Research

Funded projects

Ongoing

1. A prospective multi-centric observational study on the role of blood coagulation and fibrinolysis in emergence of ARDS in patients with new coronavirus pneumonia (COVID-19) as Co-PI, Jasmita Dass; Mukul Aggarwal, COVID Intramural, 1 year, 2020-2021, Rs 10 lakhs

2. A prospective, multi-national, non-interventional study in haemophilia A and B patients with or without inhibitors treated according to routine clinical treatment practice (explorer™ 6), Tulika Seth, Novo Nordisk, 2 years, 2020-2021, Rs 4.4 lakhs

3. Assessment of BCL-2 expression in B-Acute lymphoblastic leukemia at diagnosis and after therapy for minimal residual disease assessment, Pradeep Kumar, AIIMS early career intramural, 2 years, 2020-2022, Rs 10 lakhs

4. Comparative study of digital droplet polymerase chain reaction (dd-PCR) and quantitative real time polymerase chain reaction (qRT-PCR) for BCR-ABL1 transcript quantitation in chronic myeloid leukemia (CML) patients on tyrosine kinase inhibitor (TKI therapy) and eligible for treatment free remission (TFR), Ganesh Kumar V, AIIMS early career intramural, 2 years, 2020-2022, Rs 10 lakhs

5. Mitigation of clinical phenotype by activated platelets in severe hemophilia, M Mahapatra, DBT, 3 years, 2019- 2022, Rs 8 lakhs

6. Strengthen and standardize the National Referral and Training Centers in India, Tulika Seth, Novo Nordisk Hemophilia Foundation (NNHF), 3 years, 2020-2022, Swiss CHF 570,000

7. Study of B-cell subsets and NK cell subsets in patients of acquired Aplastic anemia, Dr Jasmita Dass, AIIMS Early career intramural, 2 years, 2020-2022, Rs 10 lakhs

8. To study whether the levels of Tissue factor pathway inhibitor (TFPI) and its polymorphisms influence bleeding severity in moderate and severe Hemophilia A patients, Mukul Aggarwal, AIIMS Early career intramural, 2 years, 2020-2022, Rs 10 lakhs

Completed

1. Concizumab label trial for Hemophilia B with Inhibitors, Tulika Seth, NOVONORDISK, 3 years, 2019-2021, Rs 3.5 lakhs

2. NN7415-4311/4307, Tulika Seth, NOVONORDISK, 3 years, 2019-2021, Rs 3.5 lakhs

Departmental projects

Ongoing

1. Analysis of Monocyte subsets by Multiparameter flow cytometry in peripheral blood in cases of Monocytosis

2. Assessment of eligibility for treatment free remission in patients of chronic phase of CML attending OPD of a tertiary care center

3. Central nervous system hemorrhage and thrombosis in acute promyelocytic leukemia

4. Characterization of immunoparesis in newly diagnosed myeloma and its impact on progression-free and overall survival with regards to anti myeloma therapy

5. Compare Hb CZE and HPLC in diagnosis of hemoglobinopathies

6. Correlation of endogenous thrombopoietin levels with response to thrombopoietin receptor agonists and assessment of serum LDH profile in adults with primary ITP

7. Effect of tyrosine kinase inhibitor on sperm parameters and pituitary gonadal axis in male patients with Chronic myeloid Leukaemia

8. Evaluation of programmed death- ligand1 (PD- L1) / CD274 expression on myeloblasts in acute myeloid leukemia (AML) by flowcytometry

9. Evaluation of response to immunosuppressive therapy and eltrombopag in aplastic anemia

10. Evaluation of transient elastography, hepatic iron concentration by MRI t2* liver, serum liver fibrosis indexes versus liver biopsy in thalassemia major patients who are candidates for hematopoietic stem cell transplant, a comparative pilot study

11. Flow cytometric ploidy analysis in B-cell acute lymphoblastic leukemia

12. Flow cytometry assessment of CD 26+ leukemia stem cells in chronic myeloid leukemia

13. Identification and in-silico characterization of molecular defects underlying inherited deficiencies of FVII and FX in India

14. Imatinib dose escalation in CML: indication, responses and outcomes

15. Immunophenotyping and MRD analysis in Multiple myeloma by flow cytometry

16. Impact of molecular genetics on the phenotype of Indian sickle cell syndrome patients.

17. Minimal residual disease analysis in acute myeloid leukemia by flow cytometry using a limited antibody panel

18. Mitigation of clinical phenotype by activated platelets in severe hemophilia

19. Molecular profiling of Myelodysplastic Syndromes subgroups – MDS with single lineage dysplasia and MDS with multi-lineage dysplasia for assessment of prognosis and treatment response.

