This Department/Centre was established in 1971 as a Joint venture of Indian Institute of Technology Delhi and All India Institute of Medical Sciences, Delhi. The Centre has applied engineering principles to address medical and biological problems. It has faculty drawn from IIT Delhi as well as AIIMS New Delhi. In addition, the centre has collaborative projects with major institutes and hospitals in India. Over the years the Centre has become premier centre in the country.

The growth rate of CBME IITD is comparable to the global R&D. Centre has provided interdisciplinary base to develop health care technologies. Over the last two decades the focus has shifted to include biological medicine, behaviour or molecular health and develop innovative biological materials, implants, devices, and informatics approaches for the prevention, diagnosis, treatment, rehabilitation and injury mechanics. Innovations in instrumentation, drug delivery, tissue engineering and biosensors have been internationally recognized.