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अखिल भारतीय आयुर्विज्ञान संस्थान, नई दिल्ली
All India Institute Of Medical Sciences, New Delhi

Out Patient Service

Publications

  1. Superior Mediastinal Syndrome : a rare presenting feature of Acute Myeloid Leukemia in childhood. Accepted for publication in Indian journal of Pediatrics 2012.
  2. Clinical Profile of Langerhans Cell Histiocytosis at a Tertiary Centre: A Prospective Study. Uppal P, Bothra M, Seth R, Iyer V, Kabra SK.Indian J Pediatr. 2012 Mar 6.
  3. Seth R, Bhat AS . Management of Common Oncologic Emergencies.Indian J Pediatr. .2011.;78(6):709-17Epub March 12, 2011 .
  4. Puri K, Singh P, Das RR, Seth R, Gupta R. Diagnostic Dilemma of JMML Coexisting with CMV Infection. Indian J Pediatr. 2011; 78: 485-7.
  5. Chopra A, Kumar R, Seth R, Anand M, Ray R. Striking morphology of leukemic phase of childhood peripheral T-cell lymphoma, not otherwise specified. Am J Hematol . 2011; 86: 373-4.
  6. R. Seth, A Kapil, M Bothra, K Verma. Rational management and predictors of adverse outcomes of febrile neutropenic episodes in childhood .Pediatric Blood Cancer, 2011; 5:7 705-897
  7. Das RR, Sami A, Lodha R, Jain R, Broor S, Kaushik S, Singh BB, Ahmed M, Seth R, Kabra SK. Clinical profile and outcome of swine flu in Indian children. Indian Pediatr. 2011 May;48(5):373-8.
  8. Saharan S, Jose B, Seth Rachna, Iyer VK, Kabra SK. Langerhans cell histiocytosis presenting as recurrent air leaks in young children. Acta Pediatrica, 2010 April.99(4) 488
  9. Sankar J, Arun S, Sankar MJ, Seth Rachna,Thavaraj V, Kabra SK. Primary cutaneous mucormycosis during induction chemotherapy in a child with acute lymphoblastic leukemia . Indian J Pediatr 2009 Nov,76(110; 1161-3
  10. Sharma R, Rachna Seth, Thavaraj V, Bagga A, Kabra SK, Karak AK, Atri S. Multicentric Castleman's disease in two cases. Indian J Pediatr. 2007 Dec;74(12):1116-20..
  11. Prabhu Savit, Gupta Ritu, Seth Rachna. Juvenile Myelomonocytic leukemia presenting with co-existent CMV infection- case report.. Journal of Pediatric Hematology/Oncology 2010 ;32(4):153-154
  12. Gupta AK, Kandasamy D, Seth Rachna . Role of FDG-PET/CT in management of Hodgkin Lymphoma. Indian J Pediatr,2009.Dec ;76(12):1273-4
  13. Ghosh I, Kumar L, Seth Rachna, Thavraj V. Sustained remission achieved with ATRA and chemotherapy in second relapse of acute promyelocytic leukemia in Down syndrome. J Pediatr Hematol Oncol. 2009 Aug;31(8):539-40.
  14. Thavaraj V, Rachna Seth. Prophylaxis of central nervous system leukemia: a case of chronic myeloid leukemia with lymphoid blast crisis treated with imatinib mesylate. World J Pediatr. 2008 May;4(2):145-7.
  15. Verma S, Sivanandan S, Aneesh MK, Gupta V, Seth R, Kabra S. Unilateral proptosis and extradural hematoma in a child with scurvy. Pediatr Radiol. 2007 Sep;37(9):937-9.
  16. Thavaraj V, Seth Rachna. Imatinib mesylate, a new drug for chronic myeloid leukemia in pediatric patients. World Journal of Pediatrics 2007;3(2)110-114.
  17. Kalra V, Rachna Seth, Mishra D. Extraneural cysticercosis - presenting as painless cervical swellings. J Trop Pediatr. 2006 Apr;52(2):141-3.
  18. S Sharma , D Mishra, Rachna Seth, NC Saha. Guillain-Barre syndrome in children. DS (Child) H J 2005;21 :69-74.
  19. Rachna Seth, Thavaraj V, Velpandian , R Gupta. Treatment of acute promyelocyte leukemia with arsenic trioxide – a single center study. Pediatric Blood and Cancer. 2007,49(4): 456.
  20. Rachna Seth, Thavaraj V, Sudan R, Arya LS, Karak AK, Atri S. Treatment of Multicentric castleman disease with CHOP regime. Pediatric Blood and Cancer. 2007,49(4): 457.
