Research
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RESEARCH:
Division is actively involved in clinical and basic sciences research in pediatric asthma, cystic fibrosis, HIV infection and other chronic lung diseases.
Research conducted or ongoing in childhood asthma
Epidemiology: Prevalence in school going children, risk factors for development of asthma, Risk factors for development of severe asthma, Socio-economic impact of asthma on child and family
Diagnosis: Pulmonary function tests
Treatment: Randomized controlled trials: Ketotifen as maintenance treatment double blind trial, Home made spacer versus commercial spacer, Rotahaler v/s spacer, Terbutalin v/s salbutamol in acute asthma, oral montelukast versus placebo in acute asthma, montelukast versus low dose inhaled steroids in long term asthma, addition of ipratropium to salbutamol in acute exacerbation; Salmeterol vs formeterol, rapid bronchodilator action of Formoterol versus salbutamol Association of vitamin D status with the level of control of asthma
Basic sciences: Integrated -omics approach to childhood asthma, CFTR polymorphisms in asthma; role of early childhood respiratory infections on development of asthma
Research: Respiratory infections:
Epidemiology: Risk factors for development of severe pneumonia, factors determining outcome of severe pneumonia
Etiology: bacterial and viral etiology
Role of Mycoplasma and chlamydia in community acquired pneumonia
Throat swab as surrogate for sensitivity of microbial agents
Treatment: Treatment of non-severe pneumonia with short course of amoxicillin, approach to child with rapid respiration and wheezing, determinants of outcome of severe pneumonia
Role of zinc as adjunct treatment in acute severe pneumonia
Collaborative research with department of microbiology in relation to multiplex PCR for respiratory viruses.
Cystic Fibrosis:
Prevalence and common mutations profile
Development and validation of inexpensive method of sweat testing
Development of alternative to sputum sample in children with CF (Throat swab after physiotherapy in place of sputum)
Molecular characterization of Pseudomonas in children with CF.
Demonstration of cross infection and multiple strains of pseudomonas in same patients by molecular techniques
Clinical profile and atypical clinical features in Indian children with CF
Documentation of effect of seasonal changes on growth of CF patients
Training of CF nurse and Physiotherapist
Randomized controlled trial of low and high doses of Azithromycin in children with cystic fibrosis
Gastrointestinal manifestations in children with cystic fibrosis
Glucose intolerance in children with cystic fibrosis
Zinc supplement in children with cystic fibrosis: randomized controlled trial
Randomized controlled trial of 3% vs 7% saline inhalation in children with cystic fibrosis
