Dr. Hariprasad G

Prof. Hariprasad G.

Photograph

Current Designation & Contact Details

Professor

Room No. 11, 5th Floor, Porta Cabin, Teaching Block, AIIMS, New Delhi

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Phone: +91-11-26594029

Recent Employment Details (Past few years)

1. Assistant Professor - Biophysics - 29/06/2012 to 30/06/2015 at Department of Biophysics, All India Institute of Medical Sciences, New Delhi

2. Associate Professor – Biophysics - 01/07/2015 to 30/06/2018 at Department of Biophysics, All India Institute of Medical Sciences, New Delhi

3. Additional Professor – Biophysics - 01/07/2018 to Till Date at Department of Biophysics, All India Institute of Medical Sciences, New Delhi

Brief Research Area

1. Current pharmacological interventions in Parkinson’s disease and schizophrenia aim to restore normal dopamine levels, overshooting of which results in adverse effects. We have identified potential biomarkers that can monitor pharmaco-efficacy in the two diseases. We are currently looking to take a step further by developing CHIP based monitoring kits to monitor therapy in the two disease states.

2. We have previously structurally characterized group III PLA2s from Humans, scorpions, and Clorenchis sinensis. We are currently looking structurally characterize PAF-AH enzyme, a PLA2 family analog, that is implicated in certain protozoal infections. The detailed characterization will pave the way for design of specific and potent inhibitory molecules against these drug targets.

Selected Publications/Patents (Last 5 years)

Google Scholar Link:

https://scholar.google.co.in/citations?user=_c0LXmkAAAAJ&hl=en

1. Koley T, Goswami A, Kumar M, Upadhyay N, Hariprasad G*. Comparative structural analysis of human ACE2 receptor with spike protein of SARS-CoV-2 variants: Implications to understand infectivity of the virus. Advances and Applications in Bioinformatics and Chemistry (2022) 15: 21-27.

2. Kaushik A , Bandyopadhyay S, Porwal C, Srinivasan A, Rukmangadachar LA, Hariprasad G, Kola S, Kataria J, Singh UB. 2D-DIGE based urinary proteomics and functional enrichment studies to reveal novel Mycobacterium tuberculosis and human protein biomarker candidates for pulmonary tuberculosis Biochemistry Biophysics Research Communications (2022) 619:15-21.

3. Pathania S, Khan MI, Bandyopadhyay S, Singh SS, Rani K, Parashar TR, Jayaram J, Mishra PR, Srivastava A, Mathur S, Hari S, Vanamail P, Hariprasad G*. iTRAQ proteomics of sentinel lymph nodes for identification of extracellular matrix proteins to flag metastasis in early breast cancer. Scientific Reports (2022) 12(1):8625.

4. Koley T, Kumar M, Goswami A, Ethayathulla AS, Hariprasad G*. Structural modeling of Omicron spike protein and its complex with human ACE-2 receptor: Molecular basis for high transmissibility of the virus. Biochemical and Biophysics Research Communications. (2022) 592:51-53.

5. Naqvi AAT, Fatima K, Mohammad T, Fatima U, Singh IK, Singh A, Atif SM, Hariprasad G, Hasan GM, Hassan MI. Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach. BBA Molecular Basis of Disease (2020) 1866: 165878

6. Khan MI, Hariprasad G*. Structural Modeling of Wild and Mutant Forms of Human Plasma Platelet Activating Factor-Acetyl Hydrolase Enzyme. Journal of Inflammation Research. (2020) 13:1125-1139.

7. Khan MI, Hariprasad G*. Human Secretary Phospholipase A2 Mutations and Their Clinical Implications. Journal of Inflammation Research. (2020) 13: 551-561.

8. Patania S, Khan MI, Kumar A, Gupta AK, Rani K, Parashar TR, Jayaram J, Mishra PR, Srivastava A, Mathur S, Hari S, Hariprasad G*. Proteomics of sentinel lymph nodes in early breast cancer for identification of thymidylate synthase as a potential biomarker to flag metastasis: A preliminary study. Cancer Management and Research (2020) 12: 4841–4854

9. Gupta AK, Pokhriyal R, Das U, Khan MI, Kumar DR, Gupta R, Chadda RK, Ramachanran R, Goyal V, Tripathi M, Hariprasad. G*. Evaluation of α-synuclein and apolipoprotein E as potential biomarkers in CSF to monitor pharmaco-therapeutic efficacy in dopamine dictated disease states of Parkinson’s disease and schizophrenia. Neuropsychiatric Disease Treatment. (2019) 15:2073-2085

10. Gupta AK, Pokhriyal R, Khan MI, Kumar DR, Gupta R, Chadda RK, Ramachanran R, Goyal V, Tripathi M, Hariprasad. G*. Cerebrospinal fluid proteomics for identification of α2-macroglobulin as a potential biomarker to monitor pharmacological therapeutic efficacy in dopamine dictated disease states of Parkinson’s disease and schizophrenia. Neuropsychiatric Disease Treatment. (2019) 15:2853-2867

11. Gupta AK, Kumar GK, Rani K, Pokhriyal R, Khan MI, Kumar DR, Goyal V, Tripathi M, Gupta R, Chadda RK, Vanamail P, Mohanty AK, Hariprasad. G*. 2D-DIGE as a strategy to identify serum protein biomarkers to monitor pharmacological efficacy in dopamine dictated states of Parkinson’s disease and schizophrenia. Neuropsychiatric Disease Treatment. (2019) 15: 1031-1044.

12. Gupta AK, Rani K, Swarnkar S, Kumar GK, Khan MI, Pokhriyal R, Kumar DR, Goyal V, Tripathi M, Gupta R, Chadda RK, Vanamail P, Hariprasad G*. Evaluation of Serum Apolipoprotein E as a Potential Biomarker for Pharmacological Therapeutic Efficacy Monitoring in Dopamine Dictated Disease Spectrum of Schizophrenia and Parkinson's disease: A Preliminary Study. J Cent Nerv Syst Dis. (2018) 10:1179573518803585. eCollection

2. Trypamosoma cruzi PAFAH

3. Trypanosoma brucei PAFAH

4. Leishmania donovani PAFAH with D1

5. Trypanosoma cruzi PAFAH with C1

6. Trypanosoma crucei PAFAH with B1

7. Molecular modeling of JN.1 (BA.2.86.1.1) variant spike protein complex with human ACE-2 receptor: Structural basis to understand potency of the virus