Dr Krishna Kishore Inampudi

Dr Krishna Kishore Inampudi

Photograph

Current Designation & Contact Details

Additional Professor

Room No. 3011, Third Floor, Teaching Block, Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India

Email: This email address is being protected from spambots. You need JavaScript enabled to view it. & This email address is being protected from spambots. You need JavaScript enabled to view it.

Contact No: +91-11-26593834 (O)

Recent Employment Details (Past few years)

1. 2019 – Present: Associate Professor, Department of Biophysics, AIIMS, New Delhi-INDIA

2. 2015 – 2019: Assistant Professor, Department of Biophysics, AIIMS, New Delhi-INDIA

3. Jan 2013 - Dec 2014: Postdoctoral Fellow, IECB, France & Yale University, USA

4. Nov 2009 - Dec 2012: Postdoctoral Fellow, Yale University, USA

5. Oct 2008 - Oct 2009: Global Infectious Diseases Postdoctoral Fellow, University of Washington, Seattle, USA

Brief Research Area

1. Lung Cancer (NSCLC) therapeutics

• Antibody-like inhibitors (Nanobodies) against of EGFR: Employing Protein Engineering, Computational Protein design and mRNA display

• Small molecule inhibitors (TKI) against drug-resistant EGFR kinases

• Aptamer inhibitors against the EGFR

2. Multi-omics Approach of exosomes for Exploring the Molecular Mechanism and identification of early candidate biomarkers

• Non-small-cell lung carcinoma

• Oral Squamous Cell Carcinoma

• Coronary Artery Disease

3. Designing/identifying potential inhibitors for viral non-structural proteins

• SARS-CoV2

• Dengue virus

4. Understanding the catalytic mechanism of the peptidyl-tRNA hydrolase from M. tuberculosis

5. Protein-nucleic acid interactions (Computational)

Selected Publications/Patents (Last 5 years)

Google Scholar Link: https://scholar.google.com/citations?user=7G4HaXEAAAAJ&hl=en

1. Rajkumar Kulandaisamy, Tushar Kushwaha, Anu Dalal, Vikas Kumar, Deepa Singh, Kamal Baswal, Pratibha Sharma, Kokkula Praneeth, Pankaj Jorwal, Srinivas Maddur, Tamanna Sharma, Manoj Kumar, Saroj Kumar, Aparoy Polamarasetty, Aekera Singh, Deepak Sehgal, Shivajirao L Gholap, Mohan B Appaiahgari, Madhumohan R Katika, Krishna K Inampudi*. Repurposing of FDA approved drugs against SARS-CoV-2 Papain-Like protease by using computational, biochemical and in vitro studies, 2022. Frontiers in Microbiology 13, 877813, 1-23. Corresponding author* (Impact factor: 6.06)

2. Preeti Hooda, Mohd Ishtikhar, Shweta Saraswat, Pooja Bhatia, Deepali Mishra, Aditya Trivedi, Rajkumar Kulandaisamy, Soumya Aggarwal, Manoj Munde, Nemat Ali, Abdullah F. AlAsmari, Mohd A. Rauf, Krishna K. Inampudi*, and Deepak Sehgal*. Biochemical and Biophysical Characterisation of the Hepatitis E Virus Guanine-7-Methyltransferase, 2022, Molecules, 27, 1505 * Corresponding author. (Impact factor: 4.92)

3. Anu Dalal, Tushar Kushwaha , Gourav Choudhir, Krishna K Inampudi, Tarak Karmakar, P Hariprasad, Shivajirao L Gholap. Computational investigations on the potential role of hygrophorones as quorum sensing inhibitors against LasR protein of Pseudomonas aeruginosa, 2022, J Biomol Struct Dyn 25;1-11 (Impact factor: 5.23)

4. Ravi Bharadwaj, Tushar Kushwaha, Azhar Ahmad, Krishna K Inampudi, Tomoyoshi Nozaki and Somlata, An atypical EhGEF regulates phagocytosis in Entamoeba histolytica through EhRho1. 2021, PLOS Pathogens 17: 1-36 (Impact factor: 7.46)

