Dr. Saroj Kumar

Dr. Saroj Kumar

Photograph

Current Designation & Contact Details

Additional Professor

Room No: 3011, 3^rd Floor, Teaching Block, Department of Biophysics, All India Institute of Medical Sciences, New Delhi - 110029

Phone: +91-11-26594240 (O)

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Lab Website: www.skumarlab.com

Recent Employment Details (Past few years)

1. Associate Professor (2019 - Present): Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.

2. Assistant Professor (2016 - 2019): Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.

3. Project Leader (2015 - 2016): Department of Engineering Science, Uppsala University, Sweden.

4. Post-Doctoral Fellow (2014 - 2015): Canadian Light Source, Saskatoon, Canada.

5. Post-Doctoral Fellow (2011 - 2014): Université Libre de Bruxelles, Brussels, Belgium.

Brief Research Area

Dr Saroj has established the infrared-based bio-imaging laboratory for bio diagnosis. Initiated to develop the exosome-based diagnostic and therapeutic modalities for neurodegenerative (Parkinson’s and Alzheimer's) and cancer diseases. His laboratory becomes a leading place for exosome-based research. His lab website is: www.skumarlab.com

Awards & Honours

1. ICMR-DHR International Short-Term Fellowship in Foreign Institutes, 2022-2023 awarded by ICMR-DHR, Ministry of Health & Social Welfare for 3 months.

2. Adjunct Professor (2021 – Present) at Lulea Institute of Technology, Sweden.

3. Mentored an “India Science and Research Fellowship (ISRF) – International Fellowship for SAARC Countries” Dec 2021 – June 2022.

4. Membership of International Society for Extracellular Vesicles, 2021-2022.

5. Saroj Kumar, Fredrik Nikolajeff. "First meeting for Medical Technology", Researchers and teachers from Sweden, Germany and India met for the first time at Luleå University of Technology, Sweden in Aug 2021. https://www.ltu.se/org/hlv/Nyheter/Forsta-traffen-for-medicinsk-teknik-1.210670?l=en

6. Reviewer of Department of Science and technology (DST) core proposal, 2021

7. Saroj Kumar, Fredrik Nikolajeff: Early diagnosis of Parkinson's disease. IVA's (Royal Swedish Academy of Engineering Sciences) 100 list 2020: From knowledge to sustainable competitiveness. https://www.iva.se/projekt/research2business/ivas-100-lista-2020/

8. Established and developed “Infrared Spectroscopy and Imaging Laboratory” at Uppsala University, Sweden

9. Invited by MedTech4Health, Uppsala to participate in Indo-Swedish Health Year 2019 at Swedish Embassy, India

10. Joint Secretory; 19th Biennial Conference of Association of Gerontology, 2019

11. Expert reviewer of “Polish National Grant Application”, Poland, 2019

12. Mobility for Growth, Project leader, VINNOVA-VINNMER (2015) Swedish research, Sweden

13. CIHR-THRUST postdoctoral fellow (2014), Canadian light source, Canada

14. Brains back to Brussels (2011), postdoc (only given to exceptional cases non-Belgium)

15. Postdoctoral grant from National fund for scientific research, Belgium (2011)

16. Swedish postdoctoral grant (2011) to pursue postdoc studies

17. Marie Curie International outgoing fellowship for career development (2011), the proposal was placed on the reserve list

Selected Publications/Patents (Last 5 years)

PATENTS:

1. Saroj Kumar, Simran Rastogi and Komal Rani. 2022. “A Composition for Isolating Exosomes and Method Thereof”. Patent Application Number: 202211022537.

2. Gyan Prakash Modi, Himanshu Rai, Rishabh Singh, Saroj Kumar, Gauri Shankar, Brijesh Singh, Sarika Gupta, Saripella Srikrishna, Sairam Krishnamurthy. 2022. “An Imaging Probe for Detection of Key Biomarkers in Alzheimer Disease”. Reference/identification number of the patent: 6457IN034.

