Default Theme
AIIMS NEW
-
अखिल भारतीय आयुर्विज्ञान संस्थान, नई दिल्ली
All India Institute Of Medical Sciences, New Delhi

Ms. Asha Bhushan

Ms. Asha Bhushan

Designation Scientist-IV
Email This email address is being protected from spambots. You need JavaScript enabled to view it. , This email address is being protected from spambots. You need JavaScript enabled to view it.
Contact Number +91-11-26594608, +91-11-26593201
Research Interests

 

Protein Structure Determination ; Data Collection and processing on High intensity X-Ray Beam, Cryocooling: Drug Design

Awards

 

 

 

 

 

 

 

 

 

Life Member of Indian Biophysical Society
Life Member of Indian Crystallographic Association
Life member of International Union of crystallography
Member of Asian Biophysical Society
Board Member of IJBST and its associated Journals http://ijbst.org
Selected for attending  "The XIX IUCr Congress and General Assembly in Geneva” 2002
The Outstanding scientist of the 21st century award by International Biographical Centre, Cambridge in 2007
Bursary for the 9th International conference on Biology and Synchrotron radiation from 13-17 August 2007  
Invited by  Prof. Kyriacos Petratos for  structure determination (BIOXIT) course in crystallography i
Selected for attending the CCP4 study weekend, 2010, East Midland, England.  
Honored with “Bharat Jyoti Award”  in the seminar “Economic Growth & National Integration”  by IIFS society on 26th March 2014 in New Delhi.

Selected as the outstanding scientist of the 21st century award by International Biographical Centre, Cambridge, England.; 2009

Recent Significant Publications

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Singh A, Gautam L, Sinha M, Bhushan A, Kaur P, Sharma S, Singh TP. Crystal structure of peptidyl-tRNA hydrolase from a Gram-positive bacterium, Streptococcus pyogenes at 2.19 Å resolution shows the closed structure of the substrate-binding cleft. FEBS Open Bio. 2014 Oct 22;4:915-22. 
 
Singh A, Kumar A, Gautam L, Sharma P, Sinha M, Bhushan A, Kaur P, Sharma S, Arora A, Singh TP. (2014) Structural and binding studies of peptidyl-tRNA hydrolase from Pseudomonas aeruginosa provide a platform for the structure-based inhibitor design against peptidyl-tRNA hydrolase. Biochem J. 463 : 329-37.
 
Rastogi N, Singh A, Pandey SN, Sinha M, Bhushan A, Kaur P, Sharma S, Singh TP. (2014) Structure of the iron-free true C-terminal half of bovine lactoferrin produced by tryptic digestion and its functional significance in the gut. FEBS J. 281:2871-82. 
 
Kumar S, Singh N, Sinha M, Dube D, Singh SB, Bhushan A, Kaur P, Srinivasan A, Sharma S, Singh TP.(2010): Crystal structure determination and inhibition studies of a novel xylanase and alpha-amylase inhibitor protein (XAIP) from Scadoxus multiflorusFEBS J.: 277(13):2868-82. 
 
Mir, R., Singh, N., Vikram, G.,  Sinha, M., Bhushan, A., Kaur, P., Srinivasan, A., Sharma, S. & Singh, T.P. (2010).  Structural and binding studies of C-terminal half (C-lobe) of lactoferrin protein with COX-2-specific non-steroidal anti-inflammatory Drugs (NSAIDs). Arch. Biochem. Biophy.  500 , 196  - 202  
 
Mir R, Kumar RP, Singh N, Vikram GP, Sinha M, Bhushan A, Kaur P, Srinivasan A, Sharma S, Singh TP. (2010). Specific interactions of C-terminal half (C-lobe)  of lactoferrin protein with edible sugars: binding and structural studies with implications on diabetes.  Int J Biol Macromol.47,  50-9. 
 
Sheikh, I.A., Singh, A.K.,  Singh, N., Sinha, M., Singh, S.B., Bhushan, A., Kaur, P., Srinivasan, A., Sharma, S. & Singh, T.P. (2009). Structural evidence of substrate specificity in mammalian peroxidases: Structure of the thiocyanate complex with lactoperoxidase and its interactions at 2.4A resolution. J.  Biol.  Chem.  284, 14849  - 14856. 
 
Singh, A.K., Kumar, R.P., Pandey, N.,  Singh, N., Sinha, M.,  Bhushan, A.,Kaur, P.,  Sharma, S.   &  Singh, T.P. (2009). Mode of binding of the tuberculosis prodrug isoniazid to peroxidases: Crystal structure of bovine lactoperoxidase with isoniazid at 2.7A resolution. J.  Biol.  Chem.  285  ,  1569 - 1576   
 
Mir, R., Singh, N., Vikram, G., Kumar, R.P., Sinha, M., Bhushan, A., Kaur, P., Srinivasan, A., Sharma, S. & Singh, T.P. (2009)). Structural basis of the prevention  NSAID-induced damage of the gastrointestinal tract by C-terminal half (C-lobe)  of bovine colostrums protein lactoferrin: Binding andstructural studies of the C-lobe complexes with indomethacin, diclofenac, aspirin and ibuprofen. Biophys.  J.  97,  3178 – 3186   
 
Singh, R.K., Ethayathulla, A.S., Jabeen, T.,  Sharma, S.,  Kaur, P.  &  Singh, T.P. (2005) . Aspirin induces its anti-inflammatory effects through its specific binding to phospholipase A2 : Crystal structure of the complex formed between phospholipase A2 and aspirin at 1.9 Å resolution.  J. Drug Target.  13 ,  113 – 119.  
 

Contact Us

All India Institute of Medical Sciences

Ansari Nagar, New Delhi - 110029

Board Number : +91-11-26588500 / 26588700

Fax : +91-11-26588663 / 26588641

AIIMS Exam Section Helpline numbers ( Click Here)

Important E-mail Addresses at AIIMS

Top of Page