Dr Achal Srivasrtava

 

Dr. Achal Kumar Srivastava
MBBS, MD, DM 
Professor, Department of Neurology,
Head, Unit III
Room #60, Ground Floor, Neurosciences Center, AIIMS , New Delhi 
Phone: +91 11 26546688 
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Outpatients clinic ( General Neurology including Ataxia Clinic - Movement Disorder Clinic)

 Wednesday and Saturday (forenoon) 
For appointments: +91 11 26594656 or email to This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Dr. Achal Kumar Srivastava is Professor of Clinical Neurophysiology in the Department of Neurology at the All India Institute of Medical Sciences, New Delhi, India. He heads the Clinical Neurophysiology facility and Ataxia clinic at the center and is a member of the Comprehensive Epilepsy care team here. He has special interest in ataxias, epilepsy and genetics of movement disorders.  He is a recipient of more than 25 paper presentation awards and has more than 100 publications to his credit.

 

Dr. Srivastava graduated from MLN Medical College, Allahabad, Uttar Pradesh in 1991 and completed his postgraduate degree (MD) in Medicine (1994) from the same college. Subsequently he obtained post-doctoral specialist certification in DM (Neurology) in 1998 from the Department of Neurology, All India Institute of Medical Sciences, New Delhi. He worked as Senior Scientist grade scientist fellow for over a year at CSIR Institute of Genomics and Integrative Biology (formerly known as Center for Biochemical technology) and then joined as Assistant Professor in the Department of Neurology in March 2001. He has keen interest in teaching and has provided guidance and training to more than 70 DM and PhD students in their research work.

Dr. Srivastava has received academic awards at National and International scientific forums, mainly for his work in the field of ataxias and genetics of neurological disorders. Many of his students (both DM and PhD) have also won academic awards and honours, under his guidance. He was invited by Molecular Biology Division at John Hopkins USA for presentation of his work on spinocerebellar ataxia type 12. He has received outstanding paper presentation award from AINA at American Academy of Neurology conference at San Francisco in 2004 and the best paper award at Neurological Society of India conference at Hyderabad in 1998. He has received many travel fellowships to attend international conferences. He has received Young investigator award for CAG triplet repeat disorder conferences at USA and Italy. He has collaborative projects with many universities and research institutes. He is on the editorial board of Journal of Clinical Neuroscience and many other journals of repute.

Important Publications

 