  21. Rachna Seth , Sapra S, Thavaraj V, Arya LS. Psychosocial and cognitive outcomes in acute lymphoblastic leukemia survivors. Pediatric Blood and Cancer. 2007,49(4):542.
  22. Rachna Seth, Thavaraj V, Seth S, Verma S. Role of follow up left ventricular function assessment in childhood cancer survivors: perspective from developing countries. Pediatric Blood and Cancer. 2007,49(4):548.
  23. Mishra D, Kalra V, Venkatesh P, Seth R, Gulati S. Fundal changes in children receiving Vigabatrin. Indian J Pediatr. 2011 Oct;78(10):1281-
  24. Rachna Seth,U Sharma,V Kalra,NR Jagannathan. Magnetic resonance Spectroscopy in ring enhancing lesions. Indian Pediatrics 2010,47: 803-4
  25. Mishra D, Kalra V, Rachna Seth, Gulati S, Saha N. Efficacy of Pyridoxine in Early- Onset Idiopathic Intractable Seizures in Children. Indian J Pediatr. 2010 Sep 10.
  26. Rachna Seth, Seth S, Kalra V. Screening for cardiomyopathy in muscular dystrophy with tissue doppler imaging. Indian J Pediatr. 2010 May;77(5):523-8. Epub 2010 Apr 17.
  27. Kalra V, Rachna Seth, Mishra D, Saha NC. Clobazam in refractory childhood epilepsy. Indian J Pediatr. 2010 Mar;77(3):263-6. Epub 2010 Feb 22.
  28. Mishra D, Kalra V, Rachna Seth. Failure of prophylactic zinc in Wilson disease. Indian Pediatr. 2008 Feb;45(2):151-3.
  29. Sahu JK, Rachna Seth, Karak AK, Thavaraj V, Kabra SK. Primitive Neuroectodermal tumour presenting as cauda equina syndrome. Indian Journal of Medical and Pediatric Oncology. Vol 28 No 4, 2007:34-7.
  30. R. Seth, Vasantha Thavaraj. Langerhans Cell Histiocytosis. Indian Pediatrics 2006,43 :1001-2
  31. Seth Rachna , Kalra V. Autism in India . Indian Pediatr 2006 ; 43(5):456.
  32. Veena Kalra, Rachna Seth, Savita Sapra. Autism- Experiences in tertiary care hospital and brief review of literature. Indian J Pediatrics 2005; 72(3): 227-230.
  33. S Seth, R Prakash, Rachna Seth, KKTalwar. Screening for preclinical Hyprtrophic Cardiomyopathy by Tissue Doppler Imaging. Indian Heart 2005;57:245-250.
  34. Rachna Seth, Usha Sharma. Evaluation of Diagnostic Criteria for Diagnosis of Tuberculous Meningitis in Children. Indian Journal of Pediatrics 2002; 69(4): 299- 303.
  35. Rachna Seth, Gulati S, Menon PSN, Kalra V. Familial Hypercholesterolemia: a case report. Indian Journal of Pediatrics 2004; 71(1): 97-99.
  36. Rachna Seth, Kabra SK. Micropulmonary Arteriovenous fistula causing cyanosis. Indian Journal of Pediatrics 2003; 70(9):747-749.
  37. Rachna Seth, Alladi Mohan. Efficacy of monovalent human rotavirus vaccine 89-12 in infants. The National Medical Journal of India, 2000, 13(5): 253-254.
  38. Rachna Seth, BK Das. Rotavirus Vaccine. - Current Status. Pediatrics Today, 2000, III (11): p717-721.
  39. Rachna Seth. Detection of Breast Cancer. Souvenir: Xth Foundation Day of “Koshish”, Mastectomy Association of India, Jaipur Chapter. 2007 (Dec): 27-30.
  40. Veena Kalra, Rachna Seth, Savita Sapra. Autism –Unexplored scenario in the Indian Context. (Proceedings of Indo US workshop on ASD held at National Institute of Mental Health, Hyderabad 2004)
  41. Veena Kalra, Rachna Seth. Adolescent epilepsy. Pediatrics Today 2003;VI(6):324-332.
  42. Veena Kalra, Rachna Seth. Focus on Adolescent Epilepsy. Newsletter (vol II, 2003), Association of Child Neurology
  43. “Cranial Magnetic Resonance Spectroscopy in Protein Energy Malnutrition-" Brain Sparing effect" ” Rachna Seth, V Kalra, U Sharma, NR Jagannathan. 8th Asian & Oceanian Congress of Child Neurology, IJP supplement, SS-1, Oct 2004.
