EX-STUDENTS
Dr. Chriasturajan Soundara Rajan Ph.D, Thesis on Molecular study on mitochondrial dysfunction in Parkison’s disease Worked as Biochemist at Centralised Laboratory, CN Centre,AIIMS (2002- 2006) Present Status: Post Doctoral Fellow at John Hopkins’s University, USA email: This email address is being protected from spambots. You need JavaScript enabled to view it.
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Dr. Hamid Suhail Ph.D Thesis: Comparative studies of antibodies to nicotine Acetylcholine Receptors (nAChRs) and muscle specific tyrosine Kinase (MuSK) in Myasthenia Gravis patients with clinical correlation in context with genotype and phenotype variation Present Status: Post Doctoral Fellow at Canada email: This email address is being protected from spambots. You need JavaScript enabled to view it. |
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Dr. Muraleedharan Muniswamy Ph.D Thesis: Pharmacogenetics of Epilepsy Drug Therapeutics Present Status: Post Doctoral Fellow at Alabama, USA email: This email address is being protected from spambots. You need JavaScript enabled to view it. |
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Dr. Kanthaiah Y.V Ph.D, Thesis: Analysis of Classical, Nonclassical MHC I, TGF beta in glioma stem cells, effect of IFN Gamma and IL-12 on these molecules and relevance in immunotherapy Present Status: Clinical Scientist at Totipopent Rx Cell Therapy pvt ltd email: This email address is being protected from spambots. You need JavaScript enabled to view it. |
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Dr. Mohita Sriwastva Ph.D, Thesis: Mitochondrial Dysfunction And its Role in the Genesis of programmed Cell Death (PCD) pathway in patients with Amyotrophic Lateral Sclerosis (ALS) email: This email address is being protected from spambots. You need JavaScript enabled to view it. |
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Dr. Gopishankar N MSc Medical Physics and MCA Ph.D Thesis: Validation of gel docimetry as a 3D verification tool in highly conformal radiotherapy techniques Present Status: Medical pharmacist & RSO, AIIMS email: This email address is being protected from spambots. You need JavaScript enabled to view it. , This email address is being protected from spambots. You need JavaScript enabled to view it. |
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Dr Saima Naz Siddiquie Ph.D Thesis: Identification and analysis of specific nutritions in ATP7B, Hctr-1 and ATox-1 genes and study of their molecular genetics to establish genotype- phenotype correlation in Wilson Disease patients. email: This email address is being protected from spambots. You need JavaScript enabled to view it. |
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Dr. Hardeep S Gambhir Ph.D Thesis: Implantation of human retinal pigment epithelial (hRPE) cells in the 6- OHDA Iesioned rat model of Parkison’s disease (PD) email: This email address is being protected from spambots. You need JavaScript enabled to view it. |
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SONALI NIRMAL Area of Research: Pharmacogenetics study in Alzheimer’s disease MSc in Biotechnology (Bharatidasan University, Tamil Nadu) Email: This email address is being protected from spambots. You need JavaScript enabled to view it. |
PROJECTS
SL NO |
PROJECT TITLE |
FUNDING AGENCY |
DURATION |
1 |
Immunologic and Immunogenetic aspects of Multiple sclerosis patients in India |
ICMR |
1987 to 1990 |
2 |
Purine metabolic enzymes in peripheral blood T-cells in Multiple sclerosis patients |
ICMR |
1997 to 2000 |
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Antioxidant status and genetically determined differences in xenobiotic metabolism in Parkinsons disease
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ICMR |
1999 to 2002 |
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Role of CYP2D6 and Glutathione S-transferase M1 (GSTM1) polymorphism in Multiple Sclerosis patients
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ICMR |
2001 to 2003 |
