Dr. Thoudam Debraj Singh

DR. THOUDAM DEBRAJ SINGH  

Associate Professor

Department of Medical Oncology (Lab)

All India Institute of Medical Sciences (AIIMS)

DR.BRA.IRCH, 4th Floor, Room no. 411

Ansari Nagar, New Delhi-110029

Mobile:9599920045

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.  

 

Academic Experience  

S.No.	Designation	Name of the Institute	Year	Research Area
1.	Associate Professor	Dept. of Medical Oncology (Lab), All India Institute of Medical Sciences, New Delhi	July 2020 - till present	Cancer Research, Drug Delivery In vivo imaging
2.	Assistant Professor	Dept. of Medical Oncology (Lab) All India Institute of Medical Sciences, New Delhi	Nov 2016 – June 2020	Cancer Research, Drug Delivery, In vivo imaging
3.	Research Professor	Kyungpook National University, South Korea	2012 - 2016	Drug discovery for cancer and metabolic diseases, Molecular Imaging
4.	Post-Doctoral	Chungnam National University, South Korea	2010 –2011	Cardio vascular diseases

 

Educational qualification  

S.No.	Degree	Institute	Year
1	PhD in Medicine	Kyungpook National University,  South Korea	2010
2	Master in Biotechnology	University of Mysore, India	2003

 

RESEARCH GRANT As Principal Investigator (PI)  

1. DHR extramural research grant for the project entitled “Estrogen Related Receptor Gamma (ERRγ) as a potential biomarker and therapeutic target for human colorectal cancer and to investigate the antitumor efficacy of GSK5182 (Estrogen Related Receptor-γ inverse agonist) in combination with MK2206 (a novel Akt inhibitor) in colon cancer in vivo” for 3 years, (2021-2024)

2. DST- Core Extramural research grant for the project entitled “Estrogen-Related Receptor Gamma (ERRγ) as a potential biomarker in thyroid cancer”for 3 years, (2020-2023)

3. ICMR Extramural research grant for the project entitled “Multivalent targeting-based delivery of paclitaxel using elastin like polypeptide containing IL-4 receptor targeting peptide (AP1-ELP) for ovarian cancer therapy”for 3 years, (2019-2022)

4. Intramural AIIMS funding for project entitled “To study the role of Estrogen-Related Receptor Gamma (ERRγ) as a potential biomarker in thyroid cancer”for 2 years,(2018-2020)

 

International Publications (Total Impact Factor:182.11) 2022  

1. Vijaya Sarangthem, Harshita S, Ridhima Goel, Sampa Ghose, Rang-Woon Park, Sujata Mohanty, Tapan Kumar Chaudhuri, Amit Kumar Dinda, Thoudam Debraj Singh*. Application of Elastin-like Polypeptide (ELP) Containing Extra-cellular Matrix (ECM) Binding Ligands in Regenerative Medicine. International Journal of Biological Macromolecules, 2022; 207:443-453. *Corresponding Author. (Impact Factor: 8.02) 

2. Vijaya Sarangthem, Harshita Sharma, Mohini Mendiratta, Ranjit Kumar Sahoo, Rang-Woon Park, Lalit Kumar, Thoudam Debraj Singh*, Sujata Mohanty*. Application of Bio-Active Elastin-Like Polypeptide on Regulation of Human Mesenchymal Stem Cell Behavior. Biomedicines, 2022;10(5):1151. *Corresponding Author. (Impact Factor: 4.75) 

3. Thoudam Debraj Singh, Song J, Kim J, Chin J, et. al. A novel orally active inverse agonist of estrogen-related receptor gamma (ERRγ), DN200434, enhances sodium iodide symporter function in anaplastic thyroid cancer model.  Clinical Cancer Research, 2019; 15;25(16):5069-5081. (Impact factor: 13.8) 

4. Vijaya Sarangthem, Aena Yi, Yunjae Kim, Alnawaz Rehemtulla, Byung-Heon Lee, Young Hyun Jeon, Thoudam Debraj Singh*, Rang-Woon Park*. Therapeutic effect of IL-4 receptor targeting pro-apoptotic peptide (AP1-ELP-KLAK) in glioblastoma tumor model. International Journal of Nanomedicine, 2021; 16:5039-5052. * Corresponding Author. (Impact factor:  7.03) 

