Dr. Pradeep Sharma

Photograph

Current Designation & Contact Details

Assistant Professor

Room No. 9, Department of Biophysics, AIIMS, New Delhi

Email: This email address is being protected from spambots. You need JavaScript enabled to view it. & This email address is being protected from spambots. You need JavaScript enabled to view it.

Phone: +91-11-26594608

Brief Research Area

Antimicrobial therapeutics, Protein Structure based drug design, Nanomedicine.

Awards & Honours

1. INSA Young Scientist Award (2013)

2. DST-INSPIRE Faculty Award (2012)

3. Ludo Frevel Crystallography Award, ICDD, USA (2011)

4. Summer Training Award at ESRF, Grenoble, France (European Commission, 2009)

5. Chaired, Society of Young Scientists, AIIMS, New Delhi (2009-10)

6. IUCr Travel award to attend IUCr meeting at Osaka, Japan (2008)

7. Awarded CSIR-Junior Research Fellowship (03.2006 – 03.2008)

8. Awarded CSIR Senior Research Fellowship (04.2008- 03.2011)

9. Gold Medalist from Maharshi Dayanand University, Rohtak-2005

Selected Publications/Patents (Last 5 years)

Google Scholar Link:

https://scholar.google.com/citations?hl=en&user=h-T3UPYAAAAJ

1. Ahmad N, Singh A, Gupta A, Pant P, Singh TP, Sharma S, Sharma P. Discovery of the Lead Molecules Targeting the First Step of the Histidine Biosynthesis Pathway of Acinetobacter baumannii. J Chem Inf Model. (2022) 62 :1744-1759.

2. Sikarwar J, Singh J, Singh TP, Sharma P, Sharma S. The mechanism of action of Lactoferrin - Nucleoside Diphosphate Kinase complex in combating biofilm formation. Protein Pept Lett. (2022) Aug 16. doi: 10.2174/0929866529666220816160517.

3. Singh PK, Ahmad N, Yamini S, Singh RP, Singh AK, Sharma P, Smith ML, Sharma S, Singh TP. Structural evidence of the oxidation of iodide ion into hyper-reactive hypoiodite ion by mammalian heme lactoperoxidase. Protein Sci. (2022) 31:384-395.

4. Singh J, Maurya A, Singh PK, Viswanathan V, Ahmad MI, Sharma P, Sharma S, Singh TP. A Peptide Bond from the Inter-lobe Segment in the Bilobal Lactoferrin Acts as a Preferred Site for Cleavage for Serine Proteases to Generate the Perfect C-lobe: Structure of the Pepsin Hydrolyzed Lactoferrin C-lobe at 2.28 Å Resolution. Protein J. (2021) 40 :857-866.

5. Gupta A, Vijayan V, Pant P, Kaur P, Singh TP, Sharma P, Sharma S. Structure prediction and discovery of inhibitors against phosphopantothenoyl cysteine synthetase of Acinetobacter baumannii. J Biomol Struct Dyn. (2021) Aug 4:1-13

6. Singh A, Ahmad N, Varadarajan A, Vikram N, Singh TP, Sharma S, Sharma P. Lactoferrin, a potential iron-chelator as an adjunct treatment for mucormycosis - A comprehensive review. Int J Biol Macromol. (2021) Sep 30;187:988-998.

7. Singh J, Vijayan V, Ahmedi S, Pant P, Manzoor N, Singh TP, Sharma P, Sharma S. Lactosmart: A Novel Therapeutic Molecule for Antimicrobial Defense. Front Microbiol. (2021) 12:672589.

8. Gupta A, Sharma P, Singh TP & Sharma S. Phosphopantetheine Adenylyltransferase: A promising drug target to combat antibiotic resistance. Biochim Biophys Acta Proteins Proteom (2021) 1869:140566.

9. Viswanathan V, Rani C, Ahmad N, Singh PK, Sharma P, Kaur P, Sharma S & Singh TP Structure of Yak Lactoperoxidase at 1.55 Å Resolution. Protein J. (2021) 40:8-18.

