Dr. Mahendra Seervi's Lab
(Cell Death and Cancer Biology Lab)
(Cell Death and Cancer Biology Lab)
Recent Publications:
- ONC212, alone or in synergistic conjunction with Navitoclax (ABT-263), promotes cancer cell apoptosis via unconventional mitochondrial-independent caspase-3 activation Vishal Basu1†, Shabnam1†, Yamini Murghai, Maqsood Ali, Swetangini Sahu, Bhupendra K. Verma, Mahendra Seervi* Cell Communication and Signaling (2024) 22:441; doi.org/10.1186/s12964-024-01817-1
- Heat shock proteins-driven stress granule dynamics: Yet another avenue for cell survival. (review article) Akanksha Verma, Sumi S, Mahendra Seervi Apoptosis, May 2021; doi: 10.1007/s10495-021-01678-w
- Molecular profiling of anastatic cancer cells: potential role of the nuclear export pathway. Mahendra Seervi*, Sumi S, Aneesh Chandrasekharan, Abhay K. Sharma, T. R. Santhosh Kumar. (*Corresponding author) Cellular oncology, May 2019.doi: 10.1007/s13402-019-00451-1
- ROS mediated ER stress induces Bax-Bak dependent and independent apoptosis in response to Thioridazine. Mahendra Seervi*, Ankita Rani, Abhay K. Sharma, T. R. Santhosh Kumar. (*Corresponding author) Biomedicine & Pharmacotherapy, 2018; doi.org/10.1016/j.biopha.2018.06.123.
Book Chapter:
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Mitochondrial cell death pathways in Caenorhabiditis elegans.
Mahendra Seervi*, Ding Xue. (*Co-corresponding author)
Current Topics in Developmental Biology, 2015;114: 43-65.doi:10.1016 /bs.ctdb.2015.07.019.
Other important publications:
- A high-throughput image-based screen for the identification of Bax/Bak-independent caspase activators against drug-resistant cancer cells. Mahendra Seervi, Praveen K. Sobhan, Krupa Ann Mathew, Jeena Joseph, Prakash R. Pillai, Santhosh kumar T. R. Apoptosis, 2014; 19(1):269-84. doi: 10.1007/s10495-013-0921-8
- ERO1α dependent endoplasmic reticulum - mitochondrial calcium flux contributes for ER stress and mitochondrial permeabilisation by procaspase-activating compound (PAC-1). Mahendra Seervi, P K. Sobhan, Jeena Joseph, Krupa Ann Mathew, Santhosh Kumar T.R. Cell Death & Disease, 2013; 4, e968. doi:10.1038/cddis.2013.502
- Essential requirement of cytochrome c release for caspase activation by procaspase activating compound defined by cellular models. Mahendra Seervi, Jeena Joseph, P K. Sobhan, Bhavya B.C., Santhosh Kumar T.R. Cell Death & Disease, 2011; 2, e207. doi:10.1038/cddis.2011.90
- Identification of Heat Shock Protein 90 inhibitors to sensitize drug resistant side population tumor cells using a cell-based assay platform. Praveen K. Sobhan, Mahendra Seervi, Jeena Joseph, Bhavya B.C., Saneesh Varghese, Santhosh Kumar T.R. Cancer Letters, 2012; 317(1):78-88. doi: 10.1016/j.canlet.2011.11.009
For other publications, follow the link below:
https://scholar.google.com/citations?user=Gz_HQYoAAAAJ&hl=en