DR. SAMPA GHOSE
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| PERSONALINFORMATION Name, Title: Sampa Ghose, Scientist II Google Scholar:https://scholar.google.co.in/citations?user=DE4Tx24AAAAJ&hl=en Date of birth: Jan 15th 1975Nationality, Origin: Indian, India Marital Status, Children: married,1 (b: 2006) Languages: Bengali, mother tongue; English, fluently; Hindi, fluently Home Address: Ganga apartment, Arun Vihar, Sector 29, Noida, UP Office Address: Department of Medical Oncology All India Institute of Medical Sciences Ansari Nagar, New Delhi, India E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. Mobile: 91-9540946980 Website: https://www.aiims.edu/en/news/219-medical-oncology/6839-dr-sampa-ghose.html
2. EDUCATION2004 PhD from University of Kalyani, West Bengal, India 1998 MSc (Master of Sciences) from Kalyani University, West Bengal, India 1996 BSc (Bachelor of Sciences) from Assam University, Assam, India 3. EMPLOYMENT HISTORY2016- Till date Scientist II, Medical Oncology, All India Institute of Medical Sciences, New Delhi 2016-2016 Assistant Professor, Amity Institute of Molecular Medicine & Stem Cell Research 2013-2015 CSIR-Pool Scientist, Jawaharlal Nehru University, New Delhi 2009-2012 Post-doctoral Fellow, Vanderbilt University Medical Center, USA 2005- 2008 Post-doctoral Fellow, Medical University of South Carolina, USA 2003-2004 Research Associate, NIPGR, New Delhi, India.
4. INSTITUTIONAL RESPONSIBILITIESResearch, Teaching and Supervision of lab diagnostic services
5. LAB DIAGNOSTIC SERVICES
Galactomannan (GM), a component of cell wall of the aspergillus released during growth. To rule out the fungal infection, we detect GM antigen level in blood serum to diagnose invasive aspergillosis in cancer patients specially during chemotherapy and bone marrow transplantation.
New diagnostic service: Epstein - Barr virus (EBV) infection is associated with multiple types of cancer. Recently to diagnose EBV infection, started doing real-time PCR (qPCR) of EBV in Nasopharyngeal Carcinoma patients and also in bone marrow transplant patients regularly.
6. RESEARCH PROJECTS AS PI2021-2024 DBT (Indo-Sweden Project) 2019-2021 Intramural project (AIIMS, New Delhi: A-721) 2016-2019 Extramural, Department of Science and Technology: SERB: YSS/2015/000092 2012-2015Council of Scientific & Industrial Research, CSIR: 13 (8600-A)/ 2012
7. CORE AREA(S) of RESEARCH INTEREST- Endothelial dysfunction towards angiogenesis and cancer metastasis - Impact of altered macrophages plasticity in Acute Myeloid Leukemia - Invasive fungal infection in haematological malignancies
8. SUPERVISION OF JUNIOR RESEARCH FELLOWJRFs: Aditya Tyagi (2017-2018), Preity Sharma (2018-2019)
9. MEMBERSHIPS/ REVIEWING WORK- Reviewing work for Funding Bodies: Department of Science and Technology, India. - Reviewing work for peer reviewed journals, including; BMC cancer, Scientific Report (Nature group) 10. MEMBERSHIPS OF SOCIETIESIndian Association for Cancer Research (Life Time membership since 2017)Indian Society of translational research (Life time member since 2018) Research And Education Society of Molecular Oncology (Life time member since 2021)
11. PRIZES, AWARDS, FELLOWSHIPS2021 Bursary/Awards winning Conference Proceeding (EASL, The International LiverCongress 2015 Young Scientist Department of Science and Technology (DST), India. 2012 Pool scientist award from Council of Scientific and Industrial Research 2012 Both oral and poster presentation at Keystone Symposia, Pulmonary Vascular Disease Conference, USA.