1. Srivastava AK, Goel UC, Dwivedi NC, Bajaj S. Visual Evoked Response in Ethambutol induced optic Neuritis. J Assoc Physicians India. 1997; 45: 847-849.
2. Srivastava AK, Choudhry S, Gopinath MS, Tripathi M, Brahmachari SK, Jain S. Molecular and clinical correlation in five Indian families with Spinocerebellar ataxia 12. Annals of Neurology 2001; 50:796-800.
3. Behari M, Srivastava AK, Das Radhika R, Pandey RM. Risk factors of Parkinson’s disease in Indian Patients. Jr. of Neurological Sciences 2001; 190:49-55. 
4. Choudhry S, Mukerji M, Srivastava AK, Jain S, Brahmachari SK. CAG repeat instability at SCA 2 locus: anchoring CAA interruptions and linked single nucleotide polymorphisms. Human Molecular Genetics 2001; 10(21):2437-2446. 
5. Srivastava AK, Prasad K. A study of factors delaying hospital arrival of patients with acute stroke. Neurology India 2001; 49:272-276.
6. Srivastava AK, Khanna N, Sardana V, Gaikwad SB,Prasad K, Behari M. Cerebral venous thrombosis in ulcerative colitis: A case report. Neurology India 2002; 50:215-217.
7. Srivastava AK, Tripathi M, Padma MV, Gaikwad SB, Jain S. Internuclear ophthalmoplegia and torsional nystagmus: an MRI correlate. Neurology India 2003; 51(2):271-272.
8. Jain S, Tripathi M, Srivastava AK, Narula A. Phenotypic analysis of Juvenile Myoclonic Epilepsy in Indian Families.  Acta Neurologica Scandinavica 2003: 107(5):356-362.
9. Gaikwad SB, Garg A, Mishra NK, Gupta V, Srivastava AK, Sarkar C. Cerebrotendinous Xanthomatosis – Neuroimaging finding in two siblings from Indian family. Neurology India 2003; 51(3):401-403.
10. Srivastava AK, Sardana V, Prasad K, Behari M. Diagnostic Dilemma In Flaccid Paralysis Following Anti Rabies Vaccine. Neurology India 2004; 52(1):132-133.
11. Jain S, Bhatia M, Tripathi M, Srivastava AK, Padma MV, Pandey RM. Seizures among families of Indian probands with different epileptic syndromes. Acta Neurologica Scandinavica 2004; 110(1): 27-38.
12. Pandey N, Mittal U, Srivastava AK, Mukerji M. SMRCA2 and THAP11: potential candidates for polyglutamine disorders as evidenced from polymorphism and protein folding stimulation studies. J Hum Genet. 2004; 49(11):596-602.
13. Padiath QS, Srivastava AK, Roy S, Jain S, Brahmachari SK. Identification of a novel 45 repeat unstable allele associated with a disease phenotype at the MJD/SCA3 locus. Am J Med Genet B Neuropsychiatr Genet. 2005 Feb 5; 133(1):124 -126. 
14. Mittal U, Srivastava AK, Jain Satish, Jain Sanjeev, Mukerji M. Founder haplotype for Machado-Joseph disease in the Indian population: novel insights from history and polymorphism studies. Arch Neurol. 2005 Apr; 62(4):637-640.
15. Mittal U, Roy S, Jain S, Srivastava AK, Mukerji M. Post-zygotic de novo trinucleotide repeat expansion at spinocerebellar ataxia type 7 locus: evidence from an Indian family. J Hum Genet. 2005; 5 (3) 155 -157.
16. Behari M, Srivastava AK, Pandey RM. Quality of Life in Indian Patients with Parkinson’s disease. Parkinsonism Relat Disord. 2005 Jun; 11(4):221-226.
17. Mittal U, Sharma S, Chopra R, Dheeraj K, Pal PK, Srivastava AK, Mukerji M. Insights into the mutational history and prevalence of SCA1 in the Indian population through anchored polymorphisms. Hum Genet. 2005 Aug 17;:1-8 
18. Bahl S, Virdi K, Mittal U, Sachdeva MP, Kalla AK, Holmes SE, O'hearn E, Margolis RL, Jain S, Srivastava AK, Mukerji M. Evidence of a Common Founder for SCA12 in the Indian Population. Ann Hum Genet. 2005 Sep; 69(5):528-534.
19. Faruq M, Scaria V, Singh I, Tyagi S, Srivastava AK, Mukerji M. SCA-LSVD: a repeat-oriented locus-specific variation database for genotype to phenotype correlations in spinocerebellar ataxias. Hum Mutat. 2009 Jul;30(7):1037-42. 