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Impact of Nutritional strategies and antioxidant therapy on progression and management of Parkinson,s disease |
ICMR |
2002 to 2004 |
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Molecular study on mitochondrial dysfunction in Parkinson,s disease |
ICMR |
2004 to 2006 |
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Genetic polymorphism of drug metabolizing enzymes CYPC9 and CYPC19 genes in patients developing adverse drug reactions and toxicity to specific antiepileptic drug - Phenytoin
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ICMR |
2004 to 2007 |
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To find out predominant mutation(s) in Cu/Zn SOD1 gene in Familial amyotrophic lateral sclerosis patients and their first –degree relatives in Indian population
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AIIMS |
2006 to 2007 |
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Health Profile of Population of Nellore (A.P.) An ICMR task force study. |
ICMR |
2007 to 2008 |
10 10 |
Analysis of TGF B Pathway components expression and mutation in glioma patients “ |
AIIMS |
2007 to 2008 |
11 11 |
Health Profile of Population of Dhar (MP) |
ICMR |
2009 to 2010 |
1 . 12 |
Pharmacogenetic of epilepsy drug therapeutics |
DBT |
2007 to 2010 |
13 13 |
The study of mitochondrial dysfunction in patients with Amyotrophic Lateral Sclerosis |
ICMR |
2007 to 2010 |
14 14 |
Validation of Gel dosimetry as 3D verification tool for highly conformal radiotherapy techniques |
AERB |
2009 to 2010 |
15 15 |
Exploring the role of MHC and co-stimulatory molecules in immune evasion mechanism of Glioma stem cells. |
DBT |
2008 to 2011 |
16 16 |
Pharmacogenetics of Alzhemiers drug therapeutics |
DST |
2010 to 2014 |
17 17 |
Multi centric study on Pharmacogenetics of Schizophrenia drug therapeutics |
ICMR |
2011to 2015 |
PUBLICATION
1. Amit Kumar, S Vivekanandhan, Arpna Srivastava, Manjari Tripathi, M. V. Padma Srivastava, Neha Saini, Pradeep Kumar, Kameshwar Prasad. Association between angiotensin converting enzyme gene insertion/deletion polymorphism and ischemic stroke in north Indian population:a case–control study and meta-analysis. Neurological Research 2014 , Feb.12
2. Amit Kumar, Kameshwar Prasad, Manjari Tripathi, M.V Padma Srivastava, S. Vivekanadhan. Association of beta adrenergic receptor polymorphism with risk of hemorrhagic stroke in North Indian Population: A case control study. Neurology India, 2014.
3. Identification of Genetic Contribution to Ischemic Stroke by screening of Single Nucleotide Polymorphisms in Stroke Patients by using a case control study design (Study protocol) and meta-analysis. Amit Kumar, Pradeep Kumar, Jitendra Kumar Sahu, Ashoo Grover, Achal Srivastava, S Vivekanandhan and Kameshwar Prasad. BMC Neurology 2013 Oct.3:13:136
7. Sonali N, Tripathi M, Sagar R, Vivekanandhan S. Impact of CYP2D6 and CYP3A4 Genetic Polymorphism on Combined Cholinesterase Inhibitors and Memantine Treatment in Mild to Moderate Alzheimer? Disease. Dementia and Geriatric Cognitive disorders. 2014; 37: 58-70.
10. Dalal,K; Elanchezhiyan D; Vivekanandhan S; Pandey R M;Tripathi M. Role of Reflexology and Antiepileptic Drugs in Managing Intractable Epilepsy -a Randomized Controlled Trial. Forschende Komplementärmedizin 2013; 20:104-111
11. Sonali N, Tripathi M, Sagar R, Velpandian T, Subbiah V."Clinical effectiveness of Rivastigmine monotherapy and combination therapy in Alzheimer’s patients" CNS Neuroscience & Therapeutics. CNS Neurosci Ther. 2013 Feb.19(2):91-7.
12. Dhandapani S, Dhandapani M, Agarwal M, Chutani AM, Subbiah V, Sharma BS, Mahapatra AK. The prognostic significance of the timing of total enteral feeding in traumatic brain injury. Surg Neurol Int. 2012; 3: 31.
13. Natanasabapathi G, Subbiah V, Kale SS, Rath GK, Senthilkumaran S, Thulkar S, Subramani V, Laviraj MA, Bisht RK, Mahapatra AK. "MAGAT Gel and EBT2 film based Dosimetry for Evaluating Source plugging based treatment plan in Gamma Knife Stereotactic Radiosurgery". J Appl Clin Med Phys. 2012 Nov 8;13 (6):3877.
