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अखिल भारतीय आयुर्विज्ञान संस्थान, नई दिल्ली
All India Institute Of Medical Sciences, New Delhi

Patient Care

Student

 
PhD Students

Mr. Ashutosh Bansal

 
 

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Ms. Shipra 
(UGC-JRF)
 

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Ms. Priyanka Solanki

(DBT-JRF)
 

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Staff

Scientists 

Dr. Manoj Kumar Tembhre, Ph.D.

 

(October 2016 to Present)

 

 

 

Email ID

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Mobile:+918800502994

Telephone

011-26594201

Field of Research: Immunology of Autoimmune and Inflammatory (Cardiovascular and skin) diseases 

Publications: Refer to below Pubmed link:

https://pubmed.ncbi.nlm.nih.gov/?term=tembhre+m+k&sort=date  

Current Work: Research is focused on skin diseases (e.g. Vitiligo, Psoriasis, Pemphigus, Alopecia areata, allergy etc.) and Cardiovascular diseases (e.g. Cardiomyopathy, Rheumatoid Heart Diseases, Heart Failure, CHD, CAD etc. with main focus on understanding the cardiac homeostasis) using various in vivo (Human subjects and animal models) and in vitro studies. Understanding the fundamentals of cell death (Apoptosis, Necroptosis) pathways, autophagy, mitochondrial dynamics, Immune regulations via T cells (Tregs & Th17 cells), macrophages, Neutrophil extracellular trap formation and alarmins in driving cardiovascular and skin homeostasis are key aspects of research in our lab.  Lab is also having research collaborations in multidisciplinary areas (neurological disorders, Tumor Immunobiology, Human Microbiota etc.) and is open for collaboration in similar or diverse fields. Lab encouraged the highly motivated student to join the PhD programme of the department. Department is having Research facilities like qPCR (BioRad), Western Blot platform (BioRad), Flow Cytometer (BD-Lyrics), HPLC and other equipments.  

Lab members:

PhD students:

Ms. Shipra (UGC-JRF)-2020

Ms. Priyanka Solanki (DBT-JRF)-2022  

Project Research Fellow

Mr. Ritesh Raj (ICMR-Senior Research Fellow, PhD (Amity University))-2021

Dr. Ransi Ann Abraham, PhD

(Sepember 2021 to present)

 

 

Email ID

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Mobile:+919911716130

Telephone

011-26594426

1)      Role of fatty acids in CVD

2)      Aging and cardiovascular health

Publications: Refer to below pubmed link

https://www.ncbi.nlm.nih.gov/myncbi/ransi.abraham.1/bibliography/public/

Publications

PUBLICATIONS

Few selected recent publications

1.       Ramakrishnan L, Sachdev HS, Sharma M, Abraham R, Prakash S, Gupta D, Singh Y, Bhaskar S, Sinha S, Chandak GR, Reddy KS, Bhargava S. Relationship of APOA5, PPAR gamma and HL gene variants with serial changes in childhood body mass index and coronary artery disease risk factors in young adulthood. Lipids Health Dis. 2011 May 8;10(1):68

2.   Lakshmy R, Fall CH, Sachdev HS, Osmond C, Prabhakaran D, Biswas SD, Tandon N, Ramji S, Reddy KS, Barker DJ, Bhargava SK. Childhood body mass index and adult pro-inflammatory and pro-thrombotic risk factors: data from the New Delhi birth cohort. Int J Epidemiol. 2010 Jul 26.

3.   Lakshmy R, Ahmad D, Abraham RA, Sharma M, Vemparala K, Das S, Reddy KS, Prabhakaran D. Paraoxonase gene Q192R & L55M polymorphisms in Indians with acute myocardial infarction & association with oxidized low density lipoprotein. Indian J Med Res. 2010 Apr;131:522-9.

  1. Ramakrishnan Lakshmy, Ruby Gupta, Dorairaj Prabhakaran, Uma Snehi, K. Srinath Reddy. Utility of Dried Blood Spots for Measurement of Cholesterol and Triglycerides in a Surveillance Study. Journal of Diabetes Science and Technology, March 2010, Volume 4, Issue 2: pages 258-262

5.   Huffman MD, Prabhakaran D, Osmond C, Fall CHD, Tandon N, Lakshmy R, Ramji S,Khalil A, Gera T, Prabhakaran P, Biswas SKD, Reddy KS, Bhargava SK, Sachdev HS, on behalf on the New Delhi Birth Cohort. Incidence of cardiovascular risk factors in an Indian urban cohort. JACC, 2011, 57: 1766-74. 