20. Singh I, Faruq M, Mukherjee O, Jain S, Pal PK, Srivastav MV, Behari M, Srivastava AK, Mukerji M. North and South Indian populations share a common ancestral origin of Friedreich's ataxia but vary in age of GAA repeat expansion. Ann Hum Genet. 2010 May;74(3):202-10.
21. Swarup V, Srivastava AK, Padma MV, Rajeswari MR. Quantification of circulating plasma DNA in Friedreich's ataxia and spinocerebellar ataxia types 2 and 12. DNA Cell Biol. 2011, Jun;30(6):389-94.
22. Nanda A, Jain V, Srivastava AK. An electromyographic study to assess the minimal time duration for using the splint to raise the vertical dimension in patients with generalized attrition of teeth. Indian J Dent Res. 2011 Mar-Apr;22(2):303-8. 
23. Swarup V, Srivastava AK, Rajeswari MR. Identification and quantification of differentially expressed proteins in plasma of spinocerebellarataxia type 12. Neurosci Res. 2012 Jun;73(2):161-7. 
24. Rai NK, Srivastava AK, Pahwa S, Garg A. Idiopathic thrombocytopenic purpura and neuropathy: A case report and review. Neurology Asia 2012; 17(1) : 63 – 66. 
25. Swarup V, Srivastava AK, Padma MV, Moganty RR. Quantitative Profiling and Identification of Plasma Proteins of Spinocerebellar Ataxia Type 2 Patients. Neurodegenerative Diseases. 2013, 12(4):199-206.
26. Swarup V, Srivastava AK, Padma MV, Rajeswari MR. Quantitative profiling and identification of differentially expressed plasma proteins in Friedreich's ataxia. J Neurosci Res. 2013 Nov;91(11):1483-91.
27. Faruq M, Shakya S, Garg A, Srivastava AK. Spinocerebellar Ataxia 2 and 12 Mutations in an Indian Family with Cerebellar Ataxia and Slow Saccades. Mov Disord Clin Practice 2014 Apr; 1 (3): 267-70.
28. Faruq M, Narang A, Kumari R, Pandey R, Garg A, Behari M, Dash D, Srivastava AK, Mukerji M. Novel mutations in typical and atypical genetic loci through exome sequencing in autosomal recessive cerebellar ataxia families. Clin Genet. 2014 Oct;86(4):335-41.
29. Faruq M, Srivastava AK, Suroliya V, Kumar D, Garg A, Shukla G, Behari M. Identification of FXTAS presenting with SCA 12 like phenotype in India. Parkinsonism Relat Disord. 2014 Oct;20 (10):1089-93.
30. Faruq M, Srivastava AK, Singh S, Gupta R, Dada T, Garg A, Behari M, Mukerji M. Spinocerebellar ataxia 7 (SCA7) in Indian population: predilection of ATXN7-CAG expansion mutation in an ethnic population. Indian J Med Res. 2015 Feb;141(2):187-98. 
31. Roy S, Srivastava AK, Jaryal AK, Deepak KK. Cardiovascular responses during cold pressor test are different in Parkinson disease and multiple system atrophy with parkinsonism. Clin Auton Res. 2015 Aug;25(4):219-24.
32. Singh I, Faruq M, Padma MV, Goyal V, Behari M, Grover A, Mukerji M, Srivastava AK. Investigation of mitochondrial DNA variations among Indian Friedreich's ataxia (FRDA) patients. Mitochondrion. 2015 Nov;25:1-5. doi:10.1016/j.mito.2015.08.003. Epub 2015 Aug 29. PubMed PMID: 26321457.
33. Dantham S, Srivastava AK, Gulati S, Rajeswari MR. Plasma circulating cell-free mitochondrial DNA in the assessment of Friedreich's ataxia. J Neurol Sci. 2016 Jun 15;365:82-8.
34. Singh I, Shakya S, Singh RK, Ahmad I, Goyal V, Shukla G, Srivastava MV, Faruq M, Srivastava AK. Iron related hemochromatosis (HFE) gene mutations in Friedreich Ataxia patients. Parkinsonism Relat Disord. 2017 Jan;34:71-72.
35. Srivastava AK, Takkar A, Garg A, Faruq M. Clinical behaviour of spinocerebellar ataxia type 12 and intermediate length abnormal CAG repeats in PPP2R2B. Brain. 2017 Jan;140(Pt 1):27-36.
36. Erwin GS, Grieshop MP, Ali A, Qi J, Lawlor M, Kumar D, Ahmad I, McNally A, Teider N, Worringer K, Sivasankaran R, Syed DN, Eguchi A, Ashraf M, Jeffery J, Xu M, Park PMC, Mukhtar H, Srivastava AK, Faruq M, Bradner JE, Ansari AZ.  Synthetic  transcription elongation factors license transcription across repressive chromatin. Science, 2017. Nov 30. pii: eaan6414. doi: 10.1126/science.aan6414.