3. Gyan Prakash Modi, Yash Pal Singh, C. Praveen Kumar, Meenu Yadav, Gauri Shankar, Gourav Singh, Saroj Kumar, S Srikrishna. 2021. “A multifunctional diarylurea-hydroxyamidine based compound for treatment of Alzheimer’s disease”. TEMP/E-1/1680/2021-DEL. Patent App. No: 202111001482; Ref. No. P.2116.IN. (Patent Filed Jan 2021).

PUBLICATIONS: (Last 5 years)

Google scholar link: https://scholar.google.co.in/citations?user=kAU_84kAAAAJ&hl=en

1. Priya Kumari Gorai, Simran Rastogi, Prahalad Singh Bharti, S Shivani, Priyanka Soni, Harshit Jain, Seema Singh, Shipra Agarwal, Sujoy Pal, Tapas Chandra Nag, Renu Dhingra, Mehar Chand Sharma, Rakesh Kumar, Fredrik Nikolajeff, Saroj Kumar*, Neerja Rani*. 2023. “Plasma-derived extracellular vesicles reveal pancreatic neuroendocrine tumors.” Molecular Oncology. (Under Review, MOLONC-23-0074) (IF: 7.449)

2. Abhay Mishra, Prahalad Singh Bharti, Fredrik Nikolajeff, Saroj Kumar*. 2023. “A Tale of Exosomes and their Implication in Cancer”. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. (Under Review, BBACAN-D-23-00038) (IF: 11.414)

3. Simran Rastogi, Komal Rani, Vaibhav Sharma, Prahalad Singh Bharti, Krishna Deo, Veena Jain, Aditi Nanda, Saroj Kumar*, Dheeraj Kumar Koli*. 2023. “Osteogenic markers in perimplant crevicular fluid (PICF) in immediate and delayed loaded dental implants: A randomized controlled trial”. Clinical Implant Dentistry and Related Research. (Under Revision, CID-22-290.R2) (IF: 4.259)

4. Simran Rastogi, Komal Rani, Sanskriti Rai, Rishabh Singh, Vaibhav Sharma, Prahalad Singh Bharti, Vrinda Kapoor, Poorvi Vishwakarma, Shivaji Gholap, Krishna Inampudi, Gyan Prakash Modi, Neerja Rani, Madhavi Tripathi, Achal Srivastava, Roopa Rajan, Fredrik Nikolajeff, Saroj Kumar*. 2023. “Fluorescence tagged salivary exosomes as a nano tool in early diagnosis of Parkinson’s disease”. Translational Neurodegeneration. (Under Revision, TNEU-D-22-00393R1) https://doi.org/10.21203/rs.3.rs-1621589/v1 (IF: 9.88)

5. Vaibhav Sharma, Fredrik Nikolajeff, Saroj Kumar*. 2023. “Employing nanoparticle tracking analysis of salivary neuronal exosomes for early detection of neurodegenerative diseases”. Translational Neurodegeneration (Accepted, TNEU-D-22-00341) (IF: 9.88)

6. Sunil Kumar, Faheem Abbas, Iqra Ali, Manoj K Gupta, Saroj Kumar, Deepak Kumar. 2023. Integrated network pharmacology and in-silico approaches to decipher the pharmacological mechanism of Selaginella tamariscinain the treatment of non-small cell lung cancer. Phytomedicine Plus. (Accepted, PHYPLU_100419)

7. Vaibhav Sharma, Saptamita Paul Choudhury, Saroj Kumar, Fredrik Nikolajeff. 2023. “Saliva based diagnostic methodologies for a fast-track detection of autism spectrum disorder: A mini-review”. Frontiers in Neuroscience. 2023;16. https://doi.org/10.3389/fnins.2022.893251 (IF: 5.152)

8. Himanshu Rai, Sarika Gupta, Saroj Kumar, Jian Yang, Sushil K Singh, Chongzhao Ran, Gyan Modi. 2022. “Near-Infrared Fluorescent Probes as Imaging and Theranostic Modalities for Amyloid Beta and Tau Aggregates in Alzheimer’s Disease”. ACS Journal of Medicinal Chemistry (Accepted) https://doi.org/10.1021/acs.jmedchem.1c01619 (IF: 7.446)