5. Rajkumar K, Tushar K, Vikas Kumar, Soumya De, Manoj Kumar, Saroj Kumar, Santosh K Upadhyay, Krishna K Inampudi*, Characterization of Active/Binding Site Residues of peptidyl-tRNA Hydrolase Using Biophysical and Computational Studies. 2020, International Journal of Biological Macromolecules 159: 877-885 * Corresponding author (Impact factor: 8.02)

6. Sayantani Roy, Soumendu Boral, Snigdha Maiti, Tushar Kushwaha, Aditya J. Basak, Woonghee Lee, Amit Basak, Shivajirao L. Gholap, Krishna K. Inampudi and Soumya De, Structural and dynamic studies of the human RNA binding protein RBM3 reveals the molecular basis of its oligomerization and RNA recognition. 2021, The FEBS Journal 1-18 (Impact factor: 5.62)

7. Sulaiman A, McGarry S, El-Sahli S, Li L, Chambers J, Phan A, Al-Kadi E, Krishna K Inampudi, Gadde S, Wang L, Nanoparticles loaded with Wnt and YAP/mevalonate inhibitors in combination with paclitaxel stop the growth of TNBC patient-derived xenografts and diminish cancer stem cells and tumorigenesis. 2020, Advanced Therapeutics 3(11), 1-14

8. A. Carolin Seefeldt, Fabian Nguyen, Stéphanie Antunes, Natacha Pérébaskine, Michael Graf, Stefan Arenz, Krishna K Inampudi, Céline Douat, Gilles Guichard, Daniel N. Wilson & C. Axel Innis, 2015. The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the post-initiation complex. Nature Structural & Molecular Biology 22: 470-475. (Impact factor: 18.36)

9. Stanley Howell*, Krishna K. Inampudi*, Doyle P Bean and Corey J. Wilson, 2014. Understanding thermal adaptation of enzymes through the multistate rational design and stability prediction of 100 adenylate kinases. Structure 22: 218-29. (Impact factor: 5.87) * equally contributed to this work

10. Paul A. Beales, Nienke Geerts, Krishna K. Inampudi, Corey J. Wilson and T. Kyle Vanderlick, 2013. Reversible assembly of stacked membrane nano-platforms with reduced dimensionality and variable periodicity. Journal of American Chemical Society 135: 3335-8. (Impact factor: 16.38)

11. Sarai Meyer*, Roee Ramot*, Krishna K. Inampudi*, Beibei Luo, Chenyu Lin, Swathi Amere and Corey J. Wilson, 2013. Engineering alternate cooperative-communications in the lactose repressor protein scaffold. Protein Engineering Design and Selection 6: 433-443. * equally contributed to this work (Impact factor: 1.95)

12. Roee Ramot, Krishna K. Inampudi and Corey J. Wilson, 2012. The Lactose Repressor Experimental Folding Landscape: Fundamental Functional Unit and Tetramer Folding Mechanisms; Biochemistry 51: 7569–79. (Impact factor: 3.16)

13. Kayode K. Ojo, Eric T. Larson, Katelyn R. Keyloun, Lisa J. Castaneda, Amy E. DeRocher, Krishna K. Inampudi, Jessica E. Kim, Tracy L. Arakaki, Ryan Murphy, Li Zhang, Alberto J. Napuli, Dustin J. Maly, Christophe L. M. J. Verlinde, Frederick S. Buckner, Marilyn Parsons, Wim G. J. Hol, Ethan A. Merritt and Wesley C. VanVoorhis, 2010. A Unique Variation of the ATP binding site makes Toxoplasma gondii Calcium-Dependent Protein Kinase 1 a drug target for selective kinase inhibitors; Nature Structural & Molecular Biology 17: 602-07. (Impact factor: 18.36)