  44. “Autism -Experience in a tertiary care hospital” V Kalra, Rachna Seth, S Sapra. 8th Asian & Oceanian Congress of Child Neurology, IJP supplement, SS-1, Oct 2004.
  45. “Myocardial Dysfunction in Duchenne Muscular Dystrophy-Tissue Doppler Imaging (TDI) VS Conventional Echocardiography”. V Kalra, Rachna Seth, S Seth. 8th Asian & Oceanian Congress of Child Neurology, IJP supplement, SS-1, Oct 2004.
  46. V Kalra, Rachna Seth, D Mishra, NC Saha “Add on Clobazam in Resistant Childhood Epilepsy-Adverse drug reaction study”. 8th Asian & Oceanian Congress of Child Neurology, IJP supplement, SS-1, Oct 2004.
  47. V.Kalra, D Mishra, S Gulati, Rachna Seth, NC Saha. Health education intervention among school children for prevention of taeniasis and neurocysticercosis. 8th Asian & Oceanian Congress of Child Neurology, IJP supplement, SS-1, Oct 2004.
  48. Veena Kalra, D Mishra, Rachna Seth, S Gulati, NC Saha . Multiple parenchymal neurocysticercosis: 8th Asian & Oceanian Congress of Child Neurology, IJP supplement 2004.
  49. V Kalra, D Mishra, K Agarwal, M Kamate, Rachna Seth. Feasibility and Efficacy of School based health education intervention for prevention of taeniasis and neurocysticercosis. 8th Asian & Oceanian Congress of Child Neurology, IJP supplement, SS-1, Oct 2004:106.
  50. Molecular studies and Prenatal Diagnosis in Duchenne Muscular Dystrophy. M Tiwari, R Vijaya, M Kabra, M R Choudhary, S Gulati, Rachna Seth, MC Sharma, C Sarkar, V Kalra. 8th Asian & Oceanian Congress of Child Neurology, IJP supplement, SS-1, Oct 2004: 149.
  51. V Kalra, D Mishra, S Gulati, Rachna Seth, M Kamate, A Sharma. Efficacy of pyridoxine in early onset intractable seizures in children. 8th Asian & Oceanian Congress of Child Neurology, IJP supplement, SS-1, Oct 2004: 149.
  52. V Kalra, D Mishra, Rachna Seth, S Gulati , M Kamate, A Sharma. Multiple parenchymal neurocysticercosis – clinical profile, graduated cysticidal therapy schedule and outcome in Indian children. 8th Asian & Oceanian Congress of Child Neurology, IJP supplement, SS-1, Oct 2004: 166.
  53. Laxman S Arya; Veronique Dinand Current strategies in the treatment of childhood Hodgkins disease. Indian pediatrics 2005;42(11):1115-28.
  54. S Sazawal; Kishor Bhatia; Marina I Gutierrez; Renu Saxena; Laxman S Arya; Manorama Bhargava Paucity of TEL-AML 1 translocation, by multiplex RT-PCR, in B-lineage acute lymphoblastic leukemia (ALL) in Indian patients.American journal of hematology 2004;76(1):80-2.
  55. R Mohta; Abha Saxena; Yogesh Jain; S Gupta; Vasantha Thavaraj; Sunil Narain; Laxman S Arya.Anthracycline associated cardiac toxicity in children with malignancies. Indian pediatrics 2002;39(6):549-55.
  56. Supriyo Ghose; S H M Nizamuddin; Anita Sethi; Bidhu K Mohanti; Harsh Kumar; Laxman S Arya; Vasantha Thavaraj.Efficacy of induction chemotherapy in retinoblastoma, alone or combined with other adjuvant modalities.Journal of pediatric ophthalmology and strabismus 2002;39(3):143-50.
  57. Laxman S Arya; Sunil Narain; Vasantha Thavaraj; Anita Saxena; M Bhargava Leukemic pericardial effusion causing cardiac tamponade. Medical and pediatric oncology 2002;38(4):282-4.
  58. S Sazawal; S Gurbuxani; Kishor Bhatia; A Khattar; Vinod Raina; Laxman S Arya; Tribhuvan S Vats; Ian Magrath; Manorama Bhargava Incidence, clinical characteristics and early treatment outcome in Indian patients of childhood acute lymphoblastic leukemia with ALL-1 gene rearrangement. Leukemia research 2001;25(8):693-8.
  59. Yogesh Jain; Laxman S Arya; R Kataria Neutropenic enterocolitis in children with acute lymphoblastic leukemia. Pediatric hematology and oncology 2000;17(1):99-103.