9. Vaibhav Sharma, Saptamita Choudhury, Srijon Sen, Sarika Bano, Kapil Suchal, Saroj Kumar, Fredrik Nikolajeff, and Sanjay Dey. 2022. “Altered Neural Cell Junctions and Ion-channels Leading to Disrupted Neuron Communication in Parkinson’s Disease”. NPJ Parkinson's Disease 8 (1): 66. https://doi.org/10.1038/s41531-022-00324-9 (IF: 9.304)

10. Rajkumar Kulandaisamy, Tushar Kushwaha, Anu Dalal, Vikas Kumar, Deepa Singh, Kamal Baswal, Pratibha Sharma, Kokkula Praneeth, Pankaj Jorwal, Sarala R Kayampeta, Tamanna Sharma, Srinivas Maddur, Manoj Kumar, Saroj Kumar, Aparoy Polamarasetty, Aekagra Singh, Deepak Sehgal, Shivajirao L Gholap, Mohan B Appaiahgari, Madhumohan R Katika, Krishna K Inampudi. 2022. “Repurposing of FDA Approved Drugs Against SARS-CoV-2 Papain-Like Protease: Computational, Biochemical, and in Vitro Studies.” Frontiers in Microbiology 13: 877813. https://www.frontiersin.org/article/10.3389/fmicb.2022.877813 (IF: 5.640)

11. Nithin KV, Veena Jain, Dheeraj Kumar Koli, Saroj Kumar, Aditi Nanda. 2022. “Comparative Evaluation of Osteocalcin in Peri-Implant Crevicular Fluid and Radiographic Bone Loss in Immediate Loading and Delayed Loading Protocols: A Preliminary Split-Mouth Randomized Controlled Trial”. International Journal of Prosthodontics 35 (2): 174–180. http://dx.doi.org/10.11607/ijp.7489 (IF: 1.785)

12. Rastogi, Simran, Komal Rani, and Saroj Kumar*. 2021. “Progression of Cognitive Impairment to Alzheimer’s Disease: Through the Lens of Salivary Extracellular Vesicles.” Neuroscience Insights 16: 26331055211058690. https://doi.org/10.1177/26331055211058687 (IF: 2.640)

13. Singh Y, Kumar N, Khushbu P, Chauhan BS, Shankar G, Kumar S, Singh G, Srikrishna S, Garg P, Singh G, Rai G, Modi GP*. 2021. Exploration of Neuroprotective Properties of Naturally Inspired Multifunctional Molecule (F24) Against Oxidative Stress and Amyloid β Induced Neurotoxicity in Alzheimer's Disease Models. ACS Chemical Neuroscience 13 (1): 27-42. https://doi.org/10.1021/acschemneuro.1c00443 (IF: 5.780)

14. Yash Pal Singh, Himanshu Rai, Gourav Singh, Gireesh Kumar Singh, Sunil Mishra, Saroj Kumar, S. Srikrishna, and Gyan Modi. 2021. “A Review on Ferulic Acid and Analogs Based Scaffolds for the Management of Alzheimer’s Disease.” European Journal of Medicinal Chemistry 215: 113278. https://doi.org/10.1016/j.ejmech.2021.113278 (IF: 7.088)

15. Simran Rastogi, Vaibhav Sharma, Prahalad Singh Bharti, Komal Rani, Gyan P. Modi, Fredrik Nikolajeff, and Saroj Kumar*. 2021. “The Evolving Landscape of Exosomes in Neurodegenerative Diseases: Exosomes Characteristics and a Promising Role in Early Diagnosis.” International Journal of Molecular Sciences 22 (1): 440. https://doi.org/10.3390/ijms22010440 (IF: 6.208)