12. RESEARCH OUTPUT
https://scholar.google.co.in/citations?user=DE4Tx24AAAAJ&hl=en I. Selected Publications in international peer-reviewed journals #Corresponding Author
1. R Pramanik, S Arora, P Sharma, A Biswas, B Nayak, A Thakar, A Sharma, S Ghose#(2021). Cell-free EBV DNA as a biomarker during clinical management of nasopharyngeal carcinoma in a non-endemic region. Journal of Medical Virology (In Press) (#Corresponding Author)
2. S Sharma, MS Ghufran, B Das, B Roy, S. Ghose, S Biswas* (2021). Survivin expression is essential for early activation of hepatic stellate cells and fibrosis progression in chronic liver injury. Life Sciences- Elsevier doi.org/10.1016/j.lfs.2021.120119 IF: 5.037
3 Roy B, Ghose S, Biswas S (2021). Therapeutic strategies for miRNA delivery to reduce hepatocellular carcinoma. Seminars in Cell & Developmental Biology26:S1084-9521(21)00079-3. doi: 10.1016/j.semcdb.2021.04.006.IF: 6.69
4. S Sharma MS Gufran, S Ghose, C. Bihari, S Biswas (2021). Survivin inhibition ameliorates liver fibrosis via inducing senescence in hepatic stellate cells. Journal of Hepatology –Elsevier 2021 vol. 75(2) | S389 IF: 20.85
5. Sharma S, Ghufran S M, Ghose S, Biswas S (2021).Cytoplasmic vacuolation with endoplasmic reticulum stress directs sorafenib induced non-apoptotic cell death in hepatic stellate cells Scientific Report 11: 3089: IF: 5.133
6. S Ghose#, S Biswas#, Kasturi Datta, Rakesh K. Tyagi (2018) Dynamic mechanism of Hyaluronan in liver endothelial cells towards angiogenesis. BMC Cancer18:648 IF: 4.4 (#Corresponding Author)
7. S. Biswas and S. Ghose (2018). Divergent impact of Gender in Advancement of Liver injuries, diseases, and carcinogenesis. Frontier in Biosciences. Jan 1; 10:65-100, 2018 IF: 3.5
8. Andrea L. Frump, ArunimaDatta, Sampa Ghose, James West, Mark P. de Caestecker (2016) Genotype-phenotype effects of Bmpr2 mutations on disease severity in mouse models of pulmonary hypertension. Pulmonary Circulation, Nov 2; 6(4): 597-607. DOI: 10.1086/688930. IF: 6.364 9. Deepak Kotiya, Bharti Jaiswal, Sampa Ghose, Rachnakaul, Kasturi Datta, Rakesh K Tyagi (2016). Role of PXR in hepatic cancer: its influences on liver detoxification capacity and cancer progression.PLOS ONE, Oct 19; 11(10):e0164087IF: 4.4
10. Sampa Ghose, Yongfen Min, Laura DeBusk and P.Charles Lin (2015). δ-catenin regulates lymphatic endothelial cell motility and lymphangiogenesis through regulation of RhoGTPase.,PLOS ONE, Jan 30; 10(1): e0116338. IF: 4.4
11. Allison R Prewitt, Sampa Ghose, (Equal 1st author) Andrea L Frump, Arumima Datta, Eric D Austin3, Anne K Kenworthy, Mark P de Caestecker (2015). Heterozygous Bone Morphogenetic Protein Receptor Type 2 Mutations Promote Src-Dependent Caveolar Trafficking Defects and Endothelial Dysfunction in the Pulmonary Vasculature.The Journal of Biological Chemistry (JBC),290 (2): 960–971. IF: 5.15
12. Annamalai Prakasam, Sampa Ghose, Natalia V. Oleinik, Yuri K. Peterson, Natalia I. Krupenko and Sergey A. Krupenko. (2014) JNK1/2 regulate BID by direct phosphorylation at Thr59. Cell Death and Disease (Nature Group),5, e1358; doi: 10.1038/cddis. 2014. 316. IF: 10.17
13. Suchandra Deb Roy; Inga I. Kramarenko; Sampa Ghose, Natalia V. Oleinik; Sergey A. Krupenko; Natalia I. Krupenko(2013) A novel tumor suppressor function of glycine N-methyltransferase is independent of its catalytic activity but requires the nuclear localization. PLOS ONE, Jul 30; 8 (7):e70062. IF: 4.4
14. Yongfen Min*, Sampa Ghose*(*Equal 1st author), Kimberly Boelte, Jianhua Huang, Jingdong Li, Xiubao Ren, Li Yang and P. Charles Lin (2011) C/EBP-δ regulates VEGF-c induced lymphatic metastasis of lung cancer through HIf-1α transcription. Oncogene (Nature Group), 30(49):4901-4909. IF: 9.867
15. Sampa Ghose, Natalia O Oleinik, Natalia I Krupenko, Sergey A Krupenko (2009) FDH-induced JNK pathway diverge at JNK substrate level in cells with different p53 status. Molecular Cancer Research, 7(1):99-107. IF: 5.852
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