PMID: 33074037]

5. Sharawat SK Bansal AK, , Gupta R, Vishnubhatla S, Dhawan D, Bakhshi S. Regulatory T cells in pediatric AML are associated with disease load and their serial assessment suggests role in leukemogenesis. Am J Blood Res. 2020 Aug 25;10(4):90-96. eCollection 2020. [PubMed PMID: 32923088]

6. Kumar S, Sharawat SK, Ali A, Gaur V, Malik PS, Pandey M, Kumar S, Mohan A, Guleria R. Differential expression of circulating serum miR-1249-3p, miR-3195 and miR-3692-3p in non-small cell lung cancer. Human Cell. 2020 Jul;33(3):839-849 [PubMed PMID: 32215864]

7. Kumar S, Sharawat SK, Ali A, Gaur V, Malik PS, Kumar S, Mohan A, Guleria R. Identification of differentially expressed circulating serum microRNA for the diagnosis and prognosis of Indian non-small cell lung cancer patients. Curr Probl Cancer 2020 Aug;44(4):100540. [PubMed PMID: 32007320]

8. Bhat AA, Younes SN, Raza SS, Zarif L, Nisar S, Ahmed I, Mir R, Kumar S, Sharawat SK, et al. Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance. Mol Cancer. 2020 Mar 12;19(1):57. [PubMed PMID: 32164715]

9. Gaur V, Chaudhary S, Tyagi A, Agarwal S, Sharawat SK, Sarkar S, Singh H, Bakhshi S, Sharma P, Kumar S. Dysregulation of miRNA expression and their prognostic significance in pediatric cytogenetically normal acute myeloid leukemia. British J of Hematology, 2020 188: e90–e94. (IF 5.2) 145 [PubMed PMID: 32077100]

10. Baccarani M, Castagnetti F, Gugliotta G, Rosti G, Soverini S, Albeer A, Pfirrmann M, Sharawat SK, Kumar L. (for the International BCR-ABL Study Group) The proportion of different BCR-ABL1 transcript types in chronic myeloid leukemia. An international overview,Leukemia 2019; 33, 1173–1183 (IF 12.03) [PubMed PMID: 30675008]

11. Kumar S and Sharawat SK. Epigenetic Regulators of PD-L1 Expression in Human Cancers. Transl Res. 2018; 202:129-145 [PubMed PMID: 30401465] (IF 4.915)

12. KumarS, Gaur V, Khurana S, Bose S, Kiran M, Sharawat SK. Proteomics – An Update on Recent Tools and Techniques. EC Proteomics and Bioinformatics 2.2 (2018): 57-73.

13. Sharawat SK*, Akhter M Z*, Kumar V*, Kochat V, Equbal Z, Ramakrishnan M , Kumar U, Mathur S, Kumar L, Mukhopadhyay A. Aggressive serous epithelial ovarian cancer is potentially propagated by EpCAM+CD45+ phenotype. Oncogene; 2018 Apr;37(16):2089-2103.[PubMed PMID: 29379166]*Contributed Equally

14. Sharawat SK, Vishnubhatla S, Bakhshi R, Raina V,Kumar L,Sharma A,Bakhshi S. High fms-like tyrosine kinase-3 (FLT3) receptor surface expression predicts poor outcome in FLT3 internal tandem duplication (ITD) negative patients in adult acute myeloid leukaemia: a prospective pilot study from India. Indian J Med Res. 2016 May;143 (Supplement): S11-S16. [PubMed PMID: 27748272]

15. Sharawat SK, Vishnubhatla S, Bakhshi R, Raina V,Kumar L,Sharma A,Bakhshi S.Relative Receptor Tyrosine Kinases and Anti-Apoptotic Transcripts Hold Potential for Predicting Inferior Outcome in Adult Acute Myeloid Leukemia: A Prospective Pilot Study. Blood Cells Mol Dis. 2015 Jan;54(1):56-64[PubMed ID: 22420668]

16. Kesherwani V, Nandi SS, Sharawat SK, Shahshahan HR and Mishra PK. Hydrogen sulfide mitigates homocysteine-mediated pathological remodeling by inducing miR-133a in cardiomyocytes. Mol Cell Biochem. 2015 Jun;404(1-2):241-50 [PubMed ID: 25763715]