16. Komal Rani, Simran Rastogi, Poorvi Vishwakarma, Prahalad Singh Bharti, Vaibhav Sharma, Km Renu, Gyan P. Modi, Venugopalan Y. Vishnu, Prashun Chatterjee, Aparajit Ballav Dey, Fredrik Nikolajeff, and Saroj Kumar*. 2021. “A Novel Approach to Correlate the Salivary Exosomes and Their Protein Cargo in the Progression of Cognitive Impairment into Alzheimer’s Disease.” Journal of Neuroscience Methods 347: 108980. https://doi.org/10.1016/j.jneumeth.2020.108980 (IF: 2.987)

17. Lakshay Malhotra, Harsh K. V. Goyal, Sunita Jhuria, Kapil Dev, Saroj Kumar, Manoj Kumar, Punit Kaur, and Abdul S. Ethayathulla*. 2021. “Curcumin Rescue P53Y220C in BxPC-3 Pancreatic Adenocarcinomas Cell Line: Evidence-Based on Computational, Biophysical, and in Vivo Studies.” Biochimica et Biophysica Acta (BBA) - General Subjects 1865 (2): 129807. https://doi.org/10.1016/j.bbagen.2020.129807 (IF: 4.117)

18. Simran Rastogi, Komal Rani, Fredrik Nikolajeff, and Saroj Kumar*. 2020. “Finding a Novel Method to Understand the Role of Salivary Exosome in Progression of Cognitive Impairment to Alzheimer’s Disease.” Alzheimer’s & Dementia 16 (S4): e041920. https://doi.org/10.1002/alz.041920 (IF: 21.566)

19. Vaibhav Sharma, Simran Rastogi, Kaushal Kumar Bhati, Alagiri Srinivasan, Ajoy Roychoudhury, Fredrik Nikolajeff, and Saroj Kumar*. 2020. “Mapping the Inorganic and Proteomic Differences among Different Types of Human Teeth: A Preliminary Compositional Insight.” Biomolecules 10 (11): 1540. https://doi.org/10.3390/biom10111540 (IF: 6.064)

20. Rajkumar Kulandaisamy, Tushar Kushwaha, Vikas Kumar, Soumya De, Saroj Kumar, Santosh Kumar Upadhyay, Manoj Kumar, Krishna K. Inampudi*. 2020. "Characterization of active/binding site residues of peptidyl-tRNA hydrolase using biophysical and computational studies". International Journal of Biological Macromolecules 159: 877-885. https://doi.org/10.1016/j.ijbiomac.2020.05.133 (IF: 6.953)

21. Vaibhav Sharma, Alagiri Srinivasan, Fredrik Nikolajeff, Saroj Kumar*. 2020. "Biomineralization Process in Hard Tissues: The Interaction Complexity within Protein and Inorganic Counterparts". Acta Biomaterialia 120: 20-37. https://doi.org/10.1016/j.actbio.2020.04.049 (IF: 10.633)

22. Komal Rani, Mitali Tyagi, Mohit Majumdar, Akanksha Singh, Annaian Shanmugam, Krishna Dalal, Manoj Pillai, Gourinath Samudrala, Saroj Kumar, Alagiri Srinavasan*. 2020. “Accelerated identification of serine racemase inhibitor from Centella asiatica". Scientific Reports 10 (1): 4640. https://doi.org/10.1038/s41598-020-61494-1 (IF: 5.134)

23. Javeed Ahmad, Mohd Khubaib, Javaid Ahmad Sheikh, Rita Pancsa, Saroj Kumar, A. Srinivasan, M. Madan Babu, Seyed E. Hasnain, and Nasreen Z*. Ehtesham. 2020. “Disorder-to-Order Transition in PE-PPE Proteins of Mycobacterium tuberculosis Augments the pro-Pathogen Immune Response.” FEBS Open Bio. 10: 70-85. https://doi.org/10.1002/2211-5463.12749 (IF: 2.126)

24. Komal Rani, Ranjan Mukherjee, Ekta Singh, Sanjeev Kumar, Vaibhav Sharma, Poorvi Vishwakarma, Prahalad Singh Bharti, Fredrik Nikolajeff, Ashok Kumar Dinda, Vinay Goyal and Saroj Kumar*. 2019. “Neuronal Exosomes in Saliva of Parkinson’s Disease Patients: A Pilot Study.” Parkinsonism & Related Disorders. 67: 21-23. https://doi.org/10.1016/j.parkreldis.2019.09.008 (IF: 4.36)