10. Singh PK, Pandey S, Rani C, Ahmad N, Viswanathan V, Sharma P, Kaur P, Sharma S & Singh TP. Potassium-induced partial inhibition of lactoperoxidase: structure of the complex of lactoperoxidase with potassium ion at 2.20 Å resolution. J Biol Inorg Chem (2021) 26: 149-159

11. Sharma P, Singla A, Gupta A, Khan NI, Rani C, Singh TP & Sharma S. Biophysical characterization of Type III Pantothenate kinase (PanK) from Acinetobacter baumannii. Protein Pept Lett (2021) 28(4), 450-458.

12. Sharma P, Vijayan V, Pant P, Sharma M, Vikram N, Kaur P, Singh TP, Sharma S. Identification of potential drug candidates to combat COVID-19: a structural study using the main protease (mpro) of SARS-CoV-2. J Biomol Struct Dyn. 2020; 3:1-11

13. Gupta A, Singh PK, Iqbal N, Sharma P, Baraigya HR, Kaur P, Umar MS, Ahmad F, Sharma A, Owais M, Sharma S, Singh TP. Structural and binding studies of phosphopantetheine adenylyl transferase from Acinetobacter baumannii. Biochim Biophys Acta Proteins Proteom. (2019) 1867:537-547.

14. Pandey SN, Iqbal N, Singh PK, Rastogi N, Kaur P, Sharma S & Singh TP. Binding and structural studies of the complexes of type 1 ribosome inactivating protein from Momordica balsamina with uracil and uridine. Proteins. (2019) 87:99-109.

15. Chaudhary A, Kumar V, Singh PK, Sharma P, Bairagya HR, Kaur P, Sharma S & Singh TP. A glycoprotein from mammary gland secreted during involution promotes apoptosis: Structural and biological studies. Arch Biochem Biophys. (2018) 644:72-80

16. Kaushik S, Iqbal N, Singh N, Sikarwar JS, Singh PK, Kaur P, Sharma S & Singh TP. Search of multiple hot spots on the surface of peptidyl-tRNA hydrolase: structural, binding and antibacterial studies. Biochem J. (2018) 475:547-560.

17. Singh PK, Iqbal N, Sirohi HV, Bairagya HR, Kaur P, Sharma S & Singh TP. Structural basis of activation of mammalian heme peroxidases. Prog Biophys Mol Biol. (2018)133:49-55.

18. Singh PK, Sirohi HV, Iqbal N, Tiwari P, Kaur P, Sharma S, Singh TP. Structure of bovine lactoperoxidase with a partially linked heme moiety at 1.98Å resolution. Biochim Biophys Acta. (2017) 1865:329-335.

19. Iqbal N, Kumar M, Sharma P, Yadav SP, Kaur P, Sharma S, Singh TP. Binding studies and structure determination of the recombinantly produced type-II 3-dehydroquinate dehydratase from Acinetobacter baumannii. Int J Biol Macromol. (2017) 94:459-465.

20. Sirohi HV, Singh PK, Iqbal N, Sharma P, Singh AK, Kaur P, Sharma S, Singh TP. Design of anti-thyroid drugs: Binding studies and structure determination of the complex of lactoperoxidase with 2-mercaptoimidazole at 2.30 Å resolution. Proteins. (2017) 85:1882-1890.

21. Singh RP, Singh A, Sirohi HV, Singh AK, Kaur P, Sharma S, Singh TP. Dual binding mode of antithyroid drug methimazole to mammalian heme peroxidases - structural determination of the lactoperoxidase-methimazole complex at 1.97 Å resolution. FEBS Open Bio. (2016) 6:640-50.

22. Rastogi N, Singh A, Singh PK, Tyagi TK, Pandey S, Shin K, Kaur P, Sharma S, Singh TP. Structure of iron saturated C-lobe of bovine lactoferrin at pH 6.8 indicates a weakening of iron coordination. Proteins. (2016) 84:591-9.