15. Deepika Shukla, Seema Hallikerimath, Venkatakanthaiah Yerramalla, and Vivekanandhan Subbiah, Can Quantifying Free-Circulating DNA Be a Diagnostic and Prognostic Marker in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma? American Association of Oral and Maxillofacial Surgeons2012
16. Khan S, Behari M, Vivekanandhan S, Goyal V, Thelma BK. Mutation Profile in Wilson’s Disease from North Indian Patients. International Journal of Human Genetics ; 2012; 12 (2); 125-132
17. Sivashanmugam D, Manju D, Meena A, Alka MC, Vivekanandhan S, Bhawani SS, Ashok KM. The prognostic significance of the timing of total enteral feeding in traumatic brain injury. Surgical Neurology International ; 2012; 3 :31
18. Murali M, Manjari T, Madhuri B, Raghavan S, Jain DC and Vivekanandhan S. Genetic Polymorphism of NAT2 Metabolizing Enzymes on Phenytoin Pharmacokinetics in Indian Epileptic Patients Developing Toxicity. CNS Neurosci Ther; 2012 April 18 (4):350-8
19. Vivekanadhan S, Bhardwaj D, Munisamy M and Sagar R. Angiotensin Converting Enzyme Gene Insertion/Deletion Polymorphism: Case-Control Association with Schizophrenia in a North Indian Population. J Mol Biomark Diagn ; 2011; (2); 105.
20. Nirmal S, Tripathi M, Shastri S, Sagar R and Vivekanandhan S. Association of angiotensin converting enzyme I/D genotype in Alzheimer’s Disease patients of North Indian population. The International Journal of Neuroscience; 2011; 121 (10); 557-561
21. Tripathi M, Vibha D, Gupta P, Padma MV, Bhatia R, Prasad K, Singh MB and Vivekanandan S. Risk factors of dementia in North India: a case control study. Aging and Mental Health; June 2011; Epub DOI:10.1080/13607863.2011.583632
22. Srivastava M, Vivekanandhan S, Pathy U, Behari M and Das TK. Mitochondrial perturbance and execution of apoptosis in platelet mitochondria of patients with Amyotrophic lateral Sclerosis. International Journal of Neuroscience; 2011; 121(3); 149-158
23. Srivastava M, Das TK, Behari M and Vivekanandhan S. Ultrastructural variations in platelets and platelet mitochondria: a novel feature in amyotrophic lateral sclerosis. Ultrastruct Pathology; 2011; 35(2); 52-59
24. Srivastava M and Vivekanandhan S. An Insight into Ultrastructural and Morphological Alterations of Platelets in Neurodegenerative Diseases. Ultrastruct Pathol; 2011; 35(3); 110–116
25. Gopishankar N, Watanabe Y and Vivekanandhan S. MRI-based polymer gel dosimetry for validating plans with multiple matrices in Gamma Knife stereotactic radiosurgery. Journal of Applied Clinical Medical Physics; 2011;12 (2); 133-145
26. Gopishankar N, Vivekanandhan S and Thulkar S. MAGAT gel dosimetry for its application in small field treatment techniques. Journal of Physics: Conferences Series; 2010; 250; 12061
27. Kannan L, Lodha R, Vivekanandhan S, Bagga A, Kabra SK and Kabra M. Intravenous fluid regimen and hyponatraemia among children: a randomized controlled trial. Pediatr Nephorolog; 2010; 25(11); 2303-2309
28. Suhail H,Vivekanandhan S, Singh S and Behari M. Serological and clinical features of patients with myasthenia gravis in north Indian population. The International Journal Neuroscience, 2010; 120 (2); 115-119
29. Suhail H, Soundararajan CC, Singh S, Vivekanandhan S and Behari M. Apo-E genotypes and Myasthenia Gravis. Neurology India; 2010; 58 (3); 443-445
30. Suhail H, Vivekanandhan S, Singh S and Behari M. Coexistent of MuSK and AChR antibodies in a myasthenia gravis patient. Neurology India; 2010; 58 (4); 668-669
31. Biswas A, Ranjan R, Meena A, Akhter MS, Yadav BK, Munisamy M, Vivekanandhan S , Behari M and Saxena R. Homocystine Levels, Polymorphisms and the Risk of Ischemic Stroke in Young Asian Indians. Journal of Stroke and Cerebrovascular Diseases; 2009; 18(2); 103-110
32. Lodha R, Arun S, Vivekanandhan S, Kohli U and Kabra SK. Myocardial cell injury is common in children with septic shock. Acta Paediatr; 2009; 98 (3); 478-481