Book s / Manuals published

  1. Neurocognitive and psychosocial deficits in childhood cancers .A manual for school and health professionals (Hindi & English). Rachna Seth & Savita Sapra
  2. Autism (English): Veena Kalra, Rachna Seth, Savita Sapra. Arya Book Depot , 2004, New Delhi.
  3. Autism (Hindi): Veena Kalra, Rachna Seth, Savita Sapra. Arya Book Depot , 2004, New Delhi.
  4. Development through Activity (English):Veena Kalra, Savita Sapra, Rachna Seth. Arya Book Depot, 2004, New Delhi.
  5. Development through Activity (Hindi):Veena Kalra, Savita Sapra, Rachna Seth. Arya Book Depot, 2004, New Delhi.
  6. Childhood Cancer : What parents must know(bilingual )

Chapters in books

  1. Rachna Seth. Tuberculosis and childhood malignancy in Essentials of Tuberculosis in children. V Seth & SK Kabra , 4th edition, 2011 Jaypee Brothers Medical Publishers 241-245.
  2. PM Udani, S Gulati, Rachna Seth et al. Case studoes. In Essentials of Tuberculosis, 4th edition, Seth V and Kabra SK(eds), New Delhi Jaypee, 180-199, 2011.
  3. Rachna Seth, Hodgkin Lymphoma in Advances in Pediatrics. A Sachdeva & AK Dutta. 2nd Edition 2012, Jaypee Brothers Medical Publishers. (1)666-670.
  4. Udhani PM, Gulati S, Seth R, Kalra V, Seth V. Case Studies in Essential of Tuberculosis in Children V Seth, S K Kabra 4th Edition 2011, Jaypee Borthers Medical Publishers,180-199.
  5. R Seth, AS Bhat. Oncologic emergencies in SK Kabra & R Lodha ‘Pediatric Intensive care protocols of AIIMS’ . 1st edition published by Indian Journal of Pediatrics. 136-152
  6. Rachna Seth. Hematological emergencies in Children.In Meharban Singh in’ Medical Emergencies in Children’. ‘Fifth edition. 2012 .620-636
  7. T Singhal, Rachna Seth, et al. Infection/Infestations. Ghai Essential Pediatrics VII edition 2009:181-250.
  8. Childhood malignancies LS Arya, Rachna Seth Ghai Essential Pediatrics VII edition 2009:580-597
  9. V Kalra, S Gulati, Rachna Seth, V Seth. Neurotuberculosis : Clinical manifestations, Diagnosis and Treatment. In: Essentials of Tuberculosis in Children (3nd Edition). V Seth (ed). Jaypee Publishers Ltd, New Delhi, 2005
  10. Rachna Seth. Acute Encephalitis. In: SAARC Training Module for Childhood Neurological Diseases. V Kalra (ed). New Delhi 2000, p 100-5.
  11. Seth V, Rachna Seth. History of Tuberculosis. In: Essentials of Tuberculosis in Children (2nd Edition). V Seth (ed). Jaypee Publishers Ltd, New Delhi, 2001. p3-8.
  12. Seth V, Kabra SK, Rachna Seth. Epidemiology : Special Reference to Children. In: Essentials of Tuberculosis in Children (2nd Edition). V Seth (ed). Jaypee Publishers Ltd, New Delhi, 2001. p32-40.
  13. V Seth, L Simpson, Rachna Seth. Antituberculosis Drugs: conventional therapeutic agents. In: Essentials of Tuberculosis in Children (2nd Edition). V Seth (ed). Jaypee Publishers Ltd, New Delhi, 2001, p295-316.

Research

AREAS OF RESEARCH  (Research Projects as Chief Investigator ) 

Clinical research in pathogenesis and treatment of Hematological malignancies, solid tumors particularly Retinoblastoma and Hodgkin’s lymphoma, effect of chemotherapy on survivors of various childhood malignancies, neurocognitive outcomes of hematological malignancies, childhood anemias

&nbps;&nbps;Source of fundingYear Total Amount
1   “Cranial Magnetic Resonance Spectroscopy in Protein Energy     Malnutrition-" Brain Sparing effect"

CSIR

2002

&nbps;
2 To understand the deviation in cell signaling pathway of autism through neurotrophic factors (Insulin like growth factor-1) & undertake a randomized blinded trial with Olanzapine to evaluate its effect on Insulin like Growth fator-1 (IGF-1), clinical symptoms of autism and Autism rating scales

Department of Science & Technology

2006

3 years

Rs 4,08,000/-

  3

Assessment of psychosocial and neurocognitive   outcomes in childhood Leukemia

All India Institute of Medical Sciences, New Delhi

1 year

2006

Rs 67,000/-

&nbps;
4 Evaluation of Anthracycline induced myocardial cardiotoxicity  in children with Cancer: A comparative study  with echocardiography and MUGA All India Institute of Medical Sciences, New Delhi

1 year

2007

Rs40,000/-
5 Detection of minimal residual disease (MRD) in B cell lineage acute lymphoblastic leukemia at end of induction by flow cytometry. (2009 onwards)

Indian Council of Medical Research (ICMR).