5. Vijaya Sarangthem, Bo-Yeon Seo, Aena Yi, Young-Jin Lee, Sun-Ha Cheon, Sang Kyoon Kim, Thoudam Debraj Singh, Rang-Woon Park. Effects of molecular weight and structural conformation of multivalent-based elastin-like polypeptides on tumor accumulation and tissue biodistribution.  Nanotheranostics, 2020; 4(2): 57-70. (IF: 5.28) 

6. Sun-Ha Cheon, Bo-Yeon Seo, Young-Jin Lee, Dahye Sim, Seon-Boon Lee, Thoudam Debraj Singh, Byung-Heon Lee et al. Targeting of Cisplatin-resistant Melanoma Using a Multivalent Ligand-presenting an Elastin-like polypeptide. ACS Biomaterials Science & Engineering, 2020; 6, 9, 5024–5031. (IF: 4.79) 

7. M Singh, CP Prasad, Thoudam Debraj Singh, L Kumar.  Cancer research in India: Challenges & opportunities. M Singh, CP Prasad, Thoudam Debraj Singh, L Kumar. Indian J Med Res. 2018; 148(4):362-365. (IF: 2.35) 

8. Su-Bi Ahn, Sang-Bong Lee, Thoudam Debraj Singh, Sung Jin Cho et al. Multimodality Imaging of Bone Marrow-derived Dendritic Cell Migration and Antitumor Immunity. Translational Oncology, 2017;10(2):262-270. (Impact factor:  4.24) 

9. Gangadaran P, Li XJ, Lee HW, Oh JM, Kalimuthu S, Rajendran RL, Son SH, Baek SH, Thoudam Debraj Singh, Zhu L, Jeong SY, et. al. A new bioluminescent reporter system to study the biodistribution of systematically injected tumor-derived bioluminescent extracellular vesicles in mice. Oncotarget, 2017; 8(66):109894-109914. (IF: 5.0) 

10. Vijaya Sarangthem, Thoudam Debraj Singh, Amit Kumar Dinda. Emerging Role of Elastin-Like Polypeptides (ELPs) in Regenerative Medicine. Adv Wound Care (New Rochelle), 2021; (5):257-269. (IF: 4.7) 

11. Sang Bong Lee, Ho Won Lee, Thoudam Debraj Singh, Yinghua Li, Sung Jin Cho, et al. Visualization of Macrophage Recruitment to Inflammation lesions using Highly Sensitive and Stable Radionuclide Embedded Gold Nanoparticles as a Nuclear Bio-Imaging Platform. Theranostics, 2017; 7(4):926-934. (Impact Factor: 11.6) 

12. Oh SG, Li X, Lee HW, Thoudam Debraj Singh, Lee SB, Ji HD, et al. Non-invasive visualization of mast cell recruitment and its effects in lung cancer by optical reporter gene imaging and glucose metabolism monitoring.  Biomaterials, 2017; 112:192-203. (Impact Factor: 15.86) 

13. Thoudam Debraj Singh, Shin Young Jeong, Sang-Woo Lee, et al. Inverse agonist of estrogen-related receptor gamma (ERRγ) enhances sodium iodide symporter function through mitogen-activated protein kinase signaling in anaplastic thyroid cancer cells. Journal of Nuclear Medicine, 2015; 56(11):1690-6. (Impact Factor: 11.08) 

14. Sarangthem V, Kim YJ, Thoudam Debraj Singh*, et al. Multivalent Targeting Based Delivery of Therapeutic Peptide using AP1-ELP Carrier for Effective Cancer Therapy. Theranostics, (2016); 6(12):2235-2249. *Equal contribution, (Impact Factor: 11.6) 

15. Thoudam Debraj Singh, Jaetae Lee, and Yong Hyun Jeon. Non-invasive imaging of Natural killer cell-mediated apoptosis in a mouse tumor model. Methods in Molecular Biology (Springer), 2016; 1441:297-306. (Impact Factor: 1.6) 

16. Thoudam Debraj Singh, Ho Won Lee, et al. Non-invasive imaging of apoptosis induced by adenoviral-mediated gene therapy using a caspase-3 biosensor in living subjects. Molecular Imaging, 2014; 13. doi: 10.2310/7290.2014.00019. (IF- 3.48) 