6.   Jeemon P, Prabhakaran D, Ramakrishnan L, Gupta R, Ahmed F, Thankappan K, Kartha C, Chaturvedi V, Reddy K, Population study Group TS. Association of high sensitive C-reactive protein (hsCRP) with established cardiovascular risk factors in the Indian population. Nutr Metab (Lond) 2011, 8(1): 19

7.   Ramakrishnan L, Thangjam R, Roy A, Singh S, Ramakrishnan L, Seth S, Narang R, Bhargava B. Acute effect effects of tobacco chewing on the systemic, pulmonary and coronary circulation. Am J Cardiovasc Drugs 2011, 11(2) 109-14.

  1. Caroline HD Fall, Harshpal Singh Sachdev, Clive Osmond, Ramakrishnan Lakshmy, Sushant Dey Biswas, Dorairaj Prabhakaran, Nikhil Tandon, Siddharth Ramji, K Srinath Reddy, David JP Barker, Santosh K Bhargava.Adult metabolic syndrome and impaired glucose tolerance are associated with different patterns of body mass index gain during infancy; Data from the New Delhi birth cohort. Diabetes Care. 2008 Oct 3.

  2. R.Lakshmy, R.Gupta, C.C.Kartha, T.Malathi, P.K.Nigam, N.R.Akarte, U.Sampson, S.Borkotoky, D.N.Doiphode, U.Arora, D.Prabhakaran, K.Srinath Reddy (2008) A simple cost effective quality assurance model for measurement of lipids in a large epidemiological study The Natl. Med J of India 21:279-83.

  3. Dorairaj Prabhakaran, Panniyammakal Jeemon,Shifalika Goenka,  Ramakrishnan Lakshmy, K. R. Thankappan, Faruq Ahmed, Prashant P. Joshi, B. V. Murali Mohan, Ramanathan Meera, Mohas S. Das, Ramesh C. Ahuja, Ram Kirti Saran,Vivek Chaturvedi, K. Srinath Reddy, (2009) Impact of a Worksite Intervention Program on Cardiovascular Risk Factors: A Demonstration Project in an Indian Industrial Population Journal of American College of Cardiology  53:1718-28

  4. Ramakrishnan Lakshmy and Ruby Gupta. Measurement of Glycated Hemoglobin A1c from Dried Blood by Turbidimetric Immunoassay J Diabetes Science Technology .2009, 3(5): 1203-1206

  5. Kumar J, Garg G, Kumar A, Sundaramoorthy E, Sanapala KR, Ghosh S,Karthikeyan G, Ramakrishnan L; Indian Genome Variation Consortium, Sengupta S Single nucleotide polymorphisms in homocysteine metabolism pathway genes: association of CHDH A119C and MTHFR C677T with hyperhomocysteinemia..Circulation Cardiovasc Genet. 2009 Dec;2 (6):599-606.

 

Introduction

Introduction

 

The department of cardiac biochemistry under the Cardiothoracic center (CTC) caters to the inpatients and outpatients of Cardiology and CTVS. In addition to patient care services the department is active in research in the area of developmental origin of adult chronic diseases, telomere biology, endothelial progenitor cells and trans fatty acids.

 

Patient care

 

The department under one roof does testing in the areas of clinical chemistry, hematology, coagulation, hormones, cardiac drugs, lipids, catecholamine, marker of heart transplant evaluation, markers of inflammation and in addition assessment of novel risk factors for CAD like homocysteine, lipoprotein(a), apolipoproteins A1 and B. The department has excellent infrastructure and most of the investigations are carried out on automated instruments. Facilities for doing genetic analysis are also available. On an average 250 patients samples are analyzed in the lab every day.

 

The cardiac biochemistry lab is externally validated through quality assessment scheme (UKNEQAS) accredited to BIRMINGHAM, UK and RIQAS (Randox external quality assessment scheme) and has shown a consistently good performance.

 

Research

Research

 

The department is actively involved in research in the following areas:

1)      Understanding the mechanism of developmental origin of adult chronic diseases

2)      Telomere biology

3)      Regulation of endothelial progenitor cells

4)      Single nucleotide polymorphisms in genes involved in lipoprotein metabolism

5)      Non invasive/minimally invasive methods of collection for measurement of analytes

 

Projects

 

  • Role of Telomere shortening and Telomerase activity on EPC senescence in premature CAD patients and controls
  • Evaluation of HDL2, HDL3 and apolipoprotein A1 levels in a large Indian industrial population: Association with genetic variants in CETP, LCAT, hepatic lipase and LPL gene

 

  • Relation of APOA-V gene variants to serial changes in childhood body mass index and coronary artery disease risk factors in young adulthood

 

  • LDL particle heterogeneity and its association with other established risk factors for CHD in an Indian industrial population: Role of CETP gene

 

  • Recovery and stability of routine chemistry analytes from filter paper

 

  • Serum fatty acid levels and their correlation with other CVD risk factors in Industrial population from Delhi and Trivandrum
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