2009-2012

3 years 5

Rs 34,82,53

6 A study of infections in Febrile neutropenic pediatric oncology patients at a tertiary care hospital &nbps; All India Institute of Medical Sciences, New Delhi 1 year

2009

Rs 1,00,000

7 Understanding the biology of childhood Cancer survivorship in India

All India Institute of Medical Sciences, New Delhi

Rs 1,00,000

2010

1 year

&nbps;
8 Chemo to Cure (C to C): A study of cancer Survivorship Jiv Daya Foundation

Rs 20,00,000/-

2011-2014

9. Neuroimaging and cerebral metabolite changes in children undergoing treatment for acute lymphoblastic leukemia: a pilot study’

AIIMS

Rs 1,00,000/-

2011-2013

Other areas of research

  1. Evaluation of incidence and predictors of tumor lysis syndrome in newly diagnosed
  2.       children of acute lymphoblastic leukemia
  3.    To study the effect of hyperhydration vs hyperhydration and hydroxyurea in management of newly diagnosed hyperleukocytosis of acute childhood leukemia
  4.      Study the outcome of childhood langerhans cell histiocytosis
  5.    Vincristine induced neuropathy in Childhood ALL (Acute Lymphoblastic Leukemia) Prevalence and Electrophysiological Characteristics
  6.     Nucleophosmin mutation in acute myeloid leukemia:  evaluation of screening by        immunohistochemistry - a simple front-line surrogate for molecular analysis.
  7.     Evaluation of focal consolidation and systemic chemo reduction in management of intraocular retinoblastoma
  8.     Outcome in children with extraocular retinoblastoma.: A RCT using two treatment protocols.
  9.     Aspergillosis in immunecompromised patients: Epidemiology and Drug resistance

OPD Services

Day  
Monday

Dr. Rachna Seth

Pediatric Oncology Clinic

Morning 9 am onwards

Room No. 14

Wednesday OPD Services

Room No. 07

Thursday

Dr. Rachna Seth

Pediatric Cancer Survivor Clinic

Afternoon 2.00 pm

Room No. 14

Saturday OPD Services

Morning 9 am onwards

Room No. 07

Social Support

Financial / Medical / Social Support

  1. Medical Social Worker at the department of Pediatrics
  2.      Financial aid from AIIMS
  3. Financial aid from central and state government (Rashtriya Arogya Nidhi, Prime minister relief fund)
  4.      NGO support (CANKIDS -KIDSCAN, Cancer patients aid association

Other activities of the Division are:

  1.      Interspecialty consultations pertaining to patient care
  2.      Parent interactive forums 4-6 monthly
  3.      Patient education program; Distribution of parent education material
  4.    ‘Parent meets a parent’ initiative where a parent of a childhood cancer survivor meets parents of children taking treatment ;the two relate to each other
  5.      Arranging financial assistance via Rashtriya Arogya Nidhi, PM relief fund
 

ASSISTING  DEPARTMENTS

  1.     Laboratory  Oncology
  2.      Radiology
  3.      Radiotherapy
  4.      Hematology
  5.      Ophthalmology
  6.      Pediatric Surgery
  7.      Medical Oncology

Education

  1. Short term, long term training in Pediatric Oncology .Applications are submitted through Dean, AIIMS.details may be obtained from website
  2. Post graduate teaching including training in laboratory oncology & Hematology
  3. Senior Residency program :specialty based posting of senior residents for 1 year during senior residency
  4. PhD program
  5. Workshops & CME on various aspects of Oncology & Hematology are organized from time to time.
  6. Organized the first childhood cancer survivor conference
  7. Patient & parent education

Childhood cancer: What parents must know (Hindi  &  English)

Leaflets on day to day care of children with cancer ((Hindi) )

Booklet on neurocognitive & psychosocial deficits in childhood cancer (bilingual)

General instructions for hospitalized cancer children care and day care patients

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