17. Ho Won Lee, Thoudam Debraj Singh, Sang-Woo Lee, et al. Evaluation of therapeutic effects of natural killer (NK) cell-based immunotherapy in mice using in vivo apoptosis bioimaging with a caspase-3 sensor. FASEB, 2014; (7):2932-41. (IF- 5.19) 

18. Yunju Choi, Seulgi Oh, Thoudam Debraj Singh, Sang-Woo Lee, et al. "Visualization of the biological behavior of tumor-associated macrophages in living mice with colon cancer using multimodal optical reporter gene imaging." Neoplasia, 2016; 18(7):458.  (IF- 6.02) 

19. Kim Jina, Woo Seo Yeon, Im Chun Young, Yoo Eun Kyung, Thoudam Debraj Singh, et al. Insights of a Lead Optimization Study and Biological Evaluation of Novel 4-Hydroxytamoxifen Analogs as Estrogen-related Receptor Gamma (ERRγ) Inverse Agonists. Journal of Medicinal Chemistry, 2016; 59(22):10209-10227. (IF- 7.44) 

20. Ho Won Lee, Seung Yun Yoon, Thoudam Debraj Singh, Yoon Ju Choi, Hong Je Lee, Ji Young Park, et al. Tracking of dendritic cell migration into lymph nodes using molecular imaging with sodium iodide symporter and enhanced firefly luciferase genes. Scientific Reports, 2015; 5:9865. doi: 10.1038/srep09865. (IF- 4.37) 

21. Min-Jeong Son, Joon-Chul Kim, Thoudam Debraj Singh, et al. Shear stress activates monovalent cation channel TRPM4 in rat atrial myocytes via type 2 IP3Rs and Ca2+ release. Journal of Physiology, 2016; 594(11):2985-3004. (IF- 5.18) 

22. Vijaya Sarangthem, Eun A Cho, Sang Mun Bae, Thoudam Debraj Singh, Sun-Ji Kim, et al. Construction and application of elastin like polypeptide containing IL-4 receptor targeting peptide.” Plos One, 2013; 8(12):e81891. (IF- 3.24) 

23. Sungmin Kang, Ho Won Lee, Young Hyun Jeon, Thoudam Debraj Singh, Yunju Choi, et al. Combined Fluorescence and Magnetic Resonance Imaging of Primary Macrophage Migration to Sites of Acute Inflammation Using Near-Infrared Fluorescent Magnetic Nanoparticles. Molecular Imaging and Biology, 2015; (5):643-51. (IF- 3.48) 

24. Krishna P. Subedi, Thoudam Debraj Singh*, Kim Jun Chul, Sun-Hee Woo. Cloning and expression of new inositol 1,4,5- trisphosphate receptor type 1 splice variant in adult rat atrial myocytes. Cellular and Molecular Biology Letters, 2011; 17(1):124-35. * Equal contribution, (IF- 5.78) 

25. Thoudam Debraj Singh, Park SY, Bae JS, Yun Y, Bae YC, Park RW, Kim IS. MEGF10 functions as a receptor for the uptake of Amyloid-beta in neuronal cells. FEBS lett, 2010; 584(18):3936-42. (Impact factor - 4.12) 

26. Kim HJ, Kim PK, Bae SM, Son HN, Thoudam Debraj Singh, Kim JE, Lee BH, Park RW, Kim IS. Transforming growth factor-beta-induced protein (TGFBIp/beta ig-h3) activates platelets and promotes thrombogenesis. Blood, 2009; 114(25):5206-15. (Impact factor - 22.11) 

 

Research Interest

• Identification of new Biomarkers for cancers (Thyroid, Ovarian, Colon, Breast)
• Molecular imaging of apoptosis, cancer metabolism and inflammation Cancer drug designing, discovery and delivery (Preclinical trials)
• Cancer Drug delivery using biopolymer.
• Tissue engineering and regenerative medicine
• Molecular imaging of immune cell migration in cancer and inflammation model
• Endocytosis and phagocytosis of apoptotic cells and Amyloid beta in neuronal cells

 

Publication link: https://pubmed.ncbi.nlm.nih.gov/?term=thoudam+debraj+singh