Dr. Vijay L. Kumar

(डॉ.विजय एल. कुमार)

 

Present Position: Professor and Head आचार्य एवं अध्यक्ष, Department of Pharmacology भेषजगुण विज्ञान विभाग, AIIMS, New Delhi  अ.भ.आ.सं.,  नईदिल्ली

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Education: M.Sc. (Pharmacology): All India Institute of Medical Sciences, New Delhi

Ph.D.: All India Institute of Medical Sciences, New Delhi

Postdoctoral Research: Institut de Chimie Biologique, Strasbourg, France

 

Awards and Honors:  

British Government fellowship for training in Medical Education and Technology, 1990.  

Chandra Kanta Dandiya Prize of Prem Chand Dandiya Endowment Trust for best research publication in Pharmacology, 1999.  

C.L. Malhotra Research Prize in Pharmacology by the Association of Physiologists and Pharmacologists of India for research, 2000. 

A.V. Tilak Parvathy Devi Prize by the Association of Physiologists and Pharmacologists of India for best research paper in endocrinology, 2006. 

Dev Raj Bajaj Research Prize by the Association of Physiologists and Pharmacologists of India for the best research paper in developing a new technique, 2009.

AIIMS Excellence Research Award 2020 under the category Basic Sciences

 

Member - National Academy of Medical Sciences, India, 2004.

 

Member – National Academy of Sciences, India, 2007.

 

Research Interest:

• Anti-cancer and anti-inflammatory mechanisms of drugs and botanicals.

• Molecular biology of steroid receptors, regulation of receptors and its relevance in hormone dependent cancers.

• Awareness for poison prevention

Outline of Research:

• Anti-inflammatory, analgesic and antiarthritic properties of non-protein and protein fractions of latex of Calotropis procera and the effect of these fractions on inflammatory and oxidative stress markers.

• Other medicinal properties of latex of C. procera - Antipyretic, antidiarrhoeal, antihyperglycemic, anticancer, hepatoprotective, antiulcer, maintenance of coagulation homeostasis in in vivo models.

• Purification and pharmacological characterization of active constituents of latex of C. procera.

• Pleiotropic effects of drugs and plant derived preparations - atorvastatin, artesunate.

• Development of models for screening of anti-inflammatory and cytotoxic drugs.

• Trends on poisoning based on analysis of data of National Poisons Information Centre related to accidental and intentional exposure to various products.

• Differentially expressed genes associated with lead exposure and their functional relevance, protein-protein interaction and identification of hub genes.

• Steroid and growth factor receptors - in vivo regulation and implication to prostate cancer, regulatory mechanisms and splice variants of estrogen receptor in breast cancer.

Selected Publications:

1. Kumar V.L., Majumder P.K. and Kumar V. Androgen deprivation causes up-regulation of androgen receptor transcript in the rat prostate. Mol. Cell. Biochem. 171: 133-138, 1997.

2. Kumar V.L.,Majumder P.K., Gujral S., Kumar V. Comparative analysis of epidermal growth factor receptor mRNA levels in normal, benign hyperplastic and carcinomatous prostate. Cancer Letters 134: 177-180, 1998.

3. Kumar V.L., Kumar S., Srivastava A. and Kumar V. Observations on the presence of E domain variants of estrogen receptor-α in the breast tumors. J Surg. Oncol. 94: 332-337, 2006.

4. Wahane V.D. and Kumar V.L. Atorvastatin ameliorates inflammatory hyperalgesia in rat model of monoarticular arthritis. Pharmacol. Res.61: 329-333, 2010.

5. Guruprasad B., Chaudhary P., Choedon T. and Kumar V.L. Artesunate ameliorates functional limitations in Freund’s complete adjuvant-induced monoarthritis in rat by maintaining oxidative homeostasis and inhibiting COX-2 expression. Inflammation 38: 1028-1035, 2015.

6. Verma S., Das P. and Kumar V.L. Chemoprevention by artesunate in a preclinical model of colorectal cancer involves down regulation of β-catenin, suppression of angiogenesis, cellular proliferation and induction of apoptosis. Chem. Biol. Interact. 278: 84-91, 2017.

7. Kumar V.L., Pandey A., Verma S. and Das P. Protection afforded by methanol extract of Calotropis procera latex in experimental model of colitis is mediated through inhibition of oxidative stress and pro-inflammatory signaling. Biomed. Pharmacother. 109: 1602-1609, 2019.

8. Vangaveti S., Das P. and Kumar V.L. Metformin and silymarin afford protection in cyclosporine A induced hepatorenal toxicity in rat by modulating redox status and inflammation. J. Biochem. Mol. Toxicol. 2020 doi: 10.1002/jbt.22614.

9. Kumar V.L., Verma S. and Das P. Protective effect of methanol extract of latex of Calotropis procera in an experimental model of colorectal cancer. J. Ethnopharmacol. 2022 doi: 10.1016/j.jep.2021.114668.

10. Sharma S., Kumar V.L., Bhardwaj A.Identification of critical genes associated with lead exposure based on in silico analysis. Toxicol. Ind. Health 39: 356-363, 2023.