20. Myeloid-derived suppressor cells and Precursor B cell acute lymphoblastic leukemias: Identification and quantification in peripheral blood samples

21. Prevalence of common variable immunodeficiency and autoimmune lymphoproliferative disorder in autoimmune hemolytic anemia/evans syndrome and their impact on clinical outcomes

22. Study of the expression of GATA1 protein by immunohistochemistry in BCRABL negative myeloproliferative neoplasm.

23. Study of the role of thromboelastography in predicting risk of hemorrhage in patients with acute leukemia

24. To assess utility of MPN 10 questionnaire for assessment of symptoms burden and quality of life) and assessment of various scoring systems being used in patients of myelofibrosis

25. To compare the diagnostic performance of Whole Body Low dose Computed Tomography (WB LDCT) and Conventional Skeletal Survey (CSS) in diagnosis and management of patients with Multiple Myeloma (MM) in a Tertiary Care Centre

26. To compare the side effect profile, minimal residual disease and early event free survival in patients of CD20 positive precursor B acute lymphoblastic leukemia who receive rituximab versus those who do not receive rituximab with induction therapy

27. To evaluate the utility of enumerating circulating stem cells with aberrant h-MICL expression by flowcytometry in the diagnosis and prognosis of philadelphia chromosome negative Myeloproliferative Neoplasms

28. To study the combined role the BCR-ABL1 Kinase Domain and Elsewhere mutation in Chronic Myeloid Leukemia patients with resistance to Tyrosine Kinase Inhibitors (TKIs)

Completed

1. Abdominal infections in immunocompromised hosts: a clinical, microbiological and radiological correlation

2. Assessment of Nutritional status/Parameters in acute leukemia patients undergoing induction chemotherapy

3. Clinical and laboratory profile of patients with hypereosinophilia presenting to a tertiary care center on north India

4. Correlation of serum iron profile and Hepcidin level in patient with microcytic hypochromic anemia.

5. Efficacy of low dose rasburicase in management of tumor lysis syndrome in leukaemia and lymphoma patients

6. Evaluate The Role Of Tissue Factor And Tissue Factor Pathway Inhibitor Gene Polymorphisms In The Pathogenesis Of Deep Vein Thrombosis In India

7. Nilotinib versus Imatinib deep molecular response in CML

8. Role of IHC with CD 61 and p53 on bone marrow biopsies in enhancing diagnosis in suspected MDS casesretrospective and prospective study.

9. Study of expression of cereblon protein by immunohistochemistry in newly diagnosed and treated multiple myeloma patient

Collaborative projects

Ongoing

1. A population based prospective cohort study to unravel the causes of stroke and cognitive decline: a cross cultural perspective. DBT international co-operation division. AIIMS and Erasmus Medical Center Rotterdam, Netherlands, Clinical Epidemiology Unit, AIIMS

2. Autoimmune haemolyticanaemia: Clinical and Serological correlation. Transfusion Medicine, AIIMS

3. Development of a quick and specific detection system of BCR-ABL proteins, Department of Anatomy

4. Efficacy of intravenous iron therapy compared to oral iron treatment in iron deficient adult cyanotic, congenital heart disease patients for improvement in clinical outcome at 3 months.Cardiology, AIIMS

5. Electrochemical Sensor Detection of microbial infections and antibiotic resistance within 2hours in Patients with Febrile neutropenia in hematological malignancies. RAMJA Genosensor Pvt, Ltd, IIT Delhi

6. Identifying association of gene polymorphism and Prakriti in responders & non responders to dual antiplatelet therapy in coronary artery disease patients.Cardiology, AIIMS

7. Immune reconstitution in Haplo identical HSCT, Transplant Immuology & Immunogenetics, AIIMS

8. Ocular GVHD in post Allogeneic HSCT patients, Ophthalmology, AIIMS

9. Prospective observational study to assess the prevalence of platelet refractoriness and its reasons in patients receiving multiple platelet transfusion in an Indian setting. Transfusion Medicine, AIIMS

10. Randomized control trial to evaluate safety and efficacy of intra vitreal injection of autologous bone marrow derived stem cells in acute cases of ischaemic central retinal vein occlusion, Ophthalmology, AIIMS

11. Real Time PCR for Diagnosis of Invasive Fungal Infections, Microbiology, AIIMS

12. Relevance of WT1 gene expression in AML, BRAIRCH

13. Role of platelet activation in the development of systemic inflammations in patients with type-2 diabetes, Endocrinology, AIIMS and Regional Centre for Biotechnology (RCB)

14. To evaluate the role of serum d-dimer, neutrophil: lymphocyte ratio, platelet: lymphocyte ratio and CA125 in assessment of ovarian masses, Obstetrics and Gynaecology, AIIMS

Completed

1. Clinical and aetiological Profile Of Patients With Eosinophilia, Department of Medicine

2. Outcome predictors in Secondary HLH, Department of Infectious Diseases

3. Ras homolog gene family (RHOA) and Isocitrate dehydrogenase 2 (IDH2) mutation in Angioimmunoblastic T cell Lymphoma (AITL), Department of Pathology