17. Sharawat SK,Bakhshi R, Vishnubhatla S, Gupta R,Bakhshi S. FLT3-ITD Mutation in Relation to FLT3 Expression in Pediatric AML: a Prospective Study from India. Pediatr Hematol Oncol. 2014 Mar;31(2):131-7 [PMID: 24498869]

18. Sharawat SK, Raina V,Kumar L,Sharma A,Bakhshi R, Vishnubhatla S, Gupta R, Bakhshi S. Prospective Evaluation of Significance of Transcript and Flow-cytometric Expression of Bax in Acute Myeloid Leukemia. Hematology. 2014 Jan 3. [PMID:24620954]

19. Tilak TVSVGK, Sharawat SK, Gupta R, Agarwala S, Vishnubhatla S, Bakhshi S, Circulating T-Regulatory Cells in Neuroblastoma: a Pilot Prospective Study. PediatrHematolOncol. 2014 Mar 31 [PMID: 24684178]

20. Sharawat SK, Radhika Bakhshi, Vishnubhatla S, Gupta R, Bakhshi S. Bax/Bcl2 RMFI Ratio Predicts Better Induction Response in Pediatric Acute Myeloid Leukemia. Pediatric Blood and Cancer 2013 Aug; 60(8):E63-6 [PubMed ID: 23553948]

21. Tilak TVSVGK, Sharawat SK , Gupta R, Agarwala S, Vishnubhatla S, Bakhshi S, Circulating T-Regulatory Cells in PNET: a Prospective Study. Pediatric Blood and Cancer, 2013 [PubMed ID: 23997029]

22. Sharawat SK , Gupta R, Raina V,Kumar L,Sharma A,Iqbal S, Bakhshi R, Vishnubhatla S, Bakhshi S. Increased Co-Expression of c-KIT and FLT-3 Receptors on Myeloblasts: Independent Predictor of Poor Outcome in Acute Myeloid Leukemia. Cytometry B Clinical Cytometry 2013 [PubMed ID: 23740774]

23. Sharawat SK, Vishnubhatla S, Bakhshi R, Raina V,Kumar L,Sharma A,Bakhshi S. Relative Receptor Tyrosine Kinases and Anti-apoptotic Transcripts Hold Potential for Predicting Inferior Outcome in Adult Acute Myeloid Leukemia: A Prospective Pilot Study.Clin Lymphoma Myeloma Leuk 2013[PMID: 25065779]

24. Mandhaniya S, Iqbal S, Sharawat SK, Xess I, Bakhshi S. Diagnosis of invasive fungal infections using real-time PCR assay in paediatric acute leukaemia induction. Mycoses. 2012 Jul; 55(4):372-9 [PubMed ID: 22420668].

25. Gogia A, Sharawat SK, Kumar R, Sarkar C, Bakhshi S. Systemic Mastocytosis Associated With Childhood Acute Myeloid Leukemia. J PediatrHematolOncol. 2012 May 10 [PubMed ID: 22584780].

26. Sharawat SK,Bakhshi R, Vishnubhatla S, Bakhshi S. Mitochondrial D-loop variations in paediatric acute myeloid leukaemia: a potential prognostic marker. Br J Haematol. 2010 May; 149(3):391-8. Epub 2010 Mar 8 [PubMed ID: 20230407].

27. Gupta N, Gupta R, Sharawat SK, Bakhshi S. Childhood chronic myeloid leukemia with monocytosis. Indian J Pediatr. 2010 Oct; 77 (10):1143-5. Epub 2010 Sep 30 [PubMed ID: 20882436].

Educational Awards

• Early career research Award (Serb-DST): 2019, Ministry of Science and Technology, Government of India New Delhi

• First Prize for best oral presentation award by society of young scientist (SYS) 2012, AIIMS, New Delhi.

• Young Investigator Travel Award by European Society of Medical Oncology (ESMO) 2012 in Vienna Austria.

• Awarded Institute Fellowship grant (AIIMS) form 1st February 2012 to 31October, 2012

• Awarded Junior Research Fellowship from Indian council of Medical Research (ICMR) and qualified examination in July 2005

• Awarded Junior Research Fellowship from Indian council of Medical Research (ICMR) and qualified examination in July 2006 (1st February 2007 to 31 January 2009)

• Awarded Senior research fellow from Indian council of Medical Research (ICMR) from 1st February 2009 to August 2012

• Qualified CSIR-UGC JRF exam for National Eligibility Test (NET), conducted by Council for Scientific and Industrial Research (CSIR) and University Grant Commission (UGC) of INDIA in June 2005