33. Sarthi M, Lodha R, Vivekanandhan S and Arora NK. Adrenal status in children with septic shock using low –dose stimulation test. Pediatric Critical Care Medicine;2007; 8(1); 23-28
34. Khandelwal D, Bhatia M, Vivekanandhan S, Singh S, Shukla G, Goyal V and Behari M. IgM anti GM1 antibody titers in patients with monomelic amyotrophy. Neurology India; 2006; 54 (4 ); 399-401
35. Kailash U, Soundararajan CC, Lakshmy R, Arora R, Vivekanandhan S and Das BC. Telomerase activity as an adjunct to high – risk human papillomavirus types 16 and 18 and cytology screening in cervical cancer. British Journal of Cancer; 2006; 95 (9); 1250 -1257
36. Lodha R, Vivekanandhan S, Sarathi M and Kabra SK. Serial circulating Vasopressin levels in children with septic shock. Pediatr Crit Care Med, 2006; 7(3), 220-224
38. Soundararajan CC, Adhin A, Tripathi M, Prasad HK, Jain S and Vivekanandhan S. Association of CYP2D6 100 C > T and 2850 C > T polymorphisms with generalized tonic clonic seizures among Indians. Neural Transm; 2006; 113 (12); 1873-1876
Text Book publication:-
Co - Author of the chapter: “Digital filtering techniques to reduce image noise and improve dose resolution in X-Ray CT based normoxic gel dosimetry”
Book : “Radiation Therapy” (ISBN 979-953-307-341-4)
RESEARCH LABORATORY
· BIOCHEMICAL AND MOLECULAR STUDIES
Basic research techniques in biochemistry and molecular biology are used to explore various aspects of diseases in CNS. Following neurodegenerative diseases are the main focus of our research:-
ALZHEIMER’S DISEASE
CNS ISCHEMIA
EPILEPSY
SCHIZOPHRENIA
SPINOCEREBELLAR ATAXIA
WILSON DISEASE
MULTIPLE SCLEROSIS
PARKINSON’S DISEASE
BIPOLAR DISORDER
AMYOTRPIC LATERAL SCLEROSIS (ALS)
· DRUG/ PHARMACOGENETIC STUDIES
We explore the genetic involvement of neurodegenerative diseases and the metabolic effects of therapeutic drugs. Genetic polymorphisms of disease related genes and drug metabolizing enzymes in Indian population are of the main focus of our study
· CELL CULTURE STUDIES
We are working on Human cortical Neurons and HepG2 cell lines.
FACILITIES IN THE NEUROBIOCHEMISTRY RESEARCH LABORATORY
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FACILITY |
MANUFACTURER |
BIOCHEMISTRY ANALYZER |
BECKMANN COULTER |
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CELL CULTURE FACILITY |
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CELL CULTURE CO2 INCUBATOR |
THERMO SCIENTIFIC |
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CELL IMAGING- PHASE CONTRAST MICROSCOPE |
NIKON |
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CHEMILUMINESCENCE |
SIEMENS |
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COLD CENTRIFUGE |
ALC- THERMO |
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ELISA PLATE READER |
TECAN, BIORAD |
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GAMMA COUNTER-RIA |
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GEL DOCUMENTATION SYSTEM |
ALPHA INNOTECH |
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GRADIENT PCR |
EPPENDROF |
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HPLC |
WATERS |
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ISOELECTRIC FOCUSING |
SEBIA |
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PCR- RFLP |
APPLIED BIOSYSTEMS, BIORAD |
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PROTEIN ELECTROPHORESIS UNITS |
BANGLORE GENEI |
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QUANTITATIVE RT PCR |
BIORAD |
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SSCP |
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WESTERN BLOT FACILITY |
BANGLORE GENEI |
All India Institute of Medical Sciences
Ansari Nagar, New Delhi - 110029
Board Number : +91-11-26588500 / 26588700
Fax : +91-11-26588663 / 26588641