25. Vaibhav Sharma, Komal Rani, Ajoy Roychoudhury, Amita Chawla, Fredrik Nikolajeff and Saroj Kumar*. 2019. "Novel Insights into Regulation of Human Teeth Biomineralization: Deciphering the Role of Post-Translational Modifications in a Tooth Protein Extract." International Journal of Molecular Sciences. 20 (16): 4035. https://doi.org/10.3390/ijms20164035 (IF: 4.331)

26. Sharma, Vaibhav, Alagiri Srinivasan, Ajoy Roychoudhury, Komal Rani, Mitali Tyagi, Kapil Dev, Fredrik Nikolajeff, and Saroj Kumar*. 2019. “Characterization of Protein Extracts from Different Types of Human Teeth and Insight in Biomineralization.” Scientific Reports 9 (1): 9314. https://doi.org/10.1038/s41598-019-44268-2 (IF: 4.5)

27. Saroj Kumar*. 2019. “Infrared Spectroscopy Could Be a Diagnostic Tool in Dermatology.” The British Journal of Dermatology 180 (3): 459–60. https://doi.org/10.1111/bjd.17410 (IF:6.2)

28. Das, Uddipan*, Ekta Singh, Sudhaker Dharavath, Udaya Kumar Tiruttani Subhramanyam, Ravi Kant Pal, Ramachandran Vijayan, Saji Menon, Saroj Kumar, Samudrala Gourinath, and Alagiri Srinivasan. 2019. “Structural Insights into the Substrate Binding Mechanism of Novel ArgA from Mycobacterium tuberculosis.” International Journal of Biological Macromolecules 125 (March): 970–78. https://doi.org/10.1016/j.ijbiomac.2018.12.163 (IF: 4.7)

29. Saibu, Yusuf*, Saroj Kumar, Ankur Jamwal, Derek Peak, and Som Niyogi. 2018. “A FTIRM Study of the Interactive Effects of Metals (Zinc, Copper and Cadmium) in Binary Mixtures on the Biochemical Constituents of the Gills in Rainbow Trout (Oncorhynchus mykiss).” Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP 211 (September): 48–56. https://doi.org/10.1016/j.cbpc.2018.05.009 (IF: 2.02)

30. Saroj Kumar*, Alagiri Srinivasan, and Fredrik Nikolajeff. 2018. “Role of Infrared Spectroscopy and Imaging in Cancer Diagnosis.” Current Medicinal Chemistry 25 (9): 1055–72. https://doi.org/10.2174/0929867324666170523121314 (IF: 3.9)

31. Saroj Kumar*, Xia Liu, Ferenc Borondics, Qunfeng Xiao, Renfei Feng, Erik Goormaghtigh, and Fredrik Nikolajeff. 2017. “Insights into Biochemical Alteration in Cancer-Associated Fibroblasts by Using Novel Correlative Spectroscopy.” ChemistryOpen 6 (1): 149–57. https://doi.org/10.1002/open.201600102 (IF:2.2)

32. Divekar, Monali Trimbak, Chithra Karunakaran, Rachid Lahlali, Saroj Kumar, Vellaichamy Chelladurai, Xia Liu, Ferenc Borondics, Saravanan Shanmugasundaram, and Digvir Singh Jayas*. 2017. “Effect of Microwave Treatment on the Cooking and Macronutrient Qualities of Pulses.” International Journal of Food Properties 20 (2): 409–22. https://doi.org/10.1080/10942912.2016.1163578 (IF: 1.8)

33. Lahlali, Rachid, Tao Song, Mingguang Chu, Fengqun Yu, Saroj Kumar, Chithra Karunakaran, and Gary Peng*. 2017. “Evaluating Changes in Cell-Wall Components Associated with Clubroot Resistance Using Fourier Transform Infrared Spectroscopy and RT-PCR.” International Journal of Molecular Sciences 18 (10). https://doi.org/10.3390/ijms18102058 (IF: 3.1)